메뉴 건너뛰기




Volumn 1, Issue 1, 2008, Pages

P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; IMATINIB; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

EID: 65749091319     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-1-15     Document Type: Review
Times cited : (47)

References (56)
  • 1
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • DOI 10.1056/NEJM199904293401706
    • Sawyers CL: Chronic myeloid leukemia. N Engl J Med 1999, 340:1330-1340. (Pubitemid 29196596)
    • (1999) New England Journal of Medicine , vol.340 , Issue.17 , pp. 1330-1340
    • Sawyers, C.L.1
  • 2
    • 0003224009 scopus 로고
    • A minute chromosome (Phl) in chronic granulocytic leukemia
    • Nowell PC: A minute chromosome (Phl) in chronic granulocytic leukemia. Blut 1962, 8:65-66.
    • (1962) Blut , vol.8 , pp. 65-66
    • Nowell, P.C.1
  • 3
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD: Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973, 243:290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 4
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D: Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990, 247:824-830.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 6
    • 0020972981 scopus 로고
    • Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
    • Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, Geurts vK, Bootsma D, Grosveld G, Ferguson-Smith MA, Davies T, Stone M, Heisterkamp N, Stephenson JR, Groffen J: Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1983, 306:277-280. (Pubitemid 14232360)
    • (1983) Nature , vol.306 , Issue.5940 , pp. 277-280
    • Bartram, C.R.1    De Klein, A.2    Hagemeijer, A.3
  • 7
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G: Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984, 36:93-99. (Pubitemid 14155374)
    • (1984) Cell , vol.36 , Issue.1 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3
  • 8
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON: Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990, 247:1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 11
    • 34548825795 scopus 로고    scopus 로고
    • Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
    • DOI 10.1182/blood-2007-03-066936
    • O'Hare T, Eide CA, Deininger MWN: Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 2007, 110:2242-2249. (Pubitemid 47523141)
    • (2007) Blood , vol.110 , Issue.7 , pp. 2242-2249
    • O'Hare, T.1    Eide, C.A.2    Deininger, M.W.N.3
  • 12
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • DOI 10.1182/blood-2002-09-2896
    • Branford S, Rudzki Z, Walsh S, Parkinson I, Grigg A, Szer J, Taylor K, Herrmann R, Seymour JF, Arthur C, Joske D, Lynch K, Hughes T: Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003, 102:276-283. (Pubitemid 36759665)
    • (2003) Blood , vol.102 , Issue.1 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6    Taylor, K.7    Herrmann, R.8    Seymour, J.F.9    Arthur, C.10    Joske, D.11    Lynch, K.12    Hughes, T.13
  • 17
    • 73649088465 scopus 로고    scopus 로고
    • New York, NY: BristolMyers Squibb Company
    • Sprycel [prescribing information]. New York, NY: BristolMyers Squibb Company; 2007.
    • (2007) Sprycel [prescribing Information]
  • 18
    • 84873581670 scopus 로고    scopus 로고
    • East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Tasigna [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2007.
    • (2007) Tasigna [prescribing Information]
  • 19
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • DOI 10.1182/blood-2004-08-3097
    • Deininger M, Buchdunger E, Druker BJ: The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005, 105:2640-2653. (Pubitemid 40446252)
    • (2005) Blood , vol.105 , Issue.7 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 26
    • 60049093162 scopus 로고    scopus 로고
    • Dasatinib long-term efficacy in patients with chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to imatinib: A 2-year update of the START-C Study
    • (EHA Annual Meeting Abstracts) Abstract 0934
    • Cervantes F, Baccarani M, Lipton J, Matloub Y, Sinha S, Stone R, Mauro M: Dasatinib long-term efficacy in patients with chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to imatinib: a 2-year update of the START-C Study. Haematologica (EHA Annual Meeting Abstracts) 2008, 93:372-372. Abstract 0934.
