Immunosuppressive effects of demethylzeylasteral in a rat kidney transplantation model

International Immunopharmacology

Volumn 9, Issue 7-8, 2009, Pages 996-1001

  Xu, Wenping ^a   Lin, Zongming ^a   Yang, Chunxin ^a   Zhang, Yongkang ^a   Wang, Guomin ^a   Xu, Xunhui ^a   Lv, Qianzhou ^a   Ren, Yushen ^a   Dong, Ying ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cyclosporin A; Demethylzeylasteral; Immunosuppression; Kidney transplantation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLOSPORIN A; DEMETHYLZEYLASTERAL; HERBACEOUS AGENT; IMMUNOSUPPRESSIVE AGENT; PREDNISONE; T 96; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CELL PROLIFERATION; CHINESE MEDICINE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; HERBAL MEDICINE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; SURVIVAL TIME;

ANIMALS; CELL PROLIFERATION; CONCANAVALIN A; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GRAFT REJECTION; IMMUNOSUPPRESSION; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; PLANT ROOTS; PREDNISONE; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; TRIPTERYGIUM; TRITERPENES;

EID: 65849458940     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.04.007     Document Type: Article

References (24)

1. First M.R., and Fitzsimmons W.E. New drugs to improve transplant outcomes. Transplantation 77 Suppl. (2004) 88-92
2. Kunzendorf U., Ziegler E., and Kabelitz D. FTY720-the first compound of a new promising class of immunosuppressive drugs. Nephrol Dial Transplant 19 (2004) 1677-1681
3. Tao X.L., and Lipsky P.E. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook f. Rheum Dis Clin N Amer 26 (2000) 29-50
4. Li H., Zhang Y.Y., Huang X.Y., Sun Y.N., Jia Y.F., and Li D. Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in BALB/c mice. Eur J Pharmacol 512 (2005) 231-237
5. Brinker A.M., Lipsky J.M.P.E., and Raskin I. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68 (2007) 732-766
6. Chou C.T., and Chang S.C. The inhibitory effect of common traditional anti-rheumatic herb formulas on prostaglandin E and interleukin 2 in vitro: a comparative study with Tripterygium wilfordii. J Ethnopharmacol 62 (1998) 167-171
7. Ren B., Sun J., Hu C., Cong L., Zhang L., King N., et al. Immunosuppressive effects of Tripterygium wilfordii Hook F in a rat liver transplant model. Transpl P 33 (2001) 520-521
8. Li R.W., Lin G.D., Myers S.P., and Leach D.N. Anti-inflammatory activity of Chinese medicinal vine plants. J Ethnopharmacol 85 (2003) 61-67
9. 2+ channels in mouse spermatogenic cells by male antifertility compounds from Tripterygium wilfordii Hook f. Contraception 65 (2002) 441-445
10. 2+ channels and progesterone-induced sperm acrosome reaction. Eur J Pharmacol 464 (2003) 9-15
11. Morota T., Yang C.X., Sasaki H., Qin W.Z., Sugama K., Miao K.L., et al. Triterpenes from Tripterygium wilfordii. Phytochemistry 39 (1995) 1159-1163
12. Morota T., Yang C.X., Ogino T., Qin W.Z., Katsuhara T., Xu L.H., et al. D-A-friedo-24-Noroleanane triterpennes from Tripterygium wilfordii. Phytochemistry 39 (1995) 1153-1157
13. Morota T., Yang C.X., Ikoya Y., Qin W.Z., Nishimura H., Xu L.H., et al. Chemical studies on the root bark of Tripterigium wilfordii. 3. Sesquiterpene alkaloids from Tripterygium wilfordii. Phytochemistry 39 (1995) 1219-1222
14. Denizot F., and Lang R. Rapid colorimetric assay for cell growth and survival modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89 (1986) 271-277
15. Li H., Zhang Y.Y., Tan H.W., Jia Y.F., and Li D. Therapeutic effect of tripterine on adjuvant arthritis in rats. J Ethnopharmacol 118 (2008) 479-484
16. Liu Y., Chen Y., Liu F.Q., Lamb J.R., and Tam P.K.H. Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation. Transpl Int 21 (2008) 483-494
17. Chan E.W.C., Cheng S.C.S., Sin F.W.Y., and Xie Y. Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicol Lett 122 (2001) 81-87
18. Tengchaisri T., Chawengkirttikul R., and Rachaphaew N. Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters. Cancer Lett 133 (1998) 169
19. Gu W.Z., and Brandwein S.R. Inhibition of type II collagen-induced arthritis in rats by triptolide. Int J Immunopharmacol 20 (1998) 389-400
20. Yu D.F., Hu B.H., Chen G.P., Yang C.X., Yang J., Xu J.Y., and Li L.Z. Structure revision of triptophenolide. Acta Pharm Sin 25 (1990) 929-931
21. Halloran P.F. Immunosuppressive drugs for kidney transplantation. N Engl J Med 351 (2004) 2715-2729
22. Tamaki T., Morota T., Kawamula H., Maruyama H., Kaneko A., Nunome S., et al. Immunosuppressive and anti-inflammatory effects of phenolic nortriterpenoid, demethylzeylasteral, from Tripterygium wilfordii. J Nat Med 51 (1997) 98-104
23. Lee K.Y., Chang W.T., Qiu D., Kao P.N., and Rosen G.D. PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells. J Biol Chem 274 (1999) 13451-13455
24. Yang Y., Liu Z.H., Tolosa E., Yang J.W., and Li L.S. Triptolide induces apoptotic death of T lymphocyte. Immunopharmacology 40 (1998) 139-149