An efficient preparation of N-alkyl-2-benzazepine derivatives and investigation of their biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3193-3195

  Kamimura, Akio ^a   So, Masahiro ^a   Kuratani, Tomohiro ^a   Matsuura, Kenji ^a   Inui, Makoto ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

2 Benzazepines; Epithelial cell migration; HaCat cell; N Alkylation; Promotion of skin wound; Radical cyclization; SAR studies

Indexed keywords

ACRYLAMIDE DERIVATIVE; ALKYL GROUP; BENZAZEPINE DERIVATIVE; BENZENE DERIVATIVE; BROMINE DERIVATIVE; METHYL GROUP;

ALKYLATION; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYCLIZATION; DERIVATIZATION; HUMAN; HUMAN CELL; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; ALKYLATION; BENZAZEPINES; CELL LINE; CELL MOVEMENT; CYCLIZATION; EPITHELIAL CELLS; HUMANS; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; WOUND HEALING;

EID: 65749095016     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.117     Document Type: Article

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12. 2: C, 77.26; H, 7.17; N, 4.74. Found: C, 77.11; H, 7.32; N, 4.63.