-
1
-
-
0013692526
-
-
Alzheimer's disease update [online]. Accessed: Oct 1
-
1. Klysh AO. Alzheimer's disease update [online]. Available from: URL: http://www.inetce.org/Articles/alzheimers.html [Accessed: 1999 Oct 1]
-
(1999)
-
-
Klysh, A.O.1
-
2
-
-
0030801772
-
Diagnosis and treatment of Alzheimer disease and related disorders: Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society
-
Oct 22-29
-
2. Small GW, Rabins PV, Barry PP, et al. Diagnosis and treatment of Alzheimer disease and related disorders: consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. JAMA 1997 Oct 22-29; 278: 1363-71
-
(1997)
JAMA
, vol.278
, pp. 1363-1371
-
-
Small, G.W.1
Rabins, P.V.2
Barry, P.P.3
-
3
-
-
0025221468
-
Estimated prevalence of Alzheimer's disease in the United States
-
3. Evans DA et al. Estimated prevalence of Alzheimer's disease in the United States. Milbank Quarterly 1990; 68 (2): 267-89
-
(1990)
Milbank Quarterly
, vol.68
, Issue.2
, pp. 267-289
-
-
Evans, D.A.1
-
4
-
-
0028109336
-
The U.S. economic and social cost of Alzheimer's disease revisited
-
4. Ernst RL, Hay JW. The U.S. economic and social cost of Alzheimer's disease revisited. Am J Public Health 1994; 84: 1261-4
-
(1994)
Am J Public Health
, vol.84
, pp. 1261-1264
-
-
Ernst, R.L.1
Hay, J.W.2
-
5
-
-
0024317904
-
Prevalence of Alzheimer's disease in a community population of older persons: Higher than previously reported
-
5. Evans DA, Funkenstein HH, Albert MS, et al. Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported. JAMA 1989; 262: 2551-6
-
(1989)
JAMA
, vol.262
, pp. 2551-2556
-
-
Evans, D.A.1
Funkenstein, H.H.2
Albert, M.S.3
-
6
-
-
0030818058
-
Current concepts in the pathogenesis of Alzheimer's disease
-
6. Carr DB, Goate PD, Morris JC. Current concepts in the pathogenesis of Alzheimer's disease. Am J Med 1997; 103 (3A): 3S-10S
-
(1997)
Am J Med
, vol.103
, Issue.3 A
-
-
Carr, D.B.1
Goate, P.D.2
Morris, J.C.3
-
7
-
-
0031051503
-
Researchers find evidence of a new gene for late-onset Alzheimer disease
-
7. Stephenson J. Researchers find evidence of a new gene for late-onset Alzheimer disease. JAMA 1997; 277 (10): 755
-
(1997)
JAMA
, vol.277
, Issue.10
, pp. 755
-
-
Stephenson, J.1
-
8
-
-
0032571732
-
Treatment of Alzheimer's disease: Current approaches and promising developments
-
Apr 27
-
8. Small GW. Treatment of Alzheimer's disease: current approaches and promising developments. Am J Med 1998 Apr 27; 104: 32S-8S
-
(1998)
Am J Med
, vol.104
-
-
Small, G.W.1
-
9
-
-
0031821608
-
Pharmacological drug treatment of Alzheimer disease: The cholinergic hypothesis revisited
-
9. Ladner CJ, Lee JM. Pharmacological drug treatment of Alzheimer disease: the cholinergic hypothesis revisited. J Neuropathol Exp Neurol 1998; 57 (8): 719-31
-
(1998)
J Neuropathol Exp Neurol
, vol.57
, Issue.8
, pp. 719-731
-
-
Ladner, C.J.1
Lee, J.M.2
-
10
-
-
0020686674
-
Alzheimer's disease: A disorder of cortical cholinergic innervation
-
10. Coyle JT, Price DL, DeLong MR. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 1983; 219: 1184-90
-
(1983)
Science
, vol.219
, pp. 1184-1190
-
-
Coyle, J.T.1
Price, D.L.2
DeLong, M.R.3
-
11
-
-
0025732261
-
The distribution of cerebral muscarine acetylcholine receptors in vivo in patients with dementia
-
11. Weinberger DR, Gibson R, Copploa R, et al. The distribution of cerebral muscarine acetylcholine receptors in vivo in patients with dementia. Arch Neurol 1991; 48: 169-76
-
(1991)
Arch Neurol
, vol.48
, pp. 169-176
-
-
Weinberger, D.R.1
Gibson, R.2
Copploa, R.3
-
12
-
-
0027969107
-
Effects of disrupting the cholinergic system on short-term spatial memory in rats
