Mechanisms of chloroquine-induced body-scratching behavior in rats: Evidence of involvement of endogenous opioid peptides

Pharmacology Biochemistry and Behavior

Volumn 65, Issue 2, 2000, Pages 333-337

  Onigbogi, O ^a   Ajayi, A A ^a   Ukponmwan, O E ^a  

^a OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

Chloroquine; Convulsions; Dexamethasone; Naltrexone; Opioids; Pruritus; Rats

Indexed keywords

CHLOROQUINE; DEXAMETHASONE; NALTREXONE; OPIATE PEPTIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; PRURITUS; RAT; SCRATCHING; SKIN SENSATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; MALE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; OPIOID PEPTIDES; PRURITUS; RATS;

EID: 0033976685     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00221-X     Document Type: Article

References (28)

1. Abila B., Ikueze R. Effects of clemastine, ketotifen and prednisolone on chloroquine induced pruritus in healthy Africans. J. Trop. Med. Hyg. 92:1989;356-359.
2. Adamolekun B. Seizures associated with chloroquine therapy. Cent. Afr. Med. J. 38:1992;350-352.
3. Adebayo R.A., Sofowora G.G., Onayemi O., Udoh S.J., Ajayi A.A. Chloroquine-induced pruritus in malaria fever. Contribution of malaria parasitemia and the effects of prednisolone, niacin and their combination, compared to antihistamine Br. J. Clin. Pharmacol. 44:1997;157-161.
4. Ajayi A.A., Oluokun O., Sofowora O., Akinleye A., Ajayi A.T. Epidemiology of antimalarial-induced pruritus in Africans. Eur. J. Clin. Pharmacol. 37:1989;539-540.
5. Ajayi A.A., Akinleye A.O., Udoh S.J., Ajayi O.O., Oyelese O., Ijaware C.O. The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. Eur. J. Clin. Pharmacol. 41:1991;383-385.
6. Ajayi A.A., Ukponmwan O.E. Evidence of angiotensin II and endogenous opioid modulation of novelty induced rearing in the rat. Afr. J. Med. Med. Sci. 23:1994;287-290.
7. Ajayi A.A., Rubin P.C., Fox S.C., Allen B.R. A study of the 12-lipoxygenase pathway in chloroquine-induced prutitus. Niger. Med. J. 29:1995;77-78.
8. Ajayi A.A., Olotu T.C., Sofowora G.G. Knowledge, attitude and practice of prednisolone prevention of chloroquine-induced pruritus among Nigerian Health workers. Trop. Doctor. 28:1998;210-211.
9. Borgeat A., Stirnemann R. Ondansentron is effective to treat spinal or epidural morphine-induced pruritus. Anesthesiology. 90:1999;432-436.
10. Dodman N.H., Shuster L., White S.D., Court M.H., Parker D., Dixon R. Use of narcotic antagonists to modify stereotypic self licking, self chewing and scratching behavior in dogs. J. Am. Vet. Med. Assoc. 193:1988;815-819.
11. Ezeamuzie C.I., Igbigbi P.S., Asomugba L., Ambakederemo A.W., Abila B., Assem E. Urine methylhistamine concentration before and after chloroquine in healthy black subjects. J. Trop. Med. Hyg. 93:1990;423-425.
12. Greaves M.W., Wall P.D. Pathophysiology of itching. Lancet. 348:1996;938-940.
13. Hagermark O., Strandberg K., Hamberg M. Potentiation of itch and flare response in human skin by prostaglandin E2 and H2 and a prostaglandin endoperoxide analog. J. Invest. Dermatol. 69:1977;527-530.
14. Hagermark O., Fiellner B. Enhancement of histamine induced pruritus by enkephalins and morphine. J. Invest. Dermatol. 74:1980;459.
15. Jimenez-Alonso J., Tercerder J., Jaimez L.et al. Antimalarial drug induced aquagenic type pruritus in patients with lupus. Arthritis Rheum. 41:1998;744-745.
16. Jones E.A., Bergass N.V. The pruritus of cholestasis and the opioid system. JAMA. 268:1992;3359-3362.
17. Myinka K.S., Kihamia K.M. Chloroquine induced prutitus. Its impact on chloroquine utilization in malaria control in Dar es Salam J. Trop. Med. Hyg. 94:1991;27-31.
18. N'Gouemo P., Ben Attia M., Belaidi M. Effects of chloroquine on pentylene tetrazole induced convulsions in mice. Pharmacol. Res. 30:1994;99-103.
19. Ogunranti J.O., Ajayi J.C., Roma S., Onwukeme K.E. Chloroquine pruritus and sickle cell gene trait in Africans. Possible pharmacogenetic relationships Eur. J. Clin. Pharmacol. 43:1992;323-324.
20. Olatunde A. Practical and therapeutic implications of chloroquine induced pruritus in tropical Africa. Afr. J. Med. Med. Sci. 6:1977;27-31.
21. Osifo N.G. Mechanisms of enhanced pruritogenicity of chloroquine among subjects with malaria. A review Afr. J. Med. Med. Sci. 18:1989;121-129.
22. Osifo N.G. The antipruritic effects of chlorpheniramine, cyproheptadine, and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus, among patients with malaria. Afr. J. Med. Med. Sci. 24:1995;67-73.
23. Peer G., Kivity S., Agami O., Fireman D., Silverberg D., Blum M., Laina A. Randomized cross-over trial of Naltrexone in Uremic pruritus. Lancet. 348:1996;1552-1554.
24. Pollock J., Kornetsky C. Reexpression of morphine induced oral stereotypy six months after last morphine sensitizing dose. Pharmacol. Biochem. Behav. 53:1996;67-71.
25. Thomas D.A., Hammond D.L. Microinjection of morphine into the rat medullary dorsal horn produces a dose dependent increase in facial scratching. Brain Res. 695:1995;267-270.
26. Tohda C., Yamaguchi T., Kuraishi Y. Intracisternal injection of opioids induces itch associated response through mu-opioid receptors in mice. Jpn. J. Pharmacol. 74:1997;77-82.
27. Ukponmwan O.E., Poel-heisterkamp L., Dzoljic M.R. REM Sleep deprivation decreases grooming and scratching behavior induced by enkephalinase inhibition or opiate withdrawal. Pharmacol. Biochem. Behav. 23:1985;385-389.
28. Yamaguchi T., Kitagawa K., Kuraishi Y. Itch associated response and antinociception induced by intracisternal endomorphins in mice. Jpn. J. Pharmacol. 78:1998;337-343.