Dead adipocytes and metabolic dysfunction: Recent progress

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 16, Issue 2, 2009, Pages 178-182

  West, Michael ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adipocytes; Adipose tissue macrophages; Crown like structures; Metabolic dysfunction; Obesity

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANGIOGENESIS; BIOLOGY; BODY MASS; BUDDING; CARDIOVASCULAR DISEASE; CELL AGING; CELL SIZE; ENDOTHELIUM CELL; GENE IDENTIFICATION; GENE MUTATION; GENETIC MODEL; HUMAN; LIPID STORAGE; MACROPHAGE; METABOLIC DISORDER; NONHUMAN; OBESITY; PHENOTYPE; PREVALENCE; REVIEW; TURNOVER TIME; ANIMAL; APOPTOSIS; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; ULTRASTRUCTURE;

ADIPOCYTES; ANIMALS; APOPTOSIS; HUMANS; MACROPHAGES; METABOLIC DISEASES; MICE; OBESITY;

EID: 66149102103     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e3283292327     Document Type: Review

References (29)

1. Apovian CM, Bigornia S, Mott M, et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol 2008; 28:1654-1659. The first study associating CLS and impaired cardiovascular function in humans.
2. Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005; 46:2347-2355.
3. Strissel KJ, Stancheva Z, Miyoshi H, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 2007; 56:2910-2918.
4. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-1808.
5. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112:1785-1788.
6. Domingo P, Matias-Guiu X, Pujol RM, et al. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS 1999; 13:2261-2267.
7. Pajvani UB, Trujillo ME, Combs TP, et al. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 2005; 11:797-803.
8. Segura S, Requena L. Anatomy and histology of normal subcutaneous fat, necrosis of adipocytes, and classification of the panniculitides. Dermatol Clin 2008; 26:419-424; v.
9. Surmi BK, Hasty AH. Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future Lipidol 2008; 3:545-556.
10. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117:175-184.
11. Monteiro R, de Castro PM, Calhau C, Azevedo I. Adipocyte size and liability to cell death. Obes Surg 2006; 16:804-806.
12. Tasali E, Van Cauter E, Hoffman L, Ehrmann DA. Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2008; 93:3878-3884.
13. Trakada G, Chrousos G, Pejovic S, Vgontzas A. Sleep apnea and its association with the stress system, inflammation, insulin resistance and visceral obesity. Sleep Med Clin 2007; 2:251-261.
14. Murano I, Barbatelli G, Parisani V, et al. Dead adipocytes, detected as crownlike structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 2008; 49:1562-1568. A detailed survey of adipocyte size and CLS densities in a variety of fat depots from two different genetic mouse models of obesity.
15. Demerath EW, Reed D, Rogers N, et al. Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. Am J Clin Nutr 2008; 88:1263-1271.
16. Tchernof A. Visceral adipocytes and the metabolic syndrome. Nutr Rev 2007; 65 (6 Pt 2):S24-S29.
17. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature 2008; 453:783-787. Elegant use of radioisotopic data to carbon date fat cells in humans and determine adipocyte birth and death rates between lean and obese individuals.
18. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008; 57:3239-3246. An elegant pulse-chase experimentation to distinguish M1 and M2 subtype macrophages and follow the infiltration of adipose tissue by M1 macrophages in a diet-induced obese mouse model.
19. Zeyda M, Farmer D, Todoric J, et al. Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond) 2007; 31:1420-1428.
20. Bourlier V, Zakaroff-Girard A, Miranville A, et al. Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation 2008; 117:806-815. An attempt to distinguish ATM subtypes in humans and identified matrix metalloprotease-9 as a novel secreted cytokine specific to ATMs.
21. Monteiro R, Calhau C, Azevedo I. Obstructive sleep apnoea and adipocyte death. Eur J Heart Fail 2007; 9:103-104; author reply 104-105.
22. Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006; 116:115-124.
23. Schneemann M, Schoeden G. Macrophage biology and immunology: man is not a mouse. J Leukoc Biol 2007; 81:579; discussion 580.
24. Nomiyama T, Perez-Tilve D, Ogawa D, et al. Osteopontin mediates obesityinduced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 2007; 117:2877-2888.
25. Bertola A, Deveaux V, Bonnafous S, et al. Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity. Diabetes 2009; 58:125-133. An extension of previous mouse studies to show that human ATM infiltration is also affected by osteopontin signaling.
26. Fleischer J, Stein EM, Bessler M, et al. The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss. J Clin Endocrinol Metab 2008; 93:3735-3740.
27. Riedl M, Vila G, Maier C, et al. Plasma osteopontin increases after bariatric surgery and correlates with markers of bone turnover but not with insulin resistance. J Clin Endocrinol Metab 2008; 93:2307-2312.
28. Kamei N, Tobe K, Suzuki R, et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 2006; 281:26602-26614.
29. Han CY, Subramanian S, Chan CK, et al. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 2007; 56:2260-2273.