-
12. Andrews JS, Jansen JHM, Linders S, et al. Effects of disrupting the cholinergic system on short-term spatial memory in rats. Psychopharmacology 1994; 114:485-94
-
(1994)
Psychopharmacology
, vol.114
, pp. 485-494
-
-
Andrews, J.S.1
Jansen, J.H.M.2
Linders, S.3
-
13
-
-
0027361997
-
Comparative behavioral and neurochemical activities of cholinergic antagonists in rats
-
13. Bymaster FP, Heath I, Hendrix JC, et al. Comparative behavioral and neurochemical activities of cholinergic antagonists in rats. J Pharmacol Exp Ther 1993; 267: 16-24
-
(1993)
J Pharmacol Exp Ther
, vol.267
, pp. 16-24
-
-
Bymaster, F.P.1
Heath, I.2
Hendrix, J.C.3
-
14
-
-
0028173810
-
Blockade of hippocampal M1 muscarine receptors impairs working memory performance of rats
-
14. Ohno M, Yamamoto T, Watanabe S. Blockade of hippocampal M1 muscarine receptors impairs working memory performance of rats. Brain Res 1994; 650: 260-6
-
(1994)
Brain Res
, vol.650
, pp. 260-266
-
-
Ohno, M.1
Yamamoto, T.2
Watanabe, S.3
-
15
-
-
0015965912
-
Human memory and cholinergic system: A relationship to aging
-
15. Drachman DA, Leavitt J. Human memory and cholinergic system: a relationship to aging. Arch Neurol 1974; 30: 113-21
-
(1974)
Arch Neurol
, vol.30
, pp. 113-121
-
-
Drachman, D.A.1
Leavitt, J.2
-
16
-
-
0029609867
-
Cholinergic receptor agonists inhibit pirenzepine-induced dysfunction of spontaneous alteration performance in the mouse
-
16. Ukai M, Shinkai N, KameyamaT. Cholinergic receptor agonists inhibit pirenzepine-induced dysfunction of spontaneous alteration performance in the mouse. Gen Pharmacol 1995; 26 (7): 1529-32
-
(1995)
Gen Pharmacol
, vol.26
, Issue.7
, pp. 1529-1532
-
-
Ukai, M.1
Shinkai, N.2
Kameyama, T.3
-
17
-
-
0000202260
-
Cholinergic therapies for Alzheimer's disease: Acetylcholinesterase inhibitors of current clinical interest
-
Apr; 2
-
17. Jaen JC, Davis RE. Cholinergic therapies for Alzheimer's disease: acetylcholinesterase inhibitors of current clinical interest. Curr Opin Invest Drug 1993 Apr; 2: 363-77
-
(1993)
Curr Opin Invest Drug
, pp. 363-377
-
-
Jaen, J.C.1
Davis, R.E.2
-
18
-
-
0001307702
-
The role of cholinesterase inhibitors in Alzheimer's disease
-
Feb; 1
-
18. Lamy PP. The role of cholinesterase inhibitors in Alzheimer's disease. CNS Drugs 1994 Feb; 1: 146-65
-
(1994)
CNS Drugs
, pp. 146-165
-
-
Lamy, P.P.1
-
19
-
-
0021822534
-
A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease
-
19. Little A, Levy R, Chuaqui-Kidd P, et al. A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985; 48 (8): 736-42
-
(1985)
J Neurol Neurosurg Psychiatry
, vol.48
, Issue.8
, pp. 736-742
-
-
Little, A.1
Levy, R.2
Chuaqui-Kidd, P.3
-
20
-
-
0019363538
-
Physostigmine and arecoline: Effects of intravenouis infusions in Alzheimer presenile dementia
-
20. Christie JE, Shering A, Ferguson J, et al. Physostigmine and arecoline: effects of intravenouis infusions in Alzheimer presenile dementia. Br J Psychiatry 1981; 138: 46-50
-
(1981)
Br J Psychiatry
, vol.138
, pp. 46-50
-
-
Christie, J.E.1
Shering, A.2
Ferguson, J.3
-
21
-
-
0032078728
-
Invited review. Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications
-
21. Giacobini E. Invited review. Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications. Neurochem Int 1998; 32 (5-6): 413-9
-
(1998)
Neurochem Int
, vol.32
, Issue.5-6
, pp. 413-419
-
-
Giacobini, E.1
-
22
-
-
0031896106
-
Preclinical pharmacology of metrifonate
-
Mar-Apr
-
22. Jann MW. Preclinical pharmacology of metrifonate. Pharmaco-therapy 1998 Mar-Apr; 18 (2 Pt 2): 55S-67S
-
(1998)
Pharmaco-therapy
, vol.18
, Issue.2 PT 2
-
-
Jann, M.W.1
