-
1
-
-
0029891262
-
The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor
-
39277 8643606 10.1073/pnas.93.11.5512
-
Junghans RP Anderson CL The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor Proc Natl Acad Sci USA 1996, 93:5512-5516. 39277 8643606 10.1073/pnas.93.11.5512
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5512-5516
-
-
Junghans, R.P.1
Anderson, C.L.2
-
2
-
-
0023897194
-
The binding site for C1q on IgG
-
10.1038/332738a0 3258649
-
Duncan A Winter G The binding site for C1q on IgG Nature 1988, 332:738-740. 10.1038/332738a0 3258649
-
(1988)
Nature
, vol.332
, pp. 738-740
-
-
Duncan, A.1
Winter, G.2
-
3
-
-
0023933120
-
Localization of the binding site for the human high-affinity Fc receptor on IgG
-
10.1038/332563a0 2965792
-
Duncan A Woof J Partridge L Burton D Winter G Localization of the binding site for the human high-affinity Fc receptor on IgG Nature 1988, 332:563-564. 10.1038/332563a0 2965792
-
(1988)
Nature
, vol.332
, pp. 563-564
-
-
Duncan, A.1
Woof, J.2
Partridge, L.3
Burton, D.4
Winter, G.5
-
4
-
-
0026050344
-
Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG
-
1833457
-
Lund J Winter G Jones PT Pound JD Tanaka T Walker MR Artymiuk PJ Arata Y Burton DR Jefferis R Woof JM Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG J Immunol 1991, 147:2657-2662. 1833457
-
(1991)
J Immunol
, vol.147
, pp. 2657-2662
-
-
Lund, J.1
Winter, G.2
Jones, P.T.3
Pound, J.D.4
Tanaka, T.5
Walker, M.R.6
Artymiuk, P.J.7
Arata, Y.8
Burton, D.R.9
Jefferis, R.10
Woof, J.M.11
-
5
-
-
0032532012
-
Therapy with monoclonal antibodies II. The contribution of Fcg receptor binding and the influence of Ch1 and Ch3 domains on in vivo effector function
-
9780151
-
Isaacs J Greenwood J Waldmann H Therapy with monoclonal antibodies II. The contribution of Fcg receptor binding and the influence of Ch1 and Ch3 domains on in vivo effector function J Immunol 1998, 161:3863-3869. 9780151
-
(1998)
J Immunol
, vol.161
, pp. 3863-3869
-
-
Isaacs, J.1
Greenwood, J.2
Waldmann, H.3
-
6
-
-
0032918724
-
IMGT, the international ImMunoGeneTics database
-
148137 9847182 10.1093/nar/27.1.209
-
Lefranc MP Giudicelli V Ginestoux C Bodmer J Muller W Bontrop R Lemaitre M Malik A Barbie V Chaume D IMGT, the international ImMunoGeneTics database Nucleic Acids Res 1999, 27:209-212. 148137 9847182 10.1093/nar/ 27.1.209
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 209-212
-
-
Lefranc, M.P.1
Giudicelli, V.2
Ginestoux, C.3
Bodmer, J.4
Muller, W.5
Bontrop, R.6
Lemaitre, M.7
Malik, A.8
Barbie, V.9
Chaume, D.10
-
7
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
10.1038/256495a0 1172191
-
Kohler G Milstein C Continuous cultures of fused cells secreting antibody of predefined specificity Nature 1975, 256:495-497. 10.1038/ 256495a0 1172191
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
8
-
-
0023502527
-
Monoclonal anti-CD4 in arthritis
-
2892019 10.1016/S0140-6736(87)91158-5
-
Herzog C Walker C Pichler W Aeschlimann A Wassmer P Stockinger H Knapp W Rieber P Muller W Monoclonal anti-CD4 in arthritis Lancet 1987, 8573:1461-1462. 2892019 10.1016/S0140-6736(87)91158-5
-
(1987)
Lancet
, vol.8573
, pp. 1461-1462
-
-
Herzog, C.1
Walker, C.2
Pichler, W.3
Aeschlimann, A.4
Wassmer, P.5
Stockinger, H.6
Knapp, W.7
Rieber, P.8
Muller, W.9
-
9
-
-
0025176641
-
Antimurine antibody formation following OKT3 therapy
-
10.1097/00007890-199001000-00010 2301026
-
Schroeder TJ First MR Mansour ME Hurtubise PE Hariharan S Ryckman FC Munda R Melvin DB Penn I Ballistreri WF Alexander JW Antimurine antibody formation following OKT3 therapy Transplantation 1990, 49:48-51. 10.1097/ 00007890-199001000-00010 2301026
-
(1990)
Transplantation
, vol.49
, pp. 48-51
-
-
Schroeder, T.J.1
First, M.R.2
Mansour, M.E.3
Hurtubise, P.E.4
Hariharan, S.5
Ryckman, F.C.6
Munda, R.7
Melvin, D.B.8
Penn, I.9
Ballistreri, W.F.10
Alexander, J.W.11
-
11
-
-
