An experimental comparative study of dexamethasone, melatonin and tacrolimus in noise-induced hearing loss

Acta Oto-Laryngologica

Volumn 129, Issue 4, 2009, Pages 385-389

  Bas, Esperanza ^a   Martinez Soriano, Francisco ^b   Láinez, José M ^c   Marco, Jaime ^b,c  

^a Hospital Clnico Universitario Research Foundation

^b UNIVERSITY OF VALENCIA   (Spain)

^c Hospital Clnico Universitario   (Spain)

Author keywords

ABR threshold; Anti inflammatory; Antioxidant; Calcineurin inhibitor; DPOAE; Otoprotection; Rat

Indexed keywords

DEXAMETHASONE; MELATONIN; PROTEIN C FOS; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISTORTION PRODUCT OTOACOUSTIC EMISSION; DRUG EFFECT; EAR PROTECTION; ELECTROCOCHLEOGRAPHY; EVOKED BRAIN STEM AUDITORY RESPONSE; GENE EXPRESSION; HAIR CELL; HEARING LOSS; NOISE POLLUTION; NONHUMAN; PRIORITY JOURNAL; RAT; WHITE NOISE; WISTAR RAT; ANIMAL; COMPARATIVE STUDY; MALE; METABOLISM; NOISE INJURY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPONTANEOUS OTOACOUSTIC EMISSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; DEXAMETHASONE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS, NOISE-INDUCED; IMMUNOSUPPRESSIVE AGENTS; MALE; MELATONIN; OTOACOUSTIC EMISSIONS, SPONTANEOUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TACROLIMUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 66349083612     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480802566279     Document Type: Article

References (5)

1. So H, Kim H, Lee J, Park C, Kim Y, Kim E, et al. Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kB. J Assoc Res Otolaryngol 2007;/8:/338-55.
2. Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, et al. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 2000;/20:/43-50.
3. Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U. Blockade of c-Jun N-terminal kinase pathway attenuates gentamicininduced cochlear and vestibular hair cell death. Hear Res 2002;/163:/71-81. (Pubitemid 34098843)
4. Coleman J, Littlesunday C, Jackson R, Meyer T. AM-111 protects against permanent hearing loss from impulse noise trauma. Hear Res 2007;/226:/70-8.
5. Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy- from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta 2005;/1754:/ 253-262