The cardiac adrenergic system in ischaemia: Differential role of acidosis and energy depletion

Cardiovascular Research

Volumn 38, Issue 3, 1998, Pages 646-654

  Simonis, Gregor ^a   Marquetant, Rainer ^a   Röthele, Jochen ^a   Strasser, Ruth H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

adrenergic receptors; Acidosis; Acute myocardial infarction; Adenylyl cyclase; Heart; Protein kinase C; Rat; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; PROTEIN KINASE C;

ACUTE HEART INFARCTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CELL PH; CONTROLLED STUDY; ENZYME ACTIVATION; HEART INNERVATION; MALE; METABOLIC ACIDOSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SIGNAL TRANSDUCTION;

ACIDOSIS; ADENYLATE CYCLASE; ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; CYANIDES; CYTOSOL; ENERGY METABOLISM; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA;

EID: 0032102645     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(98)00057-1     Document Type: Article

References (56)

1. [1] Schömig A, Dart AM, Dietz R, Mayer E, Kübler W. Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: locally mediated release. Circ Res 1984;55:689-701.
2. [2] Vatner DE, Knight DR, Shen YT, Thomas JXJ, Homey CJ, Vatner SF. One hour of myocardial ischemia in conscious dogs increases β-adrenergic receptors, but decreases adenylate cyclase activity. J Mol Cell Cardiol 1988;20:75-82.
3. [3] Strasser RH, Krimmer J, Braun-Dullaeus R, Marquetant R, Kübler W. Dual sensitization of the adrenergic system in early myocardial ischemia: Independent regulation of the β-adrenergic receptors and the adenylyl cyclase. J Mol Cell Cardiol 1990;22:1405-1423.
4. [4] Vatner DE, Young MA, Knight DR, Vatner SF. β-Receptors and adenylate cyclase: Comparison of nonischemic, ischemic, and postmortem tissue. Am J Physiol 1990;258:H140-H144.
5. [5] Mukherjee A, Bush LR, McKoy KE, et al. Relationship between β-adrenergic receptor numbers and physiological response during experimental canine myocardial ischemia. Circ Res 1982;50:735-741.
6. [6] Mukherjee A, Wong TM, Buja LM, Lefkowitz RJ, Willerson JT. β-adrenergic and muscarinic cholinergic receptors in canine myocardium: Effects of ischemia. J Clin Invest 1979;64:1423-1428.
7. s. Circ Res 1989;65:1145-1150.
8. [8] Wolff AA, Hines DK, Karliner JS. Preserved β-adrenoceptor-mediated adenylyl cyclase activity despite receptor and postreceptor dysfunction in acute myocardial ischemia. Am Heart J 1994;128:542-550.
9. [9] Podzuweit T, Darby AJ, Cherry GW, Opie LH. Cyclic AMP levels in ischemic and non-ischemic myocardium following coronary artery ligation: Relation to ventricular fibrillation. J Mol Cell Cardiol 1978;10:81-94.
10. [10] Mori K. Studies on adenylyl cyclase system in myocardium (P II). Adenyl cyclase system in myocardial infarction of dogs. J Med Sci 1976;39:9-14.
11. [11] Mori H, Ishikawa S, Kojima S, et al. Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. Cardiovasc Res 1993;27:192-198.
12. 1-receptor-independent activation of protein kinase C in acute myocardial ischemia: Mechanism of sensitization of the adenylyl cyclase system. Circ Res 1992;70:1304-1312.
13. [13] Sugden PH, Bogoyevitch MA. Intracellular signalling through protein kinases in the heart. Cardiovasc Res 1995;30:478-492.
14. [14] McFadden PN, Mandpe A, Koshland DE Jr. Calcium-and lipid-independent protein kinase C autophosphorylation. Activation by low pH. J Biol Chem 1989;264:12765-12771.
15. [15] Fiolet JWT, Baartscheer A, Schumacher CA, Coronel R, Wele HF. The change of the free energy of ATP-hydrolysis during global ischemia and anoxia in the rat heart. J Mol Cell Cardiol 1984;16:1023-1036.
16. [16] De Albuquerque CP, Gerstenblith G, Weiss RG. Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts. Circ Res 1994;74:139-150.
17. [17] Cobbe SM, Poole-Wilson PA. The time of onset and severity of acidosis in myocardial ischaemia. J Mol Cell Cardiol 1980;12:745-760.
18. [18] Langendorff O. Untersuchungen am ueberlebenden Saeugetierherzen. Arch Gen Physiol 1895;230:183-186.
19. [19] Schömig A, Fischer S, Kurz T, Richardt G, Schömig E. Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic heart: Mechanism and metabolic requirements. Circ Res 1987;60:194-205.
20. 125I]Iodocyanopindolol, a new ligand for β-adrenoceptors: Identification and quantitation of subclasses of β-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol 1981;317:277-285.
21. [21] Strasser RH, Krimmer J, Marquetant R. Regulation of β-adrenergic receptors: Impaired desensitization in myocardial ischemia. J Cardiovasc Pharmacol 1988;12:S15-S24.
22. [22] Stiles GL, Caron MG, Lefkowitz RJ. β-adrenergic receptors: Biochemical mechanisms of physiological regulation. Pharmacol Rev 1984;64:661-743.
23. [23] Salomon Y, Londos C, Rodbell MA. A highly sensitive adenylate cyclase assay. Anal Biochem 1974;58:541-548.
24. [24] Jakobs KH, Saur W, Schultz G. Reduction of adenylate cyclase activity in lysates of human platelets by the α-adrenergic component of epinephrine. J Cyclic Nucleotide Res 1976;2:381-392.
