Motor cortex bilateral motor representation depends on subcortical and interhemispheric interactions

Journal of Neuroscience

Volumn 29, Issue 19, 2009, Pages 6196-6206

  Brus Ramer, Marcel ^a   Carmel, Jason B ^a   Martin, John H ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; BRAIN REGION; CONTROLLED STUDY; FEMALE; FORELIMB; HEMISPHERE; INTRACORTICAL MICROSTIMULATION; MOTOR CORTEX; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; STIMULUS RESPONSE;

4-AMINOPYRIDINE; ANALYSIS OF VARIANCE; ANIMALS; CORPUS CALLOSUM; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; FORELIMB; FUNCTIONAL LATERALITY; MICROELECTRODES; MOTOR CORTEX; MUSCLE, SKELETAL; NEURAL INHIBITION; POTASSIUM CHANNEL BLOCKERS; PYRAMIDAL TRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 66049101587     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5852-08.2009     Document Type: Article

References (50)

1. Asanuma H, Okuda O (1962) Effects of transcallosal volleys on pyramidal tract cell activity of cat. J Neurophysiol 25:198-208.
2. Bawa P, Hamm JD, Dhillon P, Gross PA (2004) Bilateral responses of upper limb muscles to transcranial magnetic stimulation in human subjects. Exp Brain Res 158:385-390. (Pubitemid 39304305)
3. Brösamle C, Schwab ME (1997) Cells of origin, course, and termination patterns of the ventral, uncrossed component of the mature rat corticospinal tract. J Comp Neurol 386:293-303. (Pubitemid 27392135)
4. Brus-Ramer M, Carmel JB, Chakrabarty S, Martin JH (2007) Electrical stimulation of spared corticospinal axons augments connections with ipsilateral spinal motor circuits after injury. J Neurosci 27:13793-13801. (Pubitemid 350278261)
5. Bury SD, Jones TA (2004) Facilitation of motor skill learning by callosal denervation or forced forelimb use in adult rats. Behav Brain Res 150:43-53. (Pubitemid 38368957)
6. Castro AJ (1975) Ipsilateral corticospinal projections after large lesions of the cerebral hemisphere in neonatal rats. Exp Neurol 46:1-8.
7. Chakrabarty S, Friel KM, Martin JH (2009) Activity-dependent plasticity improves M1 motor representation and corticospinal tract connectivity. J Neurophysiol 101:1283-1293.
8. Cisek P, Crammond DJ, Kalaska JF (2003) Neural activity in primary motor and dorsal premotor cortex in reaching tasks with the contralateral versus ipsilateral arm. J Neurophysiol 89:922-942. (Pubitemid 36206140)
9. Donchin O, Gribova A, Steinberg O, Mitz AR, Bergman H, Vaadia E (2002) Single-unit activity related to bimanual arm movements in the primary and supplementary motor cortices. J Neurophysiol 88:3498-3517. (Pubitemid 35448725)
10. Edgley SA, Jankowska E, Hammar I (2004) Ipsilateral actions of feline corticospinal tract neurons on limb motoneurons. J Neurosci 24:7804-7813. (Pubitemid 39215683)
11. Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD (1992) Interhemispheric inhibition of the human motor cortex. J Physiol 453:525-546.
12. Friel KM, Martin JH (2007) Bilateral activity-dependent interactions in the developing corticospinal system. J Neurosci 27:11083-11090. (Pubitemid 47574163)
13. Friel KM, Drew T, Martin JH (2007) Differential activity-dependent development of corticospinal control of movement and final limb position during visually-guided locomotion. J Neurophysiol 97:3396-3406. (Pubitemid 47084755)
14. Hanajima R, Ugawa Y, Machii K, Mochizuki H, Terao Y, Enomoto H, Furubayashi T, Shiio Y, Uesugi H, Kanazawa I (2001) Interhemispheric facilitation of the hand motor area in humans. J Physiol 531:849-859. (Pubitemid 32243761)
15. Hess G, Donoghue JP (1994) Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical motor maps. J Neurophysiol 71:2543-2547. (Pubitemid 24184887)
16. Jankowska E, Edgley SA (2006) How can corticospinal tract neurons contribute to ipsilateral movements? A question with implications for recovery of motor functions. Neuroscientist 12:67-79. (Pubitemid 43122384)
17. Jankowska E, Lundberg A, Rudomin P, Sykova E (1982) Effects of 4-aminopyridine on synaptic transmission in the cat spinal cord. Brain Res 240:117-129.
18. Jankowska E, Cabaj A, Pettersson LG (2005) How to enhance ipsilateral actions of pyramidal tract neurons. J Neurosci 25:7401-7405. (Pubitemid 41129813)
19. Jones RD, Donaldson IM, Parkin PJ (1989) Impairment and recovery of ipsilateral sensory-motor function following unilateral cerebral infarction. Brain 112:113-132. (Pubitemid 19056477)
20. Kartje-Tillotson G, Neafsey EJ, Castro AJ (1985) Electrophysiological analysis of motor cortical plasticity after cortical lesions in newborn rats. Brain Res 332:103-111. (Pubitemid 15107087)
21. Kartje-Tillotson G, O'Donoghue DL, Dauzvardis MF, Castro AJ (1987) Pyramidotomy abolishes the abnormal movements evoked by intracortical microstimulation in adult rats that sustained neonatal cortical lesions. Brain Res 415:172-177. (Pubitemid 17097390)
22. Kleim JA, Bruneau R, Calder K, Pocock D, VandenBerg PM, MacDonald E, Monfils MH, Sutherland RJ, Nader K (2003) Functional organization of adult motor cortex is dependent upon continued protein synthesis. Neuron 40:167-176. (Pubitemid 37222471)
