Deregulation of the tumour suppressor genes p14ARF, p15 INK4b, p16INK4a and p53 in basal cell carcinoma

British Journal of Dermatology

Volumn 160, Issue 6, 2009, Pages 1215-1221

  Kanellou, P ^a   Zaravinos, A ^a   Zioga, M ^b   Spandidos, D A ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Basal cell carcinoma; Microsatellite instability loss of heterozygosity; mRNA expression; mutations; p14ARF; p15INK4b; p16INK4a; p53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; MESSENGER RNA; PROTEIN P53;

ARTICLE; BASAL CELL CARCINOMA; CONTROLLED STUDY; DEREGULATION; DNA POLYMORPHISM; EXON; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MARKER GENE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

AGED; AGED, 80 AND OVER; CARCINOMA, BASAL CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; GENES, P53; GENES, TUMOR SUPPRESSOR; HETEROZYGOTE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE REPEATS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN NEOPLASMS; STATISTICS AS TOPIC; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEINS;

EID: 66149100107     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09079.x     Document Type: Article

References (45)

1. Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 1994 30 : 774 8.
2. Gailani MR, Leffell DJ, Ziegler A et al. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Inst 1996 88 : 349 54.
3. Saridaki Z, Koumantaki E, Liloglou T et al. High frequency of loss of heterozygosity on chromosome region 9p21-p22 but lack of p16INK4a/p19ARF mutations in Greek patients with basal cell carcinoma of the skin. J Invest Dermatol 2000 115 : 719 25.
4. Roewert-Huber J, Lange-Asschenfeldt B, Stockfleth E et al. Epidemiology and aetiology of basal cell carcinoma. Br J Dermatol 2007 157 (Suppl. 2 47 51.
5. Quinn AG, Campbell C, Healy E et al. Chromosome 9 allele loss occurs in both basal and squamous cell carcinomas of the skin. J Invest Dermatol 1994 102 : 300 3.
6. D'Errico M, Calcagnile AS, Corona R et al. p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age. Cancer Res 1997 57 : 747 52.
7. Oro AE, Higgins KM, Hu Z et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 1997 276 : 817 21.
8. Aszterbaum M, Beech J, Epstein EH Jr. Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinomas. J Investig Dermatol Symp Proc 1999 4 : 41 5.
9. Aszterbaum M, Epstein J, Oro A et al. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 1999 5 : 1285 91.
10. Kramer M, Stein B, Mai S et al. Radiation-induced activation of transcription factors in mammalian cells. Radiat Environ Biophys 1990 29 : 303 13.
11. Daya-Grosjean L, Dumaz N, Sarasin A. The specificity of p53 mutation spectra in sunlight induced human cancers. J Photochem Photobiol B 1995 28 : 115 24.
12. Stone S, Dayananth P, Jiang P et al. Genomic structure, expression and mutational analysis of the P15 (MTS2) gene. Oncogene 1995 11 : 987 91.
13. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993 366 : 704 7.
14. Bates S, Phillips AC, Clark PA et al. p14ARF links the tumour suppressors RB and p53. Nature 1998 395 : 124 5.
15. Stott FJ, Bates S, James MC et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998 17 : 5001 14.
16. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997 88 : 323 31.
17. Kamb A, Gruis NA, Weaver-Feldhaus J et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994 264 : 436 40.
18. Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 1994 371 : 257 61.
19. Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2001 2 : 731 7.
20. Wagner SN, Wagner C, Briedigkeit L et al. Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma. Br J Dermatol 1998 138 : 13 21.
21. Reed JA, Loganzo F Jr., Shea CR et al. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res 1995 55 : 2713 18.
22. Healy E, Rehman I, Angus B et al. Loss of heterozygosity in sporadic primary cutaneous melanoma. Genes Chromosomes Cancer 1995 12 : 152 6.
23. Healy E, Belgaid CE, Takata M et al. Allelotypes of primary cutaneous melanoma and benign melanocytic nevi. Cancer Res 1996 56 : 589 93.
24. Healy E, Belgaid C, Takata M et al. Prognostic significance of allelic losses in primary melanoma. Oncogene 1998 16 : 2213 18.
25. Kanellou P, Zaravinos A, Zioga M et al. Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis. Cancer Lett 2008 264 : 145 61.
26. Fargnoli MC, Chimenti S, Keller G et al. CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds. J Invest Dermatol 1998 111 : 1202 6.
27. Zaravinos A, Bizakis J, Soufla G et al. Mutations and differential expression of the ras family genes in human nasal polyposis. Int J Oncol 2007 31 : 1051 9.
28. Jiang P, Stone S, Wagner R et al. Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2). J Mol Evol 1995 41 : 795 802.
29. Quinn AG, Sikkink S, Rees JL. Delineation of two distinct deleted regions on chromosome 9 in human non-melanoma skin cancers. Genes Chromosomes Cancer 1994 11 : 222 5.
30. Gailani MR, Bale SJ, Leffell DJ et al. Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell 1992 69 : 111 17.
31. Flores JF, Pollock PM, Walker GJ et al. Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds. Oncogene 1997 15 : 2999 3005.
32. Hussein MR, Sun M, Tuthill RJ et al. Comprehensive analysis of 112 melanocytic skin lesions demonstrates microsatellite instability in melanomas and dysplastic nevi, but not in benign nevi. J Cutan Pathol 2001 28 : 343 50.
33. Saridaki Z, Liloglou T, Zafiropoulos A et al. Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin. Br J Dermatol 2003 148 : 638 48.
34. Ribeiro GR, Francisco G, Teixeira LV et al. Repetitive DNA alterations in human skin cancers. J Dermatol Sci 2004 36 : 79 86.
35. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000 100 : 57 70.
36. Sherr CJ. Cancer cell cycles. Science 1996 274 : 1672 7.
37. Bianchi AB, Fischer SM, Robles AI et al. Overexpression of cyclin D1 in mouse skin carcinogenesis. Oncogene 1993 8 : 1127 33.
38. Yamamoto H, Ochiya T, Takeshita F et al. Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res 2002 62 : 1641 7.
39. Sauter ER, Nesbit M, Litwin S et al. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas. Cancer Res 1999 59 : 4876 81.
40. Nindl I, Meyer T, Schmook T et al. Human papillomavirus and overexpression of P16INK4a in nonmelanoma skin cancer. Dermatol Surg 2004 30 : 409 14.
41. Nakamura S, Nishioka K. Enhanced expression of p16 in seborrhoeic keratosis; a lesion of accumulated senescent epidermal cells in G1 arrest. Br J Dermatol 2003 149 : 560 5.
42. Nilsson K, Svensson S, Landberg G. Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. Mod Pathol 2004 17 : 1464 74.
43. Eshkoor SA, Ismail P, Rahman SA et al. p16 gene expression in basal cell carcinoma. Arch Med Res 2008 39 : 668 73.
44. Svensson S, Nilsson K, Ringberg A et al. Invade or proliferate? Two contrasting events in malignant behavior governed by p16(INK4a) and an intact Rb pathway illustrated by a model system of basal cell carcinoma. Cancer Res 2003 63 : 1737 42.
45. Conscience I, Jovenin N, Coissard C et al. P16 is overexpressed in cutaneous carcinomas located on sun-exposed areas. Eur J Dermatol 2006 16 : 518 22.