Src-lnduced Cisplatin resistance mediated by cell-to-cell communication

Cancer Research

Volumn 69, Issue 8, 2009, Pages 3619-3624

  Peterson Roth, Elizabeth ^a   Brdlik, Cathleen M ^a   Glazer, Peter M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CONNEXIN 43; PROTEASOME; PROTEIN TYROSINE KINASE; ANTINEOPLASTIC AGENT; CELL NUCLEUS ANTIGEN; DNA BINDING PROTEIN; GJA1 PROTEIN, HUMAN; KU ANTIGEN; PROTEIN KINASE P60; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GAP JUNCTION; GENE EXPRESSION; GENE TRANSFER; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TREATMENT RESPONSE; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL JUNCTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; FIBROBLAST; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; ANTIGENS, NUCLEAR; ANTINEOPLASTIC AGENTS; CELL COMMUNICATION; CISPLATIN; CONNEXIN 43; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; GAP JUNCTIONS; HUMANS; MICE; ONCOGENE PROTEIN PP60(V-SRC); PHOSPHORYLATION; RNA, SMALL INTERFERING;

EID: 65949102997     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0985     Document Type: Article

References (20)

1. Engelman JA, Zejnullahu K, Mitsudomi T. et al. MET Amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316: 1039-43. (Pubitemid 46799492)
2. Gorre ME, Mohammed M, Ellwood K. et al. Clinical resistance to ST1-571 cancer therapy caused by BCR- ABL gene mutation or amplification. Science 2001 ;293: 876-80 (Pubitemid 32743979)
3. Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc. Natl. Acad. Sci. USA 2004; 101: 6134-9. (Pubitemid 38520540)
4. Lin R, Warn-Cramer BJ, Kurata WE, Lau AF. v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication. J. Cell Riol 2001; 154: 815-27 (Pubitemid 34292962)
5. Oh SY, Dupont E, Madhukar BV. et al. Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line. Eur J. Cell Biol. 1993; 60: 250-5. (Pubitemid 23139641)
6. Czyz J, Inner U, Schulz G, Mindermann A, Hulser DF, Gap-junctional coupling measured by flow cytometry, Exp Cell Res 2000; 1255: 40-6. (Pubitemid 30115286)
7. Peterson-Roth E, Reynolds M, Quievryn G, Zhitkovich A. Mismatch repair proteins are activators of toxic responses to chromium-DNA damage. Mol. Cell Biol. 2005; 25: 3596-607. (Pubitemid 40559566)
8. Gibson SL, Bindra RS, Glazer PM, CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiat Res 2006; 166: 646-51. (Pubitemid 44477718)
9. Musil LS, Le AC, VanSlyke JK, Roberts LM. Regulation of connexin degradation as a mechanism to increase gap junction assembly and function. J. Riol Chem 2000; 275: 25207-15. (Pubitemid 30658765)
10. Wiener JR, Windham TC, Estrella VC. et al. Activated SRC protein tyrosine kinase is overexpressed in latestage human ovarian cancers. Gynecol Oncol 2003; 88: 73-9. (Pubitemid 36062670)
11. Bu R, Purushotharn K, Kerr M. et al. Alterations in the level of phosphotyrosine signal transduction constituents in human parotid tumors Proc Soc Exp Biol. Med 1996; 211: 257-64. (Pubitemid 26082614)
12. Mazurenko NN, Kogan EA, Zborovskaya IB, Kisseljov FL. Expression of pp60c-src in human small cell and non-small cell lung carcinomas. Eur J. Cancer 1992; 28: 372-7.
13. Huang RP, Fan Y, Hossain MZ, Peng A, Zeng ZL, Boynton AL, Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res 1998; 58: 5089-96. (Pubitemid 28521167)
14. King TJ. Fukushima LH, Hieber AD, Shunabukuro KA, Sakr WA, Bertram JS. Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis 2000; 21: 1097-109 (Pubitemid 30389333)
15. Masumoto N, Nakano S, Fujishima H, Kohno K, Niho Y. v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells. Int J. Cancer 1999; 80: 731-7. (Pubitemid 29066286)
16. Pengetnze Y, Steed M, Roby KF, Terranova PF, Taylor CC. Src tyrosine kinase promotes survival and resistance to chemotherapeutics in a mouse ovarian cancer cell line. Biochem Biophys Res Commun 2003; 309: 377-83. (Pubitemid 37025902)
17. Qin B, Ariyama H, Baba E. et al. Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells. Cancer Chemother Pharmacol 2006; 58: 577-84. (Pubitemid 44167382)
18. Lee KW, Jung JW, Kang KS, Lee HJ, p 38 is a key signaling molecule for H-ras-induced inhibition of gap junction intercellular communication in rat liver epithelial cells. Ann N Y Acad Sci 2004; 1030: 258-63. (Pubitemid 40378921)
19. de Feijter AW, Trosko JE, Krizman DB, Lebovitz RM, Lieberman MW. Correlation of increased levels of Haras T24 protein with extent of loss of gap junction function in rat liver epithelial cells. Mol. Carcinog 1992; 5: 205-12.
20. Lau AF, Kanemitsu MY, Kurata WE, Danesh S, Boynton AL, Epidermal growth factor disrupts gapjunctional communication and induces phosphorylation of connexin43 on serine. Mol. Biol. Cell 1992; 3: 865-74. (Pubitemid 23079760)