Emergence of and risk factors for methicillin-resistant Staphylococcus aureus of community origin in intensive care nurseries

Pediatrics

Volumn 122, Issue 5, 2008, Pages 1039-1046

  Seybold, Ulrich ^a,b,c,d   Halvosa, J Sue ^c   White, Nancy ^c   Voris, Victoria ^c   Ray, Susan M ^b,c   Blumberg, Henry M ^b,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GRADY MEMORIAL HOSPITAL   (United States)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Colonization; Methicillin resistance; NICU; Pulsed field gel electrophoresis; Staphylococcus aureus

Indexed keywords

PANTON VALENTINE LEUKOCIDIN;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM CULTURE; CESAREAN SECTION; ENDOTRACHEAL INTUBATION; FEMALE; GENOTYPE; HOSPITAL INFECTION; HUMAN; INFECTION RISK; MALE; MATERNAL SMOKING; MEC GENE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIPLEX POLYMERASE CHAIN REACTION; NEWBORN; NEWBORN INFECTION; NEWBORN INTENSIVE CARE; NURSERY; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; UNITED STATES; VAGINAL DELIVERY; COMMUNICABLE DISEASE; GENETICS; HOSPITAL; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTIVARIATE ANALYSIS; PATHOGENICITY; PUBLIC HOSPITAL; RISK FACTOR; STAPHYLOCOCCUS INFECTION; STATISTICAL MODEL; STATISTICS; URBAN POPULATION;

COMMUNITY-ACQUIRED INFECTIONS; ELECTROPHORESIS, GEL, PULSED-FIELD; GENOTYPE; GEORGIA; HOSPITALS, PUBLIC; HOSPITALS, URBAN; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; LOGISTIC MODELS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MULTIVARIATE ANALYSIS; RISK FACTORS; STAPHYLOCOCCAL INFECTIONS; URBAN POPULATION;

EID: 58149154236     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-3161     Document Type: Article

References (46)