0023621441
-
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies
-
2189658 3500259 10.1084/jem.166.5.1351
-
Bruggemann M Williams G Bindon C Clark M Walker M Jefferis R Waldmann H Neuberger M Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies J Exp Med 1987, 166:1351-1361. 2189658 3500259 10.1084/jem.166.5.1351
-
(1987)
J Exp Med
, vol.166
, pp. 1351-1361
-
-
Bruggemann, M.1
Williams, G.2
Bindon, C.3
Clark, M.4
Walker, M.5
Jefferis, R.6
Waldmann, H.7
Neuberger, M.8
-
12
-
-
0026519686
-
Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential
-
1578132
-
Isaacs J Clark M Greenwood J Waldmann H Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential J Immunol 1992, 148:3062-3071. 1578132
-
(1992)
J Immunol
, vol.148
, pp. 3062-3071
-
-
Isaacs, J.1
Clark, M.2
Greenwood, J.3
Waldmann, H.4
-
13
-
-
33644931095
-
Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis
-
10.1002/art.21671 16508927
-
Wolbink GJ Vis M Lems W Voskuyl AE de Groot E Nurmohamed MT Stapel S Tak PP Aarden L Dijkmans B Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis Arthritis Rheum 2006, 54:711-715. 10.1002/art.21671 16508927
-
(2006)
Arthritis Rheum
, vol.54
, pp. 711-715
-
-
Wolbink, G.J.1
Vis, M.2
Lems, W.3
Voskuyl, A.E.4
de Groot, E.5
Nurmohamed, M.T.6
Stapel, S.7
Tak, P.P.8
Aarden, L.9
Dijkmans, B.10
-
14
-
-
0037434552
-
Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
-
10.1056/NEJMoa020888 12584368
-
Baert F Noman M Vermeire S Van Assche G Haens G Carbonez A Rutgeerts P Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease N Engl J Med 2003, 348:601-608. 10.1056/NEJMoa020888 12584368
-
(2003)
N Engl J Med
, vol.348
, pp. 601-608
-
-
Baert, F.1
Noman, M.2
Vermeire, S.3
Van Assche, G.4
Haens, G.5
Carbonez, A.6
Rutgeerts, P.7
-
15
-
-
33845882484
-
Biologic therapies in rheumatology: Lessons learned, future directions
-
10.1038/nrd2196 17195034
-
Strand V Kimberly R Isaacs JD Biologic therapies in rheumatology: lessons learned, future directions Nat Rev Drug Discov 2007, 6:75-92. 10.1038/nrd2196 17195034
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 75-92
-
-
Strand, V.1
Kimberly, R.2
Isaacs, J.D.3
-
16
-
-
0022558297
-
Replacing the complementarity-determining regions in a human antibody with those from a mouse
-
10.1038/321522a0 3713831
-
Jones PT Dear PH Foote J Neuberger MS Winter G Replacing the complementarity-determining regions in a human antibody with those from a mouse Nature 1986, 321:522-525. 10.1038/321522a0 3713831
-
(1986)
Nature
, vol.321
, pp. 522-525
-
-
Jones, P.T.1
Dear, P.H.2
Foote, J.3
Neuberger, M.S.4
Winter, G.5
-
17
-
-
0033866627
-
Antibody humanization: A case of the 'Emperor's new clothes'?
-
10.1016/S0167-5699(00)01680-7 10916143
-
Clark M Antibody humanization: A case of the 'Emperor's new clothes'? Immunol Today 2000, 21:397-402. 10.1016/S0167-5699(00)01680-7 10916143
-
(2000)
Immunol Today
, vol.21
, pp. 397-402
-
-
Clark, M.1
-
18
-
-
0026783632
-
Humanised monoclonal antibody therapy for rheumatoid arthritis
-
10.1016/0140-6736(92)92294-P 1356177
-
Isaacs J Watts R Hazleman B Hale G Keogan M Cobbold S Waldmann H Humanised monoclonal antibody therapy for rheumatoid arthritis Lancet 1992, 340:748-752. 10.1016/0140-6736(92)92294-P 1356177
-
(1992)
Lancet
, vol.340
, pp. 748-752
-
-
Isaacs, J.1
Watts, R.2
Hazleman, B.3
Hale, G.4
Keogan, M.5
Cobbold, S.6
Waldmann, H.7
-
19
-
-
1542698957
-
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
-
287235 2726754 10.1073/pnas.86.10.3833
-
Orlandi R Gussow DH Jones PT Winter G Cloning immunoglobulin variable domains for expression by the polymerase chain reaction Proc Natl Acad Sci USA 1989, 86:3833-3837. 287235 2726754 10.1073/pnas.86.10.3833
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 3833-3837
-
-
Orlandi, R.1
Gussow, D.H.2
Jones, P.T.3
Winter, G.4
-
20
-
-
0026057989
-
Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning
-
51246 1826052 10.1073/pnas.88.6.2432
-
Persson MA Caothien RH Burton DR Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning Proc Natl Acad Sci USA 1991, 88:2432-2436. 51246 1826052 10.1073/pnas.88.6.2432
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 2432-2436
-
-
Persson, M.A.1
Caothien, R.H.2
Burton, D.R.3
-
22
-
-
0028141993
-
Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen
-
10.1038/nbt0994-899 7521646
-
Jespers LS Roberts A Mahler SM Winter G Hoogenboom HR Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen Biotechnology (N Y) 1994, 12:899-903. 10.1038/ nbt0994-899 7521646
-
(1994)
Biotechnology (N Y)
, vol.12
, pp. 899-903
-
-
Jespers, L.S.1
Roberts, A.2
Mahler, S.M.3
Winter, G.4
Hoogenboom, H.R.5
-
23
-
-
0028291823
-
Isolation of high affinity human antibodies directly from large synthetic repertoires
-
395221 8045255
-
Griffiths AD Williams SC Hartley O Tomlinson IM Waterhouse P Crosby WL Kontermann RE Jones PT Low NM Allison TJ Prospero TD Hoogenboom HR Nissim A Cox JPL Harrison JL Zaccolo M Gherardi E Winter G Isolation of high affinity human antibodies directly from large synthetic repertoires EMBO J 1994, 13:3245-3260. 395221 8045255
-
(1994)
EMBO J
, vol.13
, pp. 3245-3260
-
-
Griffiths, A.D.1
Williams, S.C.2
Hartley, O.3
Tomlinson, I.M.4
Waterhouse, P.5
Crosby, W.L.6
Kontermann, R.E.7
Jones, P.T.8
Low, N.M.9
Allison, T.J.10
Prospero, T.D.11
Hoogenboom, H.R.12
Nissim, A.13
Cox, J.P.L.14
Harrison, J.L.15
Zaccolo, M.16
Gherardi, E.17
Winter, G.18
-
24
-
-
0025226085
-
Phage antibodies: Filamentous phage displaying antibody variable domains
-
10.1038/348552a0 2247164
-
McCafferty J Griffiths AD Winter G Chiswell DJ Phage antibodies: filamentous phage displaying antibody variable domains Nature 1990, 348:552-554. 10.1038/348552a0 2247164
-
(1990)
Nature
, vol.348
, pp. 552-554
-
-
McCafferty, J.1
Griffiths, A.D.2
Winter, G.3
Chiswell, D.J.4
-
25
-
-
0013675850
-
A repertoire of monoclonal antibodies with human heavy chains from transgenic mice
-
297915 2505258 10.1073/pnas.86.17.6709
-
Bruggemann M Caskey HM Teale C Waldmann H Williams GT Surani MA Neuberger MS A repertoire of monoclonal antibodies with human heavy chains from transgenic mice Proc Natl Acad Sci USA 1989, 86:6709-6713. 297915 2505258 10.1073/pnas.86.17.6709
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 6709-6713
-
-
Bruggemann, M.1
Caskey, H.M.2
Teale, C.3
Waldmann, H.4
Williams, G.T.5
Surani, M.A.6
Neuberger, M.S.7
-
26
-
-
27144532832
-
Human antibodies from transgenic animals
-
10.1038/nbt1135 16151405
-
Lonberg N Human antibodies from transgenic animals Nat Biotechnol 2005, 23:1117-1125. 10.1038/nbt1135 16151405
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1117-1125
-
-
Lonberg, N.1
-
27
-
-
66149163687
-
-
Medarex - UltiMAb Human Antibody Development System®
-
Medarex - UltiMAb Human Antibody Development System® http://www.medarex.com/Development/UltiMAb.htm
-
-
-
-
28
-
-
48649094750
-
Fully human antibodies from transgenic mouse and phage display platforms
-
10.1016/j.coi.2008.06.004 18606226
-
Lonberg N Fully human antibodies from transgenic mouse and phage display platforms Curr Opin Immunol 2008, 20:450-459. 10.1016/j.coi.2008.06.004 18606226
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 450-459
-
-
Lonberg, N.1
-
29
-
-
36749070996
-
Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor alpha agents
-
10.1002/ibd.20225 17636564
-
Nesbitt A Fossati G Bergin M Stephens P Stephens S Foulkes R Brown D Robinson M Bourne T Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents Inflamm Bowel Dis 2007, 13:1323-1332. 10.1002/ibd.20225 17636564
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 1323-1332
-
-
Nesbitt, A.1
Fossati, G.2
Bergin, M.3
Stephens, P.4
Stephens, S.5
Foulkes, R.6
Brown, D.7
Robinson, M.8
Bourne, T.9
-
30
-
-
33644755600
-