-
23
-
-
0018163960
-
Metrifonate: Summary of toxicological and pharmacological information available
-
Oct 13
-
23. Holmstedt B, Nordgren I, Sandoz M, et al. Metrifonate: summary of toxicological and pharmacological information available. Arch Toxicol 1978 Oct 13; 41: 3-29
-
(1978)
Arch Toxicol
, vol.41
, pp. 3-29
-
-
Holmstedt, B.1
Nordgren, I.2
Sandoz, M.3
-
24
-
-
0031818646
-
Metrifonate
-
May
-
24. Mucke HAM. Metrifonate. Drugs Future 1998 May; 23: 491-7
-
(1998)
Drugs Future
, vol.23
, pp. 491-497
-
-
Mucke, H.A.M.1
-
25
-
-
0023226136
-
A comparison of the effects of two inhibitors on brain cholinesterase
-
25. Hallak M, Giacobini E. A comparison of the effects of two inhibitors on brain cholinesterase. Neuropharmacology 1987; 26 (6): 521-30
-
(1987)
Neuropharmacology
, vol.26
, Issue.6
, pp. 521-530
-
-
Hallak, M.1
Giacobini, E.2
-
26
-
-
0024589925
-
Physostigmine, tacrine and metrifonate: The effect of multiple doses on acetylcholine metabolism in rat brain
-
26. Hallak M, Giacobini E. Physostigmine, tacrine and metrifonate: The effect of multiple doses on acetylcholine metabolism in rat brain. Neuropharmacology 1989; 28 (3): 199-206
-
(1989)
Neuropharmacology
, vol.28
, Issue.3
, pp. 199-206
-
-
Hallak, M.1
Giacobini, E.2
-
27
-
-
0025272542
-
Effects of metrifonate, a long-acting cholinesterase inhibitor, in Alzheimer disease: Report of an open trial
-
27. Becker RE, Colliver J, Elble R, et al. Effects of metrifonate, a long-acting cholinesterase inhibitor, in Alzheimer disease: report of an open trial. Drug Dev Res 1990; 19 (4): 425-34
-
(1990)
Drug Dev Res
, vol.19
, Issue.4
, pp. 425-434
-
-
Becker, R.E.1
Colliver, J.2
Elble, R.3
-
28
-
-
0029778404
-
Receptor interaction profile and CNS general pharmacology of metrifonate and its transformation product dichlorvos in rodents
-
28. Hinz VC, Blokland A, Van der Staay F-J, et al. Receptor interaction profile and CNS general pharmacology of metrifonate and its transformation product dichlorvos in rodents. Drug Dev Res 1996; 38 (1): 31-42
-
(1996)
Drug Dev Res
, vol.38
, Issue.1
, pp. 31-42
-
-
Hinz, V.C.1
Blokland, A.2
Van Der Staay, F.-J.3
-
29
-
-
0029915565
-
Metrifonate induces cholinesterase inhibition exclusively via slow release of dichlorvos
-
Mar
-
29. Hinz VC, Grewig S, Schmidt BH. Metrifonate induces cholinesterase inhibition exclusively via slow release of dichlorvos. Neurochem Res 1996 Mar; 21: 331-7
-
(1996)
Neurochem Res
, vol.21
, pp. 331-337
-
-
Hinz, V.C.1
Grewig, S.2
Schmidt, B.H.3
-
30
-
-
0019838974
-
Chemistry of metrifonate and dichlorvos
-
30. Hofer W. Chemistry of metrifonate and dichlorvos. Acta Pharmacol Toxicol 1981; 49 Suppl V: 7-14
-
(1981)
Acta Pharmacol Toxicol
, vol.49
, Issue.SUPPL. V
, pp. 7-14
-
-
Hofer, W.1
-
31
-
-
0029029759
-
Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: Selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase
-
Aug
-
31. Pacheco G, Palacios Esquivel R, Moss DE. Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase. J Pharmacol Exp Ther 1995 Aug; 274: 767-70
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 767-770
-
-
Pacheco, G.1
Palacios Esquivel, R.2
Moss, D.E.3
-
32
-
-
0013693383
-
Cortical cholesterinases in Alzheimer's disease: Anatomical and enzymatic shifts from the normal pattern
-
Becker R, Giacobini E, editors. Boston (MA): Birkhauser
-
32. Mesulam M-M, Geula C. Cortical cholesterinases in Alzheimer's disease: anatomical and enzymatic shifts from the normal pattern. In: Becker R, Giacobini E, editors. Cholinergic basis for Alzheimer therapy. Boston (MA): Birkhauser, 1991: 25-30
-
(1991)
