The radical Trap 5,5-dimethyl-1-pyrroline N/-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 2, 2009, Pages 515-523

  Zuo, Li ^a   Chen, Yeong Renn ^a   Reyes, Levy A ^a   Lee, Hsin Ling ^a   Chen, Chwen Lih ^a   Villamena, Frederick A ^a,b   Zweier, Jay L ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ANTIBODY; CYTOCHROME C OXIDASE; HYDROETHIDINE; MITOCHONDRIAL PROTEIN; OXYGEN; OXYGEN RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; 5,5-DIMETHYL-1-PYRROLINE-1-OXIDE; AMINE OXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOSE RESPONSE; DRUG EFFECT; FLUOROMETRY; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; HOMEOSTASIS; IMMUNOBLOTTING; ISOLATED HEART; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; UPREGULATION; ANIMAL; BLOOD PRESSURE; ELECTRON TRANSPORT; ENZYMOLOGY; HEART INFARCTION; HEART MITOCHONDRION; HEART RATE; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BLOOD PRESSURE; CORONARY CIRCULATION; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; FREE RADICAL SCAVENGERS; HEART RATE; MALE; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 65649134278     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.143479     Document Type: Article

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