메뉴 건너뛰기




Volumn 106, Issue 16, 2009, Pages 6441-6446

Modularity and interactions in the genetics of gene expression

Author keywords

Computational biology; Gene regulation; Molecular networks; Systems biology

Indexed keywords

ALLELE; ARTICLE; GENE EXPRESSION; GENE INTERACTION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOME; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; ALGORITHM; FUNGAL GENOME; GENE EXPRESSION REGULATION; GENETICS; SACCHAROMYCES CEREVISIAE;

EID: 66149119826     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810208106     Document Type: Article
Times cited : (48)

References (30)
  • 1
    • 84969213492 scopus 로고    scopus 로고
    • Genomewide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Consortium WTCC
    • Consortium WTCC (2007) Genomewide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 2
    • 0037177625 scopus 로고    scopus 로고
    • Genetic dissection of transcriptional regulation in budding yeast
    • Brem RB, Yvert G, Clinton R, Kruglyak L (2002) Genetic dissection of transcriptional regulation in budding yeast. Science 296:752-755.
    • (2002) Science , vol.296 , pp. 752-755
    • Brem, R.B.1    Yvert, G.2    Clinton, R.3    Kruglyak, L.4
  • 3
    • 0037370311 scopus 로고    scopus 로고
    • Natural variation in human gene expression assessed in lymphoblastoid cells
    • Cheung VG, et al. (2003) Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 33:422-425.
    • (2003) Nat Genet , vol.33 , pp. 422-425
    • Cheung, V.G.1
  • 4
    • 0037456823 scopus 로고    scopus 로고
    • Genetics of gene expression surveyed in maize, mouse, and man
    • Schadt EE, et al. (2003) Genetics of gene expression surveyed in maize, mouse, and man. Nature 422:297-302.
    • (2003) Nature , vol.422 , pp. 297-302
    • Schadt, E.E.1
  • 5
    • 0042856391 scopus 로고    scopus 로고
    • Trans -acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
    • Yvert G, et al. (2003) Trans -acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 35:57-64.
    • (2003) Nat Genet , vol.35 , pp. 57-64
    • Yvert, G.1
  • 6
    • 13444306165 scopus 로고    scopus 로고
    • The landscape of genetic complexity across 5,700 gene expression traits in yeast
    • Brem RB, Kruglyak L (2005) The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci USA 102:1572-1577.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1572-1577
    • Brem, R.B.1    Kruglyak, L.2
  • 7
    • 43249129715 scopus 로고    scopus 로고
    • Gene-environment interaction in yeast gene expression
    • Smith EN, Kruglyak L (2008) Gene-environment interaction in yeast gene expression. PLoS Biol 6:e83.
    • (2008) PLoS Biol , vol.6
    • Smith, E.N.1    Kruglyak, L.2
  • 8
    • 23644434473 scopus 로고    scopus 로고
    • Multiple locus linkage analysis of genomewide expression in yeast
    • Storey JD, Akey JM, Kruglyak L (2005) Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol 3:e267.
    • (2005) PLoS Biol , vol.3
    • Storey, J.D.1    Akey, J.M.2    Kruglyak, L.3
  • 9
    • 23644434284 scopus 로고    scopus 로고
    • Genetic interactions between polymorphisms that affect gene expression in yeast
    • Brem RB, Storey JD, Whittle J, Kruglyak L (2005) Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 436:701-703.
    • (2005) Nature , vol.436 , pp. 701-703
    • Brem, R.B.1    Storey, J.D.2    Whittle, J.3    Kruglyak, L.4
  • 10
    • 45149106353 scopus 로고    scopus 로고
    • Integrating large-scale functional genomic dadta to dissect the complexity of yeast regulatory networks
    • Zhu J, et al. (2008) Integrating large-scale functional genomic dadta to dissect the complexity of yeast regulatory networks. Nat Genet 40:854-861.
    • (2008) Nat Genet , vol.40 , pp. 854-861
    • Zhu, J.1
  • 11
    • 34047179422 scopus 로고    scopus 로고
    • Genetic basis of individual differences in the response to small-molecule drugs in yeast
    • Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L (2007) Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet 39:496-502.
    • (2007) Nat Genet , vol.39 , pp. 496-502
    • Perlstein, E.O.1    Ruderfer, D.M.2    Roberts, D.C.3    Schreiber, S.L.4    Kruglyak, L.5
  • 13
    • 0037941585 scopus 로고    scopus 로고
    • Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data
    • Segal E, et al. (2003) Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet 34:166 -176.
    • (2003) Nat Genet , vol.34 , pp. 166-176