1. Deresinski S. Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey. Clin Infect Dis. 2005;40(4):562-573
2. Zetola N, Francis JS, Nuermberger EL, Bishai WR. Community- acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis. 2005;5(5):275-286
3. McDougal LK, Steward CD, Killgore GE, Chaitram JM, McAllister SK, Tenover FC. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol. 2003; 41(11):5113-5120
4. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med. 2006;144(5):309-317
5. Seybold U, Kourbatova EV, Johnson JG, et al. Emergence of community-associated methicillin-resistant Staphylococcus au- reus USA300 genotype as a major cause of health care- associated blood stream infections. Clin Infect Dis. 2006;42(5):647-656
6. Centers for Disease Control and Prevention. Methicillin- resistant Staphylococcus aureus infections in correctional facilities: Georgia, California, and Texas, 2001-2003. MMWR Morb Mortal Wkly Rep. 2003;52(41):992-996
7. Centers for Disease Control and Prevention. Methicillin-resistant Staphylococcus aureus infections among competitive sports participants: Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000-2003. MMWR Morb Mortal Wkly Rep. 2003;52(33):793-795
8. Fridkin SK, Hageman JC, Morrison M, et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med. 2005;352(14):1436-1444
9. Miller LG, Perdreau-Remington F, Rieg G, et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med. 2005; 352(14):1445-1453
10. Lina G, Piemont Y, Godail-Gamot F, et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999; 29(5):1128-1132
11. Naimi TS, LeDell KH, Como-Sabetti K, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003;290(22):2976 -2984
12. Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus: Minnesota and North Dakota, 1997-1999. JAMA. 1999;282(12):1123-1125
13. Buckingham SC, McDougal LK, Cathey LD, et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus at a Memphis, Tennessee, children's hospital. Pediatr Infect Dis J. 2004;23(7):619-624
14. Healy CM, Hulten KG, Palazzi DL, Campbell JR, Baker CJ. Emergence of new strains of methicillin-resistant Staphylo- coccus aureus in a neonatal intensive care unit. Clin Infect Dis. 2004;39(10):1460-1466
15. Herold BC, Immergluck LC, Maranan MC, et al. Community- acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA. 1998;279(8):593-598
16. Regev-Yochay G, Rubinstein E, Barzilai A, et al. Methicillin-resistant Staphylococcus aureus in neonatal intensive care unit. Emerg Infect Dis. 2005;11(3):453-456
17. Klevens RM, Morrison MA, Fridkin SK, et al. Community- associated methicillin-resistant Staphylococcus aureus and healthcare risk factors. Emerg Infect Dis. 2006;12(12):1991-1993
18. Saiman L. Hospital-acquired infections in the neonatal intensive care unit: introduction. Semin Perinatol. 2002;26(5):313-314
19. Stoll BJ, HansenN, Fanaroff AA, et al. Late-onset sepsis invery low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2):285-291
20. Huang Y-C, Chou Y-H, Su L-H, Lien R-I, Lin T-Y. Methicillin-resistant Staphylococcus aureus colonization and its association with infectionamong infants hospitalized inneonatal intensive care units. Pediatrics. 2006;118(2):469-474
21. Saiman L. Risk factors for hospital-acquired infections in the neonatal intensive care unit. Semin Perinatol. 2002;26(5):315-321
22. Gerber SI, Jones RC, Scott MV, et al. Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement. Infect Control Hosp Epidemiol. 2006;27(2):139-145
23. Sax H, Posfay-Barbe K, Harbarth S, et al. Control of a cluster of community-associated, methicillin-resistant Staphylococcus au- reus in neonatology. J Hosp Infect. 2006;63(1):93-100
24. David MD, Kearns AM, Gossain S, Ganner M, Holmes A. Community-associated meticillin-resistant Staphylococcus aureus: nosocomial transmission in a neonatal unit. J Hosp Infect. 2006;64(3):244-250
25. Al-Tawfiq JA. Father-to-infant transmission of community- acquired methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2006;27(6):636-637
26. Kuint J, Barzilai A, Regev-Yochay G, Rubinstein E, Keller N, Maayan-Metzger A. Comparison of community-acquired me-thicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit. Eur J Pediatr. 2007;166(4):319-325
27. Gastelum DT, Dassey D, Mascola L, Yasuda LM. Transmission of community-associated methicillin-resistant Staphylococcus aureus from breast milk in the neonatal intensive care unit. Pediatr Infect Dis J. 2005;24(12):1122-1124
28. Siegel JD, Rhinehart E, Jackson M, Chiarello L, Healthcare Infection Control Practices Advisory Committee (HICPAC). Management ofMultidrug-Resistant Organisms in Healthcare Settings, 2006. Atlanta, GA: Centers for Disease Control and Prevention; 2006. Available at www.cdc.gov/ncidod/dhqp/ pdf/ar/mdroGuideline2006.pdf. Accessed September 4, 2008
29. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically: Approved Standard M7-A6. 6th ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2003
30. Oliveira DC, de Lencastre H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2002;46(7):2155-2161
31. Zhang K, McClure JA, Elsayed S, Louie T, Conly JM. Novel multiplex PCR assay for characterization and concomitant sub- typing of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 2005;43(10):5026-5033
32. Diep BA, Carleton HA, Chang RF, Sensabaugh GF, Perdreau- Remington F. Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin- resistant Staphylococcus aureus. J Infect Dis. 2006;193(11):1495-1503
33. Oken E, Kleinman KP, Rich-Edwards J, Gillman MW. A nearly continuous measure of birth weight for gestational age using a United States national reference. BMC Pediatr. 2003;3:6
34. Tenover FC, McDougal LK, Goering RV, et al. Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States. J Clin Microbiol. 2006;44(1):108-118
35. Bertin ML, Vinski J, Schmitt S, et al. Outbreak of methicillin-resistant Staphylococcus aureus colonization and infection in a neonatal intensive care unit epidemiologically linked to a healthcare worker with chronic otitis. Infect Control Hosp Epidemiol. 2006;27(6):581-585
36. Stein M, Navon-Venezia S, Chmelnitsky I, et al. An outbreak of new, nonmultidrug-resistant, methicillin-resistant Staphylococcus aureus strain (SCCmec type IIIA variant-1) in the neonatal intensive care unit transmitted by a staff member. Pediatr Infect Dis J. 2006;25(6):557-559
37. Behari P, Englund J, Alcasid G, Garcia-Houchins S, Weber SG. Transmission of methicillin-resistant Staphylococcus aureus to preterm infants through breast milk. Infect Control Hosp Epidemiol. 2004;25(9):778-780
38. Shiojima T, Ohki Y, Nako Y, Morikawa A, Okubo T, Iyobe S. Immediate control of a methicillin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit. J Infect Che-mother. 2003;9(3):243-247
39. Eckhardt C, Halvosa JS, Ray SM, Blumberg HM. Transmission of methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit from a patient with community-acquired disease. Infect Control Hosp Epidemiol. 2003;24(6):460-461
40. Mitsuda T, Arai K, Fujita S, Yokota S. Demonstration of mother- to-infant transmission of Staphylococcus aureus by pulsed-field gel electrophoresis. Eur J Pediatr. 1996;155(3):194-199
41. Morel AS, Wu F, Della-Latta P, Cronquist A, Rubenstein D, Saiman L. Nosocomial transmission of methicillin-resistant Staphylococcus aureus from a mother to her preterm quadruplet infants. Am J Infect Control. 2002;30(3):170-173
42. Bratu S, Eramo A, Kopec R, et al. Community-associated me- thicillin-resistant Staphylococcus aureus in hospital nursery and maternity units. Emerg Infect Dis. 2005;11(6):808-813
43. Centers for Disease Control and Prevention. Community- associated methicillin-resistant Staphylococcus aureus infection among healthy newborns: Chicago and Los Angeles County, 2004. MMWR Morb Mortal Wkly Rep. 2006;55(12):329-332
44. Altoparlak U, Kadanali A, Kadanali S. Genital flora in pregnancy and its association with group B streptococcal colonization. Int J Gynaecol Obstet. 2004;87(3):245-246
45. Chen KT, Huard RC, Della-Latta P, Saiman L. Prevalence of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in pregnant women. Obstet Gynecol. 2006;108(3):482-487
46. L'Hériteau F, Lucet JC, Scanvic A, Bouvet E. Community-acquired methicillin-resistant Staphylococcus aureus and familial transmission. JAMA. 1999;282(11):1038-1039