Polypseudorotaxane formation of randomly-pegylated insulin with cyclodextrins: Slow release and resistance to enzymatic degradation

Chemical and Pharmaceutical Bulletin

Volumn 57, Issue 5, 2009, Pages 541-544

  Higashi, Taishi ^a   Hirayama, Fumitoshi ^b   Misumi, Shogo ^a   Motoyama, Keiichi ^a   Arima, Hidetoshi ^a   Uekama, Kaneto ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b SOJO UNIVERSITY   (Japan)

Author keywords

Cyclodextrin; Pegylated insulin; Polypseudorotaxane; Randomly pegylated insulin; Stabilization; Sustained release

Indexed keywords

CYCLODEXTRIN; INSULIN; MACROGOL; ROTAXANE;

ARTICLE; COMPLEX FORMATION; DRUG RELEASE; ENZYMATIC DEGRADATION; PROTEIN DEGRADATION; SUSTAINED DRUG RELEASE; X RAY DIFFRACTION;

CYCLODEXTRINS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ENZYME ACTIVATION; HYPOGLYCEMIC AGENTS; INSULIN; POLYETHYLENE GLYCOLS; POLYMERS; ROTAXANES; SURFACE PROPERTIES;

EID: 65949117016     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.57.541     Document Type: Article

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