Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD

American Journal of Physiology - Renal Physiology

Volumn 296, Issue 4, 2009, Pages

  Nechama, Morris ^a   Ben Dov, Iddo Z ^a   Silver, Justin ^a   Naveh Many, Tally ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Calcium receptor; Chronic kidney disease; K homology splicing regulatory protein; Parathyroid hormone; Protein ribonucleic acid interactions; Secondary hyperparathyroidism

Indexed keywords

ADENOSINE URIDINE BINDING FATOR 1; CALCIMIMETIC AGENT; K HOMOLOGY SPLICING REGULATORY PROTEIN; LANTHANUM CARBONATE; MESSENGER RNA; PARATHYROID EXTRACT; PARATHYROID HORMONE; PHOSPHORUS; R 568; REGULATOR PROTEIN; RIBONUCLEASE; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EXOSOME; GENE EXPRESSION REGULATION; IN VITRO STUDY; MALE; NONHUMAN; PARATHYROID GLAND; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN TARGETING; RAT; RNA STABILITY; SECONDARY HYPERPARATHYROIDISM;

EID: 65949095862     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90625.2008     Document Type: Article

References (31)

1. Behets GJ, Verberckmoes SC, D'Haese PC, De Broe ME. Lanthanum carbonate: a new phosphate binder. Curr Opin Nephrol Hypertens 13: 403-409, 2004.
2. Ben Dov IZ, Pappo O, Sklair-Levy M, Galitzer H, Ilan Y, Naveh-Many T, Silver J. Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats. Nephrol Dial Transplant 22: 362-368, 2007. (Pubitemid 46189878)
3. Ben Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 117: 4003-4008, 2007. (Pubitemid 350224109)
4. Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, Hercz G, Cunningham J, Abu-Alfa AK, Messa P, Coyne DW, Locatelli F, Cohen RM, Evenepoel P, Moe SM, Fournier A, Braun J, McCary LC, Zani VJ, Olson KA, Drueke TB, Goodman WG. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 350: 1516-1525, 2004. (Pubitemid 38477776)
5. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 107: 451-464, 2001. (Pubitemid 33152781)
6. Chou CF, Mulky A, Maitra S, Lin WJ, Gherzi R, Kappes J, Chen CY. Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay. Mol Cell Biol 26: 3695-3706, 2006. (Pubitemid 43726388)
7. Colloton M, Shatzen E, Miller G, Stehman-Breen C, Wada M, Lacey D, Martin D. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int 67: 467-476, 2005. (Pubitemid 40139838)
8. D'Haese PC, Spasovski GB, Sikole A, Hutchison A, Freemont TJ, Sulkova S, Swanepoel C, Pejanovic S, Djukanovic L, Balducci A, Coen G, Sulowicz W, Ferreira A, Torres A, Curic S, Popovic M, Dimkovic N, De Broe ME. A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients. Kidney Int Suppl S73-S78, 2003. (Pubitemid 36605868)
9. DeMaria CT, Brewer G. AUF1 binding affinity to A+U-rich elements correlates with rapid mRNA degradation. J Biol Chem 271: 12179-12184, 1996. (Pubitemid 26160876)
10. Dinur M, Kilav R, Sela-Brown A, Jacquemin-Sablon H, Naveh-Many T. In vitro evidence that upstream of N-ras participates in the regulation of parathyroid hormone messenger ribonucleic acid stability. Mol Endocrinol 20: 1652-1660, 2006. (Pubitemid 43967572)
11. Fritz DT, Ford LP, Wilusz J. An in vitro assay to study regulated mRNA stability. Sci STKE 2000: L1, 2000.
12. Gherzi R, Lee KY, Briata P, Wegmuller D, Moroni C, Karin M, Chen CY. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell 14: 571-583, 2004. (Pubitemid 38739081)