An APRIL to remember: Novel TNF ligands as therapeutic targets
-
10.1038/nrd1982 16474316
-
Dillon SR Gross JA Ansell SM Novak AJ An APRIL to remember: Novel TNF ligands as therapeutic targets Nat Rev Drug Discov 2006, 5:235-246. 10.1038/nrd1982 16474316
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 235-246
-
-
Dillon, S.R.1
Gross, J.A.2
Ansell, S.M.3
Novak, A.J.4
-
34
-
-
0024461313
-
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
-
10.1038/341544a0 2677748
-
Ward ES Gussow D Griffiths AD Jones PT Winter G Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli Nature 1989, 341:544-546. 10.1038/341544a0 2677748
-
(1989)
Nature
, vol.341
, pp. 544-546
-
-
Ward, E.S.1
Gussow, D.2
Griffiths, A.D.3
Jones, P.T.4
Winter, G.5
-
36
-
-
0020518331
-
Hybrid hybridomas and their use in immunohistochemistry
-
10.1038/305537a0 6137772
-
Milstein C Cuello AC Hybrid hybridomas and their use in immunohistochemistry Nature 1983, 305:537-540. 10.1038/305537a0 6137772
-
(1983)
Nature
, vol.305
, pp. 537-540
-
-
Milstein, C.1
Cuello, A.C.2
-
37
-
-
33748416499
-
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
-
10.1056/NEJMoa063842 16908486
-
Suntharalingam G Perry MR Ward S Brett SJ Castello-Cortes A Brunner MD Panoskaltsis N Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412 N Engl J Med 2006, 355:1018-1028. 10.1056/ NEJMoa063842 16908486
-
(2006)
N Engl J Med
, vol.355
, pp. 1018-1028
-
-
Suntharalingam, G.1
Perry, M.R.2
Ward, S.3
Brett, S.J.4
Castello-Cortes, A.5
Brunner, M.D.6
Panoskaltsis, N.7
-
38
-
-
45549090117
-
Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities
-
10.1158/0008-5472.CAN-07-6297 18483271
-
Natsume A In M Takamura H Nakagawa T Shimizu Y Kitajima K Wakitani M Ohta S Satoh M Shitara K Niwa R Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities Cancer Res 2008, 68:3863-3872. 10.1158/0008-5472.CAN-07-6297 18483271
-
(2008)
Cancer Res
, vol.68
, pp. 3863-3872
-
-
Natsume, A.1
In, M.2
Takamura, H.3
Nakagawa, T.4
Shimizu, Y.5
Kitajima, K.6
Wakitani, M.7
Ohta, S.8
Satoh, M.9
Shitara, K.10
Niwa, R.11
-
40
-
-
38249027688
-
Clinical use of OKT3: The role of cytokine release and xenosensitization
-
10.1016/0896-8411(88)90054-6
-
Chatenoud L Ferran C Legendre C Franshimont P Reuter A Kreis H Bach J Clinical use of OKT3: The role of cytokine release and xenosensitization J Autoimmun 1988, 1:631-640. 10.1016/0896-8411(88)90054-6
-
(1988)
J Autoimmun
, vol.1
, pp. 631-640
-
-
Chatenoud, L.1
Ferran, C.2
Legendre, C.3
Franshimont, P.4
Reuter, A.5
Kreis, H.6
Bach, J.7
-
41
-
-
0033572786
-
Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection
-
10.1097/00007890-199912150-00005 10609938
-
Friend PJ Hale G Chatenoud L Rebello P Bradley J Thiru S Phillips JM Waldmann H Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection Transplantation 1999, 68:1632-1637. 10.1097/00007890-199912150-00005 10609938
-
(1999)
Transplantation
, vol.68
, pp. 1632-1637
-
-
Friend, P.J.1
Hale, G.2
Chatenoud, L.3
Rebello, P.4
Bradley, J.5
Thiru, S.6
Phillips, J.M.7
Waldmann, H.8
-
42
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
10.1056/NEJMoa043980 15972866
-
Keymeulen B Vandemeulebroucke E Ziegler A Mathieu C Kaufman L Hale G Gorus F Goldman M Walter M Candon S Schandene L Crenier L De Block C Seigneurin JM De Pauw P Pierard D Weets I Rebello P Bird P Berrie E Frewin M Waldmann H Bach JF Pipeleers D Chatenoud L Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes N Engl J Med 2005, 352:2598-2608. 10.1056/NEJMoa043980 15972866
-
(2005)
N Engl J Med
, vol.352
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.3
Mathieu, C.4
Kaufman, L.5
Hale, G.6
Gorus, F.7
Goldman, M.8
Walter, M.9
Candon, S.10
Schandene, L.11
Crenier, L.12
De Block, C.13
Seigneurin, J.M.14
De Pauw, P.15
Pierard, D.16
Weets, I.17
Rebello, P.18
Bird, P.19
Berrie, E.20
Frewin, M.21
Waldmann, H.22
Bach, J.F.23
Pipeleers, D.24
Chatenoud, L.25
more..