    • (2008) Haematologica , vol.93 , pp. 372-372
    • Cervantes, F.1    Baccarani, M.2    Lipton, J.3    Matloub, Y.4    Sinha, S.5    Stone, R.6    Mauro, M.7
  • 33
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • DOI 10.1126/science.1099480
    • Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004, 305:399-401. (Pubitemid 38938156)
    • (2004) Science , vol.305 , Issue.5682 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 34
    • 0037115644 scopus 로고    scopus 로고
    • Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571)
    • La Rosée P, Corbin AS, Stoffregen EP, Deininger MW, Druker BJ: Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res 2002, 62:7149-7153. (Pubitemid 36025227)
    • (2002) Cancer Research , vol.62 , Issue.24 , pp. 7149-7153
    • La Rosee, P.1    Corbin, A.S.2    Stoffregen, E.P.3    Deininger, M.W.4    Druker, B.J.5
  • 36
    • 37349092298 scopus 로고    scopus 로고
    • Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations
    • (EHA Annual Meeting Abstracts) Abstract 0356
    • Mueller MC, Branford S, Radich J, Shah N, Erben P, Ernst T: Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations. Haematologica (EHA Annual Meeting Abstracts) 2007, 92:127-127. Abstract 0356.
    • (2007) Haematologica , vol.92 , pp. 127-127
    • Mueller, M.C.1    Branford, S.2    Radich, J.3    Shah, N.4    Erben, P.5    Ernst, T.6
  • 38
    • 33749325184 scopus 로고    scopus 로고
    • Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
    • DOI 10.1182/blood-2006-02-004580
    • Bradeen HA, Eide CA, O'Hare T, Johnson KJ, Willis SG, Lee FY, Druker BJ, Deininger MW: Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood 2006, 108:2332-2338. (Pubitemid 44497517)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2332-2338
    • Bradeen, H.A.1    Eide, C.A.2    O'Hare, T.3    Johnson, K.J.4    Willis, S.G.5    Lee, F.Y.6    Druker, B.J.7    Deininger, M.W.8
  • 40
  • 44
    • 49249125102 scopus 로고    scopus 로고
    • Nilotinib is associated with minimal cross intolerance to imatinib in patients with imatinib-intolerant Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) in either chronic phase (CP) or accelerated phase (AP)
    • (ASH Annual Meeting Abstracts) Abstract 1040
    • Cortes J, Jabbour E, Hochhaus A, le Coutre P, Baccarani M, Bhalla KN, Ossenkoppel G, Gattermann N, Haque A, Gallagher N, Giles F, Kantarjian HM: Nilotinib is associated with minimal cross intolerance to imatinib in patients with imatinib-intolerant Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) in either chronic phase (CP) or accelerated phase (AP). Blood (ASH Annual Meeting Abstracts) 2007, 110:. Abstract 1040.
    • (2007) Blood , vol.110
    • Cortes, J.1    Jabbour, E.2    Hochhaus, A.3    Le Coutre, P.4    Baccarani, M.5    Bhalla, K.N.6    Ossenkoppel, G.7    Gattermann, N.8    Haque, A.9    Gallagher, N.10    Giles, F.11    Kantarjian, H.M.12
  • 45
    • 48249105193 scopus 로고    scopus 로고
    • Responses and disease progression in CML-CP patients treated with nilotinib after imatinib failure appear to be affected by the BCR-ABL mutation status and types
    • (ASH Annual Meeting Abstracts) Abstract 320
    • Hughes T, Saglio G, Martinelli G, Kim DW, Soverini S, Mueller M, Haque A, Gallagher N, Shou Y, Radich J, Branford S, Hochhaus A: Responses and disease progression in CML-CP patients treated with nilotinib after imatinib failure appear to be affected by the BCR-ABL mutation status and types. Blood (ASH Annual Meeting Abstracts) 2007, 110:. Abstract 320.
