메뉴 건너뛰기




Volumn 22, Issue 2, 2009, Pages 93-106

Breast cancer biomarkers and HER2 testing after 10 years of anti-HER2 therapy

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2 ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ESTROGEN RECEPTOR; FC RECEPTOR; HERMES ANTIGEN; LAPATINIB; MICRORNA; MUCIN 4; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 65649133129     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2009.22.2.1334452     Document Type: Article
Times cited : (49)

References (153)
  • 2
    • 2542638621 scopus 로고    scopus 로고
    • Targeted therapy in breast cancer. The HER-2/neu gene and protein
    • Ross, J.S., Fletcher, J.A., Bloom, K.J. et al. Targeted therapy in breast cancer. The HER-2/neu gene and protein. Mol Cell Proteomics 2004, 3(4): 379-98.
    • (2004) Mol Cell Proteomics , vol.3 , Issue.4 , pp. 379-398
    • Ross, J.S.1    Fletcher, J.A.2    Bloom, K.J.3
  • 3
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • Hudis, C.A. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med 2007, 357(1): 39-51.
    • (2007) N Engl J Med , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 4
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • Yarden, Y. and Sliwkowski, M.X. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001, 2(2): 127-37.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 5
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • Tzahar, E., Waterman, H., Chen, X. et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996, 16(10): 5276-87.
    • (1996) Mol Cell Biol , vol.16 , Issue.10 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3
  • 6
    • 2442701289 scopus 로고    scopus 로고
    • The ErbB/HER receptor protein-tyrosine kinases and cancer
    • Roskoski, R. Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004, 319(1): 1-11.
    • (2004) Biochem Biophys Res Commun , vol.319 , Issue.1 , pp. 1-11
    • Roskoski Jr., R.1
  • 7
    • 0030030072 scopus 로고    scopus 로고
    • ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer
    • Karunagaran, D., Tzahar, E., Beerli, R.R. et al. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J 1996, 15(2): 254-64.
    • (1996) EMBO J , vol.15 , Issue.2 , pp. 254-264
    • Karunagaran, D.1    Tzahar, E.2    Beerli, R.R.3
  • 8
    • 0026718827 scopus 로고
    • ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization
    • Kallioniemi, O., Kallioniemi, A., Kurisu, W. et al. ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc Natl Acad Sci U S A 1992, 89(12): 5321-25.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.12 , pp. 5321-5325
    • Kallioniemi, O.1    Kallioniemi, A.2    Kurisu, W.3
  • 9
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • Moasser, M. M. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 2007, 26(45): 6469-87.
    • (2007) Oncogene , vol.26 , Issue.45 , pp. 6469-6487
    • Moasser, M.M.1
  • 10
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C.M., Sorlie, T., Eisen, M.B. et al. Molecular portraits of human breast tumours. Nature 2000, 406(6797): 747-52.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 11
    • 37049183697 scopus 로고
    • Human breast concer Correlation of relapse and survival with amplification of the Her2/neu oncogene
    • Slamon, D.J., Clark, G.M., Wong, S.G. et al. Human breast concer Correlation of relapse and survival with amplification of the Her2/neu oncogene. Science 1987, 235(4785): 177-82.
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 12
    • 0033868761 scopus 로고    scopus 로고
    • Assessment of Her2/neu overexpression in primary breast cancers and their metastatic lesions: An immunohistochemical study
    • Masood, S. and Bui, M.M. Assessment of Her2/neu overexpression in primary breast cancers and their metastatic lesions: An immunohistochemical study. Ann Clin Lab Sci 2000, 30(3): 259-65.
    • (2000) Ann Clin Lab Sci , vol.30 , Issue.3 , pp. 259-265
    • Masood, S.1    Bui, M.M.2
  • 13
    • 0035715619 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu in serum and tissue of primary and metastatic breast cancer patients using an automated enzyme immunoassay
    • Dittadi, R., Zancan, M., Perasole, A. et al. Evaluation of HER-2/neu in serum and tissue of primary and metastatic breast cancer patients using an automated enzyme immunoassay. Int J Biol Markers 2001, 16(3): 255-261.