Cholinergic Basis for Alzheimer Therapy
, pp. 25-30
-
-
Mesulam, M.-M.1
Geula, C.2
-
33
-
-
0022887783
-
Glycolipid membrane binding of human erthrocyte acetylcholinesterase
-
33. Rosenberry TL, Roberts WL, Hass R. Glycolipid membrane binding of human erthrocyte acetylcholinesterase. Fed Proc 1986; 45: 2970-5
-
(1986)
Fed Proc
, vol.45
, pp. 2970-2975
-
-
Rosenberry, T.L.1
Roberts, W.L.2
Hass, R.3
-
34
-
-
0027090064
-
Inhibition of human brain and red blood cell acetylcholinesterase (AChE) by heptylphysostigmine
-
34. Moriearty PL, Becker RE. Inhibition of human brain and red blood cell acetylcholinesterase (AChE) by heptylphysostigmine. Methods Find Exp Clin Pharmacol 1992; 14: 615-21
-
(1992)
Methods Find Exp Clin Pharmacol
, vol.14
, pp. 615-621
-
-
Moriearty, P.L.1
Becker, R.E.2
-
35
-
-
0025213932
-
Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain
-
35. Siek GC, Katz LS, Fishman EB. et al. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biol Psychiatry 1990; 27: 573-80
-
(1990)
Biol Psychiatry
, vol.27
, pp. 573-580
-
-
Siek, G.C.1
Katz, L.S.2
Fishman, E.B.3
-
36
-
-
0022878972
-
Molecular forms of acetylcholinesterasc in Alzheimer's disease
-
36. Younkin SG, Goodridge B, Katz J, et al. Molecular forms of acetylcholinesterasc in Alzheimer's disease. Fed Proc 1986; 45: 2982-8
-
(1986)
Fed Proc
, vol.45
, pp. 2982-2988
-
-
Younkin, S.G.1
Goodridge, B.2
Katz, J.3
-
37
-
-
0022616905
-
Distribution of the molecular forms of acetylcholinesterase in human brain: Alterations in dementia of the Alzheimer type
-
37. Fishman EB, Siek GC, MacCallum RD, et al. Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia of the Alzheimer type. Ann Neurol 1986; 19: 246-52
-
(1986)
Ann Neurol
, vol.19
, pp. 246-252
-
-
Fishman, E.B.1
Siek, G.C.2
MacCallum, R.D.3
-
38
-
-
0026645616
-
Preferential inhibition of acetylcholinesterase molecular forms in rat brain
-
May
-
38. Ogane N, Giacobini E, Messamore E. Preferential inhibition of acetylcholinesterase molecular forms in rat brain. Neurochem Res 1992 May; 17: 489-95
-
(1992)
Neurochem Res
, vol.17
, pp. 489-495
-
-
Ogane, N.1
Giacobini, E.2
Messamore, E.3
-
39
-
-
0031710171
-
Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats
-
Jul 31
-
39. Giovannini MG, Scali C, Bartolini L, et al. Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats. Eur J Pharmacol 1998 Jul 31; 354: 17-24
-
(1998)
Eur J Pharmacol
, vol.354
, pp. 17-24
-
-
Giovannini, M.G.1
Scali, C.2
Bartolini, L.3
-
40
-
-
0030917597
-
Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats
-
May 1
-
40. Scali C, Giovannini MG, Bartolini L, et al. Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats. Eur J Pharmacol 1997 May 1; 325: 173-80
-
(1997)
Eur J Pharmacol
, vol.325
, pp. 173-180
-
-
Scali, C.1
Giovannini, M.G.2
Bartolini, L.3
-
41
-
-
0028842909
-
Metrifonate effects on acetylcholine and biogenic amines in rat cortex
-
Sep
-
41. Mori F, Cuadra G, Giacobini E. Metrifonate effects on acetylcholine and biogenic amines in rat cortex. Neurochem Res 1995 Sep; 20: 1081-8
-
(1995)
Neurochem Res
, vol.20
, pp. 1081-1088
-
-
Mori, F.1
Cuadra, G.2
Giacobini, E.3
-
42
-
-
0002670880
-
Rapid attainment of steady-state acetylcholinesterase inhibition by administration of metrifonate loading and maintenance doses once-daily in elderly volunteers
-
Jul
-
42. Heinig R, Versavel M, Breuel HP, et al. Rapid attainment of steady-state acetylcholinesterase inhibition by administration of metrifonate loading and maintenance doses once-daily in elderly volunteers [abstract no. 39-26]. Biol Psychiatry 1997 Jul; 42 Suppl.: 94S
-
(1997)
Biol Psychiatry
, vol.42
, Issue.SUPPL.
