Overaccumulation of transforming growth factor-β1 and basic fibroblast growth factor in lens epithelial cells of congenital cataract

Canadian Journal of Ophthalmology

Volumn 44, Issue 2, 2009, Pages 189-192

  Xiao, Ying ^a   Zhao, Bojun ^b   Gao, Zhijuan ^a   Pan, Qingmin ^a  

^a THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Basic fibroblast growth factor; Congenital cataract; Lens epithelial cells; Transforming growth factor 1

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CASE CONTROL STUDY; CHILD; COMPARATIVE STUDY; CONGENITAL CATARACT; CONTROLLED STUDY; CORRELATION ANALYSIS; EPITHELIUM CELL; EXTRACAPSULAR CATARACT EXTRACTION; EYE; FEMALE; GENE; HUMAN; HUMAN CELL; LENS EPITHELIUM; MALE; NEWBORN; OPTICAL INSTRUMENTATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE; WESTERN BLOTTING;

EID: 66249099892     PISSN: 00084182     EISSN: 17153360     Source Type: Journal    
DOI: 10.3129/i09-006     Document Type: Article

References (12)

1. Cerra A, Mansfield KJ, Chamberlain CG. Exacerbation of TGF-beta-induced cataract by FGF-2 in cultured rat lenses. Mol Vis 2003;9:689-700.
2. Gordon-Thomson C, de Iongh RU, Hales AM, Chamberlain CG, McAvoy JW. Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci 1998;39:1399-409.
3. Hales AM, Chamberlain CG, Dreher B, McAvoy JW. Intravitreal injection of TGF beta induces cataract in rats. Invest Ophthalmol Vis Sci 1999;40:3231-6.
4. Symonds JG, Lovicu FJ, Chamberlain CG. Posterior capsule opacification-like changes in rat lens explants cultured with TGF beta and FGF: effects of cell coverage and regional differences. Exp Eye Res 2006;82:693-9.
5. Hales AM, Chamberlain CG, McAvoy JW. Cataract induction in lenses cultured with transforming growth factor-beta. Invest Ophthalmol Vis Sci 1995;36:1709-13.
6. McAvoy JW, Chamberlain CG. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development 1989;107:221-8.
7. Lee EH, Joo CK. Role of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells. Invest Ophthalmol Vis Sci 1999;40:2025-32.
8. Rasmussen R. Quantification on the lightcycler real-time PCR. In Meuer S, Witter C, Nakagawara K, eds. Rapid Cycle Real-Time PCR, Methods and Applications. Springer Press, Heidelberg; 2001:21-30.
9. Liu J, Hales AM, Chamberlain CG, McAvoy JW. Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Invest Ophthalmol Vis Sci 1994;35:388-401.
10. Srinivasan Y, Lovicu FJ, Overbeek PA. Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest 1998;101:625-34.
11. Lovicu FJ, Ang S, Chorazyczewska M, McAvoy JW. Deregulation of lens epithelial cell proliferation and differentiation during the development of TGF beta-induced anterior subcapsular cataract. Dev Neurosci 2004;26:446-55.
12. Mansfield KJ, Cerra A, Chamberlain CG. FGF-2 counteracts loss of TGF beta affected cells from rat lens explants: implications for PCO (after cataract). Mol Vis 2004;10:521-32.