    • (2001) Int J Biol Markers , vol.16 , Issue.3 , pp. 255-261
    • Dittadi, R.1    Zancan, M.2    Perasole, A.3
  • 14
    • 0035421454 scopus 로고    scopus 로고
    • Patterns of her-2/neu amplification and overexpression in primary and metastatic breast cancer
    • Simon, R., Nocito, A., Hubscher, T. et al. Patterns of her-2/neu amplification and overexpression in primary and metastatic breast cancer. J Natl Cancer Inst 2001, 93(15): 1141-6.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.15 , pp. 1141-1146
    • Simon, R.1    Nocito, A.2    Hubscher, T.3
  • 15
    • 0037089578 scopus 로고    scopus 로고
    • HER2 status in patients with breast carcinoma is not modified selectively by preoperative chemotherapy and is stable during the metastatic process
    • Vincent-Salomon, A., Jouve, M., Genin, P. et al. HER2 status in patients with breast carcinoma is not modified selectively by preoperative chemotherapy and is stable during the metastatic process. Cancer 2002, 94(8): 2169-73.
    • (2002) Cancer , vol.94 , Issue.8 , pp. 2169-2173
    • Vincent-Salomon, A.1    Jouve, M.2    Genin, P.3
  • 16
    • 0036180273 scopus 로고    scopus 로고
    • Amplification of Her-2/neu gene in Her-2/neu-overexpressing and -nonexpressing breast carcinomas and their synchronous benign, premalignant, and metastatic lesions detected by FISH in archival material
    • Xu, R., Perle, M.A., Inghirami, G., Chan, W., Delgado, Y. and Feiner, H. Amplification of Her-2/neu gene in Her-2/neu-overexpressing and -nonexpressing breast carcinomas and their synchronous benign, premalignant, and metastatic lesions detected by FISH in archival material. Mod Pathol 2002, 15(2): 116-24.
    • (2002) Mod Pathol , vol.15 , Issue.2 , pp. 116-124
    • Xu, R.1    Perle, M.A.2    Inghirami, G.3    Chan, W.4    Delgado, Y.5    Feiner, H.6
  • 17
    • 0028857450 scopus 로고
    • Breast cancer heterogeneity. evaluation of clonality in primary and metastatic lesions
    • Symmans, W.F., Liu, J., Knowles, D.M. and Inghirami, G. Breast cancer heterogeneity. evaluation of clonality in primary and metastatic lesions. Hum Pathol 1995, 26(2): 210-6.
    • (1995) Hum Pathol , vol.26 , Issue.2 , pp. 210-216
    • Symmans, W.F.1    Liu, J.2    Knowles, D.M.3    Inghirami, G.4
  • 18
    • 0141891477 scopus 로고    scopus 로고
    • HER-2/neu amplification by fluorescence in situ hybridization in cytologic samples from distant metastatic sites of breast carcinoma
    • Bozzetti, C., Personeni, N., Nizzoti, R. et al. HER-2/neu amplification by fluorescence in situ hybridization in cytologic samples from distant metastatic sites of breast carcinoma. Cancer 2003, 99(5): 310-5.
    • (2003) Cancer , vol.99 , Issue.5 , pp. 310-315
    • Bozzetti, C.1    Personeni, N.2    Nizzoti, R.3
  • 19
    • 34548554590 scopus 로고    scopus 로고
    • HER2 gene status in primary breast cancers and matched distant metostases
    • Tapia, C., Savic, S., Wagner, U. et al. HER2 gene status in primary breast cancers and matched distant metostases. Breast Cancer Res 2007, 9(3): R31.
    • (2007) Breast Cancer Res , vol.9 , Issue.3
    • Tapia, C.1    Savic, S.2    Wagner, U.3
  • 20
    • 58149237085 scopus 로고    scopus 로고
    • HER-2/neu expression in primary and metastatic breast cancer
    • Lower, E.E., Glass, E., Blau, R. and Harman, S. HER-2/neu expression in primary and metastatic breast cancer. Breast Cancer Res Treat 2009, 113(2): 301-6.