    • (2007) Blood , vol.110
    • Hughes, T.1    Saglio, G.2    Martinelli, G.3    Kim, D.W.4    Soverini, S.5    Mueller, M.6    Haque, A.7    Gallagher, N.8    Shou, Y.9    Radich, J.10    Branford, S.11    Hochhaus, A.12
  • 46
    • 77954813173 scopus 로고    scopus 로고
    • The P-loop mutations Y253H and E255K/V may develop more frequently than T315I during nilotinib therapy after imatinib failure and are associated with progression in patients with Ph-positive leukemias
    • (EHA Annual Meeting Abstracts) Abstract 0904
    • Branford S, Shou Y, Lawrence R, Rudzki Z, Hughes T: The P-loop mutations Y253H and E255K/V may develop more frequently than T315I during nilotinib therapy after imatinib failure and are associated with progression in patients with Ph-positive leukemias. Haematologica (EHA Annual Meeting Abstracts) 2007, 92:337-338. Abstract 0904.
    • (2007) Haematologica , vol.92 , pp. 337-338
    • Branford, S.1    Shou, Y.2    Lawrence, R.3    Rudzki, Z.4    Hughes, T.5
  • 47
    • 66249126387 scopus 로고    scopus 로고
    • Correlation of clinical response to nilotinib with BCR-ABL mutation status in advanced phase chronic myelogenous leukemia (CML-AP) patients with imatinib-resistance or intolerance
    • (ASH Annual Meeting Abstracts) Abstract 1940
    • Saglio G, Kim DW, Hochhaus A, Soverini S, Erben P, Branford S, Haque A, Gallagher N, Shou Y, Hughes T, Martinelli G, Radich J: Correlation of clinical response to nilotinib with BCR-ABL mutation status in advanced phase chronic myelogenous leukemia (CML-AP) patients with imatinib-resistance or intolerance. Blood (ASH Annual Meeting Abstracts) 2007, 110:. Abstract 1940.
    • (2007) Blood , vol.110
    • Saglio, G.1    Kim, D.W.2    Hochhaus, A.3    Soverini, S.4    Erben, P.5    Branford, S.6    Haque, A.7    Gallagher, N.8    Shou, Y.9    Hughes, T.10    Martinelli, G.11    Radich, J.12
  • 48
    • 34248994815 scopus 로고    scopus 로고
    • A phase 1/2 study of SKI-606, a dual inhibitor of src and abl kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory or intolerant of imatinib
    • (ASH Annual Meeting Abstracts) Abstract 168
    • Cortes J, Kantarjian HM, Baccarani M, Brummendorf TH, Liu D, Ossenkoppele G, Volkert ADG, Hewes B, Moore L, Zacharchuk C, Gambacorti C: A phase 1/2 study of SKI-606, a dual inhibitor of src and abl kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory or intolerant of imatinib. Blood (ASH Annual Meeting Abstracts) 2006, 108:. Abstract 168.
    • (2006) Blood , vol.108
    • Cortes, J.1    Kantarjian, H.M.2    Baccarani, M.3    Brummendorf, T.H.4    Liu, D.5    Ossenkoppele, G.6    Volkert, A.D.G.7    Hewes, B.8    Moore, L.9    Zacharchuk, C.10    Gambacorti, C.11
  • 49
    • 0037439689 scopus 로고    scopus 로고
    • SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
    • Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, Frost P, Ye F, Boschelli DH, Boschelli F: SKI-606, a 4-anilino-3-quinoline-carbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res 2003, 63:375-381. (Pubitemid 36152495)
    • (2003) Cancer Research , vol.63 , Issue.2 , pp. 375-381
    • Golas, J.M.1    Arndt, K.2    Etienne, C.3    Lucas, J.4    Nardin, D.5    Gibbons, J.6    Frost, P.7    Ye, F.8    Boschelli, D.H.9    Boschelli, F.10
  • 51
    • 39049158657 scopus 로고    scopus 로고
