Seven-year experience with a surveillance program to reduce methicillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit

Pediatrics

Volumn 123, Issue 5, 2009, Pages

  Gregory, Mary Lucia ^a,b,c   Eichenwald, Eric C ^d,e   Puopolo, Karen M ^b,c,f  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d TEXAS CHILDREN S HOSPITAL   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Infant; Infection control; Methicillin resistance; Newborn; NICU; Staphylococcus aureus

Indexed keywords

AMPICILLIN; CHLORAMPHENICOL; CLINDAMYCIN; COTRIMOXAZOLE; ERYTHROMYCIN; GENTAMICIN; LEVOFLOXACIN; LINEZOLID; OXACILLIN; PENICILLIN G; RIFAMPICIN; TETRACYCLINE; VANCOMYCIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ISOLATION; DATA COLLECTION METHOD; FEMALE; GESTATIONAL AGE; HEALTH SURVEY; HOSPITAL ADMISSION; HOSPITAL INFECTION; HOSPITAL LABORATORY; HUMAN; INCIDENCE; INFANT; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NEWBORN INTENSIVE CARE; NOSE SMEAR; PRIORITY JOURNAL; RECTUM; SCREENING;

BOSTON; CROSS INFECTION; FEMALE; HOSPITALS, URBAN; HUMANS; INCIDENCE; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PATIENT ISOLATION; POPULATION SURVEILLANCE; RETROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS;

EID: 66049131189     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2008-1526     Document Type: Article

References (37)