-
43
-
-
0036733642
-
Modified anti-CD3 therapy in psoriatic arthritis: A phase I/II clinical trial
-
12233885
-
Utset TO Auger JA Peace D Zivin RA Xu D Jolliffe L Alegre ML Bluestone JA Clark MR Modified anti-CD3 therapy in psoriatic arthritis: A phase I/ II clinical trial J Rheumatol 2002, 29:1907-1913. 12233885
-
(2002)
J Rheumatol
, vol.29
, pp. 1907-1913
-
-
Utset, T.O.1
Auger, J.A.2
Peace, D.3
Zivin, R.A.4
Xu, D.5
Jolliffe, L.6
Alegre, M.L.7
Bluestone, J.A.8
Clark, M.R.9
-
44
-
-
35648941736
-
A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis
-
10.1053/j.gastro.2007.08.035 17920064
-
Plevy S Salzberg B Van Assche G Regueiro M Hommes D Sandborn W Hanauer S Targan S Mayer L Mahadevan U Frankel M Lowder J A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis Gastroenterology 2007, 133:1414-1422. 10.1053/j.gastro.2007.08.035 17920064
-
(2007)
Gastroenterology
, vol.133
, pp. 1414-1422
-
-
Plevy, S.1
Salzberg, B.2
Van Assche, G.3
Regueiro, M.4
Hommes, D.5
Sandborn, W.6
Hanauer, S.7
Targan, S.8
Mayer, L.9
Mahadevan, U.10
Frankel, M.11
Lowder, J.12
-
45
-
-
33646070900
-
Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alphamannosidase II
-
10.1002/bit.20777 16435400
-
Ferrara C Brunker P Suter T Moser S Puntener U Umana P Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alphamannosidase II Biotechnol Bioeng 2006, 93:851-861. 10.1002/ bit.20777 16435400
-
(2006)
Biotechnol Bioeng
, vol.93
, pp. 851-861
-
-
Ferrara, C.1
Brunker, P.2
Suter, T.3
Moser, S.4
Puntener, U.5
Umana, P.6
-
46
-
-
33845590523
-
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: The high-mannose, hybrid, and complex types
-
10.1093/glycob/cwl057 17012310
-
Kanda Y Yamada T Mori K Okazaki A Inoue M Kitajima-Miyama K Kuni-Kamochi R Nakano R Yano K Kakita S Shitara K Satoh M Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: The high-mannose, hybrid, and complex types Glycobiology 2007, 17:104-118. 10.1093/glycob/cwl057 17012310
-
(2007)
Glycobiology
, vol.17
, pp. 104-118
-
-
Kanda, Y.1
Yamada, T.2
Mori, K.3
Okazaki, A.4
Inoue, M.5
Kitajima-Miyama, K.6
Kuni-Kamochi, R.7
Nakano, R.8
Yano, K.9
Kakita, S.10
Shitara, K.11
Satoh, M.12
-
47
-
-
0035921175
-
Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII
-
10.1002/bit.1119 11410853
-
Davies J Jiang L Pan LZ LaBarre MJ Anderson D Reff M Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII Biotechnol Bioeng 2001, 74:288-294. 10.1002/bit.1119 11410853
-
(2001)
Biotechnol Bioeng
, vol.74
, pp. 288-294
-
-
Davies, J.1
Jiang, L.2
Pan, L.Z.3
LaBarre, M.J.4
Anderson, D.5
Reff, M.6
-
48
-
-
0029852737
-
A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans
-
2200623 8973608 10.1046/j.1365-2249.1996.d01-876.x
-
Isaacs J Wing M Greenwood J Hazleman B Hale G Waldmann H A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans Clin Exp Immunol 1996, 106:427-433. 2200623 8973608 10.1046/ j.1365-2249.1996.d01-876.x
-
(1996)
Clin Exp Immunol
, vol.106
, pp. 427-433
-
-
Isaacs, J.1
Wing, M.2
Greenwood, J.3
Hazleman, B.4
Hale, G.5
Waldmann, H.6
-
49
-
-
0023691376
-
Importance of antigen specificity for complement mediated lysis by monoclonal antibodies
-
10.1002/eji.1830181006 2973413
-
Bindon C Hale G Waldmann H Importance of antigen specificity for complement mediated lysis by monoclonal antibodies Eur J Immunol 1988, 18:1507-1514. 10.1002/eji.1830181006 2973413
-
(1988)
Eur J Immunol
, vol.18
, pp. 1507-1514
-
-
Bindon, C.1
Hale, G.2
Waldmann, H.3
-
50
-
-
0027283918
-
Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen
-
10.1016/0161-5890(93)90155-5 8366859
-
Xia M Hale G Waldmann H Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen Mol Immunol 1993, 30:1089-1096. 10.1016/0161-5890(93)90155-5 8366859
-
(1993)
Mol Immunol
, vol.30
, pp. 1089-1096
-
-
Xia, M.1
Hale, G.2
Waldmann, H.3
-
51
-
-
37749032491
-
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: Better understanding the causes to improve preclinical testing of immunotherapeutics
-
17709549
-
Stebbings R Findlay L Edwards C Eastwood D Bird C North D Mistry Y Dilger P Liefooghe E Cludts I Fox B Tarrant G Robinson J Meager T Dolman C Thorpe SJ Bristow A Wadhwa M Thorpe R Poole S "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: Better understanding the causes to improve preclinical testing of immunotherapeutics J Immunol 2007, 179:3325-3331. 17709549
-
(2007)
J Immunol
, vol.179
, pp. 3325-3331
-
-
Stebbings, R.1
Findlay, L.2
Edwards, C.3
Eastwood, D.4
Bird, C.5
North, D.6
Mistry, Y.7
Dilger, P.8
Liefooghe, E.9
Cludts, I.10
Fox, B.11
Tarrant, G.12
Robinson, J.13
Meager, T.14
Dolman, C.15
Thorpe, S.J.16
Bristow, A.17
Wadhwa, M.18
Thorpe, R.19
Poole, S.20
more..