    • Segal, E.1
  • 14
    • 0034616930 scopus 로고    scopus 로고
    • Functional discovery via a compendium of expression profiles
    • Hughes TR, et al. (2000) Functional discovery via a compendium of expression profiles. Cell 102:109-126.
    • (2000) Cell , vol.102 , pp. 109-126
    • Hughes, T.R.1
  • 15
    • 0032052761 scopus 로고    scopus 로고
    • Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast
    • Kwast KE, Burke PV, Poyton RO (1998) Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J Exp Biol 201:1177-1195.
    • (1998) J Exp Biol , vol.201 , pp. 1177-1195
    • Kwast, K.E.1    Burke, P.V.2    Poyton, R.O.3
  • 16
    • 0033610793 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II)
    • Dibrov E, Fu S, Lemire BD (1998) The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). J Biol Chem 273:32042-32048.
    • (1998) J Biol Chem , vol.273 , pp. 32042-32048
    • Dibrov, E.1    Fu, S.2    Lemire, B.D.3
  • 17
    • 33645769260 scopus 로고    scopus 로고
    • An improved map of conserved regulatory sites for Saccha-romyces cerevisiae
    • MacIsaac KD, et al. (2006) An improved map of conserved regulatory sites for Saccha-romyces cerevisiae . BMC Bioinformatics 7:113.
    • (2006) BMC Bioinformatics , vol.7 , pp. 113
    • MacIsaac, K.D.1
  • 18
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families
    • Corder EH, et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families. Science 261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1
  • 19
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll SA, et al. (2008) Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40:1107-1112.
    • (2008) Nat Genet , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1
  • 21
    • 43249119095 scopus 로고    scopus 로고
    • Fernando MM, et al. (2008) Defining the role of the MHC in autoimmunity: A review and pooled analysis. PLoS Genet 4:e1000024.
    • Fernando MM, et al. (2008) Defining the role of the MHC in autoimmunity: A review and pooled analysis. PLoS Genet 4:e1000024.
  • 22
    • 46449111382 scopus 로고    scopus 로고
    • Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network
    • Iossifov I, Zheng T, Baron M, Gilliam TC, Rzhetsky A (2008) Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network. Genome Res 18:1150-1162.
    • (2008) Genome Res , vol.18 , pp. 1150-1162
    • Iossifov, I.1    Zheng, T.2    Baron, M.3    Gilliam, T.C.4    Rzhetsky, A.5
  • 23
    • 42949096140 scopus 로고    scopus 로고
    • eQED: An efficient method for interpreting eQTL associations using protein networks
    • Suthram S, Beyer A, Karp RM, Eldar Y, Ideker T (2008) eQED: An efficient method for interpreting eQTL associations using protein networks. Mol Syst Biol 4:162.
    • (2008) Mol Syst Biol , vol.4 , pp. 162
    • Suthram, S.1    Beyer, A.2    Karp, R.M.3    Eldar, Y.4    Ideker, T.5
  • 24
  • 25
    • 33749037129 scopus 로고    scopus 로고
    • Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification
    • Lee SI, Pe'er D, Dudley AM, Church GM, Koller D (2006) Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification. Proc Natl Acad Sci USA 103:14062-14067.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14062-14067
    • Lee, S.I.1    Pe'er, D.2    Dudley, A.M.3    Church, G.M.4    Koller, D.5
  • 26
    • 34247556038 scopus 로고    scopus 로고
    • Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations
    • Zhu J, et al. (2007) Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol 3:e69.
    • (2007) PLoS Comput Biol , vol.3
    • Zhu, J.1
  • 27
    • 40749105508 scopus 로고    scopus 로고
    • Variations in DNA elucidate molecular networks that cause disease
    • Chen Y, et al. (2008) Variations in DNA elucidate molecular networks that cause disease. Nature 452:429-435.
    • (2008) Nature , vol.452 , pp. 429-435
    • Chen, Y.1
  • 28
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 29
    • 0000576729 scopus 로고
    • The significance of the difference between two means when the population variances are unequal
    • Welch BL (1938) The significance of the difference between two means when the population variances are unequal. Biometrika 29:350-362.
    • (1938) Biometrika , vol.29 , pp. 350-362
    • Welch, B.L.1
  • 30
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc B 57:289-300.
    • (1995) J R Stat Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.