rhBMP-2 enhances the bone healing response in a diabetic rat segmental defect model

Journal of Orthopaedic Trauma

Volumn 23, Issue 4, 2009, Pages 267-276

  Azad, Vikrant ^a   Breitbart, Eric ^a   Al Zube, Loay ^a,b   Yeh, Sloane ^a   O'Connor, J Patrick ^a   Lin, Sheldon S ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY   (United States)

^b HASHEMITE UNIVERSITY   (Jordan)

Author keywords

Defect; Diabetes; Neoangiogenesis; New bone; rhBMP 2; Segmental defect

Indexed keywords

CD31 ANTIGEN; COLLAGEN SPONGE; MONOCLONAL ANTIBODY; POLYIMIDE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DEFECT; BONE PLATE; BONE RADIOGRAPHY; BONE REGENERATION; BONE SCREW; BONE STRENGTH; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; FEMUR; HEALING; IMMUNOHISTOCHEMISTRY; IMPLANTATION; MICRORADIOGRAPHY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SCORING SYSTEM; TREATMENT OUTCOME; ANIMAL; DISEASE MODEL; DRUG EFFECT; DRUG IMPLANT; FEMUR FRACTURE; FRACTURE HEALING; HUMAN; MALE; WISTAR RAT;

ANIMALS; BONE MORPHOGENETIC PROTEINS; DIABETES COMPLICATIONS; DISEASE MODELS, ANIMAL; DRUG IMPLANTS; FEMORAL FRACTURES; FRACTURE HEALING; HUMANS; MALE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 66149097475     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31819f290e     Document Type: Article

References (48)