13. Joy MS, Finn WF. Randomized, double-blind, placebo-controlled, dose-titration, phase III study assessing the efficacy and tolerability of lanthanum carbonate: a new phosphate binder for the treatment of hyperphosphatemia. Am J Kidney Dis 42: 96-107, 2003.
14. Kilav R, Silver J, Naveh-Many T. Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest 96: 327-333, 1995.
15. Kilav R, Silver J, Naveh-Many T. A conserved cis-acting element in the parathyroid hormone 3′-untranslated region is sufficient for regulation of RNA stability by calcium and phosphate. J Biol Chem 276: 8727-8733, 2001. (Pubitemid 37385440)
16. Kiledjian M, DeMaria CT, Brewer G, Novick K. Identification of AUF1 (heterogeneous nclear ribonucleoprotein D) as a component of the α-globin mRNA stability complex. Mol Cell Biol 17: 4870-4876, 1997. (Pubitemid 27318162)
17. Lazar ES, Stankus N. Cinacalcet-induced hungry bone syndrome. Semin Dial 20: 83-85, 2007.
18. Levi R, Ben Dov IZ, Lavi-Moshayoff V, Dinur M, Martin D, Naveh-Many T, Silver J. Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. J Am Soc Nephrol 17: 107-112, 2006.
19. Lewin E, Huan J, Olgaard K. Parathyroid growth and suppression in renal failure. Semin Dial 19: 238-245, 2006.
20. Moallem E, Silver J, Kilav R, Naveh-Many T. RNA protein binding and post-transcriptional regulation of PTH gene expression by calcium and phosphate. J Biol Chem 273: 5253-5259, 1998. (Pubitemid 28108690)
21. Moe SM, Chertow GM, Coburn JW, Quarles LD, Goodman WG, Block GA, Drueke TB, Cunningham J, Sherrard DJ, McCary LC, Olson KA, Turner SA, Martin KJ. Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl. Kidney Int 67: 760-771, 2005. (Pubitemid 40139871)
22. Moe SM, Cunningham J, Bommer J, Adler S, Rosansky SJ, Urena-Torres P, Albizem MB, Guo MD, Zani VJ, Goodman WG, Sprague SM. Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl. Nephrol Dial Transplant 20: 2186-2193, 2005. (Pubitemid 41510096)
23. Naveh-Many T, Nechama M. Regulation of parathyroid hormone mRNA stability by calcium, phosphate and uremia. Curr Opin Nephrol Hypertens 16: 305-310, 2007. (Pubitemid 46944327)
24. Nechama M, Ben Dov IZ, Briata P, Gherzi R, Naveh-Many T. The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. FASEB J 22: 3458-3468, 2008.
25. 2+/polyvalent cation-sensing protein in rat kidney. Am J Physiol Renal Physiol 274: F611-F622, 1998.
26. Rodriguez M, Nemeth E, Martin D. The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism. Am J Physiol Renal Physiol 288: F253-F264, 2005. (Pubitemid 40105383)
27. Rodriguez ME, Almaden Y, Canadillas S, Canalejo A, Siendones E, Lopez I, Aguilera-Tejero E, Martin D, Rodriguez M. The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands. Am J Physiol Renal Physiol 292: F1390-F1395, 2007. (Pubitemid 46701865)
28. Sela-Brown A, Silver J, Brewer G, Naveh-Many T. Identification of AUF1 as a parathyroid hormone mRNA 3′-untranslated region binding protein that determines parathyroid hormone mRNA stability. J Biol Chem 275: 7424-7429, 2000. (Pubitemid 30146298)
29. Silver J, Naveh-Many T, Mayer H, Schmelzer HJ, Popovtzer MM. Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest 78: 1296-1301, 1986. (Pubitemid 17181568)
30. Yalcindag C, Silver J, Naveh-Many T. Mechanism of increased parathyroid hormone mRNA in experimental uremia: roles of protein RNA binding and RNA degradation. J Am Soc Nephrol 10: 2562-2568, 1999.
31. Yokozawa T, Zheng PD, Oura H, Koizumi F. Animal model of adenine-induced chronic renal failure in rats. Nephron 44: 230-234, 1986. (Pubitemid 16002549)