메뉴 건너뛰기




Volumn 136, Issue 7, 2009, Pages 2048-2051

Treatment of Hyperammonemia in Liver Failure: A Tale of Two Enzymes

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; GLUTAMATE AMMONIA LIGASE; GLUTAMINASE; ORNITHINE ASPARTATE; PHENYLACETIC ACID; PLACEBO;

EID: 66149086491     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.04.016     Document Type: Editorial
Times cited : (15)

References (23)
  • 1
    • 0024340940 scopus 로고
    • Early indicators of prognosis in fulminant hepatic failure
    • O'Grady J., Alexander G., Hayllar K., et al. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 97 (1989) 439-445
    • (1989) Gastroenterology , vol.97 , pp. 439-445
    • O'Grady, J.1    Alexander, G.2    Hayllar, K.3
  • 2
    • 0041506991 scopus 로고    scopus 로고
    • Intracranial hypertension in acute liver failure: pathophysiological basis of rational management
    • Jalan R. Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis 23 (2003) 271-282
    • (2003) Semin Liver Dis , vol.23 , pp. 271-282
    • Jalan, R.1
  • 3
    • 0017579832 scopus 로고
    • Glutamine synthetase: glial localization in brain
    • Martinez-Hernandez A., Bell K.P., and Norenberg M.D. Glutamine synthetase: glial localization in brain. Science 195 (1977) 1356-1358
    • (1977) Science , vol.195 , pp. 1356-1358
    • Martinez-Hernandez, A.1    Bell, K.P.2    Norenberg, M.D.3
  • 4
    • 0033055873 scopus 로고    scopus 로고
    • Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration
    • Clemmesen J.O., Larsen F.S., Kondrup J., et al. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29 (1999) 648-653
    • (1999) Hepatology , vol.29 , pp. 648-653
    • Clemmesen, J.O.1    Larsen, F.S.2    Kondrup, J.3
  • 5
    • 29244463889 scopus 로고    scopus 로고
    • Predictive value of arterial ammonia for complications and outcome in acute liver failure
    • Bhatia V., Singh R., and Acharya S.K. Predictive value of arterial ammonia for complications and outcome in acute liver failure. Gut 55 (2006) 98-104
    • (2006) Gut , vol.55 , pp. 98-104
    • Bhatia, V.1    Singh, R.2    Acharya, S.K.3
  • 6
    • 4644341574 scopus 로고    scopus 로고
    • Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia, cerebral blood flow
    • Jalan R., Olde Damink S.W., Hayes P.C., et al. Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia, cerebral blood flow. J Hepatol 41 (2004) 613-620
    • (2004) J Hepatol , vol.41 , pp. 613-620
    • Jalan, R.1    Olde Damink, S.W.2    Hayes, P.C.3
  • 7
    • 37749006615 scopus 로고    scopus 로고
    • Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
    • Bernal W., Hall C., Karvellas C.J., et al. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology 46 (2007) 1844-1852
    • (2007) Hepatology , vol.46 , pp. 1844-1852
    • Bernal, W.1    Hall, C.2    Karvellas, C.J.3
  • 8
    • 0343238857 scopus 로고    scopus 로고
    • Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema?
    • Häussinger D., Kircheis G., Fischer R., et al. Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema?. J Hepatol 32 (2000) 1035-1038
    • (2000) J Hepatol , vol.32 , pp. 1035-1038
    • Häussinger, D.1    Kircheis, G.2    Fischer, R.3
  • 9
    • 34250327519 scopus 로고    scopus 로고
    • Endotoxemia produces coma and brain swelling in bile duct ligated rats
    • Wright G., Davies N.A., Shawcross, et al. Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology 45 (2007) 1517-1526
    • (2007) Hepatology , vol.45 , pp. 1517-1526
    • Wright, G.1    Davies, N.A.2    Shawcross3
  • 10
    • 34347399958 scopus 로고    scopus 로고
    • Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital
    • Pedersen H.R., Ring-Larsen H., Olsen N.V., et al. Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital. J Hepatol 47 (2007) 245-252
    • (2007) J Hepatol , vol.47 , pp. 245-252
    • Pedersen, H.R.1    Ring-Larsen, H.2    Olsen, N.V.3
  • 11
    • 66149127267 scopus 로고    scopus 로고
    • Efficacy of l-ornithine l-aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study
    • Acharya S.K., Bhatia V., Sreenivas V., et al. Efficacy of l-ornithine l-aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study. Gastroenterology 136 (2009) 2159-2168
    • (2009) Gastroenterology , vol.136 , pp. 2159-2168
    • Acharya, S.K.1    Bhatia, V.2    Sreenivas, V.3
  • 12
    • 0036829480 scopus 로고    scopus 로고
    • Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS
    • Olde Damink S.W., Jalan R., Redhead D.N., et al. Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology 36 (2002) 1163-1171
    • (2002) Hepatology , vol.36 , pp. 1163-1171
    • Olde Damink, S.W.1    Jalan, R.2    Redhead, D.N.3
  • 13
    • 3442900767 scopus 로고    scopus 로고
    • Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy
    • Romero-Gómez M., Ramos-Guerrero R., Grande L., et al. Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy. J Hepatol 41 (2004) 49-54
    • (2004) J Hepatol , vol.41 , pp. 49-54
    • Romero-Gómez, M.1    Ramos-Guerrero, R.2    Grande, L.3
  • 14
    • 0032868948 scopus 로고    scopus 로고
    • L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain oedema in rats with acute liver failure
    • Rose C., Michalak A., Rao K.V., et al. L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain oedema in rats with acute liver failure. Hepatology 30 (1999) 636-640
    • (1999) Hepatology , vol.30 , pp. 636-640
    • Rose, C.1    Michalak, A.2    Rao, K.V.3
  • 15
    • 1642491776 scopus 로고    scopus 로고
    • Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
    • Shawcross D.L., Davies N.A., Williams R., et al. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 40 (2004) 247-254
    • (2004) J Hepatol , vol.40 , pp. 247-254
    • Shawcross, D.L.1    Davies, N.A.2    Williams, R.3
  • 16
    • 0041317597 scopus 로고    scopus 로고
    • Acute liver failure in the United States
    • Lee W.M. Acute liver failure in the United States. Semin in Liver Dis 23 (2003) 217-226
    • (2003) Semin in Liver Dis , vol.23 , pp. 217-226
    • Lee, W.M.1
  • 17
    • 17844365270 scopus 로고    scopus 로고
    • AASLD position paper: the management of acute liver failure. American Association for the Study of Liver Disease
    • Polson J., and Lee W.M. AASLD position paper: the management of acute liver failure. American Association for the Study of Liver Disease. Hepatology 41 (2005) 1179-1197
    • (2005) Hepatology , vol.41 , pp. 1179-1197
    • Polson, J.1    Lee, W.M.2
  • 18
    • 30444461539 scopus 로고    scopus 로고
    • Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy
    • Vaquero J., Fontana R.J., Larson A.M., et al. Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl 11 (2005) 1581-1589
    • (2005) Liver Transpl , vol.11 , pp. 1581-1589
    • Vaquero, J.1    Fontana, R.J.2    Larson, A.M.3
  • 19
    • 13144260678 scopus 로고    scopus 로고
    • Dispelling myths in the treatment of hepatic encephalopathy
    • Shawcross D., and Jalan R. Dispelling myths in the treatment of hepatic encephalopathy. Lancet 365 (2005) 431-433
    • (2005) Lancet , vol.365 , pp. 431-433
    • Shawcross, D.1    Jalan, R.2
  • 20
    • 34548737013 scopus 로고    scopus 로고
    • L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy
    • Jalan R., Wright G., Davies N.A., et al. L-Ornithine phenylacetate (OP): a novel treatment for hyperammonemia and hepatic encephalopathy. Med Hypotheses 69 (2007) 1064-1069
    • (2007) Med Hypotheses , vol.69 , pp. 1064-1069
    • Jalan, R.1    Wright, G.2    Davies, N.A.3
  • 21
    • 67651146951 scopus 로고    scopus 로고
    • L-ornithine and phenylacetate synergistically produces sustained reduction in ammonia and brain water in cirrhotic rats
    • in press
    • Davies N.A., Wright G., Ytrebø L.M., et al. L-ornithine and phenylacetate synergistically produces sustained reduction in ammonia and brain water in cirrhotic rats. Hepatology (2009) in press
    • (2009) Hepatology
    • Davies, N.A.1    Wright, G.2    Ytrebø, L.M.3
  • 22
    • 67651164008 scopus 로고    scopus 로고
    • l-Ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure
    • in press
    • Ytrebø L.M., Kristiansen R.G., Mæhre H., et al. l-Ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure. Hepatology (2009) in press
    • (2009) Hepatology
    • Ytrebø, L.M.1    Kristiansen, R.G.2    Mæhre, H.3
  • 23
    • 66149098373 scopus 로고    scopus 로고
    • Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure
    • ALFSG in press
    • Lee W.N., Hynan L.S., Rossaro L., et al., ALFSG. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology (2009) in press
    • (2009) Gastroenterology
    • Lee, W.N.1    Hynan, L.S.2    Rossaro, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.