-
-
Heinig, R.1
Versavel, M.2
Breuel, H.P.3
-
43
-
-
0025611649
-
Metrifonate in healthy volunteers = interrelationship between pharmacokinetic properties, cholinesterase inhibition and side-effects
-
43. Aden-Abdi Y, Villen T, Ericsson O, et al. Metrifonate in healthy volunteers = interrelationship between pharmacokinetic properties, cholinesterase inhibition and side-effects. Bull World Health Organ 1990; 68 (6): 731-6
-
(1990)
Bull World Health Organ
, vol.68
, Issue.6
, pp. 731-736
-
-
Aden-Abdi, Y.1
Villen, T.2
Ericsson, O.3
-
44
-
-
0031894164
-
Pharmacokinetics, pharmacodynamics, and safety of metrifonate in patients with Alzheimer's disease
-
Mar
-
44. Pettigrew LC, Bieber F, Lettieri J, et al. Pharmacokinetics, pharmacodynamics, and safety of metrifonate in patients with Alzheimer's disease. J Clin Pharmacol 1998 Mar; 38: 236-45
-
(1998)
J Clin Pharmacol
, vol.38
, pp. 236-245
-
-
Pettigrew, L.C.1
Bieber, F.2
Lettieri, J.3
-
45
-
-
0030575536
-
Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats
-
Aug 8
-
45. Riekkinen Jr P, Schmidt B, Stefanski R, et al. Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats. Eur J Pharmacol 1996 Aug 8; 309: 121-30
-
(1996)
Eur J Pharmacol
, vol.309
, pp. 121-130
-
-
Riekkinen P., Jr.1
Schmidt, B.2
Stefanski, R.3
-
46
-
-
0030931020
-
Effects of metrifonate on memory impairment and cholinergic dysfunction in rats
-
Mar 12
-
46. Itoh A, Nitta A, Katono Y, et al. Effects of metrifonate on memory impairment and cholinergic dysfunction in rats. Eur J Pharmacol 1997 Mar 12; 322: 11-9
-
(1997)
Eur J Pharmacol
, vol.322
, pp. 11-19
-
-
Itoh, A.1
Nitta, A.2
Katono, Y.3
-
47
-
-
0030061097
-
Effects of metrifonate on escape and avoidance learning in young and aged rats
-
Jan
-
47. van der Staay FJ, Hinz VC, Schmidt BH. Effects of metrifonate on escape and avoidance learning in young and aged rats. Behav Pharmacol 1996 Jan; 7: 56-64
-
(1996)
Behav Pharmacol
, vol.7
, pp. 56-64
-
-
Van Der Staay, F.J.1
Hinz, V.C.2
Schmidt, B.H.3
-
48
-
-
0030440897
-
Effects of metrifonate, its transformation product dichlorvos, and other organophosphorus and reference cholinesterase inhibitors on Morris water escape behavior in young-adult rats
-
Aug
-
48. van der Staay FJ, Hinz VC, Schmidt BH. Effects of metrifonate, its transformation product dichlorvos, and other organophosphorus and reference cholinesterase inhibitors on Morris water escape behavior in young-adult rats. J Pharmacol Exp Ther 1996 Aug; 278: 697-708
-
(1996)
J Pharmacol Exp Ther
, vol.278
, pp. 697-708
-
-
Van Der Staay, F.J.1
Hinz, V.C.2
Schmidt, B.H.3
-
49
-
-
0029610697
-
Effects of metrifonate and tacrine in the spatial Morris task and modified Irwin tesl: Evaluation of the efficacy/safety profile in rats
-
Dec
-
49. Blokland A, Hinz V, Schmidt BH. Effects of metrifonate and tacrine in the spatial Morris task and modified Irwin tesl: evaluation of the efficacy/safety profile in rats. Drug Dev Res 1995 Dec; 36: 166-79
-
(1995)
Drug Dev Res
, vol.36
, pp. 166-179
-
-
Blokland, A.1
Hinz, V.2
Schmidt, B.H.3
-
50
-
-
0026020174
-
Pharmacokinetics of metrifonate and its rearrangement product dichlorvos in whole blood
-
Feb
-
50. Aden-Abdi YA, Villen T. Pharmacokinetics of metrifonate and its rearrangement product dichlorvos in whole blood. Pharmacol Toxicol 1991 Feb; 68: 137-9
-
(1991)
Pharmacol Toxicol
, vol.68
, pp. 137-139
-
-
Aden-Abdi, Y.A.1
Villen, T.2
-
51
-
-
0028301181
-
Pharmacokinetics and pharmacodynamics of metrifonate in humans
-
May
-
51. Unni LK, Womack C, Hannant ME, et al. Pharmacokinetics and pharmacodynamics of metrifonate in humans. Methods Find Exp Clin Pharmacnl 1994 May; 16: 285-9
-
(1994)
Methods Find Exp Clin Pharmacnl
, vol.16
, pp. 285-289
-
-
Unni, L.K.1
Womack, C.2
Hannant, M.E.3
-
52
-
-
0033007092
-
Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor metrifonate in patients with renal impairment
-
Jun
-