    • (2009) Breast Cancer Res Treat , vol.113 , Issue.2 , pp. 301-306
    • Lower, E.E.1    Glass, E.2    Blau, R.3    Harman, S.4
  • 21
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
    • Eccles, S.A. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol Neoplasia 2001, 6(4): 393-406.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , Issue.4 , pp. 393-406
    • Eccles, S.A.1
  • 22
    • 0034761909 scopus 로고    scopus 로고
    • The predictive value of HER2 in breast cancer
    • Piccart, M., Lohrisch, C., Di Leo, A. et al. The predictive value of HER2 in breast cancer. Oncology 2001 61(Suppl. 2): 73-82.
    • (2001) Oncology , vol.61 , Issue.SUPPL. 2 , pp. 73-82
    • Piccart, M.1    Lohrisch, C.2    Di Leo, A.3
  • 23
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • Yarden, Y. Biology of HER2 and its importance in breast cancer. Oncology 2001, 61(Suppl. 2): 1-13.
    • (2001) Oncology , vol.61 , Issue.SUPPL. 2 , pp. 1-13
    • Yarden, Y.1
  • 24
    • 0035189256 scopus 로고    scopus 로고
    • Current status of HER2 testing: Caught between a rock and a hard place
    • Schnitt, S.J. and Jacobs, T.W. Current status of HER2 testing: caught between a rock and a hard place. Am J Clin Pathol 2001, 116(6): 806-10.
    • (2001) Am J Clin Pathol , vol.116 , Issue.6 , pp. 806-810
    • Schnitt, S.J.1    Jacobs, T.W.2
  • 25
    • 0036274024 scopus 로고    scopus 로고
    • c-erbB-2 in breast cancer: Development of a clinically useful marker
    • Hayes, D.F. and Thor, A.D. c-erbB-2 in breast cancer: development of a clinically useful marker. Semin Oncol 2002, 29(3): 231-45.
    • (2002) Semin Oncol , vol.29 , Issue.3 , pp. 231-245
    • Hayes, D.F.1    Thor, A.D.2
  • 26
    • 0037108416 scopus 로고    scopus 로고
    • Prognostic and predictive value of HER2/neu oncogene in breast cancer
    • Masood, S. and Bui, M.M. Prognostic and predictive value of HER2/neu oncogene in breast cancer. Microsc Res Tech 2002, 59(2): 102-8.
    • (2002) Microsc Res Tech , vol.59 , Issue.2 , pp. 102-108
    • Masood, S.1    Bui, M.M.2
  • 27
    • 58749099837 scopus 로고    scopus 로고
    • Systematic review of HER2 breast cancer testing
    • Cuadros, M. and Villegas, R. Systematic review of HER2 breast cancer testing. Appl Immunohistochem Mol Morphol 2009, 17(1): 1-7.
    • (2009) Appl Immunohistochem Mol Morphol , vol.17 , Issue.1 , pp. 1-7
    • Cuadros, M.1    Villegas, R.2
  • 28
    • 0028232729 scopus 로고
    • Sensitivity of HER-2/neu antibodies in archival tissue samples: Potential source of error in immunohistochemicol studies of oncogene expression
    • Press, M.F., Hung, G., Godolphin, W. et al. Sensitivity of HER-2/neu antibodies in archival tissue samples: Potential source of error in immunohistochemicol studies of oncogene expression. Cancer Res 1994, 54(10): 2771-7.
    • (1994) Cancer Res , vol.54 , Issue.10 , pp. 2771-2777
    • Press, M.F.1    Hung, G.2    Godolphin, W.3
  • 29
    • 0037023986 scopus 로고    scopus 로고
    • Real-world performance of HER2 testing-national Surgical Adjuvant Breast and Bowel Project experience
    • Paik, S., Bryant, J., Tan-Chiu, E. et al. Real-world performance of HER2 testing-national Surgical Adjuvant Breast and Bowel Project experience. J Natl Cancer Inst 2002, 94(11): 852-4.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.11 , pp. 852-854
    • Paik, S.1    Bryant, J.2    Tan-Chiu, E.3
  • 30
    • 0012809562 scopus 로고    scopus 로고
    • Successful quality assurance program for HER-2 testing in the NSAPB trial for Herceptin
    • Paik, S., Tan-chui, E., Bryan, J. et al. Successful quality assurance program for HER-2 testing in the NSAPB trial for Herceptin. Breast Cancer Res Treat 2002, 76(Suppl. 1): S31.
