Theoretical and experimental optimization of laser speckle contrast imaging for high specificity to brain microcirculation

Journal of Cerebral Blood Flow and Metabolism

Volumn 27, Issue 2, 2007, Pages 258-269

  Wang, Zheng ^a,b   Hughes, Sarah ^b   Dayasundara, Sudath ^b   Menon, Ravi S ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Functional neuroimaging; Hemodynamics; Hypercapnia; Laser speckle contrast imaging

Indexed keywords

CARBON DIOXIDE; ISOFLURANE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN MICROCIRCULATION; CARBON DIOXIDE TENSION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; HEMODYNAMICS; LASER DOPPLER FLOWMETRY; LASER SPECKLE CONTRAST IMAGING; NEUROIMAGING; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; THEORETICAL MODEL;

ALGORITHMS; ANIMALS; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; DATA INTERPRETATION, STATISTICAL; DIAGNOSTIC IMAGING; HYPERCAPNIA; IMAGE PROCESSING, COMPUTER-ASSISTED; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; PROBABILITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33846455834     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600357     Document Type: Article

References (45)

1. Ayata C, Dunn AK, Gursoy-Ozdemir Y, Huang ZH, Boas DA, Moskowitz MA (2004) Laser speckle flowmetry for the study of cerebrovascular physiology in normaland ischemic mouse cortex. J Cereb Blood Flow Metab 24:744-55
2. Bandyopadhyay R, Gittings , Suh SS, Dixon PK, Durian DJ (2005) Speckle-visibility spectroscopy: a tool to study time-varying dynamics. Rev Sci Instrum 76:093110
3. Bolay H, Reuter U, Dunn AK, Huang ZH, Boas DA, Moskowitz MA (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8:136-42
4. Bonner R, Nossal R (1981) Model for laser Doppler measurements of blood flow in tissue. Appl Opt 20:2097-107
5. Briers JD (1996) Laser Doppler and time-varying speckle: a reconciliation. J Opt Soc Am 13:345-50
6. Briers JD (2001) Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. Physiol Meas 22:R35-66
7. Briers JD, Richards G, He XW (1999) Capillary blood flow monitoring using laser speckle contrast analysis (LASCA). J Biomed Opt 4:164-75
8. Choi B, Kang NM, Nelson JS (2004) Laser speckle imaging for monitoring blood flow dynamics in the in vivo rodent dorsal skin fold model. Microvasc Res 68:143-6
9. Dainty JC (1975) Recent developments. In: Laser speckle and related topics, vol 9 in series topics in applied physics (Dainty JC, ed), Berlin: Springer-Verlag, 321-35
10. Detre JA, Ances BM, Takahashi K, Greenberg JH (1998) Signal averaged Laser Doppler measurements of activation-flow coupling in the rat forepaw somatosensory cortex. Brain Res 796:91-8
11. Dunn AK, Bolay H, Moskowitz MA, Boas DA (2001) Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab 21:195-201
12. Duong TQ, Kim D-S, Ugurbil K, Kim S-G (2001) Localized cerebral blood flow response at submillimeter columnar resolution. Proc Natl Acad Sci USA 98:10904-9
13. Durduran T, Burnett MG, Yu GQ, Zhou C, Furuya D, Yodh AG, Detre JA, Greenberg JH (2004) Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry. J Cereb Blood Flow Metab 24:518-25
14. Fercher AF, Briers JD (1981) Flow visualization by means of single-exposure speckle photography. Opt Commun 37:326-9
15. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83:1140-4
16. Goodman JW (1965) Some effects of target-induced scintillations on optical radar performance. Proc IEEE 53:1688-700
17. Goodman JW (1975) Statistical properties of laser speckle patterns. In: Laser speckle and related topics, vol. 9 in series topics in applied physics (Dainty JC, ed), Berlin: Springer-Verlag, 9-75
18. Goodman JW (1985) Statistical optics. Wiley: New York 237
19. Goodman JW (2006) Speckle phenomena in optics: theory and applications. Greenwood Village: Roberts & Company
20. Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN (1986) Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature 324:361-4
