Neuropathy-induced apoptosis: Protective effect of physostigmine

Journal of Neuroscience Research

Volumn 87, Issue 8, 2009, Pages 1871-1876

  Di Cesare Mannelli, Lorenzo ^a   Bartolini, A ^a   Ghelardini, C ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

AChE; CCI; Peripheral nerve; Tissue degeneration; XIAP

Indexed keywords

CASPASE 3; CYTOCHROME C; GABAPENTIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHYSOSTIGMINE; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHOLINERGIC STIMULATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE COMPRESSION; NERVE DEGENERATION; NERVE LIGATION; NEUROPROTECTION; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION; WESTERN BLOTTING;

ACETYLCHOLINE; ANIMALS; APOPTOSIS; AXONS; CASPASE 3; CHOLINESTERASE INHIBITORS; CYTOCHROMES C; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; ENERGY METABOLISM; MALE; MITOCHONDRIA; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSOSTIGMINE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NEUROPATHY; SENSORY RECEPTOR CELLS;

EID: 66049148619     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22007     Document Type: Article

References (31)

1. Andre N, Carre M, Brasseur G, Pourroy B, Kovacic H, Briand C, Braguer D. 2002. Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells. FEBS Lett 532:256-260.
2. Ben-Ari S, Toiber D, Sas AS, Soreq H, Ben-Shaul Y. 2006. Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants. J Neurochem 97:24-34.
3. Bennett GJ, Xie YK. 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107.
4. Cervia D, Martini D, Garcia-Gil M, Di Giuseppe G, Guella G, Dini F, Bagnoli P. 2006. Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells. Apoptosis 115:829-843.
5. Dalakas MC, Semino-Mora C, Leon-Monzon M. 2001. Mitochondrial alterations with mitochondrial DNA depletion in the nerves of AIDS patients with peripheral neuropathy induced by 2030-dideoxycytidine (ddC). Lab Invest 81:1537-1544.
6. Di Cesare Mannelli L, Ghelardini C, Calvani M, Nicolai R, Mosconi L, Vivoli E, Pacini A, Bartolini A. 2007. Protective effect of acetyl-l-carnitine on the apoptotic pathway of peripheral neuropathy. Eur J Neurosci 26:820-827.
7. Eckelman BP, Salvesen GS, Scott FL. 2006. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 7:988-994.
8. Finnerup NB, Sindrup SH, Jensen TS. 2007. Chronic neuropathic pain: mechanisms, drug targets and measurement. Fundam Clin Pharmacol 21:129-136.
9. Galeotti N, Bartolini A, Ghelardini C. 2003. The phospholipase C-IP3 pathway is involved in muscarinic antinociception. Neuropsychopharmacology 28:888-897.
10. Gorczyca W, Gong J, Darzynkiewicz Z. 1993. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53:1945-1951.
11. Huang X, Lee B, Johnson G, Naleway J, Guzikowski A, Dai W, Darzynkiewicz Z. 2005. Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis. Cell Cycle 4:140-147.
12. Hughes RAC. 2002. Peripheral neuropathy. Br Med J 324:466-469.
13. Jensen TS, Gottrup H, Sindrup SH, Bach FW. 2001. The clinical picture of neuropathic pain. Eur J Pharmacol 429:1-11.
14. Jiang H, Zhang XJ. 2008. Acetylcholinesterase and apoptosis: a novel perspective for an old enzyme. FEBS J 275:612-617.
15. Jin QH, He HY, Shi YF, Lu H, Zhang XJ. 2004. Overexpression of acetylcholinesterase inhibited cell proliferation and promoted apoptosis in NRK cells. Acta Pharmacol Sin 25:1013-1021.
16. Joseph EK, Levine LD. 2004. Caspase signaling in neuropathic and inflammatory pain in the rat. Eur J Neurosci 20:2896-2902.
17. Kim MH, Kim MO, Heo JS, Kim JS, Han HJ. 2008. Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells. Apoptosis 13: 295-304.
18. Leinninger GM, Edwards JL, Lipshaw MJ, Feldman EL. 2006. Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathy. Nat Clin Pract Neurol 2:620-628.
19. Melli G, Keswani SC, Fischer A, Chen W, Hoke A. 2006. Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy. Brain 129:1330-1338.
20. Moulder KL, Fu T, Melbostad H, Cormier RJ, Isenberg KE, Zorumski CF, Mennerick S. 2002. Ethanol-induced death of postnatal hippocampal neurons. Neurobiol Dis 10:396-409.
21. Obrosova IG, Van Huysen C, Fathallah L, Cao XC, Greene DA, Stevens MJ. 2002. An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense. FSSEB J 16:123-125.
22. Park SE, Kim ND, Yoo YH. 2004. Acetylcholinesterase plays a pivotal role in apoptosome formation. Cancer Res 64:2652-2655.
23. Pöyhiä R, Xu M, Kontinen VK, Paananen S, Kalso E. 1999. Systemic physostigmine shows antiallodynic effects in neuropathic rats. Anesth Analg 89:428-433.
24. Riedl SJ, Shi Y. 2004. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5:897-907.
25. Salvesen GS, Duckett CS. 2002. IAP proteins: blocking the road to death;s door. Nat Rev Mol Cell Biol 3:401-410.
26. Siler-Marsiglio KI, Shaw G, Heaton MB. 2004. Pycnogenol and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells. J Neurobiol 59:261-271.
27. Soreq H, Seidman S. 2001. Acetylcholinesterase - new roles for an old actor. Nat Rev Neurosci 2:294-302.
28. Vaux DL, Silke J. 2005. IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol 6:287-297.
29. Villaroya M, Garcia AG, Marco-Contelles J, Lopez MG. 2007. An update on the pharmacology of galantamine. Expert Opin Invest Drugs 16:1987-1998.
30. Yang L, He HY, Zhang XJ. 2002. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res 42:261-268.
31. Zhang XJ, Yang L, Zhao Q, Caen JP, He HY, Jin QH, Guo LH, Alemany M, Zhang LY, Shi YF. 2002. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ 9:790-800.