    • Bosutinib (SKI-606) exhibits clinical activity in patients with Philadelphia chromosome positive CML or ALL who failed imatinib
    • (ASCO Annual Meeting Abstracts) Abstract 7006
    • Gambacorti-Passerini C, Brummendorf T, Kantarjian H, Martinelli G, Liu D, Fisher T, Hewes B, Volkert A, Abbas R, Cortes J: Bosutinib (SKI-606) exhibits clinical activity in patients with Philadelphia chromosome positive CML or ALL who failed imatinib. J Clin Oncol (ASCO Annual Meeting Abstracts) 2007, 25(Suppl 18S):. Abstract 7006.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18S
    • Gambacorti-Passerini, C.1    Brummendorf, T.2    Kantarjian, H.3    Martinelli, G.4    Liu, D.5    Fisher, T.6    Hewes, B.7    Volkert, A.8    Abbas, R.9    Cortes, J.10
  • 52
    • 33846240316 scopus 로고    scopus 로고
    • MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
    • DOI 10.1182/blood-2006-05-025049
    • Giles FJ, Cortes J, Jones D, Bergstrom D, Kantarjian H, Freedman SJ: MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007, 109:500-502. (Pubitemid 46105945)
    • (2007) Blood , vol.109 , Issue.2 , pp. 500-502
    • Giles, F.J.1    Cortes, J.2    Jones, D.3    Bergstrom, D.4    Kantarjian, H.5    Freedman, S.J.6
  • 53
    • 38349062828 scopus 로고    scopus 로고
    • MK-0457, a novel multikinase inhibitor, is active in patients with chronic myeloid leukemia (CML) and acute lymphocytic leukemia (ALL) with the T315I BCR-ABL resistance mutation and patients with refractory JAK2-positive myeloproliferative diseases (MPD)
    • (EHA Annual Meeting Abstracts) Abstract 0927
    • Giles J, Cortes J, Bergstrom DA, Xiao A, Jones D, Verstovsek S, Thomas D, Rizzieri D, Freedman SJ, Kantarjian H: MK-0457, a novel multikinase inhibitor, is active in patients with chronic myeloid leukemia (CML) and acute lymphocytic leukemia (ALL) with the T315I BCR-ABL resistance mutation and patients with refractory JAK2-positive myeloproliferative diseases (MPD). Haematologica (EHA Annual Meeting Abstracts) 2007, 92:347-347. Abstract 0927.
    • (2007) Haematologica , vol.92 , pp. 347-347
    • Giles, J.1    Cortes, J.2    Bergstrom, D.A.3    Xiao, A.4    Jones, D.5    Verstovsek, S.6    Thomas, D.7    Rizzieri, D.8    Freedman, S.J.9    Kantarjian, H.10
  • 54
    • 61849136570 scopus 로고    scopus 로고
    • PHA-739358, an aurora kinase inhibitor, induces clinical responses in chronic myeloid leukemia harboring T315I mutations of BCR-ABL
    • (ASH Annual Meeting Abstracts) Abstract 1030
    • Paquette R, Shah NP, Sawyers CL, Martinelli G, John N, Chalukya M, Rocchetti M, Fiocchi C, Comis S, Capolongo L, Laffranchi B: PHA-739358, an aurora kinase inhibitor, induces clinical responses in chronic myeloid leukemia harboring T315I mutations of BCR-ABL. Blood (ASH Annual Meeting Abstracts) 2007, 110:. Abstract 1030.
    • (2007) Blood , vol.110
    • Paquette, R.1    Shah, N.P.2    Sawyers, C.L.3    Martinelli, G.4    John, N.5    Chalukya, M.6    Rocchetti, M.7    Fiocchi, C.8    Comis, S.9    Capolongo, L.10    Laffranchi, B.11
  • 56
    • 37149007976 scopus 로고    scopus 로고
    • Inhibition of the drug-resistant T315I mutant of BCR-Abl
    • Abstract 171
    • Zhang W: Inhibition of the drug-resistant T315I mutant of BCR-Abl. Eur J Cancer Supplements 2006, 12(Suppl 4):54-54. Abstract 171.
    • (2006) Eur J Cancer Supplements , vol.12 , Issue.SUPPL. 4 , pp. 54-54
    • Zhang, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.