Enhancement of fracture repair in rats with streptozotocin-induced diabetes by a single injection of biodegradable microcapsules containing a bone formation stimulant, TAK-778

Journal of Biomedical Materials Research

Volumn 51, Issue 3, 2000, Pages 299-306

  Hoshino, Tetsuo ^a   Muranishi, Hiroya ^a   Saito, Kazuhiro ^a   Notoya, Kohei ^a   Makino, Haruhiko ^a   Nagai, Hirofumi ^a   Sohda, Takashi ^a   Ogawa, Yasuaki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Bone fracture; Diabetic rats; Microcapsules; Sustained release; TAK 778

Indexed keywords

BENDING STRENGTH; BIODEGRADATION; BONE; COPOLYMERS; DRUG PRODUCTS; MOLECULAR WEIGHT; POLYESTERS;

FRACTURE REPAIR; MICROCAPSULES; STREPTOZOTOCIN;

BIOMATERIALS;

ALKALINE PHOSPHATASE; BENZOTHIEPIN DERIVATIVE; N (4 DIETHOXYPHOSPHORYLMETHYLPHENYL) 1,2,4,5 TETRAHYDRO 4 METHYL 7,8 METHYLENEDIOXY 5 OXO 3 BENZOTHIEPIN 2 CARBOXAMIDE; STREPTOZOCIN; TAK 778; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; FRACTURE HEALING; FRACTURE TREATMENT; MALE; MICROCAPSULE; NONHUMAN; OSSIFICATION; RAT; SUSTAINED RELEASE PREPARATION;

ANIMALS; BENZOTHIEPINS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; CAPSULES; DIABETES MELLITUS, EXPERIMENTAL; FIBULA; FRACTURE HEALING; FRACTURES, BONE; LACTIC ACID; MALE; MATERIALS TESTING; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034609635     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4636(20000905)51:3<299::AID-JBM2>3.0.CO;2-8     Document Type: Article

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