Monitoring of release of cargo from nanocarriers by MRI/MR spectroscopy (MRS): Significance of T2/T2* effect of iron particles

Magnetic Resonance in Medicine

Volumn 61, Issue 5, 2009, Pages 1059-1065

  Kato, Yoshinori ^a   Artemov, Dmitri ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 fluorouracil; Activated MR contrast agent; Dual contrast technique; Fe based contrast agents; Gd based contrast agents; MRI; MRS

Indexed keywords

IRON OXIDES; LIPOSOMES; MAGNETIC RESONANCE IMAGING; MOLECULES; PARAMAGNETISM;

5-FLUOROURACIL; 5-FLUOROURACIL (5-FU); CONTRAST AGENT; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; DIFFUSION PROPERTIES; DUAL CONTRAST TECHNIQUE; MR CONTRAST AGENTS; PARAMAGNETIC CONTRASTS;

GADOLINIUM COMPOUNDS;

AGAROSE; FLUOROURACIL; GADODIAMIDE; GADOLINIUM; IRON; LIPOSOME; NANOCARRIER; NANOPARTICLE; SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; DIFFUSION COEFFICIENT; DRUG RELEASE; FLUORINE NUCLEAR MAGNETIC RESONANCE; HYPOTHESIS; IMAGE ENHANCEMENT; IMAGING SYSTEM; IN VITRO STUDY; IRON KINETICS; MOLECULAR SIZE; NANOENCAPSULATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHANTOM; SIGNAL DETECTION; TECHNIQUE;

EID: 66149090408     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21939     Document Type: Article

References (18)

1. Weissleder R, Saini S, Stark DD, Wittenberg J, Ferrucci JT. Dual-contrast MR imaging of liver cancer in rats. AJR Am J Roentgenol 1988;150:561-566. (Pubitemid 18075393)
2. Suto Y, Shimatani Y. Dual contrast magnetic resonance imaging with combined use of positive and negative contrast agent in human hepatocellular carcinoma. Br J Radiol 1995;68:116-120.
3. Aboagye EO, Artemov D, Senter PD, Bhujwalla ZM. Intratumoral conversion of 5-fluorocytosine to 5-fluorouracil by monoclonal antibody-cytosine deaminase conjugates: noninvasive detection of prodrug activation by magnetic resonance spectroscopy and spectroscopic imaging. Cancer Res 1998;58:4075-4078. (Pubitemid 28440558)
4. Guerquin-Kern JL, Volk A, Chenu E, Lougerstay-Madec R, Monneret C, Florent JC, Carrez D, Croisy A. Direct in vivo observation of 5-fluorouracil release from a prodrug in human tumors heterotransplanted in nude mice: a magnetic resonance study. NMR Biomed 2000;13:306-310. (Pubitemid 30663794)
5. 19F NMR. Br J Cancer 1984;50:113-117.
6. 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits. Proc Natl Acad Sci USA 1990;87:492-496.
7. Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta 1979;557:9-23. (Pubitemid 10245657)
8. MacDonald RC, MacDonald RI, Menco BPM, Takeshita K, Subbarao NK, Hu LR. Small-volume extrusion apparatus for preparing of large, unilamellar vesicles. Biochim Biophys Acta 1991;1061:297-303.
9. Bhujwalla ZM, Artemov D, Natarajan K, Ackerstaff E, Solaiyappan M. Vascular differences detected by MRI for metastatic versus non-metastatic breast and prostate cancer xenografts. Neoplasia 2001;3:143-153. (Pubitemid 32410355)
10. Dreher MR, Liu W, Michelich CR, Dewhirst MW, Yuan F, Chilkoti A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J Natl Cancer Inst 2006;98:335-344. (Pubitemid 43338213)
11. Shapiro EM, Skrtic S, Sharer K, Hill JM, Dunbar CE, Koretsky AP. MRI detection of single particles for cellular imaging. Proc Natl Acad Sci USA 2004;101:10901-10906. (Pubitemid 38989558)
12. Paran Y, Bendel P, Margalit R, Degani H. Water diffusion in the different microenvironments of breast cancer. NMR Biomed 2004;17:170-180. (Pubitemid 39089244)
13. Walstedt RE, Walker LR. Nuclear-resonance line shapes due to magnetic impurities in metals. Phys Rev B 1974;9:4857-4867.
14. Martina MS, Fortin JP, Ménager C, Clément O, Barratt G, Grabielle-Madelmont C, Gazeau F, Cabuil V, Lesieur S. Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging. J Am Chem Soc 2005;127:10676-10685. (Pubitemid 41061441)
15. Weissleder R, Stark DD, Engelstad BL, Bacon BR, Compton CC, White DL, Jacobs P, Lewis J. Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol 1989;152:167-173. (Pubitemid 19024086)
16. Louie AY, Huber MM, Ahrens ET, Rothbacher U, Moats R, Jacobs RE, Fraser SE, Meade TJ. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol 2000;18:321-325.
17. Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol 2002;20:816-820.
18. Zhao M, Josephson L, Tang Y, Weissleder R. Magnetic sensors for protease assays. Angew Chem Int Ed Engl 2003;42:1375-1378. (Pubitemid 36459976)