-
52
-
-
0024308844
-
The immunogenicity of chimeric antibodies
-
2189553 2584938 10.1084/jem.170.6.2153
-
Bruggemann M Winter G Waldmann H Neuberger MS The immunogenicity of chimeric antibodies J Exp Med 1989, 170:2153-2157. 2189553 2584938 10.1084/jem.170.6.2153
-
(1989)
J Exp Med
, vol.170
, pp. 2153-2157
-
-
Bruggemann, M.1
Winter, G.2
Waldmann, H.3
Neuberger, M.S.4
-
53
-
-
0025516477
-
Humanisation of monoclonal antibodies for therapy
-
2104282
-
Gorman SD Clark MR Humanisation of monoclonal antibodies for therapy Semin Immunol 1990, 2:457-466. 2104282
-
(1990)
Semin Immunol
, vol.2
, pp. 457-466
-
-
Gorman, S.D.1
Clark, M.R.2
-
54
-
-
40849142102
-
Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose
-
2361129 18337601 10.1056/NEJMoa074943
-
Chung CH Mirakhur B Chan E Le QT Berlin J Morse M Murphy BA Satinover SM Hosen J Mauro D Slebos RJ Zhou Q Gold D Hatley T Hicklin DJ Platts-Mills TA Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose N Engl J Med 2008, 358:1109-1117. 2361129 18337601 10.1056/NEJMoa074943
-
(2008)
N Engl J Med
, vol.358
, pp. 1109-1117
-
-
Chung, C.H.1
Mirakhur, B.2
Chan, E.3
Le, Q.T.4
Berlin, J.5
Morse, M.6
Murphy, B.A.7
Satinover, S.M.8
Hosen, J.9
Mauro, D.10
Slebos, R.J.11
Zhou, Q.12
Gold, D.13
Hatley, T.14
Hicklin, D.J.15
Platts-Mills, T.A.16
-
55
-
-
0038752054
-
Pure red-cell aplasia due to anti-erythropoietin antibodies
-
10.1093/ndt/gfg182 12686654
-
Eckardt K Casadevall N Pure red-cell aplasia due to anti-erythropoietin antibodies Nephrol Dial Transplant 2003, 18:865-869. 10.1093/ndt/gfg182 12686654
-
(2003)
Nephrol Dial Transplant
, vol.18
, pp. 865-869
-
-
Eckardt, K.1
Casadevall, N.2
-
56
-
-
0036160920
-
CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis
-
11838838
-
Mason U Aldrich J Breedveld F Davis C Elliott M Jackson M Jorgensen C Keystone E Levy R Tesser J Totoritis M Truneh A Weisman M Wiesenhutter C Yocum D Zhu J CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis J Rheumatol 2002, 29:220-229. 11838838
-
(2002)
J Rheumatol
, vol.29
, pp. 220-229
-
-
Mason, U.1
Aldrich, J.2
Breedveld, F.3
Davis, C.4
Elliott, M.5
Jackson, M.6
Jorgensen, C.7
Keystone, E.8
Levy, R.9
Tesser, J.10
Totoritis, M.11
Truneh, A.12
Weisman, M.13
Wiesenhutter, C.14
Yocum, D.15
Zhu, J.16
-
57
-
-
36348937220
-
Biosimilar drugs: Concerns and opportunities
-
10.2165/00063030-200721060-00003 18020619
-
Genazzani AA Biggio G Caputi AP Del Tacca M Drago F Fantozzi R Canonico PL Biosimilar drugs: Concerns and opportunities BioDrugs 2007, 21:351-356. 10.2165/00063030-200721060-00003 18020619
-
(2007)
BioDrugs
, vol.21
, pp. 351-356
-
-
Genazzani, A.A.1
Biggio, G.2
Caputi, A.P.3
Del Tacca, M.4
Drago, F.5
Fantozzi, R.6
Canonico, P.L.7
-
58
-
-
33847613926
-
Process economics of industrial monoclonal antibody manufacture
-
Farid SS Process economics of industrial monoclonal antibody manufacture J Chromatogr A 2007, 848:8-18.