    • (2002) Breast Cancer Res Treat , vol.76 , Issue.SUPPL. 1
    • Paik, S.1    Tan-chui, E.2    Bryan, J.3
  • 31
    • 34250811980 scopus 로고    scopus 로고
    • HER2 testing in the UK: Consensus from a national consultation
    • and National HER2 Consultation Steering Group
    • Dowsett, M., Hanby, A.M., Laing, R., Walker, R. and National HER2 Consultation Steering Group. HER2 testing in the UK: consensus from a national consultation. J Clin Pathol 2007, 60(6): 685-9.
    • (2007) J Clin Pathol , vol.60 , Issue.6 , pp. 685-689
    • Dowsett, M.1    Hanby, A.M.2    Laing, R.3    Walker, R.4
  • 32
    • 0036717202 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formolin-fixed and paraffin-processed cell lines and breast tumors: A comparative study involving results from laboratories in 27 countries
    • Rhodes, A., Jasani, B., Anderson, E. et al. Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formolin-fixed and paraffin-processed cell lines and breast tumors: a comparative study involving results from laboratories in 27 countries. Am J Clin Pathol 2002, 118(3): 408-17.
    • (2002) Am J Clin Pathol , vol.118 , Issue.3 , pp. 408-417
    • Rhodes, A.1    Jasani, B.2    Anderson, E.3
  • 33
    • 0035542711 scopus 로고    scopus 로고
    • Assessment of HER-2/ neu status in breast cancer. Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in situ hybridization assay as the standard
    • Wang, S., Saboorian, M.H., Frenkel, E.P. et al. Assessment of HER-2/ neu status in breast cancer. Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in situ hybridization assay as the standard. Am J Clin Pathol 2001, 116(4): 495-503.
    • (2001) Am J Clin Pathol , vol.116 , Issue.4 , pp. 495-503
    • Wang, S.1    Saboorian, M.H.2    Frenkel, E.P.3
  • 34
    • 0002884780 scopus 로고    scopus 로고
    • Comparison of HER-2/neu analysis using FISH and IHC when HercepTest is scored using conventional microscopy and image analysis
    • Bloom, K.J., Torre-Bueno, J., Press, M., Gown, A., Bauer, K. and Harrington, D. Comparison of HER-2/neu analysis using FISH and IHC when HercepTest is scored using conventional microscopy and image analysis. Breast Cancer Res Treat 2000, 64: 99.
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 99
    • Bloom, K.J.1    Torre-Bueno, J.2    Press, M.3    Gown, A.4    Bauer, K.5    Harrington, D.6
  • 35
    • 38949121249 scopus 로고    scopus 로고
    • National HER2 proficiency test results using standardized quantitative controls: Characterization of laboratory failures
    • Vani, K., Sompuram, S.R., Fitzgibbons, P. and Bogen, S.A. National HER2 proficiency test results using standardized quantitative controls: characterization of laboratory failures. Arch Pathol Lab Med 2008, 132(2): 211-6.
    • (2008) Arch Pathol Lab Med , vol.132 , Issue.2 , pp. 211-216
    • Vani, K.1    Sompuram, S.R.2    Fitzgibbons, P.3    Bogen, S.A.4
  • 36
    • 40449087743 scopus 로고    scopus 로고
    • HER2+ breast cancer: Review of biologic relevance and optimal use of diagnostic tools
    • Hicks, D.G. and Kulkarni, S. HER2+ breast cancer: review of biologic relevance and optimal use of diagnostic tools. Am J Clin Pathol 2008, 129(2): 263-73.
    • (2008) Am J Clin Pathol , vol.129 , Issue.2 , pp. 263-273
    • Hicks, D.G.1    Kulkarni, S.2
  • 37
    • 0034018946 scopus 로고    scopus 로고
    • Laboratory assessment of the status of Her2/neu protein and oncogene in breast cancer specimens: Comparison of immunohistochemistry assay with fluorescence in situ hybridization assays
    • Wang, S., Saboorian, M.H., Frenkel, E. et al. Laboratory assessment of the status of Her2/neu protein and oncogene in breast cancer specimens: comparison of immunohistochemistry assay with fluorescence in situ hybridization assays. J Clin Pathol 2000, 53(5): 374-81.
