Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B1

Biology of Reproduction

Volumn 80, Issue 6, 2009, Pages 1232-1238

  Lin, Han ^b   Hu, Guo Xin ^b   Dong, Lei ^b   Dong, Qiang ^c   Mukai, Motoko ^d   Chen, Bing Bing ^b   Holsberger, Denise R ^d   Sottas, Chantal M ^a   Cooke, Paul S ^d   Lian, Qing Quan ^b   Li, Xiao Kun ^b   Ge, Ren Shan ^a,b,e  

^a ROCKEFELLER UNIVERSITY   (United States)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e POPULATION COUNCIL   (United States)

Author keywords

Cell cycle; Cyclin dependent kinase inhibitor; Mitogenesis; Testosterone

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; BROXURIDINE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYCLIN DEPENDENT KINASE INHIBITOR 1B; MESSENGER RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROL GROUP; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; KNOCKOUT MOUSE; LEYDIG CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; CELL COUNT; CELL PROLIFERATION; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE EXPRESSION; LEYDIG CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOPROTEINS; STEROIDS; TESTIS; TESTOSTERONE;

MUS;

EID: 66149151285     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.074229     Document Type: Article

References (26)

1. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995; 9:1149-1163.
2. Tokumoto YM, Apperly JA, Gao FB, Raff MC. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Dev Biol 2002; 245:224-234. (Pubitemid 34461816)
3. Coats S, Flanagan WM, Nourse J, Roberts JM. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 1996; 272:877-880. (Pubitemid 26154591)
4. Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY, Nakayama K. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996; 85:707-720. (Pubitemid 126334351)
5. Beumer TL,Kiyokawa H, Roepers-Gajadien HL, van den Bos LA, Lock TM, Gademan IS, Rutgers DH, Koff A, de Rooij DG. Regulatory role of p27kip1 in the mouse and human testis. Endocrinology 1999; 140:1834-1840. (Pubitemid 29149256)
6. Cipriano SC, Chen L, Burns KH, Koff A, Matzuk MM. Inhibin and p27 interact to regulate gonadal tumorigenesis.Mol Endocrinol 2001; 15:985-996.
7. Holsberger DR, Jirawatnotai S, Kiyokawa H, Cooke PS. Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells. Endocrinology 2003; 144:3732-3738. (Pubitemid 37088723)
8. Bryja V, Pachernik J, Faldikova L, Krejci P, Pogue R, Nevriva I, Dvorak P, Hampl A. The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo. Biochim Biophys Acta 2004; 1691:105-116. (Pubitemid 38521271)
9. Hardy MP, Kirby JD, Hess RA, Cooke PS. Leydig cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism. Endocrinology 1993; 132:2417-2420. (Pubitemid 23156889)
10. Sprando RL. Perfusion of the rat testis through the heart using heparin. In: Russell LD, Ettlin RA, Hikim APS, Clegg ED (eds.), Histological and Histopathological Evaluation of the Testis. Clearwater, FL: Cache River Press; 1990:277-280.
11. Hardy MP, Zirkin BR, Ewing LL. Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat. Endocrinology 1989; 124:762-770. (Pubitemid 19057066)
12. Wang G, Hardy MP. Development of Leydig cells in the insulin-like growth factor-I (IGF-I) knockout mouse: effects of IGF-I replacement and gonadotropic stimulation. Biol Reprod 2004; 70:632-639. (Pubitemid 38233700)
13. Ge RS, Chen GR, Dong Q, Akingbemi B, Sottas CM, Santos M, Sealfon SC, Bernard DJ, Hardy MP. Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl 2007; 28:513-520. (Pubitemid 47057032)
14. Knorr DW, Vanha-Perittula T, Lipsett MB. Structure and function of rat testis through pubescence. Endocrinology. 1970; 86:1298-1304.
15. Cochran RC, Ewing LL, Niswender GD. Serum levels of follicle-stimulating hormone, prolactin, testosterone, 5a-dihydrotestosterone, 5aandrostane- 3a,17b-diol, 5a-androstane-3b,17b-diol and 17b-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia. Invest Urol 1981; 19:142-147. (Pubitemid 12236414)
16. Mukai M, Dong Q, Hardy MP, Kiyokawa H, Peterson RE, Cooke PS. Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors. Biol Reprod 2005; 73:951-958. (Pubitemid 41507498)
17. Holsberger DR, Buchold GM, Leal MC, Kiesewetter SE, O'Brien DA, Hess RA, Franca LR, Kiyokawa H, Cooke PS. Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation. Biol Reprod 2005; 72:1429-1436. (Pubitemid 40696086)
18. Keeney DS, Ewing LL. Effects of hypophysectomy and alterations in spermatogenic function on Leydig cell volume, number, and proliferation in adult rats. J Androl 1990; 11:367-378.
19. Ge RS, Dong Q, Sottas CM, Papadopoulos V, Zirkin BR, Hardy MP. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Proc Natl Acad Sci U S A 2006; 103:2719-2724.
20. Ge R-S, Hardy MP. Regulation of Leydig cells during pubertal development. In: Payne AH, Hardy MP (eds.), The Leydig Cell in Health and Disease. Totowa: Humana Press; 2007:55-70.
21. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996; 85:733-744. (Pubitemid 126334353)
22. Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA, Koff A. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 1996; 85:721-732. (Pubitemid 126334352)
23. Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 1998; 396:177-180. (Pubitemid 28523620)
24. Cohen PE, Hardy MP, Pollard JW. CSF-1 plays a major role in the development of reproductive function of male mice. Mol Endocrinol 1997; 11:1636-1650.
25. Ge RS, Hardy MP. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Endocrinology 1998; 139:3787-3795. (Pubitemid 28512259)
26. Bay K, Matthiesson KL, McLachlan RI, Andersson AM. The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men. J Clin Endocrinol Metab 2006; 91:1108-1111. (Pubitemid 43357788)