-
(2007)
J Chromatogr A
, vol.848
, pp. 8-18
-
-
Farid, S.S.1
-
59
-
-
0028143211
-
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
-
10.1016/S0140-6736(94)90628-9 7934491
-
Elliott MJ Maini RN Feldmann M Kalden JR Antoni C Smolen JS Leeb B Breedveld FC Macfarlane JD Bijl H Woody JN Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis Lancet 1994, 344:1105-1110. 10.1016/S0140-6736(94)90628-9 7934491
-
(1994)
Lancet
, vol.344
, pp. 1105-1110
-
-
Elliott, M.J.1
Maini, R.N.2
Feldmann, M.3
Kalden, J.R.4
Antoni, C.5
Smolen, J.S.6
Leeb, B.7
Breedveld, F.C.8
Macfarlane, J.D.9
Bijl, H.10
Woody, J.N.11
-
60
-
-
2942537697
-
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
-
10.1056/NEJMoa032534 15201414
-
Edwards J Szczepanski L Szechinski J Filipowicz-Sosnowska A Emery P Close D Stevens R Shaw T Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis N Engl J Med 2004, 350:2572-2581. 10.1056/NEJMoa032534 15201414
-
(2004)
N Engl J Med
, vol.350
, pp. 2572-2581
-
-
Edwards, J.1
Szczepanski, L.2
Szechinski, J.3
Filipowicz-Sosnowska, A.4
Emery, P.5
Close, D.6
Stevens, R.7
Shaw, T.8
-
61
-
-
33749363027
-
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
-
CHARISMA Study Group 10.1002/art.22033 16947782
-
Maini RN Taylor PC Szechinski J Pavelka K Bröll J Balint G Emery P Raemen F Petersen J Smolen J Thomson D Kishimoto T CHARISMA Study Group Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate Arthritis Rheum 2006, 54:2817-2829. 10.1002/art.22033 16947782
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2817-2829
-
-
Maini, R.N.1
Taylor, P.C.2
Szechinski, J.3
Pavelka, K.4
Bröll, J.5
Balint, G.6
Emery, P.7
Raemen, F.8
Petersen, J.9
Smolen, J.10
Thomson, D.11
Kishimoto, T.12
-
62
-
-
51849148443
-
Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study
-
ACTION Study Group 10.1002/art.23732 18759293
-
Genovese MC Kaine JL Lowenstein MB Giudice JD Baldassare A Schechtman J Fudman E Kohen M Gujrathi S Trapp RG Sweiss NJ Spaniolo G Dummer W ACTION Study Group Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study Arthritis Rheum 2008, 58:2652-2661. 10.1002/art.23732 18759293
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2652-2661
-
-
Genovese, M.C.1
Kaine, J.L.2
Lowenstein, M.B.3
Giudice, J.D.4
Baldassare, A.5
Schechtman, J.6
Fudman, E.7
Kohen, M.8
Gujrathi, S.9
Trapp, R.G.10
Sweiss, N.J.11
Spaniolo, G.12
Dummer, W.13
-
63
-
-
53749095799
-
Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
-
1526638 16630358 10.1186/ar1942
-
Dorner T Kaufmann J Wegener W Teoh N Goldenberg D Burmester G Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus Arthritis Res Ther 2006, 8:R74. 1526638 16630358 10.1186/ar1942
-
(2006)
Arthritis Res Ther
, vol.8
-
-
Dorner, T.1
Kaufmann, J.2
Wegener, W.3
Teoh, N.4
Goldenberg, D.5
Burmester, G.6
-
64
-
-
55849112632
-
Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: Findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
-
10.1002/art.23964 18975346
-
Keystone E Heijde D Mason D Jr Landewe R Vollenhoven RV Combe B Emery P Strand V Mease P Desai C Pavelka K Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: Findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study Arthritis Rheum 2008, 58:3319-3329. 10.1002/ art.23964 18975346
-
(2008)
Arthritis Rheum
, vol.58
, pp. 3319-3329
-
-
Keystone, E.1
Heijde, D.2
Mason Jr., D.3
Landewe, R.4
Vollenhoven, R.V.5
Combe, B.6
Emery, P.7
Strand, V.8
Mease, P.9
Desai, C.10
Pavelka, K.11
-
65
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
10.1056/NEJMoa012864 12037148
-
Herold KC Hagopian W Auger JA Poumian-Ruiz E Taylor L Donaldson D Gitelman SE Harlan DM Xu D Zivin RA Bluestone JA Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus N Engl J Med 2002, 346:1692-1698. 10.1056/NEJMoa012864 12037148
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
66
-
-
0037231533
-
Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
-
10.1002/art.10697 12528101
-
