Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats

Journal of Physiology

Volumn 531, Issue 2, 2001, Pages 515-526

  Dreier, Jens P ^a   Petzold, Gabor ^a   Tille, Katrin ^b   Lindauer, Ute ^a   Arnold, Guy ^a   Heinemann, Uwe ^a   Einhäupl, Karl M ^b   Dirnagl, Ulrich ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Vivantes Wenckebach Klinikum   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; PAPAVERINE; POTASSIUM CHLORIDE; POTASSIUM ION; VASODILATOR AGENT; NITRIC OXIDE SYNTHASE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN PERFUSION; BRAIN SLICE; CEREBROSPINAL FLUID; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPEREMIA; IN VIVO STUDY; MALE; MIGRAINE; NERVE CONDUCTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REPOLARIZATION; SKULL; SPREADING CORTICAL DEPRESSION; SPREADING CORTICAL ISCHEMIA; STROKE; VASOCONSTRICTION; ANIMAL EXPERIMENT; BRAIN FUNCTION; CORTICAL SPREADING ISCHEMIA; ENZYME INHIBITION; NERVE CELL; OLIGEMIA; PERFUSION;

ANIMALS; BRAIN; DRUG COMBINATIONS; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; HYPEREMIA; ISCHEMIA; MALE; NEURONS; NITRIC OXIDE DONORS; OSMOLAR CONCENTRATION; PAPAVERINE; PERFUSION; POTASSIUM; RATS; RATS, WISTAR; SPREADING CORTICAL DEPRESSION; VASODILATOR AGENTS;

EID: 0035281652     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.0515i.x     Document Type: Article

References (51)

1. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: Effect on blood flow, tissue oxygeneration, and electroencephalogram
2. Imaging spreading depression and associated intracellular calcium waves in brain slices
3. 2-profiles in hippocampa slices of the guinea pig
4. Migraine stroke
5. Migraine and subsequent risk of stroke in the physician's health study
6. Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes
7. History of migraine and risk of cerebral ischemia in young adults. The Italian National Research Council Study Group on Stroke in the Young
8. MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy
9. Neuronal NO promotes cerebral cortical hyperemia during cortical spreading depression in rabbits
10. Potassium-stimulated release of nitric oxide from cerebellar slices
11. Products of hemolysis in the subarachnoid space induce cortical spreading ischemia and focal necrosis in rats: A model for delayed ischemic neurological deficits after subarachnoid haemorrhage?
12. Pharmacological transformation of spreading depression (SD) related hyperperfusion to an acute and longlasting hypoperfusion by NOS-inhibition and ouabain
13. 2+ induced epileptiform activity in rat temporal cortex slices
14. + is increased in the subarachnoid space
15. A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited
16. Arginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression
17. Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage: A systematic review
18. Nitric oxide synthesis couples cerebral blood flow and metabolism
19. +-ATPase activity in cultured mouse neurones and astrocytes
20. + during spreading depression
21. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain
22. Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures
23. Pathophysiology of the migraine aura. The spreading depression theory
24. Propagation of spreading cortical depression
25. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds
26. Plasma and cerebrospinal fluid endogenous digoxin-like immunoreactivity in patients with aneurysmal subarachnoid haemorrhage
27. o in cat cortex
28. Comparison of the effects of potassium and pH on the calibre of cerebral veins and arteries
29. A review of hemoglobin and the pathogenesis of cerebral vasospasm
30. Measurements of extracellular potassium, ECoG and pyridine nucleotide levels during cortical spreading depression in rats
31. Association between migraine and stroke in a large-scale epidemiological study of the United States
32. Modulation of extraluminally induced vasoconstrictions by endothelium-derived nitric oxide in the canine basilar artery
33. Nitric oxide: Physiology, pathophysiology, and pharmacology
34. Neurovascular and molecular mechanisms in migraine headaches
35. Gap junctions are required for the propagation of spreading depression
36. Spreading depression is not associated with neuronal injury in the normal brain
37. Factors inducing endothelium-dependent relaxation in the guinea-pig basilar artery as estimated from the actions of haemoglobin
38. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy
39. Cerebral vasospasm following ruptured intracranial aneurysms, especially some contributions of potassium ion released from subarachnoid hematoma to delayed cerebral vasospasm
40. Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?
41. The Rat Brain in Stereotaxic Coordinates
42. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
43. Sumatriptan modifies cortical free radical release during cortical spreading depression. A novel antimigraine action for sumatriptan?
44. Spreading depression, sustained potential shifts, and metabolic activity of cerebral cortex of cats
45. Bedside-microdialysis for early detection of vasospasm after subarachnoid hemorrhage. Case report and review of the literature
46. Case-control study of migraine and risk of ischaemic stroke in young women
47. Coupling of brain activity and cerebral blood flow: Basis of functional neuroimaging
48. Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilation elicited by cortical spreading depression
49. Systemic nitric oxide synthase inhibition does not affect brain oxygenation during cortical spreading depression in rats: A noninvasive near-infrared spectroscopy and laser-Doppler flowmetry study
50. Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache
51. Cerebral blood flow changes during cortical spreading depression are not altered by inhibition of nitric oxide synthesis