Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstate

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 4 50-4, 2001, Pages

  Ochiai, K ^a   Zhang, J ^a   Gong, G ^a   Zhang, Y ^a   Liu, J ^a   Ye, Y ^a   Wu, X ^a   Liu, H ^a   Muraka Mi, Y ^a   Bache, R J ^a   Ugurbil, K ^a   From, A H L ^a  

^a University of Minnesota   (United States)

Author keywords

Catecholamines; Magnetic resonance spectroscopy; Oxygen consumption

Indexed keywords

ACYL COENZYME A; ADENOSINE TRIPHOSPHATE; CARBON; CREATINE PHOSPHATE; DEOXYHEMOGLOBIN; DOBUTAMINE; DOPAMINE; PALMITOYLCARNITINE; PHOSPHATE; PYRUVIC ACID; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; FATTY ACID TRANSPORT; GLYCOLYSIS; HEART MUSCLE OXYGEN CONSUMPTION; INFUSION; MITOCHONDRION; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0034786454     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.4.h1823     Document Type: Article

References (37)

1. Relation between work and phosphate metabolites in the in vivo paced mammalian heart
2. Antioxidant pyruvate inhibits cardiac formation of reactive oxygen species through changes in redox state
3. Function and production of nitric oxide in the coronary circulation of the conscious dog during exercise
4. Nitric oxide and mitochondrial respiration
5. Fluorometric studies of oxidative metabolism in isolated papillary muscle of the rabbit
6. 1H NMR spectroscopy
7. Regulation of the oxidative phosphorylation rate in the intact cell
8. Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism
9. Construction and evaluation of a coronary catheter for chronic implantation
10. Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels
11. 1 voxel shifting of phase-modulated spectroscopic localization techniques
12. Phase modulated rotating frame spectroscopic localization using an adiabatic plane rotation pulse and a single surface coil
13. A second mechanism of respiratory control
14. Effects of β-hydroxybutyrate on oxidative metabolism and phosphorylation potential in canine heart in vivo
15. 31P NMR measurements of mitochondrial uncoupling in isolated rat hearts
16. The relationship between phosphorylation potential and redox state in the isolated working rabbit heart
17. Pyruvate and lactate metabolism in the in vivo dog heart
18. Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics
19. Role of calcium ions in regulation of mammalian intromitochondrial metabolism
20. Effect of inhibition of lipolysis on myocardial oxygen consumption in the presence of isoproterenol
21. Free fatty acids and oxygen consumption in dogs
22. Myocardial oxygenation during high work states in hearts with postinfarction remodeling
23. Myocardial utilization of carbohydrates and lipids
24. The regulation of pyruvate dehydrogenase in the isolated perfused rat heart
25. Partitioning of pyruvate between oxidation and anaplerosis in swine heart
26. 31P NMR spectroscopy
27. Spectroscopic imaging and spatial localization using adiabatic pulses and applications to detect transmural metabolite distribution in the canine heart
28. The modulation of oxygen radical production by nitric oxide in mitochondria
29. Myoglobin oxygen dissociation by multiwavelength spectroscopy
30. Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts
31. Inhibition of fatty acid metabolism alters myocardial high-energy phosphates in vivo
32. 2 consumption, high-energy phosphates, and substrate uptake in porcine right ventricle
33. Measurement of an individual rate constant in the presence of multiple exchanges: Application to myocardial creatine kinase rates
34. Peroxynitrite-mediated decarboxylation of pyruvate to both carbon dioxide and carbon dioxide radical anion
35. Nuclear magnetic resonance studies of cationic and energetic alterations with oxidant stress in the perfused heart. Modulation with pyruvate and lactate
36. Transmural bioenergetic responses of normal myocardium to high workstates
37. Oxygen delivery does not limit cardiac performance during high work states