Weinblatt ME Keystone EC Furst DE Moreland LW Weisman MH Birbara CA Teoh LA Fischkoff SA Chartash EK Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial Arthritis Rheum 2003, 48:35-45. 10.1002/art.10697 12528101
-
(2003)
Arthritis Rheum
, vol.48
, pp. 35-45
-
-
Weinblatt, M.E.1
Keystone, E.C.2
Furst, D.E.3
Moreland, L.W.4
Weisman, M.H.5
Birbara, C.A.6
Teoh, L.A.7
Fischkoff, S.A.8
Chartash, E.K.9
-
67
-
-
41649109616
-
New approaches of B-cell-directed therapy: Beyond rituximab
-
10.1097/BOR.0b013e3282f5e08d 18388516
-
Dorner T Burmester GR New approaches of B-cell-directed therapy: Beyond rituximab Curr Opin Rheumatol 2008, 20:263-268. 10.1097/ BOR.0b013e3282f5e08d 18388516
-
(2008)
Curr Opin Rheumatol
, vol.20
, pp. 263-268
-
-
Dorner, T.1
Burmester, G.R.2
-
68
-
-
54349100000
-
Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: A phase I trial in patients with systemic lupus erythematosus
-
Belimumab Study Group 2592791 18786258 10.1186/ar2506
-
Furie R Stohl W Ginzler EM Becker M Mishra N Chatham W Merrill JT Weinstein A McCune WJ Zhong J Cai W Freimuth W Belimumab Study Group Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: A phase I trial in patients with systemic lupus erythematosus Arthritis Res Ther 2008, 10:R109. 2592791 18786258 10.1186/ar2506
-
(2008)
Arthritis Res Ther
, vol.10
-
-
Furie, R.1
Stohl, W.2
Ginzler, E.M.3
Becker, M.4
Mishra, N.5
Chatham, W.6
Merrill, J.T.7
Weinstein, A.8
McCune, W.J.9
Zhong, J.10
Cai, W.11
Freimuth, W.12
-
69
-
-
66149177508
-
Golimumab, a human antibody to TNF-{alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate: The GO-FORWARD Study
-
Keystone EC Genovese MC Klareskog L Hsia EC Hall ST Miranda PC Pazdur J Bae SC Palmer W Zrubek J Wiekowski M Visvanathan S Wu Z Rahman MU Golimumab, a human antibody to TNF-{alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate: The GO-FORWARD Study Ann Rheum Dis 2008.
-
(2008)
Ann Rheum Dis
-
-
Keystone, E.C.1
Genovese, M.C.2
Klareskog, L.3
Hsia, E.C.4
Hall, S.T.5
Miranda, P.C.6
Pazdur, J.7
Bae, S.C.8
Palmer, W.9
Zrubek, J.10
Wiekowski, M.11
Visvanathan, S.12
Wu, Z.13
Rahman, M.U.14
-
70
-
-
0033611472
-
A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
-
10.1056/NEJM199901283400401 9920948
-
Weinblatt ME Kremer JM Bankhurst AD Bulpitt KJ Fleischmann RM Fox RI Jackson CG Lange M Burge DJ A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate N Engl J Med 1999, 340:253-259. 10.1056/ NEJM199901283400401 9920948
-
(1999)
N Engl J Med
, vol.340
, pp. 253-259
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Bankhurst, A.D.3
Bulpitt, K.J.4
Fleischmann, R.M.5
Fox, R.I.6
Jackson, C.G.7
Lange, M.8
Burge, D.J.9
-
71
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
-
10.1056/NEJMoa050524 16162882
-
Genovese MC Becker JC Schiff M Luggen M Sherrer Y Kremer J Birbara C Box J Natarajan K Nuamah I Li T Aranda R Hagerty DT Dougados M Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition N Engl J Med 2005, 353:1114-1123. 10.1056/NEJMoa050524 16162882
-
(2005)
N Engl J Med
, vol.353
, pp. 1114-1123
-
-
Genovese, M.C.1
Becker, J.C.2
Schiff, M.3
Luggen, M.4
Sherrer, Y.5
Kremer, J.6
Birbara, C.7
Box, J.8
Natarajan, K.9
Nuamah, I.10
Li, T.11
Aranda, R.12
Hagerty, D.T.13
Dougados, M.14
-
72
-
-
38149114077
-
Atacicept in patients with rheumatoid arthritis: Results of a multi-center, phase ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study
-
10.1002/art.23178 18163485
-
Tak PP Thurlings RM Rossier C Nestorov I Dimic A Mircetic V Rischmueller M Nasonov E Shmidt E Emery P Munafo A Atacicept in patients with rheumatoid arthritis: Results of a multi-center, phase ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study Arthritis Rheum 2008, 58:61-72. 10.1002/art.23178 18163485
-
(2008)
Arthritis Rheum
, vol.58
, pp. 61-72
-
-
Tak, P.P.1
Thurlings, R.M.2
Rossier, C.3
Nestorov, I.4
Dimic, A.5
Mircetic, V.6
Rischmueller, M.7
Nasonov, E.8
Shmidt, E.9
Emery, P.10
Munafo, A.11
|