A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12

Genetic Epidemiology

Volumn 33, Issue 3, 2009, Pages 207-216

  Bellenguez, Céline ^a,b   Ober, Carole ^c   Bourgain, Catherine ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Asthma; Complex pedigrees; Hutterite; Pedigree breaking

Indexed keywords

ARTICLE; ASTHMA; CHROMOSOME 12Q; CHROMOSOME ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOMICS; LINKAGE ANALYSIS; PEDIGREE ANALYSIS;

ASTHMA; CHROMOSOMES, HUMAN, PAIR 12; COMPUTATIONAL BIOLOGY; HUMANS; LINKAGE (GENETICS); PEDIGREE;

EID: 66249145038     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20371     Document Type: Article

References (26)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. 2002. Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101.
2. Barnes KC, Freidhoff LR, Nickel R, Chiu YE, Juo SH, Hizawa N, Naidu RP, Ehrlich E, Duffy DL, Schou C, Levett IN, March DG, Beaty TH. 1999. Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy. J Allergy Clin Immunol 104:485-491.
3. Barnes KC, Neely JD, Duffy DL, Freidhoff LR, Breazeale DR, Schou C, Naidu RP, Levett PN, Renault B, Kucherlapati R, Iozzino S, Ehrlich E, Beaty TH, Marsh DG. 1996. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics 37:41-50.
4. Blumenthal MN, Rich SS, King R, Weber J. 1998. Approaches and issues in defining asthma and associated phenotypes map to chromosome susceptibility areas in large Minnesota families. The Collaborative Study for the Genetics of Asthma (CSGA). Clin Exp Allergy 28:51-55; discussion 65-66.
5. Celedon JC, Soto-Quiros ME, Avila L, Lake SL, Liang C, Fournier E, Spesny M, Hersh Cp, Sylvia JS, Hudson TJ, Verner A, Klanderman BJ, Freimer NB, Silverman EK, Weiss ST. 2007. Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica. Hum Genet 120:691-699.
6. Chapman NH, Wijsman EM. 2001. Introduction: linkage analyses in the Hutterites. Genet Epidemiol 21:S222-S223.
7. Chapman NE, Leutenegger AL, Badzioch MD, Bogdan M, Conlon EM, Daw EW, Gagnon F, Li N, Maia JM, Wijsman EM, Thompson EA. 2001. The importance of connections: joining components of the Hutterite pedigree. Genet Epidemiol 21:S230-235.
8. Ciullo M, Bellenguez C, Colonna V, Nutile T, Calabria A, Pacente R, Iovino G, Trimarco B, Bourgain C, Persico MG. 2006. New susceptibility locus for hypertension on chromosome 8q by efficient pedigree-breaking in an Italian isolate. Hum Mol Genet 15:1735-1743.
9. Ciullo M, Nutile T, Dalmasso C, Sorice R, Bellenguez C, Colonna V, Persico MG, Bourgain C. 2008. Identification and replication of a novel obesity locus n chromosome 1q24 in isolated populations of Cilento. Diabetes 57:783-790.
10. CSGA. 1997. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 15:389-392.
11. Dizier MH, Besse-Schmittler C, Guilloud-Bataille M, Annesi-Maesano I, Boussaha M, Bousquet J, Charpin D, Degioanni A, Gormand F, Grimfeld A, Hochez J, Hyne G, Lockhart A, Luillier-Lacombe M, Matran R, Meunier F, Neukirch F, Pacheco Y, Parent V, Paty E, Pin I, Pison C, Scheinmann P, Thobie N, Vervloet D, Kauffmann F, Feingold J, Lathrop M, Demenais F. 2000. Genome screen for asthma and related phenotypes in the French EGEA study. Am J Respir Crit Care Med 162:1812-1818.
12. Dyer TD, Blangero J, Williams JT, Goring HH, Mahaney MC. 2001. The effect of pedigree complexity on quantitative trait linkage analysis. Genet Epidemiol 21:S236-S243.
13. Falchi M, Fuchsberger C. 2008. Jenti: an efficient tool for mining complex inbred genealogies. Bioinformatics 24:724-726.
14. Falchi M, Forabosco P, Mocci E, Borlino CC, Picciau A, Virdis E, Persico I, Parracciani D, Angius A, Pirastu M. 2004. A genomewide search using an original pairwise sampling approach for large genealogies identifies a new locus for total and low-density lipoprotein cholesterol in two genetically differentiated isolates of Sardinia. Am J Hum Genet 75:1015-1031.
15. Greenwood CM, Bureau A, Loredo-Osti JC, Roslin NM, Crumley MJ, Brewer CG, Fujiwara TM, Goldstein DR, Morgan K. 2001. Pedigree selection and tests of linkage in a Hutterite asthma pedigree. Genet Epidemiol 21:S244-251.
16. Gudbjartsson DF, Jonasson K, Frigge ML, Kong A, 2000. Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13.
17. Kong A, Cox NJ. 1997. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188.
18. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
19. Lander ES, Green P. 1987. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 84:2363-2367.
20. Nickel R, Wahn U, Hizawa N, Maestri N, Duffy DL, Barnes KC, Beyer K, Forster J, Bergmann R, Zepp F, Wahn V, Marsh DG. 1997. Evidence for linkage of chromosome 12q15-q241 markers to high total serum IgE concentrations in children of the German Multi-center Allergy Study. Genomics 46:159-162.
21. Ober C, Tsalenko A, Parry R, Cox NJ. 2000. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 67:1154-1162.
22. Pardo LM, MacKay I, Oostra B, van Duijn CM, Aulchenko YS. 2005. The effect of genetic drift in a young genetically isolated population. Ann Hum Genet 69:288-295.
23. Pritchard JK, Cox NJ. 2002. The allelic architecture of human disease genes: common disease-common variant..or not? Hum Mol Genet 11:2417-2423.
24. Thompson EA. 2005. Onte caRIo Genetic ANalysis (MORGAN).
25. Wjst M, Fischer G, Immervoll T, Jung M, Saar K, Rueschendorf F, Reis A, Ulbrecht M, Gomolka M, Weiss EH, Jaeger L, Nickel R, Richter K, Kjellman NI, Griese M, von Berg A, Gappa M, Riedel F, Boehle M, van Koningsbruggen S, Schoberth P, Szczepanski R, Dorsch W, Silbermann M, Wichmann HE. 1999. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 58:1-8.
26. Yokouchi Y, Nukaga Y, Shibasaki M, Noguchi E, Kimura K, Ito S, Nishihara M, Yamakawa-Kobayashi K, Takeda K, Imoto N et al. 2000. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 66:152-160.