52. Dingemanse J, Halabi A, Kleinbloesem CH, et al. Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor metrifonate in patients with renal impairment. Ther Drug Monit 1999 Jun; 21: 310-6
-
(1999)
Ther Drug Monit
, vol.21
, pp. 310-316
-
-
Dingemanse, J.1
Halabi, A.2
Kleinbloesem, C.H.3
-
53
-
-
0025374012
-
Analysis of metrifonate and diclorvos in whole blood using gas chromatography and gas chromatography mass spectrometry
-
53. Villén T, Aden Abdi Y, Ericsson Ö, et al. Analysis of metrifonate and diclorvos in whole blood using gas chromatography and gas chromatography mass spectrometry. J Chromatogr 1990; 529 (2): 309-17
-
(1990)
J Chromatogr
, vol.529
, Issue.2
, pp. 309-317
-
-
Villén, T.1
Aden Abdi, Y.2
Ö, E.3
-
54
-
-
0032769080
-
Pharmacokinetics of metrifonate and its metabolite dichlorvos in healthy volunteers and in patients with renal impairment
-
Jul
-
54. Heinig R, Dietrich H, Halabi A. Pharmacokinetics of metrifonate and its metabolite dichlorvos in healthy volunteers and in patients with renal impairment. Clin Drug Invest 1999 Jul; 18; 35-46
-
(1999)
Clin Drug Invest
, vol.18
, pp. 35-46
-
-
Heinig, R.1
Dietrich, H.2
Halabi, A.3
-
55
-
-
0013654976
-
Trichlorfon
-
World Health Organization, Geneva
-
55. World Health Organization. Trichlorfon. Environmental Health Criteria 132. World Health Organization, Geneva, 1992
-
(1992)
Environmental Health Criteria
, vol.132
-
-
-
56
-
-
0032856188
-
The effect of food and time of administration on the pharmacokinetic and pharmacodynamic profile of metrifonate
-
56. Heinig R, Sachse R. The effect of food and time of administration on the pharmacokinetic and pharmacodynamic profile of metrifonate. Int J Clin Pharmacol Ther 1999; 37 (9): 456-64
-
(1999)
Int J Clin Pharmacol Ther
, vol.37
, Issue.9
, pp. 456-464
-
-
Heinig, R.1
Sachse, R.2
-
57
-
-
0029792078
-
Double-blind, placebo-controlled study of metrifonate, an acetylcholinesterase inhibitor, for Alzheimer disease
-
57. Becker RE, Colliver JA, Markwell SJ, et al. Double-blind, placebo-controlled study of metrifonate, an acetylcholinesterase inhibitor, for Alzheimer disease. Alz Dis Assoc Disord 1996; 10 (3): 124-31
-
(1996)
Alz Dis Assoc Disord
, vol.10
, Issue.3
, pp. 124-131
-
-
Becker, R.E.1
Colliver, J.A.2
Markwell, S.J.3
-
58
-
-
0032466991
-
Effects of metrifonate on cognitive decline in Alzheimer disease: A double-blind, placebo-controlled, 6-month study
-
Mar
-
58. Becker RE, Colliver JA, Markwell SJ, et al. Effects of metrifonate on cognitive decline in Alzheimer disease: a double-blind, placebo-controlled, 6-month study. Alz Dis Assoc Disord 1998 Mar; 12: 54-7
-
(1998)
Alz Dis Assoc Disord
, vol.12
, pp. 54-57
-
-
Becker, R.E.1
Colliver, J.A.2
Markwell, S.J.3
-
59
-
-
0031842292
-
Metrifonate treatment of the cognitive deficits of Alzheimer's disease
-
May
-
59. Cummings JL, Cyrus PA, Bieber F, et al. Metrifonate treatment of the cognitive deficits of Alzheimer's disease. Neurology 1998 May; 50: 1214-21
-
(1998)
Neurology
, vol.50
, pp. 1214-1221
-
-
Cummings, J.L.1
Cyrus, P.A.2
Bieber, F.3
-
60
-
-
0031842293
-
Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease
-
May
-
60. Morris JC, Cyrus PA, Orazem J, et al. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease. Neurology 1998 May; 50: 1222-30
-
(1998)
Neurology
, vol.50
, pp. 1222-1230
-
-
Morris, J.C.1
Cyrus, P.A.2
Orazem, J.3
-
61
-
-
0033060809
-
The effecls of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients
-
May
-
61. Raskind MA, Cyrus PA, Ruzicka BB, et al. The effecls of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients. J Clin Psychiatry 1999 May; 60: 318-25
-
(1999)
J Clin Psychiatry
, vol.60
, pp. 318-325
-
-
Raskind, M.A.1
Cyrus, P.A.2
Ruzicka, B.B.3
-
62
-
-
0032749775
-
A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: The MALT study
-
62. Dubois B, McKeith, Orgogozo J-M, et al. A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: the MALT study. Int J Geriatr Psychiatry 1999; 14 (11): 973-82
-
(1999)
Int J Geriatr Psychiatry
, vol.14
