Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

Clinical Endocrinology

Volumn 70, Issue 6, 2009, Pages 863-869

  Sinclair, A J ^a,b,c   Ball, A K ^a   Curnow, S J ^b   Tomlinson, J W ^c   Burdon, M A ^b   Walker, E A ^c   Stewart, P M ^c   Nightingale, P G ^b   Clarke, C E ^a   Rauz, S ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b School of Experimental Medicine   (China)

^c Academic Unit of Ophthalmology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; RESISTIN; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; BODY MASS; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IDIOPATHIC DISEASE; INTRACRANIAL HYPERTENSION; MALE; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ADIPOKINES; ADULT; BODY MASS INDEX; CASE-CONTROL STUDIES; CYTOKINES; DRUG RESISTANCE; FEMALE; HUMANS; HYPOTHALAMUS; LEPTIN; MIDDLE AGED; PSEUDOTUMOR CEREBRI;

EID: 66149142231     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03401.x     Document Type: Article

References (44)

1. Dandy, W. (1937) Intracranial pressure without brain tumour: diagnosis and treatment. Annals of Surgery, 106, 492 513.
2. Durcan, F.J., Corbett, J.J. Wall, M. (1988) The incidence of pseudotumor cerebri. Population studies in Iowa and Louisiana. Archives of Neurology, 45, 875 877. (Pubitemid 18191125)
3. Radhakrishnan, K., Thacker, A.K., Bohlaga, N.H. et al. (1993) Epidemiology of idiopathic intracranial hypertension: a prospective and case-control study. Journal of Neurological Science, 116, 18 28. (Pubitemid 23144789)
4. Corbett, J.J., Savino, P.J., Thompson, H.S. et al. (1982) Visual loss in pseudotumor cerebri. Follow-up of 57 patients from five to 41 years and a profile of 14 patients with permanent severe visual loss. Archives of Neurology, 39, 461 474. (Pubitemid 12089644)
5. Straczkowski, M., Dzienis-Straczkowska, S., Stepien, A. et al. (2002) Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-α system. Journal of Clinical Endocrinology and Metabolism, 87, 4602 4606. (Pubitemid 35247047)
6. Straczkowski, M., Kowalska, I., Nikolajuk, A. et al. (2006) Plasma levels of soluble tumor necrosis factor-α receptors are related to total and LDL-cholesterol in lean, but not in obese subjects. Cardiovascular Diabetology, 5, 14.
7. Panagiotakos, D.B., Pitsavos, C., Yannakoulia, M. et al. (2005) The implication of obesity and central fat on markers of chronic inflammation: The ATTICA study. Atherosclerosis, 183, 308 315. (Pubitemid 41579282)
8. Dandona, P., Aljada, A. Bandyopadhyay, A. (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunology, 25, 4 7. (Pubitemid 38032801)
9. Wellen, K.E. Hotamisligil, G.S. (2005) Inflammation, stress, and diabetes. Journal of Clinical Investigation, 115, 1111 1119. (Pubitemid 40629025)
10. Weisberg, S.P., McCann, D., Desai, M. et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation, 112, 1796 1808. (Pubitemid 38063703)
11. Tilg, H. Moschen, A.R. (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology, 6, 772 783. (Pubitemid 44453463)
12. Aleffi, S., Petrai, I., Bertolani, C. et al. (2005) Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology, 42, 1339 1348. (Pubitemid 43260036)
13. Klok, M.D., Jakobsdottir, S. Drent, M.L. (2007) The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity Reviews, 8, 21 34.
14. Mercer, J.G., Hoggard, N., Williams, L.M. et al. (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters, 387, 113 116.
15. Schwartz, M.W., Peskind, E., Raskind, M. et al. (1996) Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Medicine, 2, 589 593. (Pubitemid 26151520)
16. Cote, M., Mauriege, P., Bergeron, J. et al. (2005) Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. Journal of Clinical Endocrinology and Metabolism, 90, 1434 1439. (Pubitemid 40464000)
17. Berg, A.H. Scherer, P.E. (2005) Adipose tissue, inflammation, and cardiovascular disease. Circulation Research, 96, 939 949. (Pubitemid 40712793)
18. Berg, A.H., Combs, T.P. Scherer, P.E. (2002) ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends in Endocrinology and Metabolism, 13, 84 89. (Pubitemid 36740452)
19. Park, H.S., Park, J.Y. Yu, R. (2005) Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Research and Clinical Practice, 69, 29 35. (Pubitemid 40813409)
20. Maedler, K., Sergeev, P., Ris, F. et al. (2002) Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. Journal of Clinical Investigation, 110, 851 860.