21. 2 on cerebral blood volume, blood flow and vascular mean transit time. Stroke 5:630-9
22. Henyey LG, Greenstein JL (1941) Diffuse radiation in the galaxy. Astrophys J 93:70-83
23. Hudetz AG, Biswal BB, Fehér G, Kampine JP (1997) Effects of hypoxia and hypercapnia on capillary flow velocity in the rat cerebral cortex. Microvasc Res 54:35-42
24. Iadecola C (2004) Neurovascular regulation in the normal-brain and in Alzheimer's disease. Nat Rev Neurosci 5:347-60
25. Jakeman E (1973) Photon correlation. In: Photon correlation and light beating spectroscopy (Cummins HZ, Pike ER, eds), London: Plenum Press, 75-149
26. Kety SS, Schmidt CF (1948) The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normalyoung men. J Clin Invest 27:484-91
27. Kim SG, Ugurbil K (2003) High-resolution functional magnetic resonance imaging of the animal brain. Methods 30:28-41
28. Kharlamov A, Brown BR, Easley KA, Jones SC (2004) Heterogeneous response of cerebral blood flow to hypotension demonstrated by laser speckle imaging flowmetry in rats. Neurosci Let 368:151-6
29. Matta BF, Heath KJ, Tipping K, Summors AC (1999) Direct cerebral vasodilatory effects of sevoflurane and isoflurane. Anesthesiology 91:677-80
30. Menon RS (2001) Imaging function in the working brain with fMRI. Curr Opin Neurobiol 11:630-6
31. Mirsattari SM, Bihari F, Leung LS, Menon RS, Wang Z, Ives JR, Bartha R (2005) Physiological monitoring of small animals during magnetic resonance imaging. J Neurosci Methods 144:207-13
32. Mirsattari SM, Wang Z, Ives JR, Bihari F, Leung LS, Bartha R, Menon RS (2006) Linear aspects of transformation from interictal epileptic discharges to BOLD fMRI signals in an animal model of occipital epilepsy. Neuroimage 30:1133-48
33. Ogawa S, Tank DW, Menon RS, Ellermann JM, Kim SG, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 89:5951-5
34. Petoukhova AL, Cleven E, de Mul FFM, Steenbergen W (2004) Suppression of dynamic laser speckle signals in multimode fibers of various lengths. Appl Opt 43:2059-65
35. Raichle ME (1998) Behind the scenes of functional brain imaging: a historical and physiological perspective. Proc Natl Acad Sci USA 95:765-72
36. Sicard K, Shen Q, Brevard M, Sullivan R, Ferris CF, King JA, Duong TQ (2003) Regional cerebral blood flow and BOLD response in conscious and anesthetized rats under basal and hypercapnic conditions: implications for fMRI studies. J Cereb Blood Flow Metab 23:472-81
37. Sokoloff L (1996) Circulation in the central nervous system. In: Comprehensive human physiology (Greger R, Windhorst U, eds) Berlin: Springer-Verlag, 561-78
38. Stern MD (1975) In vivo evaluation of microcirculation by coherent light scattering. Nature 254:56-8
39. Villringer A, Them A, Lindauer U, Einhäupl KM, Dirnagl U (1994) Capillary perfusion of the rat brain cortex: an in vivo confocal microscopy study. Circ Res 75:55-62
40. Vogel J, Abounader R, Schröck H, Zeller K, Duelli R, Kuschinsky W (1996) Parallel changes of blood flow and heterogeneity of capillary plasma perfusion in rat brains during hypocapnia. Am J Physiol 270:H1441-5
41. Völker AC, Zakharov P, Weber B, Buck F, Scheffold F (2005) Laser speckle imaging with an active noise reduction scheme. Opt Exp 13:9782-7
42. Wang LH, Jacques SL, Zheng LQ (1995) MCML-Monte Carlo modeling of photon transport in multi-layered tissues. Comput Methods Programs Biomed 47:131-46
43. Weber B, Burger C, Wyss MT, von Schulthess GK, Scheffold F, Buck A (2004) Optical imaging of the spatiotemporal dynamics of cerebral blood flow and oxidative metabolism in the rat barrel cortex. Euro J Neurosci 20:2664-70
44. Webster MA, Webb KJ, Weiner AM, Xu JY, Cao H (2003) Temporal response of a random medium from speckle intensity frequency correlations. J Opt Soc Am 20:2057-70
45. Yuan S, Devor A, Boas DA, Dunn AK (2005) Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. Appl Opt 44:1823-30