25. [25] Takai Y, Kishimoto A, Inoue M, Nishizuka Y. Studies on a cyclic nuleotide-independent protein kinase and its proenzyme in mammalian tissues. I Purification and characterization of an active enzyme from bovine cerebellum. J Biol Chem 1977;252:7603-7609.
26. [26] Sabina RL, Kernstine KH, Boyd RL, Holmes EW, Swain JL. Metabolism of 5-amino-4-imidazolecarboxamide riboside in cardiac and skeletal muscle. J Biol Chem 1982;257:10178-10183.
27. [27] Atkinson DE. The energy charge of the adenylate pool as a regulatory parameter: Interaction with feedback modifiers. Biochemistry 1968;7:4030-4034.
28. [28] Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal Biochem 1976;72:248-254.
29. [29] De Lean A, Stadel JM, Lefkowitz RJ. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J Biol Chem 1980;255:7108-7117.
30. [30] Stadel JM, De Lean A, Lefkowitz RJ. A high affinity agonist-β-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey erythrocyte membranes. J Biol Chem 1980;255:1436-1441.
31. 31P - NMR of high-energy phosphates in perfused rat heart during metabolic acidosis. Am J Physiol 1992;263:H903-H909.
32. [32] Momomura S, Ingwall JS, Parker JA, Sahagian P, Ferguson JJ, Grossman W. The relationships of high energy phosphates, tissue pH, and regional blood flow to diastolic distensibility in the ischemic dog myocardium. Circ Res 1985;57:822-835.
33. [33] Bright CM, Ellis D. Intracellular pH changes induced by hypoxia and anoxia in isolated sheep heart Purkinje fibres. Exp Physiol 1992;77:165-175.
34. [34] Neely JR, Whitmer JT, Rovetto MJ. Effect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts. Circ Res 1975;37:733-741.
35. [35] Williamson JR, Schaffer SW, Ford C, Safer B. Contribution of tissue acidosis to ischemic injury in the perfused rat heart. Circulation 1976;53:I3-I14.
36. [36] Simonis G, Weinbrenner C, Marquetant R, Strasser RH. Selective regulation of calcium-independent isoforms of protein kinase C in prolonged myocardial ischemia. J Mol Cell Cardiol 1994;26:CXVII.
37. [37] Weinbrenner C, Simonis G, Marquetant R, Strasser RH. Selective regulation of calcium-dependent and calcium-independent subtypes of protein kinase C in acute and prolonged myocardial ischemia. Circulation 1993;88:I-101.
38. [38] Devos C, Robberecht P, Waelbroeck M, et al. Uncoupling between β-adrenoceptors and adenylate cyclase in dog ischemic myocardium. Naunyn Schmiedebergs Arch Pharmacol 1985;331:71-75.
39. [39] Prasad MR, Jones RM. Enhanced membrane protein kinase C activity in myocardial ischemia. Basic Res Cardiol 1992;87:19-26.
40. [40] Schömig A, Richardt G. The role of catecholamines in ischemia. J Cardiovasc Pharmacol 1990;16:S105-S112.
41. [41] Nadeau RA, DeCamplain J. Plasma catecholamines in acute myocardial infarction. Am Heart J 1979;98:548-554.
42. [42] Hertel C, Coulter SJ, Perkins JP. The involvement of cellular ATP in receptor-mediated internalization of epidermal growth factor and hormone-induced internalization of β-adrenergic receptors. J Biol Chem 1986;261:5974-5980.
43. 1-adrenergic receptors. J Mol Cell Cardiol 1995;27:437-452.
44. 1-adrenergic receptor mRNA and density but not signaling in neonatal rat cardiac myocytes. Circulation 1996;27:3303-3310.
45. [45] Birnkrant DJ, Davis PB, Ernsberger P. Visualization of high-and low-affinity β-adrenergic receptors in rat lung: Upregulation by chronic hypoxia. Am J Physiol 1993;265:L389-L394.
46. [46] Reupcke C, Paraschos A, Honbo N, Karliner JS. A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced β adrenoceptor density. Cardiovasc Res 1993;27:2179-2185.
47. [47] Naghshineh S, Noguchi M, Huang KP, Londos C. Activation of adipocyte adenylate cyclase by protein kinase C. J Biol Chem 1986;261:14534-14538.
48. [48] Pfeuffer T. Hormone-and calcium-regulated adenylate cyclases. Biol Chem Hoppe-Seyler 1989;370:278-279.
49. [49] Mitchell FE, Marais RM, Parker PJ. The phosphorylation of protein kinase C as a potential measure of activation. Biochem J 1989;261:131-136.
50. [50] Messing RO, Stevens AM, Kiyasu E, Sneade AB. Nicotinic and muscarinic agonists stimulate rapid protein kinase C translocation in PC12 cells. J Neurosci 1989;9:507-512.
51. 2+ and phorbol esters. Nature 1985;317:546-551.
52. [52] Darbon JM, Oury F, Clamens S, Bayard F. TPA induces subcellular translocation and subsequent down-regulation of both phorbol ester binding and protein kinase C activities in MCF-7 cells. Biochem Biophys Res Commun 1987;146:537-546.
53. 2+-dependent increase in diacylglycerol formation and translocation of protein kinase C to membranes in cultured bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol 1992;346:76-81.
54. [54] Catalán RE, Martínez AM, Aragonés MD, Fernández I. Substance P stimulates translocation of protein kinase C in brain micro vessels. Biochem Biophys Res Commun 1989;164:595-600.
55. 6 glioma cells: TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC ζ. FEBS Lett 1993;332:169-173.
56. [56] Tippmer S, Quitterer U, Kolm V, et al. Bradykinin induces translocation of the protein kinase C isoforms α, ε, and ζ. Eur J Biochem 1994;225:297-304.