Stem cells, multiorgan failure in radiation emergency medical preparedness: A U.S./European Consultation Workshop

Stem Cells

Volumn 27, Issue 5, 2009, Pages 1205-1211

  Fliedner, Theodor M ^a   Chao, Nelson J ^b,q   Bader, Judith L ^c,d   Boettger, Axel ^e   Case Jr , Cullen ^f   Chute, John ^b   Confer, Dennis L ^f   Ganser, Arnold ^g   Gorin, Norbert Claude ^h   Gourmelon, Patrick ⁱ   Graessle, Dieter H ^a   Krawisz, Robert ^j   Meineke, Viktor ^k   Niederwieser, Dietger ^l   Port, Matthias ^g   Powles, Ray ^m   Sirohi, Bhawna ⁿ   Weinstock, David M ^o   Wiley, Albert ^p   Coleman, C Norman ^c,d  

^a UNIVERSITY OF ULM   (Germany)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d U S DEPARTMENT OF HEALTH AND HUMAN SERVICES   (United States)

^e Federal Ministry for the Environment   (Germany)

^f NATIONAL MARROW DONOR PROGRAM   (United States)

^g HANNOVER MEDICAL SCHOOL   (Germany)

^h HÔPITAL SAINT ANTOINE   (France)

ⁱ INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^j American Society for Blood and Marrow Transplantation   (United States)

^k Institute of Radiobiology   (Germany)

^l UNIVERSITY OF LEIPZIG   (Germany)

^m Parkside Oncology Clinic   (United Kingdom)

ⁿ ADDENBROOKE S HOSPITAL   (United Kingdom)

^o DANA FARBER CANCER INSTITUTE   (United States)

^p Radiation Emergency Assistance Center/Training Site (REAC/TS)   (United States)

^q DUKE UNIVERSITY   (United States)

more..

Author keywords

Hemopoietic growth factor; Irradiation; Stem cell transplantation; Stem cell microenvironment interactions

Indexed keywords

ARTICLE; CELL DAMAGE; CLINICAL ASSESSMENT; CONSULTATION; DISEASE SEVERITY; EMERGENCY CARE; EMERGENCY HEALTH SERVICE; EUROPEAN UNION; GERMANY; HEALTH CARE PLANNING; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INTERNATIONAL COOPERATION; MEDICAL EDUCATION; MEDICAL PERSONNEL; MEDICAL STAFF; MULTIPLE ORGAN FAILURE; RADIATION; STEM CELL; TERRORISM; UNITED STATES; UNIVERSITY;

CIVIL DEFENSE; EDUCATION; EUROPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTERNATIONAL COOPERATION; MEDICAL STAFF; MULTIPLE ORGAN FAILURE; RADIOACTIVE HAZARD RELEASE; REFERRAL AND CONSULTATION; RESEARCH; STEM CELLS; UNITED STATES;

EID: 66149160365     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.16     Document Type: Article

References (40)