23. Liang F, Rouiller EM, Wiesendanger M (1993) Modulation of sustained electromyographic activity by single intracortical microstimuli: comparison of two forelimb motor cortical areas of the rat. Somatosens Mot Res 10:51-61. (Pubitemid 23136476)
24. Loy DN, Talbott JF, Onifer SM, Mills MD, Burke DA, Dennison JB, Fajardo LC, Magnuson DS, Whittemore SR (2002) Both dorsal and ventral spinal cord pathways contribute to overground locomotion in the adult rat. Exp Neurol 177:575-580. (Pubitemid 35366146)
25. Maier IC, Baumann K, Thallmair M, Weinmann O, Scholl J, Schwab ME (2008) Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury. J Neurosci 28:9386-9403.
26. Marshall RS, Perera GM, Lazar RM, Krakauer JW, Constantine RC, DeLaPaz RL (2000) Evolution of cortical activation during recovery from corticospinal tract infarction. Stroke 31:656-661. (Pubitemid 30131651)
27. Martin JH (1991) Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat. Neurosci Lett 127:160-164.
28. Martin JH (2005) The corticospinal system: from development to motor control. The Neuroscientist 11:161-173. (Pubitemid 40388498)
29. Martin JH, Ghez C (2001) Dissecting the organization of cortical and subcortical circuits for skilled limb movement control in development and maturity with reversible inactivation. In: Virtual lesions: understanding behavior and perception with reversible deactivation techniques (Lomber S, Galuske R, eds). Oxford: Oxford UP.
30. Meyer BU, Röricht S, Gräfin von Einsiedel H, Kruggel F, Weindl A (1995) Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain 118:429-440.
31. Nashmi R, Fehlings MG (2001) Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channels. Brain Res Brain Res Rev 38:165-191. (Pubitemid 34066501)
32. Neafsey EJ, Bold EL, Haas G, Hurley-Gius KM, Quirk G, Sievert CF, Terreberry RR (1986) The organization of the rat motor cortex: a microstimulation mapping study. Brain Res 396:77-96. (Pubitemid 16126208)
33. Nielsen JB, Crone C, Hultborn H (2007) The spinal pathophysiology of spasticity-from a basic science point of view. Acta Physiol (Oxf) 189:171-180. (Pubitemid 46148327)
34. O'Donoghue DL, Kartje-Tillotson G, Neafsey EJ, Castro AJ (1986) A study of forelimb movements evoked by intracortical microstimulation after hemicerebellectomy in newborn, young and adult rats. Brain Res 385:311-320. (Pubitemid 16006846)
35. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, Ed 2. Sydney: Academic.
36. Piecharka DM, Kleim JA, Whishaw IQ (2005) Limits on recovery in the corticospinal tract of the rat: partial lesions impair skilled reaching and the topographic representation of the forelimb in motor cortex. Brain Res Bull 66:203-211. (Pubitemid 40981021)
37. Pierrot-Deseilligny E, Burke D (2005) The circuitry of the human spinal cord. Cambridge, UK: Cambridge UP.
38. Salimi I, Friel KM, Martin JH (2008) Pyramidal tract stimulation restores normal corticospinal tract connections and visuomotor skill after early postnatal motor cortex activity blockade. J Neurosci 28:7426-7434.
39. Sanes JN, Wang J, Donoghue JP (1992) Immediate and delayed changes of rat motor cortical output representation with new forelimb configurations. Cereb Cortex 2:141-152.
40. Schaefer SY, Haaland KY, Sainburg RL (2007) Ipsilesional motor deficits following stroke reflect hemispheric specializations for movement control. Brain 130:2146-2158. (Pubitemid 47236627)
41. Schoen JH (1964) Comparative aspects of the descending fibre systems in the spinal cord. Prog Brain Res 11:203-222.
42. Tehovnik EJ, Sommer MA (1997) Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex. J Neurosci Methods 74:17-26. (Pubitemid 27250246)
43. Ugawa Y, Hanajima R, Kanazawa I (1993) Interhemispheric facilitation of the hand area of the human motor cortex. Neurosci Lett 160:153-155. (Pubitemid 23294728)
44. Wang J, Sainburg RL (2006) The symmetry of interlimb transfer depends on workspace locations. Exp Brain Res 170:464-471.
45. Ward NS, Cohen LG (2004) Mechanisms underlying recovery of motor function after stroke. Arch Neurol 61:1844-1848.
46. Wassermann EM, Fuhr P, Cohen LG, Hallett M (1991) Effects of transcranial magnetic stimulation on ipsilateral muscles. Neurology 41:1795-1799.
47. Wassermann EM, Pascual-Leone A, Hallett M (1994) Cortical motor representation of the ipsilateral hand and arm. Exp Brain Res 100:121-132. (Pubitemid 24244892)
48. Weidner N, Ner A, Salimi N, Tuszynski MH (2001) Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A 98:3513-3518. (Pubitemid 32220876)
49. Woolsey CN, Erickson TC, Gilson WE (1979) Localization in somatic sensory and motor areas of human cerebral cortex as determined by direct recording of evoked potentials and electrical stimulation. J Neurosurg 51:476-506.
50. Z'Graggen WJ, Fouad K, Raineteau O, Metz GA, Schwab ME, Kartje GL (2000) Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal rats. J Neurosci 20:6561-6569.