Avian Aspergillus fumigatus strains resistant to both itraconazole and voriconazole

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 5, 2009, Pages 2199-2201

  Beernaert, L A ^a   Pasmans, F ^a   Van Waeyenberghe, L ^a   Dorrestein, G M ^b   Verstappen, F ^c   Vercammen, F ^d   Haesebrouck, F ^a   Martel, A ^a  

^a GHENT UNIVERSITY   (Belgium)

^b Diagnostic Pathology Laboratory   (Netherlands)

^c Veterinary Clinic Hoofdstraat   (Netherlands)

^d Antwerp Zoo   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ITRACONAZOLE; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; FUNGAL STRAIN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

AMPHOTERICIN B; ANIMALS; ANIMALS, DOMESTIC; ANIMALS, WILD; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BIRD DISEASES; DRUG RESISTANCE, FUNGAL; ITRACONAZOLE; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES; TRIAZOLES;

EID: 66149093825     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01492-08     Document Type: Article

References (23)

1. Alcazar-Fuoli, L., E. Mellado, A. Alastruey-Izquierdo, M. Cuenca-Estrella, and J. L. Rodriguez-Tudela. 2008. Aspergillus section Fumigati: antifungal susceptibility patters and sequence-based identification. Antimicrob. Agents Chemother. 52:1244-1251.
2. Alcazar-Fuoli, L., E. Mellado, G. Garcia-Effron, J. F. Lopez, J. O. Grimalt, J. M. Cuenca-Estrella, and J. L. Rodriguez-Tudela. 2008. Ergosterol biosynthesis pathway in Aspergillus fumigatus. Steroids 73:339-347.
3. Beernaert, L. A., K. Baert, P. Marin, K. Chiers, P. De Backer, F. Pasmans, and A. Martel. 2008. Designing voriconazole treatment for racing pigeons: balancing between hepatic enzyme auto induction and toxicity. Med. Mycol. 5:1-10 [Epub ahead of print.]. doi:10.1080/1 369378080 2262115.
4. Beernaert, L. A., F. Pasmans, F. Haesebrouck, and A. Martel. 2008. Modelling Aspergillus fumigatus infections in racing pigeons (Columba livia domestica). Avian Pathol. 37:545-549.
5. Dannaoui, E., F. Persat, M. F. Monier, E. Borel, M. A. Piens, and S. Picot. 1999. In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole. J. Antimicrob. Chemother. 44:553-555.
6. Dannaoui, E., E. Borel, M. F. Monier, M. A. Piens, S. Picot, and F. Persat. 2001. Acquired itraconazole resistance in Aspergillus fumigatus. J. Antimicrob. Chemother. 47:333-340.
7. da Silva Ferreira, M. E., J. L. Capellaro, E. dos Reis Marques, I. Malavazi, D. Perlin, S. Park, J. B. Anderson, A. L. Colombo, B. A. Arthington-Skaggs, M. H. S. Goldman, and G. H. Goldman. 2004. In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance. Antimicrob. Agents Chemother. 48:4405-4413.
8. Denning, D. W., S. A. Radford, K. L. Oakley, L. Hall, E. M. Johnson, and D. W. Warnock. 1997. Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection. J. Antimicrob. Chemother. 40:401-414.
9. Di Somma, A., T. Bailey, C. Silvanose, and C. Garcia-Martinez. 2007. The use of voriconazole for the treatment of aspergillosis in falcons (Falco species). J. Avian Med. Surg. 21:307-316.
10. Gothard, P., and T. R. Rogers. 2004. Voriconazole for serious fungal infections. Int. J. Clin. Pract. 58:74-80. (Pubitemid 38263237)
11. Hoff, H. 2001. Critical annotations to the use of azole antifungals for plant protection. Antimicrob. Agents Chemother. 45:2987-2990. (Pubitemid 32988818)
12. Lass-Flörl, C., G. Kofler, G. Kropshofer, J. Hermans, A. Kreczy, M. P. Dierich, and D. Niederwieser. 1998. In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. J. Antimicrob. Chemother. 42:497-502. (Pubitemid 28473010)
13. Manavathu, E. K., J. A. Vazquez, and P. H. Chandrasekar. 1999. Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent. Int. J. Antimicrob. Agents 12:213-219.
14. Manavathu, E. K., O. C. Abraham, and P. H. Chandrasekar. 2001. Isolation and in vitro susceptibility to amphotericin B, itraconazole and posaconazole of voriconazole-resistant laboratory isolates of Aspergillus fumigatus. Clin. Microbiol. Infect. 7:130-137.
15. Manavathu, E. K., J. L. Cutright, and P. H. Chandrasekar. 2005. In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B. Antimicrob. Agents Chemother. 49:428-430.
16. Mellado, E., G. Garcia-Effron, L. Alcazar-Fuoli, M. Cuenca-Estrella, and J. L. Rodriguez-Tudela. 2004. Substitutions at methionine 220 in the 14α-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs. Antimicrob. Agents Chemother. 48:2747-2750.
17. Mellado, E., G. Garcia-Effron, L. Alcazar-Fuoli, W. J. G. Melchers, P. E. Verweij, M. Cuenca-Estrella, and J. L. Rodriguez-Tudela. 2007. A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob. Agents Chemother. 51:1897-1904. (Pubitemid 46903071)
18. Messer, S. A., R. N. Jones, and T. R. Fritsche. 2006. International surveillance of Candida spp. and Aspergillus spp.: report from the SENTRY antimicrobial surveillance program (2003). J. Clin. Microbiol. 44:1782-1787.
19. Pfaller, M. A., S. A. Messer, L. Boyken, C. Rice, S. Tendolkar, R. J. Hollis, and D. J. Diekema. 2008. In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus species. J. Clin. Microbiol. 46:2568-2572.
20. Rodriguez-Tudela, J. L., L. Alcazar-Fuoli, E. Mellado, A. Alastruey-Izquierdo, A. Monzon, and M. Cuenca-Estrella. 2008. Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus. Antimicrob. Agents Chemother. 52:2468-2472.
21. Snelders, E., H. A. L. van der Lee, J. Kuijpers, A. J. M. M. Rijs, J. Varga, R. A. Samson, E. Mellado, A. R. T. Donders, W. J. G. Melchers, and P. E. Verweij. 2008. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med. 5:e219.
22. Verweij, P. E., D. T. A. Te Dorsthorst, A. J. M. M. Rijs, H. G. De Vries-Hospers, J. F. G. M. Meis, and the Dutch Interuniversity Working Party for Invasive Mycoses. 2002. Nationwide survey of in vitro activities of itraconazole and voriconazole against clinical Aspergillus fumigatus isolates cultured between 1945 and 1998. J. Clin. Microbiol. 40:2648-2650.
23. Xiao, L., V. Madison, A. S. Chau, D. Loebenberg, R. E. Palermo, and P. M. McNicholas. 2004. Three-dimensional models of wild-type and mutated forms of cytochrome P450 14α-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding. Antimicrob. Agents Chemother. 48:568-574.