Multidrug resistance phenotypes and MRS2 mitochondrial magnesium channel: Two players from one stemness?

Cancer Biology and Therapy

Volumn 8, Issue 7, 2009, Pages

  Wolf, Federica I ^a,b   Trapani, Valentina ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Adriamycin resistance; Apoptosis; Cancer stem cells; CorA; Cytochrome c release; mrs2; P gp; Proliferation

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; CYTOCHROME C; DOXORUBICIN; GLYCOPROTEIN P; ION CHANNEL; MAGNESIUM; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL PROTEIN MRS2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; CATION TRANSPORT PROTEIN; MRS2 PROTEIN, HUMAN;

CANCER CHEMOTHERAPY; CANCER STEM CELL; CELL GROWTH; CELL PROLIFERATION; EMBRYO; EMBRYONIC STEM CELL; ENZYME RELEASE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MULTIDRUG RESISTANCE; NOTE; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; TUMOR CELL; DRUG RESISTANCE; GENETICS; METABOLISM; STOMACH TUMOR;

CATION TRANSPORT PROTEINS; DRUG RESISTANCE, NEOPLASM; HUMANS; MITOCHONDRIAL PROTEINS; STOMACH NEOPLASMS;

EID: 66149149022     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.7.8152     Document Type: Note

References (25)

1. Stavrovskaya AA, Stromskaya TP. Transport proteins of the ABC family and multidrug resistance of tumor cells. Biochemistry (Mosc) 2008; 73:592-604.
2. Shukla S, Wu CP, Ambudkar SV. Development of inhibitors of ATP-binding cassette drug transporters: present status and challenges. Expert Opin Drug Metab Toxicol 2008; 4:205-223
3. Lage H. An overview of cancer multidrug resistance: a still unsolved problem. Cell Mol Life Sci 2008; 65:3145-3167
4. Chen Y, Wei X, Yan P, Han Y, Sun S, Wu K, Fan D. Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. Cancer Biol Ther 2009.
5. Zhao Y, You H, Liu F, An H, Shi Y, Yu Q, Fan D. Differentially expressed gene profiles between multidrug resistance gastric adenocarcinoma cells and their parental cells. Cancer Lett 2002; 185:211-218
6. Zsurka G, Gregán J, Schweyen RJ. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics 2001; 72:158-168 (Pubitemid 32242956)
7. Niegowski D, Eshaghi S. The CorA family: structure and function revisited. Cell Mol Life Sci 2007; 64:2564-2574 (Pubitemid 350035607)
8. Hübner CA, Jentsch TJ. Channelopathies of transepithelial transport and vesicular function. Adv Genet 2008; 63:113-152
9. Maguire ME, Cowan JA. Magnesium chemistry and biochemistry. Biometals 2002; 15:203-210
10. Wolf FI, Fasanella S, Tedesco B, Torsello A, Sgambato A, Faraglia B, et al. Regulation of magnesium content during proliferation of mammary epithelial cells (HC-11). Front Biosci 2004; 9:2056-2062
11. Wolf FI, Tra pani V. Cell (Patho)physiology of Magnesium. Clin Sci 2008; 114:27-35.
12. 2+ selective channel in mitochondria. Biophys J 2007; 93:3872-3883
13. 2+ uptake and cell death. J Cell Mol Med 2008; Epub.
14. Coenen MJ, Smeitink JA, Smeets R, Trijbels FJ, van den Heuvel LP. Mutation detection in four candidate genes (OXA1L, MRS2L, YME1L and MIPEP) for combined deficiencies in the oxidative phosphorylation system. J Inherit Metab Dis 2005; 28:1. (Pubitemid 43168946)
15. Harper ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio M, et al. Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J 2002; 16:1550-1557 (Pubitemid 35154637)
16. Villa AM, Doglia SM. Mitochondria in tumor cells studied by laser scanning confocal microscopy. J Biomed Opt 2004; 9:385-394
17. Solazzo M, Fantappiè O, Lasagna N, Sassoli C, Nosi D, Mazzanti R. P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines. Exp Cell Res 2006; 312:4070-4078
18. Tainton KM, Smyth MJ, Jackson JT, Tanner JE, Cerruti L, Jane SM, et al. Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux. Cell Death Differ 2004; 11:1028-1037 (Pubitemid 39232362)
19. Patel T, Bronk SF, Gores GJ. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J Clin Invest 1994; 94:2183-2192 (Pubitemid 24379587)
20. Chien MM, Zahradka KE, Newell MK, Freed JH. Fas-induced B cell apoptosis requires an increase in free cytosolic magnesium as an early event. J Biol Chem 1999; 274:7059-7066 (Pubitemid 129504991)
21. 2+ ions. J Cell Biol 1998; 143:217-224
22. Kim TH, Zhao Y, Barber MJ, Kuharsky DK, Yin XM. Bid-induced cytochrome C release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax. J Biol Chem 2000; 275:39474-39481
23. Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5:275-284 (Pubitemid 40488633)
24. Donnenberg VS, Donnenberg AD. Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis. J Clin Pharmacol 2005; 45:872-877 (Pubitemid 41060226)
25. Assou S, Cerecedo D, Tondeur S, Pantesco V, Hovatta O, Klein B, et al. A gene expression signature shared by human mature oocytes and embryonic stem cells. BMC Genomics 2009; 10:10.