Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKCα joins the fray

Cancer Biology and Therapy

Volumn 8, Issue 1, 2009, Pages 64-65

  Moeller, Benjamin J ^a   Pasqualini, Renata ^a   Arap, Wadih ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; ATM; Ceramide; PKC; Prostate cancer; Radiation

Indexed keywords

ATM PROTEIN; CERAMIDE; PROTEIN KINASE C ALPHA; SPHINGOSINE ACYLTRANSFERASE; TRANSCRIPTION FACTOR SP1;

APOPTOSIS; CELL STRAIN LNCAP; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; NOTE; PROSTATE CANCER; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 66149154659     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.1.7447     Document Type: Note

References (26)

1. American Cancer Society Facts and Figures 2008.
2. Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med 2008; 358:1250-1261
3. Hall EJ and Giaccia AJ. Radiobiology for the Radiologist 6. Philadelphia, PA: Lippincott Williams & Wilkins 2005.
4. Steel GG. The case against apoptosis. Acta Oncol 2001; 40:968-975 (Pubitemid 34098484)
5. Brown JM and Wouters BG. Apoptosis, p53 and tumor cell sensitivity to anticancer agents. Cancer Res 1999; 59:1391-1399 (Pubitemid 29160097)
6. Olive PL and Durand RE. Apoptosis: an indicator of radiosensitivity in vitro? Int J Radiat Biol 1997; 71:695-707.
7. Yanagihara K, Nii M, Numoto M, Kamiya K, Tauchi H, Sawada S, et al. Radiation-induced apoptotic cell death in human gastric epithelial tumour cells; correlation between mitotic death and apoptosis. Int J Radiat Biol 1995; 67:677-685
8. Aldridge DR, Arends MJ and Radford IR. Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. Br J Cancer 1995; 71:571-577
9. Kyprianou N, King ED, Bradbury D and Rhee JG. bcl-2 overexpression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Int J Cancer 1997; 70:341-348 (Pubitemid 27099605)
10. Lock RB and Stribinskiene L. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res 1996; 56:4006-4012 (Pubitemid 26284752)
11. Schenck M, Carpinteiro A, Grassme H, Lang F and Gulbins E. Ceramide: physiological and pathophysiological aspects. Arch Biochem Biophys 2007; 462:171-175 (Pubitemid 46856326)
12. Kolesnick R and Fuks Z. Radiation and ceramide-induced apoptosis. Oncogene 2003; 22:5897-5906
13. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 1994; 180:525-535 (Pubitemid 24224129)
14. Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J and Weichselbaum RR. Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res 1997; 57:1270-1275 (Pubitemid 27152550)
15. Marathe S, Schissel SL, Yellin MJ, Beatini N, Mintzer R, Williams KJ, et al. Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling. J Biol Chem 1998; 273:4081-4088 (Pubitemid 28103275)
16. Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 2001; 293:293-297 (Pubitemid 32694744)
17. Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003; 300:1155-1159 (Pubitemid 36583102)
18. Liao WC, Haimovitz-Friedman A, Persaud RS, McLoughlin M, Ehleiter D, Zhang N, et al. Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. J Biol Chem 1999; 274:17908-17917 (Pubitemid 129519151)
19. Lee JH and Paull TT. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 2007; 26:7741-7748 (Pubitemid 350242454)
20. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, 3rd, Hurov KE, Luo J, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160-1166
21. Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, et al. Downregulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem 2005; 280:23262-23272 (Pubitemid 40853238)
22. Blobe GC, Obeid LM and Hannun YA. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev 1994; 13:411-431
23. Fujii T, Garcia-Bermejo ML, Bernabo JL, Caamano J, Ohba M, Kuroki T, et al. Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J Biol Chem 2000; 275:7574-7582 (Pubitemid 30159656)
24. Garzotto M, White-Jones M, Jiang Y, Ehleiter D, Liao WC, Haimovitz-Friedman A, et al. 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer Res 1998; 58:2260-2264 (Pubitemid 28232917)
25. Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, et al. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem 2006; 281:36793-36802 (Pubitemid 46042147)
26. Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R, et al. PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther 2008.