Fluid mechanics, cell distribution, and environment in CellCube bioreactors

Biotechnology Progress

Volumn 19, Issue 1, 2003, Pages 2-8

  Auniņš, John G ^a   Bader, Brett ^a   Caola, Anthony ^a   Griffiths, Janet ^a   Katz, Maayan ^a   Licari, Peter ^a   Ram, Kripa ^a   Ranucci, Colette S ^a   Zhou, Weichang ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DISTRIBUTION;

BIOREACTORS; CELLS; COMPUTER SIMULATION; DEPOSITION; FLUID MECHANICS; VACCINES;

BIOTECHNOLOGY;

BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL LINE; CELL MOVEMENT; COMPUTER SIMULATION; CULTURE MEDIA; ENVIRONMENT; EQUIPMENT DESIGN; FIBROBLASTS; GRAVITATION; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; OXYGEN; QUALITY CONTROL; RHEOLOGY; SHEAR STRENGTH; TEMPERATURE;

HEPATITIS A VIRUS;

EID: 0037279941     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0256521     Document Type: Article

References (8)

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4. In the largest CellCube, four of these 25-channel stacks are connected in series to make a 100-channel Cube.
5. The population doubling level is the mean number of cell divisions for a population of cells from a reference culture (usually the first passage post-explant from the living organism).
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8. Stathopoulos, N. A.; Hellums, J. D. Shear stress effects on human embryonic kidney cells in vitro. Biotechnol. Bioeng. 1985, 27, 1021-1026.