21. Vozarova, B., Weyer, C., Hanson, K. et al. (2001) Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obesity Research, 9, 414 417. (Pubitemid 33603868)
22. Sartipy, P. Loskutoff, D.J. (2003) Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proceedings of the National Academy of Sciences of the USA, 100, 7265 7270. (Pubitemid 36706427)
23. Bell, L.N., Ward, J.L., Degawa-Yamauchi, M. et al. (2006) Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity. American Journal of Physiology Endocrinology and Metabolism, 291, E843 E848.
24. Nisoli, E., Tonello, C., Benarese, M. et al. (1996) Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity. Endocrinology, 137, 495 503. (Pubitemid 26043741)
25. De Pergola, G. Pannacciulli, N. (2002) Coagulation and fibrinolysis abnormalities in obesity. Journal of Endocrinological Investigation, 25, 899 904. (Pubitemid 35446358)
26. Friedman, D.I. Jacobson, D.M. (2002) Diagnostic criteria for idiopathic intracranial hypertension. Neurology, 59, 1492 1495. (Pubitemid 35387052)
27. Neville, L. Egan, R.A. (2005) Frequency and amplitude of elevation of cerebrospinal fluid resting pressure by the Valsalva maneuver. Canadian Journal of Ophthalmology, 40, 775 777. (Pubitemid 43058399)
28. Ooi, K.G., Galatowicz, G., Towler, H.M. et al. (2006) Multiplex cytokine detection versus ELISA for aqueous humor: IL-5, IL-10, and IFNγ profiles in uveitis. Investigative Ophthalmology and Visual Science, 47, 272 277. (Pubitemid 46780824)
29. Curnow, S.J., Falciani, F., Durrani, O.M. et al. (2005) Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis. Investigative Ophthalmology and Visual Science, 46, 4251 4259. (Pubitemid 44264629)
30. McDonald, W.I., Compston, A., Edan, G. et al. (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Annals of Neurology, 50, 121 127.
31. Subramanian, P.S., Goldenberg-Cohen, N., Shukla, S. et al. (2004) Plasma ghrelin levels are normal in obese patients with idiopathic intracranial hypertension (pseudotumor cerebri). American Journal of Ophthalmology, 138, 109 113. (Pubitemid 38850255)
32. Lampl, Y., Eshel, Y., Kessler, A. et al. (2002) Serum leptin level in women with idiopathic intracranial hypertension. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 642 643. (Pubitemid 34462821)
33. Nam, S.Y., Kratzsch, J., Kim, K.W. et al. (2001) Cerebrospinal fluid and plasma concentrations of leptin, NPY, and α-MSH in obese women and their relationship to negative energy balance. Journal of Clinical Endocrinology and Metabolism, 86, 4849 4853. (Pubitemid 33020531)
34. Ostlund, R.E. Jr., Yang, J.W., Klein, S. et al. (1996) Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. Journal of Clinical Endocrinology and Metabolism, 81, 3909 3913. (Pubitemid 26380395)
35. Weigle, D.S., Duell, P.B., Connor, W.E. et al. (1997) Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. Journal of Clinical Endocrinology and Metabolism, 82, 561 565. (Pubitemid 27068629)
36. Korbonits, M., Trainer, P.J., Little, J.A. et al. (1997) Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clinical Endocrinology, 46, 751 757. (Pubitemid 27304461)
37. Wong, M.L., Licinio, J., Yildiz, B.O. et al. (2004) Simultaneous and continuous 24-h plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments. Journal of Clinical Endocrinology and Metabolism, 89, 258 265. (Pubitemid 38183891)
38. Rodrigues, A.M., Radominski, R.B., Suplicy Hde, L. et al. (2002) The cerebrospinal fluid/serum leptin ratio during pharmacological therapy for obesity. Journal of Clinical Endocrinology and Metabolism, 87, 1621 1626. (Pubitemid 34615248)
39. Flier, J.S. (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell, 116, 337 350. (Pubitemid 38167322)
40. Caro, J.F., Kolaczynski, J.W., Nyce, M.R. et al. (1996) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet, 348, 159 161. (Pubitemid 26238099)
41. Van Heek, M., Compton, D.S., France, C.F. et al. (1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. Journal of Clinical Investigation, 99, 385 390. (Pubitemid 27414794)
42. Green, E.D., Maffei, M., Braden, V.V. et al. (1995) The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Research, 5, 5 12.
43. Bado, A., Levasseur, S., Attoub, S. et al. (1998) The stomach is a source of leptin. Nature, 394, 790 793. (Pubitemid 28391644)
44. Morash, B., Li, A., Murphy, P.R. et al. (1999) Leptin gene expression in the brain and pituitary gland. Endocrinology, 140, 5995 5998. (Pubitemid 30645391)