, Issue.11
, pp. 973-982
-
-
Dubois, B.1
McKeith2
Orgogozo, J.-M.3
-
63
-
-
0033009540
-
Efficacy and safety of a loading-dose regimen versus a no-loading-dose regimen of metrifonate in the symptomatic treatment of Alzheimer's disease: A randomized, double-masked, placebo-controlled trial
-
Jan
-
63. Jann MW, Cyrus PA, Eisner LS, et al. Efficacy and safety of a loading-dose regimen versus a no-loading-dose regimen of metrifonate in the symptomatic treatment of Alzheimer's disease: a randomized, double-masked, placebo-controlled trial. Clin Ther 1999 Jan; 21: 88-102
-
(1999)
Clin Ther
, vol.21
, pp. 88-102
-
-
Jann, M.W.1
Cyrus, P.A.2
Eisner, L.S.3
-
64
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of department of Health and Human Services Task Force on Alzheimer's disease
-
64. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984; 34: 939-44
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
-
66
-
-
0016823810
-
"Mini-mental state" a practical method for grading the cognitive state of patients for the clinician
-
66. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state" a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98
-
(1975)
J Psychiatr Res
, vol.12
, pp. 189-198
-
-
Folstein, M.F.1
Folstein, S.E.2
McHugh, P.R.3
-
67
-
-
0018887732
-
Pathological verification of ischemic score in differentiation of dementias
-
67. Rosen WG, Terry RD, Fuld P, et al. Pathological verification of ischemic score in differentiation of dementias. Ann Neurol 1980; 7: 486-8
-
(1980)
Ann Neurol
, vol.7
, pp. 486-488
-
-
Rosen, W.G.1
Terry, R.D.2
Fuld, P.3
-
68
-
-
0021520020
-
A new rating scale for Alzheimer's disease
-
68. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141 (11); 1356-64
-
(1984)
Am J Psychiatry
, vol.141
, Issue.11
, pp. 1356-1364
-
-
Rosen, W.G.1
Mohs, R.C.2
Davis, K.L.3
-
69
-
-
0028114429
-
The clinician Interview-Based Impression (CIBI): A clinician's global change rating scale in Alzheimer's disease
-
69. Knopman DS, Knapp MJ, Gracon SI, et al. The Clinician Interview-Based Impression (CIBI): a clinician's global change rating scale in Alzheimer's disease. Am J Psychiatry 1994; 44: 2315-21
-
(1994)
Am J Psychiatry
, vol.44
, pp. 2315-2321
-
-
Knopman, D.S.1
Knapp, M.J.2
Gracon, S.I.3
-
70
-
-
0027985334
-
The neuropsychiatric inventory: Comprehensive assessment of psychopathology in dementia
-
70. Cummings JL, Mega M, Gray K, et al. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-14
-
(1994)
Neurology
, vol.44
, pp. 2308-2314
-
-
Cummings, J.L.1
Mega, M.2
Gray, K.3
-
71
-
-
0019967975
-
The global deterioration scale for assessment of primary degenerative dementia
-
71. Reisberg B, Ferris S, De Leon MJ, et al. The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 1982; 139 (9): 1136-9
-
(1982)
Am J Psychiatry
, vol.139
, Issue.9
, pp. 1136-1139
-
-
Reisberg, B.1
Ferris, S.2
De Leon, M.J.3
-
72
-
-
0031452321
-
Functional disability in Alzheimer's disease
-
72. Gauthier S, Gélinas I, Gauthier L. Functional disability in Alzheimer's disease. Int Psychogeriatr 1997; 9 Suppl. 1: 163-5
-
(1997)
Int Psychogeriatr
, vol.9
, Issue.SUPPL. 1
, pp. 163-165
-
-
Gauthier, S.1
Gélinas, I.2
Gauthier, L.3
-
73
-
-
0034121365
-
The impact of metrifonate therapy on caregivers of patients with Alzheimer's disease: Results from the MALT clinical trial
-
73. Shikiar R, Shakespeare A, Sagnier P-P, et al. The impact of metrifonate therapy on caregivers of patients with Alzheimer's disease: results from the MALT clinical trial. J Am Geriatr Soc 2000; 48: 268-74
-
(2000)
J Am Geriatr Soc
, vol.48
, pp. 268-274
-
-
Shikiar, R.1
Shakespeare, A.2
Sagnier, P.-P.3
-
74
-
-
0034045806
-
Metrifonate therapy in Alzheimer's disease: A pooled analysis of four randomized, double blind, placebo-controlled trials
-
In press
-
74. Farlow MR, Cyrus PA. Metrifonate therapy in Alzheimer's disease: a pooled analysis of four randomized, double blind, placebo-controlled trials. Dementia Geriatr Cogn Disord 2000. In press
