Apoptosis: A potentially reversible, meta-stable state of the heart

Heart Failure Reviews

Volumn 13, Issue 2, 2008, Pages 175-179

  Masri, Carolina ^a   Chandrashekhar, Y ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Heart failure; Remodeling

Indexed keywords

CASPASE 3; CASPASE 9; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CONTRACTILE PROTEIN; CYTOCHROME C; CYTOKINE; CYTOPLASM PROTEIN; NUCLEAR PROTEIN; PROTEIN BCL XL; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; CELL DAMAGE; CELL DEATH; CELL FATE; CELL LOSS; CELL REGENERATION; CELL STRESS; CELL SURVIVAL; CONVALESCENCE; DISEASE COURSE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HEART ASSIST DEVICE; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE REVASCULARIZATION; HUMAN; MYOCARDIAL HIBERNATION; PATHOPHYSIOLOGY; PHASE TRANSITION; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION; SYSTOLIC DYSFUNCTION; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASES; DISEASE PROGRESSION; HEART FAILURE; HEART VENTRICLES; HUMANS; MYOCYTES, CARDIAC; VENTRICULAR REMODELING;

EID: 41249087880     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-007-9069-3     Document Type: Review

References (27)

1. American Heart Association: Heart Disease and Stroke Statistics (2007) Circulation 115:e69-e171
2. Narula J, Young JB (2005) Pathogenesis of heart failure: The penultimate survival instinct. Heart Fail Clin 1:iX-x
3. Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, Sonnenblick E (1995) The cellular basis of dilated cardiomyopathy in humans. J Mol Cell Cardiol 27:291-305
4. Pouleur HG, Konstam MA, Udelson JE, Rousseau MF (1993) Changes in ventricular volume, wall thickness and wall stress during progression of left ventricular dysfunction. The SOLVD investigators. J Am Coll Cardiol 22:43A-48A
5. Chandrashekhar Y, Narula J (2003) Death hath a thousand doors to let out life. Circ Res 92:710-714
6. Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM et al (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 111:1497-1504
7. Hayakawa K, Takemura G, Kanoh M, LiY, Koda M, Kawase Y et al (2003) Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodelling and dysfunctionat the chronic stage. Circulation 108:104-109
8. Chandrashekhar Y, Sen S, Anway R, Shuros A, Anand I (2004) Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction. J Am Coll Cardiol 43:295-301
9. Narula J, Haider N, Virmani R et al (1996) Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335:1182-1189
10. Olivetti G, Abbi R, Quaini F et al (1997) Apoptosis in the failing human heart. N Eng J Med 336:1131-1141
11. Garg S, Narula J, Chandrashekhar Y (2005) Apoptosis and heart failure: clinical relevance and therapeutic target. J Mol Cell Cardiol 38:73-79
12. Anversa P (2000) Myocyte death in the pathological heart. Circ Res 86:121-124
13. Narula J, Arbustini E, Chandrashekhar Y, Schwaiger M (2001) Apoptosis and the systolic dysfunction in congestive heart failure: Story of apoptosis interruptus and Zombie myocytes. Cardiol Clin 19:113-126
14. Narula J, Pandey P, Arbustini E et al (1999) Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proc Natl Acad Sci USA 96:8144-8149
15. Reed JC, Paternostro G (1999) Postmitochondrial regulation of apoptosis during heart failure. Proc Natl Acad Sci USA 996:7614-7616
16. Narula J, Haider N, Arbustini E, Chandrashekhar Y (2006) Mechanisms of disease: Apoptosis in heart failure-seeing hope in death. Nat Clin Pract Cardiovasc Med 3:681-688
17. Haider N, Narula N, Narula J (2002) Apoptosis in heart failure represents programmed cell survival, not death, of cardiomyocytes and likelihood of reverse remodelling. J Card Fail 8(6 Suppl):S512-S517
18. Kanoh M. Takemura G. Miaao J. Hayakawa Y, Aoyama T, Nishigaki K, Noda T, Fujiwara T, Fukuda K, Mitatoguchi S, Fujiwara H (1999) Significance of myocytes with DNA in situ nick-end labeling (TUNEL) in hearts with dilated cardiomyopathy: Not apoptosis but DNA repair. Circulation 99:2757-2764
19. Morissette MR, Rosenzweig A (2005) Targeting survival signaling in heart failure. Curr Opin Pharmacol 5:165-170
20. Narula N, Narula J, Zhang PJ et al (2005) Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte? Ann Thorac Surg 79:1333-1337
21. Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ (2002) Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci USA 99:6252-6256
22. Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P (1997) Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 185:1481-1486
23. Grazette LP, Boecker W, Matsui T et al (2004) Inhibition of ErbB2 causes mitochondrial dysfunction in cardio-myocytes. Implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol 44:2231-2238
24. Crone SA, Zhao YY, Fan L et al (2002) ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 8:459-465
25. Matsui T, Tao J, del Monte F et al (2001) Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104:330-335
26. Bartling B, Milting H, Schumann H et al (1999) Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure. Circulation 100:216-223
27. Arbustini E, Norbini P, Narula J et al (2001) Apoptosis in heart failure: Abrogation of cytochrome c release after ventricular unloading by LVAD (abstr). Med Pathol