    • (2000) J Clin Pathol , vol.53 , Issue.5 , pp. 374-381
    • Wang, S.1    Saboorian, M.H.2    Frenkel, E.3
  • 38
    • 85046520451 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization versus immunohistochemistry: Importance of clinical outcome
    • Seelig, S. Fluorescence in situ hybridization versus immunohistochemistry: importance of clinical outcome. J Clin Oncot 1999, 17(11): 3690-2.
    • (1999) J Clin Oncot , vol.17 , Issue.11 , pp. 3690-3692
    • Seelig, S.1
  • 39
    • 2042467574 scopus 로고    scopus 로고
    • HER-2 testing in breast cancer using immunohistochemical analysis and fluorescence in situ hybridization: A single-institution experience of 2,279 cases and comparison of dual-color and single-color scoring
    • Lal, P., Salazar, P.A., Hudis, C.A. et al. HER-2 testing in breast cancer using immunohistochemical analysis and fluorescence in situ hybridization: a single-institution experience of 2,279 cases and comparison of dual-color and single-color scoring. Am J Clin Pathol 2004, 121(5): 631-6.
    • (2004) Am J Clin Pathol , vol.121 , Issue.5 , pp. 631-636
    • Lal, P.1    Salazar, P.A.2    Hudis, C.A.3
  • 40
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens, M.A., Horten, B.C., Da Silva, M.M. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 2004, 5(1): 63-9.
    • (2004) Clin Breast Cancer , vol.5 , Issue.1 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    Da Silva, M.M.3
  • 41
    • 25144523389 scopus 로고    scopus 로고
    • Diagnostic evaluation of HER-2 as a molecular target: On assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials
    • Press, M.F., Sauter, G., Bernstein, L. et al. Diagnostic evaluation of HER-2 as a molecular target: on assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials. Clin Cancer Res 2005, 11(18): 6598-6607.
    • (2005) Clin Cancer Res , vol.11 , Issue.18 , pp. 6598-6607
    • Press, M.F.1    Sauter, G.2    Bernstein, L.3
  • 42
    • 36649015630 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization (FISH) as primary methodology for the assessment of HER2 Status in adenocarcinoma of the breast: A single institution experience
    • Tubbs, R.R., Hicks, D.G., Cook, J. et al. Fluorescence in situ hybridization (FISH) as primary methodology for the assessment of HER2 Status in adenocarcinoma of the breast: a single institution experience. Diagn Mol Pathol 2007, 16(4): 207-10.
    • (2007) Diagn Mol Pathol , vol.16 , Issue.4 , pp. 207-210
    • Tubbs, R.R.1    Hicks, D.G.2    Cook, J.3
  • 43
    • 34249822213 scopus 로고    scopus 로고
    • Standardizing slide-based assays in breast cancer. hormone receptors, HER2, and sentinel lymph nodes
    • Ross, J.S., Symmans, W.F., Pusztai, L. and Hortobagyi, G.N. Standardizing slide-based assays in breast cancer. hormone receptors, HER2, and sentinel lymph nodes. Clin Cancer Res 2007, 13(10): 2831-5.
    • (2007) Clin Cancer Res , vol.13 , Issue.10 , pp. 2831-2835
    • Ross, J.S.1    Symmans, W.F.2    Pusztai, L.3    Hortobagyi, G.N.4
  • 44
    • 34447302567 scopus 로고    scopus 로고
    • External quality assurance of HER2 fluorescence in situ hybridisation testing: Results of a UK NEQAS pilot scheme
    • Bartlett, J.M., Ibrahim, M., Jasani, B. et al. External quality assurance of HER2 fluorescence in situ hybridisation testing: results of a UK NEQAS pilot scheme. J Clin Pathol 2007, 60(7): 816-9.
    • (2007) J Clin Pathol , vol.60 , Issue.7 , pp. 816-819
    • Bartlett, J.M.1    Ibrahim, M.2    Jasani, B.3
  • 45
    • 34248579208 scopus 로고    scopus 로고
    • Testing for HER2-positive breast cancer: A systematic review and cost-effectiveness analysis
    • Dendukuri, N., Khetani, K., McIsaac, M. and Brophy, J. Testing for HER2-positive breast cancer: A systematic review and cost-effectiveness analysis. CMAJ 2007, 176(10): 1429-34.
