Relationships between fatty acid and polyketide synthase from Streptomyces coelicolor A3(2): Characterization of the fatty acid synthase carrier protein

Journal of Bacteriology

Volumn 178, Issue 19, 1996, Pages 5660-5667

  Revill, W Peter ^a   Bibb, Maureen J ^a   Hopwood, David A ^a  

^a NORWICH RESEARCH PARK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FATTY ACID SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENETIC CODE; MOLECULAR CLONING; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; STREPTOMYCES COELICOLOR;

EID: 0029841660     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.19.5660-5667.1996     Document Type: Article

References (39)

1. Bibb, M. J., and S. N. Cohen. 1982. Gene expression in Streptomyces; construction and application of promoter-probe plasmid vectors in Streptomyces lividans. Mol. Gen. Genet. 187:265-277.
2. Bibb, M. J., P. R. Findlay, and M. W. Johnson. 1984. The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein coding sequences. Gene 30: 157-166.
3. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
4. Chakraburtty, R., J. White, E. Takano, and M. J. Bibb. 1996. Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2). Mol. Microbiol. 19:357-368.
5. Champness, W. C., and K. F. Chater. 1993. The regulation and integration of antibiotic production and morphological differentiation in Streptomyces spp., p. 61-93. In P. Piggot, P. Youngman, and C. Moran (ed.), Regulation of bacterial differentiation. American Society for Microbiology, Washington, D.C.
6. Crosby, J., D. H. Sherman, M. J. Bibb, W. P. Revill, D. A. Hopwood, and T. J. Simpson. 1995. Polyketide synthase acyl carrier proteins from Streptomyces; expression in Escherichia coli, purification and partial characterization. Biochim. Biophys. Acta 1251:32-42.
7. Davis, N. K., and K. F. Chater. 1990. Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics. Mol. Microbiol. 4:1679-1691.
8. Fernández-Moreno, M. A., E. Martinez, L. Boto, D. A. Hopwood, and F. Malpartida. 1992. Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. J. Biol. Chem. 267:19278-19290.
9. Gramajo, H. C., E. Takano, and M. J. Bibb. 1993. Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol. Microbiol. 7:837-845.
10. Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, D. J. Lydiate, C. P. Smith, J. M. Ward, and H. S. Schrempf. 1985. Genetic manipulation of Streptomyces; a laboratory manual. John Innes Institute, Norwich, United Kingdom.
11. Hopwood, D. A., and D. H. Sherman. 1990. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 24:37-66.
12. Hutchinson, C. R., and I. Fujii. 1995. Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics. Annu. Rev. Microbiol. 49:201-238.
13. Jackowski, S., C. M. Murphy, J. E. Cronan, Jr., and C. O. Rock. 1989. Acetoacetyl acyl carrier protein synthase, a target for the antibiotic thiolactomycin. J. Biol. Chem. 264:7624-7629.
14. Jones, D. S. C., and J. P. Schofield. 1991. A rapid method for isolating high quality plasmid DNA suitable for DNA sequencing. Nucleic Acids Res. 18:7463-7454.
15. Kaneda, T. 1991. Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance. Microbiol. Rev. 55:288-302.
16. Katz, L., and S. Donadio. 1993. Polyketide synthesis: prospects for hybrid antibiotics. Annu. Rev. Microbiol. 47:875-912.
17. 16a.Kelemen, G. Personal communication.
18. Khosla, C., S. Ebert-Khosla, and D. A. Hopwood. 1992. Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein. Mol. Microbiol. 6:3237-3249.
19. Kim, E.-S., D. A. Hopwood, and D. H. Sherman. 1994. Analysis of type II polyketide β-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants. J. Bacteriol. 176: 1801-1804.
20. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
21. Magnuson, K., S. Jackowski, C. O. Rock, and J. E. Cronan, Jr. 1993. Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol. Rev. 57:522-542.
22. Magnuson, K., W. Oh, T. Larson, and J. E. Cronan, Jr. 1992. Cloning and nucleotide sequence of the fabD gene encoding malonyl coenzyme A-acyl carrier protein transacylase at Escherichia coli. FEBS Lett. 299:262-266.
23. McDaniel, R., S. Ebert-Khosla, H. Fu, D. A. Hopwood, and C. Khosla. 1994. Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase. Proc. Natl. Acad. Sci. USA 91:11542-11546.
24. McDaniel, R., S. Ebert-Khosla, D. A. Hopwood, and C. Khosla. 1993. Engineered biosynthesis of novel polyketides. Science 262:1546-1550.
25. O'Hagan, D. 1991. The polyketide metabolites. Ellis Horwood, Ltd., Chichester, United Kingdom.
26. Rawlings, M., and J. E. Cronan, Jr. 1992. The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes. J. Biol. Chem. 267:5751-5754.
27. Redenbach, M., and H. M. Kieser, D. Denapaite, A. Eichner, J. Cullum, H. Kinashi, and D. A. Hopwood. 1996. A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chro- mosome. Mol. Microbiol. 21:77-96.
28. 26a.Revill, W. P. Unpublished observation.
29. Revill, W. P., M. J. Bibb, and D. A. Hopwood. 1995. Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant. J. Bacteriol. 177:3946-3952.
30. Rock, C. O., J. E. Cronan, and I. M. Armitage. 1981. Molecular properties of acyl carrier protein derivatives. J. Biol. Chem. 256:2669-2674.
31. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
32. Sharp, P. M., and W.-H. Li. 1986. Codon usage in regulatory genes in Escherichia coli does not reflect selection for 'rare' codons. Nucleic Acids Res. 14:7737-7749.
33. Studier, F. W., A. H. Rosenberg, J. J. Dunn, and J. W. Dubendorff. 1990. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185:60-89.
34. Summers, R. G., A. Ali, B. Shen, W. A. Wessel, and C. R. Hutchinson. 1995. Malonyl coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis. Biochemistry 34:9389-9402.
35. Takano, E., and M. J. Bibb. 1994. The stringent response, ppGpp and antibiotic production in Streptomyces coelicolor A3(2). Actinomycetologica 8: 1-16.
36. Tsay, J.-T., W. Oh, T. J. Larson, S. Jackowski, and C. O. Rock. 1992. Isolation and characterization of the β-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12. J. Biol. Chem. 267:6807-6814.
37. Vieira, J., and J. Messing. 1987. Production of single-stranded plasmid DNA. Methods Enzymol. 153:3-11.
38. Wright, F., and M. J. Bibb. 1992. Codon usage in the G+C-rich Streptomyces genome. Gene 113:55-65.
39. Yu, T.-W., and D. A. Hopwood. 1995. Ectopic expression of the Streptomyces coelicolor whiE genes for polyketide spore pigment synthesis and their interaction with the act genes for actinorhodin biosynthesis. Microbiology 141: 2779-2791.