1. Fliedner TM, Friesecke I, Beyrer K, eds. Medical Management of Radiation Accidents - Manual on the Acute Radiation Syndrome. London: British Institute of Radiology, 2001.
2. Powles R, Apperley J. Major radiation exposure. N Engl J Med 2002;347:944-947.
3. Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol 2002;30:513. (Pubitemid 34632623)
4. Dainiak N, Waselenko K, Armitage JO et al. The haematologist and radiation casualties. Hematology (Am Soc Hematol Educ Program) 2003;473-496.
5. Confer DL. Use of hematopoietic stem cell transplants: Cord blood, peripheral blood and bone marrow. Paper presented at: Conference on Medical Planning and Care in Radiation Accidents; March 3-7, 2003; Oak Ridge.
6. Waselenko JK, MacVittie TJ, Blakely WF et al. Medical management of the acute radiation syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 2004;140:1037-1051.
7. Fliedner TM, Doerr D, Meineke V. Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. Br J Radiol 2005;27:1-8.
8. Fliedner TM. Nuclear terrorism: The role of hematology in coping with its health consequences. Curr Opin Hematol 2006;13:436-444. (Pubitemid 44607444)
9. Gorin N-C, Fliedner TM, Gourmelon P et al. Consensus conference on European preparedness for haematological and other medical management of mass radiation accidents. Ann Hematol 2006;85:671-679. (Pubitemid 44251814)
10. Bader JL, Nemhauser J, Chang F et al. Radiation Incident Medical Management (REMM): Web site guidance for health care providers. Prehosp Emerg Care 2008;12:1-11.
11. Weinstock DM, Case C Jr, Bader JL, Coleman CN, Hatchett RJ, Weisdorf DJ, Confer DL. Blood 2008;111:5440-5445.
12. Fliedner TM, Powles R, Sirohi B, Niederwieser D, on behalf of the European Group for Blood and Marrow Transplantation (EBMT) - Nuclear Accident Committee (NAC). Radiologic and nuclear events: the METREPOL severity of effect grading system. Blood 2008;111:5757-5758.
13. Coleman CN, Hrdina C, Bader JL et al. Medical Response to a Radiological/Nuclear Event: Integrated Plan from the Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services. Ann Emerg Med 2009;53:223-225.
14. Fliedner TM, Graessle D, Meineke V et al. Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of effect after accidental whole-body radiation exposure: an essential basis for an evidence-based clinical triage. Exp Hematol 2007;35:8-16. (Pubitemid 46427976)
15. Fliedner TM, Tibken B, Hofer EP et al. Stem cell responses after radiation exposure: A key to the evaluation and prediction of its effects. Health Phys 1996;70:787-797. (Pubitemid 26155846)
16. NRC (National Research Council). Biologic markers in environmental health research. Environ Health Perspect 1987;74:3-9.
17. NRC (National Research Council). Biologic Markers in Reproductive Toxicology. Washington, DC: National Academy Press, 1989.
18. Till JE, McCulloch EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961;14:213-222.
19. Fliedner TM, Cronkite EP, Robertson JS. Granulocytopoiesis I. Senescence and random loss of neutrophilic granulocytes in human beings. Blood 1964;24:402-414.
20. Fliedner TM, Cronkite EP, Killmann SA et al. Granulocytopoiesis II. Emergence and pattern of labeling of neutrophilic granulocytes in humans. Blood 1964;24:683-699.
21. Athens JW, Haub OP, Raab SO et al. Leukokinetic studies IV: The total blood, circulating and marginal granulocyte pools and granulocyte turnover rates in normal subjects. J Clin Invest 1961;50:989-995.
22. Graessle DH, Fliedner TM. Computer assisted severity of effect assessment of hematopoietic cell renewal after radiation exposure based on mathematic models. [Conference Proceedings "Biodose 2008", Hanover, NH, USA, 7-10 September 2008]. Health Phys (in press).
23. Zhang J, Niu C, Ye L et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-841. (Pubitemid 37351467)
24. Arai F, Hirao A, Ohmura M et al. Tie2/angiopoietin-1 signaling refulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004;118:149-161. (Pubitemid 38962572)
25. Shalaby F, Rossant J, Yamaguchi TP et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995;376:62-66.
26. Calvi LM, Adams GB, Weibrecht KW et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-846. (Pubitemid 37351468)
27. Oberlin E, Tavian M, Blazsek I et al. Blood-forming potential of vascular endothelium in the human embryo. Development 2002;129:4147-4157.
28. Tavian M, Coulombel L, Luton D et al. Aorta associated CD34+ hematopoietic cells in the early human embryo. Blood 1996;87:67-72. (Pubitemid 26011821)
29. Avecilla ST, Hattori K, Heissig B et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004;10:64-71. (Pubitemid 38524700)
30. Kiel MJ, Yilmaz OH, Iwashita T et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005;121:1109-1121. (Pubitemid 40884400)
31. Sugiyama T, Kohara H, Noda M et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-988.
32. Maekawa K.Overview of medical care for highly exposed victims in the Tokaimura accident. In: Ricks RC, Berger ME, O'Hara FM, eds. The Medical Bases for Radiation-Accident Preparedness: The Clinical Care of Victims. Boca Raton, FL: The Parthenon Publishing Group, 2002:313-318.
33. Gaugler M-H. A unifying system: Does the vascular endothelium have a role to play in multi-organ failure following radiation exposure? Brit J Radiol Suppl 27; 2005:100-105.
34. Konchalovsky M. Multi-organ involvement and failure in selected Russian radiation accident cases. In: Fliedner TM, Meineke V et al. eds. Radiation-Induced Multi-Organ Involvement and Failure: A Challenge for Pathogenetic, Diagnostic and Therapeutic Approaches and Research. BJR Suppl. Vol 27. London, UK: British Institute of Radiology, 2005:26-29.
35. Brucer M. The Acute Radiation Syndrome. A Medical Report on the Y12 Accident, June 16, 1958. Oak Ridge, TN, USA. UAEC Report ORINS, 1959.
36. Bennett B, Repacholi M, Carr Z, eds. Health Effects of the Chernobyl Accident and Special Healthcare Programmes. Report of the UN Chernobyl Forum Expert Group "Health", Geneva. Geneva: World Health Organization, 2006.
37. Huang S, Ye G, Liang D et al. The clinical report of 3 cases of subacute radiation sickness (in Chinese). Chin J Radiat Med Prot 1989;9:82-86.
38. Radiation Event Medical Management (REMM). Available at http://www.remm.nlm.gov. Accessed July 1, 2008.
39. Strahlenschutzkommission, ed. Medizinische Massnahmen bei Kerkraftwerksunfaellen. Veroeffentllichungen der Strahlenschutzkommission - Band 4. Berlin: Hoffmann-Fachverlag, 2007
40. REAC/TS web site. Available at http://orise.orau.gov. Accessed on September 15, 2008.