Biotransformation and in vitro assessment of metabolism-associated drug-drug interaction for CRx-102, a novel combination drug candidate

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 2, 2009, Pages 200-209

  Zhang, Zhi Yi ^a   Chen, Mei ^a   Chen, Jennifer ^a   Padval, Mahesh V ^a   Kansra, Vikram V ^a  

^a Department of Preclinical Development and Formulations   (United States)

Author keywords

Biotransformation; Combination drug; CYP3A4; Dipyridamole; Drug drug interaction; Prednisolone

Indexed keywords

CRX 102; CYTOCHROME P450 3A4; DIPYRIDAMOLE; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; PREDNISOLONE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DEHYDROGENATION; DRUG COMBINATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME INHIBITION; GLUCURONIDATION; HUMAN; HUMAN CELL; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; OXYGENATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

BIOTRANSFORMATION; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP3A; DIPYRIDAMOLE; DRUG COMBINATIONS; DRUG INTERACTIONS; HUMANS; MASS SPECTROMETRY; PREDNISOLONE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 66049147027     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.04.013     Document Type: Article

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