Hypertension and late-life dementia: A real link?

Neurology

Volumn 72, Issue 20, 2009, Pages 1716-1717

  Knopman, David S ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT;

AGING; BLOOD PRESSURE REGULATION; COGNITION; DEMENTIA; DISEASE ASSOCIATION; EDITORIAL; HUMAN; HYPERTENSION; PRIORITY JOURNAL; AGE; AGED; ALZHEIMER DISEASE; BLOOD PRESSURE; CLINICAL TRIAL; NOTE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR;

AGE FACTORS; AGED; ALZHEIMER DISEASE; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CLINICAL TRIALS AS TOPIC; DEMENTIA; HUMANS; HYPERTENSION; RISK FACTORS;

EID: 66149134058     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000345882.69564.f7     Document Type: Editorial

References (20)

1. Hoffman LB, Schmeidler J, Lesser GT, et al. Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons. Neurology 2001;72:1720-1726.
2. Haag MDM, Hofman A, Koudstaal PJ, Breteler MMB, Stricker BHC. Duration of antihypertensive drug use and risk of dementia: a prospective cohort study. Neurology 2009;72:1727-1734.
3. Lithell H, Hansson L, Skoog I, et al. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003;21:875-886.
4. Hanon O, Forette F. Treatment of hypertension and prevention of dementia. Alzheimer Dement J Alzheimer Assoc 2005;1:30-37.
5. Forette F, Seux ML, Staessen JA, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998;352:1347-1351.
6. Tzourio C, Anderson C, Chapman N, et al. Effects of blood pressure lowering with perindopril and indapam-ide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003;163:1069-1075.
7. Bosch J, YusufS, PogueJ, et al. Use of ramipril in preventing stroke: double blind randomised trial. BMJ 2002;324: 699-702.
8. Khachaturian AS, Zandi PP, Lyketsos CG, et al. Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol 2006;63:686-692.
9. Guo Z, Fratiglioni L, Zhu L, Fastbom J, Winblad B, Viitanen M. Occurrence and progression of dementia in a community population aged 75 years and older: relationship of antihypertensive medication use. Arch Neurol 1999;56:991-996.
10. Guo Z, Viitanen M, Winblad B, Fratiglioni L. Low blood pressure and incidence of dementia in a very old sample: dependent on initial cognition. J Am Geriatr Soc 1999;47: 723-726.
11. Verghese J, Lipton RB, Hall CB, Kuslansky G, Katz MJ. Low blood pressure and the risk of dementia in very old individuals. Neurology 2003;61:1667-1672.
12. Low PA. Prevalence of orthostatic hypotension. Clin Au-ton Res 2008;18 suppl 1:8-13.
13. Johnson KC, Margolis KL, Espeland MA, et al. A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmeno-pausal women: the Women's Health Initiative Memory Study. J Am Geriatr Soc 2008;56:1449-1458.
14. Thal DR, Ghebremedhin E, Orantes M, Wiestler OD. Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalino-sis with cognitive decline. J Neuropathol Exp Neurol 2003;62:1287-1301.
15. Vinters HV, Ellis WG, Zarow C, et al. Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol 2000;59:931-945.
16. Esiri MM, Wilcock GK, Morris JH. Neuropathological assessment of the lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry 1997;63:749-753.
17. Petrovitch H, White LR, Izmirilian G, et al. Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS: Honolulu-Asia Aging Study. Neurobiol Aging 2000;21:57-62.
18. Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005:28:202-208.
19. Lopez-ArrietaJM, Birks J. Nimodipine for primary degenerative, mixed and vascular dementia. Cochrane Database Syst Rev 2002;CD000147.
20. Ohrui T, Tomita N, Sato-Nakagawa T, et al. Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression. Neurology 2004;63:1324-1325.