1. Praemer A, Furner S, Rice DP. Musculoskeletal conditions in United States. Park Ridge, IL. Amer Acad of Orthopaedic Surgeons. 1992:85-124.
2. National Diabetes Statistics, 2007; Prevalence of diagnosed and undiagnosed diabetes in the United States, all ages, 2007. Available at: http://diabetes.niddk.nih.gov/dm/pubs/statistics/index.htm. Accessed October 10, 2008.
3. Macey LR, Kana SM, Jingushi S, et al. Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am. 1989;71:722-733. (Pubitemid 19179662)
4. Herbsman H, Powers JC, Hirschman A, et al. Retardation of fracture healing in experimental diabetes. J Surg Res. 1968;8:424-431.
5. Loder RT. The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res. 1988;232:210-216. (Pubitemid 18176893)
6. Cozen L. Does diabetes delay fracture healing? Clin Orthop Relat Res. 1972;82:134-140.
7. Boddenberg U. [Healing time of foot and ankle fractures in patients with diabetes mellitus: literature review and report on own cases]. Zentralbl Chir. 2004;129:453-459.
8. Papa J, Myerson M, Girard P. Salvage, with arthrodesis, in intractable diabetic neuropathic arthropathy of the foot and ankle. J Bone Joint Surg Am. 1993;75:1056-1066. (Pubitemid 23264266)
9. Stuart MJ, Morrey BF. Arthrodesis of the diabetic neuropathic ankle joint. Clin Orthop Relat Res. 1990;253:209-211.
10. Tisdel CL, Marcus RE, Heiple KG. Triple arthrodesis for diabetic peritalar neuroarthropathy. Foot Ankle Int. 1995;16:332-338.
11. Perlman MH, Thordarson DB. Ankle fusion in a high risk population: an assessment of nonunion risk factors. Foot Ankle Int. 1999;20:491-496.
12. Yasko AW, Lane JM, Fellinger EJ, et al. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg Am. 1992;74:659-670.
13. Lee SC, Shea M, Battle MA, et al. Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix. J Biomed Mater Res. 1994;28:1149-1156. (Pubitemid 24303140)
14. Ohura K, Hamanishi C, Tanaka S, et al. Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2. J Biomed Mater Res. 1999;44:168-175. (Pubitemid 28566805)
15. Cook SD, Salkeld SL, Patron LP. Bone defect healing with an osteogenic protein-1 device combined with carboxymethylcellulose. J Biomed Mater Res B Appl Biomater. 2005;75:137-145. (Pubitemid 41395754)
16. Beam HA, Parsons JR, Lin SS. The effects of blood glucose control upon fracture healing in the BBWistar rat with diabetes mellitus. J Orthop Res. 2002;20:1210-1216.
17. Marliss EB, Nakhooda AF, Poussier P, et al. The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia. 1982;22:225-232.
18. Chen X, Kidder LS, Lew WD. Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur. J Orthop Res. 2002;20:142-150. (Pubitemid 34071433)
19. Einhorn TA, Lane JM, Burstein AH, et al. The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg Am. 1984;66:274-279.
20. Feighan JE, Davy D, Prewett AB, et al. Induction of bone by a demineralized bone matrix gel: a study in a rat femoral defect model. J Orthop Res. 1995;13:881-891. (Pubitemid 26032919)
21. Hunt TR, Schwappach JR, Anderson HC. Healing of a segmental defect in the rat femur with use of an extract from a cultured human osteosarcoma cell-line (Saos-2). A preliminary report. J Bone Joint Surg Am. 1996;78:41-48.
22. Isobe M, Yamazaki Y, Mori M, et al. Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2. J Oral Maxillofac Surg. 1999;57:695-698. Discussion 699. (Pubitemid 29068436)
23. Lane NE, Kumer J, Yao W, et al. Basic fibroblast growth factor forms new trabeculae that physically connect with pre-existing trabeculae, and this new bone is maintained with an anti-resorptive agent and enhanced with an anabolic agent in an osteopenic rat model. Osteoporos Int. 2003;14:374-382. (Pubitemid 36919218)
24. Nottebaert M, Lane JM, Juhn A, et al. Omental angiogenic lipid fraction and bone repair. An experimental study in the rat. J Orthop Res. 1989;7:157-169. (Pubitemid 19071027)
25. Stevenson S, Cunningham N, Toth J, et al. The effect of osteogenin (a bone morphogenetic protein) on the formation of bone in orthotopic segmental defects in rats. J Bone Joint Surg Am. 1994;76:1676-1687. (Pubitemid 24372020)
26. Wolff D, Goldberg VM, Stevenson S. Histomorphometric analysis of the repair of a segmental diaphyseal defect with ceramic and titanium fibermetal implants: effects of bone marrow. J Orthop Res. 1994;12:439-446. (Pubitemid 24181148)
27. Harten RD, Svach DJ, Schmeltzer R, et al. Salicylic acid-derived poly (anhydride-esters) inhibit bone resorption and formation in vivo. J Biomed Mater Res A. 2005;72:354-362. (Pubitemid 40315849)
28. Gandhi A, Beam HA, O'Connor JP, et al. The effects of local insulin delivery on diabetic fracture healing. Bone. 2005;37:482-490. (Pubitemid 41317321)
29. Gandhi A, O'Connor JP, Parsons JR, et al. Localized Insulin Delivery Normalizes the Impairment of the Late Phase of Diabetic Fracture Healing. New Orleans, LA: Orthopaedic Research Society; 2003.
30. Tyndall WA, Beam HA, Zarro C, et al. Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Clin Orthop Relat Res. 2003;408:319-330. (Pubitemid 36307525)
31. Li RH, Bouxsein ML, Blake CA, et al. rhBMP-2 injected in a calcium phosphate paste (alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model. J Orthop Res. 2003;21:997-1004.
32. Seeherman HJ, Azari K, Bidic S, et al. rhBMP-2 delivered in a calcium phosphate cement accelerates bridging of critical-sized defects in rabbit radii. J Bone Joint Surg Am. 2006;88:1553-1565.
33. Gao TJ, Lindholm TS, Kommonen B, et al. The use of a coral composite implant containing bone morphogenetic protein to repair a segmental tibial defect in sheep. Int Orthop. 1997;21:194-200. (Pubitemid 27371124)
34. Hollinger JO, Schmitt JM, Buck DC, et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res. 1998;43:356-364. (Pubitemid 28544095)
35. Balint E, Szabo P, Marshall CF, et al. Glucose-induced inhibition of in vitro bone mineralization. Bone. 2001;28:21-28. (Pubitemid 32114089)
36. Cortizo AM, Lettieri MG, Barrio DA, et al. Advanced glycation end-products (AGEs) induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases (ERK). Mol Cell Biochem. 2003;250:1-10.
37. Reiser KM. Nonenzymatic glycation of collagen in aging and diabetes. Proc Soc Exp Biol Med. 1991;196:17-29.
38. Santana RB, Xu L, Chase HB, et al. A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes. 2003;52:1502-1510. (Pubitemid 36666207)
39. Terada M, Inaba M, Yano Y, et al. Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells. Bone. 1998;22:17-23. (Pubitemid 28033648)
40. Lu H, Kraut D, Gerstenfeld LC, et al. Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology. 2003;144:346-352. (Pubitemid 36076124)
41. Joyce ME, Roberts AB, SpornMB, et al. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol. 1990;110:2195-2207. (Pubitemid 20183176)
42. McCarthy TL, Centrella M, Canalis E. Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. Endocrinology. 1989;125:2118-2126. (Pubitemid 19258650)
43. Noda M, Camilliere JJ. In vivo stimulation of bone formation by transforming growth factor-beta. Endocrinology. 1989;124:2991-2994.
44. Noda M, Vogel R. Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells. J Cell Biol. 1989;109:2529-2535. (Pubitemid 19282636)
45. Kawaguchi H, Kurokawa T, Hanada K, et al. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology. 1994;135:774-781. (Pubitemid 24241262)
46. Gandhi A, Dumas C, O'Connor JP, et al. The effects of local platelet rich plasma delivery on diabetic fracture healing. Bone. 2006;38:540-546.
47. Hoshino T, Muranishi H, Saito K, et al. Enhancement of fracture repair in rats with streptozotocin-induced diabetes by a single injection of biodegradable microcapsules containing a bone formation stimulant, TAK-778. J Biomed Mater Res. 2000;51:299-306. (Pubitemid 30452131)
48. Christopher Bibbo MDH. Recombinant bone morphogenic protein- 2(rhBMP-2) in high risk foot and ankle surgery: surgical techniques and preliminary results of a prospective, intention-to-treat study. Tech Foot Ankle Surg. 2007;6:71-79.