-
(2000)
Dementia Geriatr Cogn Disord
-
-
Farlow, M.R.1
Cyrus, P.A.2
-
75
-
-
4243264876
-
Patients with Alzheimer's disease benefit from metrifonate treatment regardless of their demographic characteristics and previous cholinesterase therapy
-
Apr 12
-
75. Cyrus P, Camicioli R, Kaye J. Patients with Alzheimer's disease benefit from metrifonate treatment regardless of their demographic characteristics and previous cholinesterase therapy [abstract]. Neurology 1999 Apr 12; 52 Suppl. 2: A482
-
(1999)
Neurology
, vol.52
, Issue.SUPPL. 2
-
-
Cyrus, P.1
Camicioli, R.2
Kaye, J.3
-
76
-
-
4243271225
-
Metrifonate improves cognitive performance in patients with Alzheimer's disease despite concurrent mild ischemic damage
-
Apr 12
-
76. Forchetti C, Cyrus P. Metrifonate improves cognitive performance in patients with Alzheimer's disease despite concurrent mild ischemic damage [abstract]. Neurology 1999 Apr 12; 52 Suppl. 2: A173
-
(1999)
Neurology
, vol.52
, Issue.SUPPL. 2
-
-
Forchetti, C.1
Cyrus, P.2
-
77
-
-
0013674166
-
Bayer halts trial on new Alzheimer's drug
-
Oct 10
-
77. Bayer halts trial on new Alzheimer's drug. Pharm J 1998 Oct 10; 261: 561
-
(1998)
Pharm J
, vol.261
, pp. 561
-
-
-
78
-
-
0034090742
-
A randomized, double blind, placebo-controlled, multi-center study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease
-
78. Blass JP, Cyrus PA, Bieber F, et al. A randomized, double blind, placebo-controlled, multi-center study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease. Alz Dis Assoc Disord 2000; 14 (1): 39-41
-
(2000)
Alz Dis Assoc Disord
, vol.14
, Issue.1
, pp. 39-41
-
-
Blass, J.P.1
Cyrus, P.A.2
Bieber, F.3
-
79
-
-
4243264875
-
Metrifonate in the long-term treatment of Alzheimer's disease
-
Sep
-
79. Cyrus PA, Ruzicka B, Gulanski B. Metrifonate in the long-term treatment of Alzheimer's disease [abstract]. J Am Geriatr Soc 1998 Sep; 46: S35
-
(1998)
J Am Geriatr Soc
, vol.46
-
-
Cyrus, P.A.1
Ruzicka, B.2
Gulanski, B.3
-
80
-
-
0033021012
-
Pharmacologic treatment of Alzheimer's disease: An update on approved, unapproved therapies
-
Jan
-
80. Steinberg M. Pharmacologic treatment of Alzheimer's disease: an update on approved, unapproved therapies. Formulary 1999 Jan; 34: 32-44
-
(1999)
Formulary
, vol.34
, pp. 32-44
-
-
Steinberg, M.1
-
81
-
-
0024152063
-
Pharmacokinetics and pharmacodynamics of acetylcholinesterase inhibition: Can acetylcholine levels in the brain be improved in Alzheimer's disease?
-
81. Becker RE, Giacobini E. Pharmacokinetics and pharmacodynamics of acetylcholinesterase inhibition: can acetylcholine levels in the brain be improved in Alzheimer's disease? Drug Dev Res 1988; 14 (3-4): 235-46
-
(1988)
Drug Dev Res
, vol.14
, Issue.3-4
, pp. 235-246
-
-
Becker, R.E.1
Giacobini, E.2
-
82
-
-
0028270519
-
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease
-
Apr
-
82. Knapp MJ, Knopman DS, Solomon PR, et al. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA 1994 Apr: 271 (13): 985-91
-
(1994)
JAMA
, vol.271
, Issue.13
, pp. 985-991
-
-
Knapp, M.J.1
Knopman, D.S.2
Solomon, P.R.3
-
83
-
-
0034022308
-
Donepezil: A review of its use in Alzheimers's disease
-
83. Dooley M, Lamb H. Donepezil: A review of its use in Alzheimers's disease. Drugs Aging 2000; 16 (3): 199-226
-
(2000)
Drugs Aging
, vol.16
, Issue.3
, pp. 199-226
-
-
Dooley, M.1
Lamb, H.2
-
84
-
-
0031755416
-
Rivastigmine: A review of its use in Alzheimer's disease
-
Nov
-
84. Spencer CM, Noble S. Rivastigmine: a review of its use in Alzheimer's disease. Drugs Aging 1998 Nov; 13: 391-410
-
(1998)
Drugs Aging
, vol.13
, pp. 391-410
-
-
Spencer, C.M.1
Noble, S.2
-
85
-
-
0031816244
-
Metrifonate for Alzheimer's disease. Is the next cholinesterase inhibitor better
-
May
-
85. Knopman DS. Metrifonate for Alzheimer's disease. Is the next cholinesterase inhibitor better [abstract]? Neurology 1998 May; 50: 1203-5
-
(1998)
Neurology
, vol.50
, pp. 1203-1205
-
-
Knopman, D.S.1
|