1. Weeks JL, Garcia-Prats JA, Baker CJ. Methicillin-resistant Staphylococcus aureus osteomyelitis in a neonate. JAMA. 1981;245(16):1662-1664
2. Campbell JR, Zaccaria E, Mason EO, Baker CJ. Epidemiological analysis defining concurrent outbreaks of Serratia marcescens and methicillin-resistant Staphylococcus aureus bacteremia in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 1998;19(12):924-928 (Pubitemid 128472668)
3. Hitomi S, Kubota M, Mori N, et al. Control of methicillin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit by unselective use of nasal mupirocin ointment. J Hosp Infect. 2000;46(2):123-129
4. Nambiar S, Herwaldt LA, Singh N. Outbreak of invasive disease caused by methicillin-resistant Staphylococcus aureus in neonates and prevalence in the neonatal intensive care unit. Pediatr Crit Care Med. 2003;4(2):220-226
5. Saiman L, Cronquist A, Wu F, et al. An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2003;24(5):317-321 (Pubitemid 36612315)
6. Healy CM, Hulten KG, Palazzi DL, Campbell, JR, Baker CJ. Emergence of new strains of methicillin-resistant Staphylococcus aureus in a NICU. Clin Infect Dis. 2004;39(10):1460-1466
7. Chuang YY, Huang YC, Lee CY, Lin TY, Lien R, Chou YH. Methicillin-resistant Staphylococcus aureus bacteremia in neonatal intensive care units: analysis of 90 episodes. Acta Paediatr. 2004;93(6):786-790
8. Behari P, Englund J, Alcasid G, Garcia-Houchins S, Weber SG. Transmission of methicillin-resistant Staphylococcus aureus to preterm infants through breast milk. Infect Control Hosp Epidemiol. 2004;25(9):778-780 (Pubitemid 39312051)
9. Khoury J, Jones M, Grim A, Dunne WM Jr, Fraser V. Eradication of methicillin-resistant Staphylococcus aureus from a neonatal intensive care unit by active surveillance and aggressive infection control measures. Infect Control Hosp Epidemiol. 2005;26(7):616-621 (Pubitemid 41073401)
10. Regev-Yochay G, Rubinstein E, Barzilai A, et al. Methicillin-resistant Staphylococcus aureus in neonatal intensive care unit. Emerg Infect Dis. 2005;11(3):453-456 (Pubitemid 40315734)
11. Huang YC, Chou YH, Su LH, Lien RI, Lin TY. Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units. Pediatrics. 2006;118(2):469-474 (Pubitemid 46085400)
12. Stein M, Navon-Venezia S, Chmelnitsky I, et al. An outbreak of new, nonmultidrug-resistant, methicillin-resistant Staphylococcus aureus strain (SCCmec type IIIA variant-1) in the neonatal intensive care unit transmitted by a staff member. Pediatr Infect Dis J. 2006;25(6):557-559 (Pubitemid 43863369)
13. Sax H, Posfay-Barbe K, Harbarth S, et al. Control of a cluster of community-associated, methicillin-resistant Staphylococcus aureus in neonatology. J Hosp Infect. 2006;63(1):93-100
14. Gerber SI, Jones RC, Scott MV, et al. Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement. Infect Control Hosp Epidemiol. 2006;27(2):139-145 (Pubitemid 43384760)
15. McDonald JR, Carriker CM, Pien BC, et al. Methicillin-resistant Staphylococcus aureus outbreak in an intensive care nursery: potential for interinstitutional spread. Pediatr Infect Dis J. 2007;26(8):678-683 (Pubitemid 47424635)
16. Raymond J, Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. Infect Control Hosp Epidemiol. 2000;21(4):260-263
17. Rubin RJ, Harrington CA, Poon A, Dietrich K, Greene JA, Moiduddin A. The economic impact of Staphylococcus aureus infection in New York City hospitals. Emerg Infect Dis. 1999;5(1):9-17 (Pubitemid 29124770)
18. Shorr AF. Epidemiology and economic impact of methicillin-resistant Staphylococcus aureus: review and analysis of the literature. Pharmacoeconomics. 2007;25(9):751-768 (Pubitemid 47481640)
19. Andrews WW, Schelonka R, Waites K, Stamm A, Cliver SP, Moser S. Genital tract methicillin-resistant Staphylococcus aureus: risk of vertical transmission in pregnant women. Obstet Gynecol. 2008;111(1):113-118
20. Bertin ML, Vinski J, Schmitt S, et al. Outbreak of methicillin-resistant Staphylococcus aureus colonization and infection in a neonatal intensive care unit epidemiologically linked to a healthcare worker with chronic otitis. Infect Control Hosp Epidemiol. 2006;27(6):581-585 (Pubitemid 44023393)
21. Morel AS, Wu F, Della-Latta P, Cronquist A, Rubenstein D, Saiman L. Nosocomial transmission of methicillin-resistant Staphylococcus aureus from a mother to her preterm quadruplet infants. Am J Infect Control. 2002;30(3):170-173 (Pubitemid 34521461)
22. Al-Tawfiq JA. Father-to-infant transmission of community-acquired methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2006;27(6):636-637 (Pubitemid 44023404)
23. Hollis RJ, Barr JL, Doebbeling BN, Pfaller MA, Wenzel RP. Familial carriage of methicillin-resistant Staphylococcus aureus and subsequent infection in a premature neonate. Clin Infect Dis. 1995;21(2):328-332
24. Gastelum DT, Dassey D, Mascola L, Yasuda LM. Transmission of community-associated methicillin-resistant Staphylococcus aureus from breast milk in the neonatal intensive care unit. Pediatr Infect Dis J. 2005;24(12):1122-1124 (Pubitemid 43011079)
25. Back NA, Linnemann CC, Staneck JL, Kotagal UR. Control of methicillin-resistant Staphylococcus aureus in a neonatal intensive-care unit: use of intensive microbiologic surveillance and mupirocin. Infect Control Hosp Epidemiol. 1996;17(4):227-231 (Pubitemid 126468081)
26. Jernigan JA, Titus MG, Groschel DH, Getchell-White S, Farr BM. Effectiveness of contact isolation during a hospital outbreak of methicillin-resistant Staphylococcus aureus. Am J Epidemiol. 1996;143(5):496-504
27. Masano H, Fukuchi K, Wakuta R, Tanaka Y. Efficacy of intranasal application of povidone-iodine cream in eradicating nasal methicillin-resistant Staphylococcus aureus in neonatal intensive care unit (NICU) staff. Postgrad Med J. 1993;69(suppl 3):S122-S125 (Pubitemid 23317416)
28. Huang SS, Yokoe DS, Hinrichsen DL, et al. Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis. 2006;43(8):971-978 (Pubitemid 44631095)
29. Stark AR; American Academy of Pediatrics, Committee on Fetus and Newborn. Levels of neonatal care. Pediatrics. 2004;114(5):1341-1347
30. Popovich KJ, Hota B, Rice T, Aroutcheva A, Weinstein RA. Phenotypic prediction rule for community-associated methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 2007;45(7):2293-2295
31. Popovich KJ, Weinstein RA, Hota B. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin Infect Dis. 2008;46(6):787-794
32. Millar BC, Loughrey A, Elborn JS, Moore JE. Proposed definitions of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). J Hosp Infect. 2007;67(2):109-113 (Pubitemid 47534958)
33. Kaplan SL, Hulten KG, Gonzalez BE, et al. Three-year surveillance of community-acquired Staphylococcus aureus infections in children. Clin Infect Dis. 2005;40(12):1785-1791 (Pubitemid 40799948)
34. Fortunov RM, Hulten KG, Hammerman WA, Mason EO, Kaplan SL. Community-acquired Staphylococcus aureus infections in term and near-term previously healthy neonates. Pediatrics. 2006;118(3):874-881 (Pubitemid 46090027)
35. Kuint J, Barzilai A, Regez-Yochay G, Rubinstein E, Keller N, Maayan-Metzger A. Comparison of community-acquired methicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit. Eur J Pediatr. 2007;166(4):319-325 (Pubitemid 46295085)
36. Eckhardt C, Halvosa JS, Ray SM, Blumberg HM. Transmission of methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit from a patient with community-acquired disease. Infect Control Hosp Epidemiol. 2003;24(6):460-461 (Pubitemid 36818519)
37. Seybold U, Halvosa JS, White N, Voris V, Ray SM, Blumberg HM. Emergence of and risk factors for methicillin-resistant Staphylococcus aureus of community origin in intensive care nurseries. Pediatrics. 2008;122(5):1039-1046