    • (2007) CMAJ , vol.176 , Issue.10 , pp. 1429-1434
    • Dendukuri, N.1    Khetani, K.2    McIsaac, M.3    Brophy, J.4
  • 46
    • 33747622311 scopus 로고    scopus 로고
    • HER2 testing in breast cancer. NCCN Task Force report and recommendations
    • Carlson, R.W., Moench, S.J., Hammond, M.E. et al. HER2 testing in breast cancer. NCCN Task Force report and recommendations. J Natl Compr Canc Netw 2006, 4(Suppl. 3): S1-22.
    • (2006) J Natl Compr Canc Netw , vol.4 , Issue.SUPPL. 3
    • Carlson, R.W.1    Moench, S.J.2    Hammond, M.E.3
  • 47
    • 58749099837 scopus 로고    scopus 로고
    • Systematic review of HER2 breast cancer testing
    • Cuadros, M. and Villegas, R. Systematic review of HER2 breast cancer testing. Appl Immunohistochem Mol Morphol. 2009, 17(1): 1-7.
    • (2009) Appl Immunohistochem Mol Morphol , vol.17 , Issue.1 , pp. 1-7
    • Cuadros, M.1    Villegas, R.2
  • 48
    • 46349097513 scopus 로고    scopus 로고
    • HER2-positive breast cancer. current treatment strategies
    • Perez, E.A. and Baweja, M. HER2-positive breast cancer. current treatment strategies. Cancer Invest 2008, 26(6): 545-52.
    • (2008) Cancer Invest , vol.26 , Issue.6 , pp. 545-552
    • Perez, E.A.1    Baweja, M.2
  • 49
    • 45549093907 scopus 로고    scopus 로고
    • Trastuzumab as adjuvant therapy for early breast cancer: The importance of accurate human epidermal growth factor receptor 2 testing
    • Hicks, D.G. and Kulkarni, S. Trastuzumab as adjuvant therapy for early breast cancer: the importance of accurate human epidermal growth factor receptor 2 testing. Arch Pathol Lab Med 2008, 132(6): 1008-15.
    • (2008) Arch Pathol Lab Med , vol.132 , Issue.6 , pp. 1008-1015
    • Hicks, D.G.1    Kulkarni, S.2
  • 50
    • 65649150003 scopus 로고    scopus 로고
    • Cost-effectiveness of HER2 testing and trastuzumab therapy for metastatic breast cancer
    • Lidgren, M., Wilking, N., Jonsson, B. et al. Cost-effectiveness of HER2 testing and trastuzumab therapy for metastatic breast cancer. Acta Oncol 2008, 1: 1-11.
    • (2008) Acta Oncol , vol.1 , pp. 1-11
    • Lidgren, M.1    Wilking, N.2    Jonsson, B.3
  • 51
    • 0033694650 scopus 로고    scopus 로고
    • Chromogenic in situ hybridization: A practical alternative for fluorescence in situ hybridization to detect HER-2/neu oncogene amplification in archival breast cancer samples
    • Tanner, M., Gancberg, D., Di Leo, A. et al. Chromogenic in situ hybridization: a practical alternative for fluorescence in situ hybridization to detect HER-2/neu oncogene amplification in archival breast cancer samples. Am J Pathol 2000, 157(5): 1467-72.
    • (2000) Am J Pathol , vol.157 , Issue.5 , pp. 1467-1472
    • Tanner, M.1    Gancberg, D.2    Di Leo, A.3
  • 52
    • 0036082527 scopus 로고    scopus 로고
    • Determination of HER2 gene amplification by chromogenic in situ hybridization (CISH) in archival breast carcinoma
    • Zhao, J., Wu, R., Au, A. et al. Determination of HER2 gene amplification by chromogenic in situ hybridization (CISH) in archival breast carcinoma. Mod Pathol. 2002, 15(6): 657-65.
    • (2002) Mod Pathol , vol.15 , Issue.6 , pp. 657-665
    • Zhao, J.1    Wu, R.2    Au, A.3
  • 53
    • 35748985896 scopus 로고    scopus 로고
    • Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of American Pathologists
    • Dietel, M., Ellis, I.O., Höfler, H. et al. Comparison of automated silver enhanced in situ hybridisation (SISH) and fluorescence ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology and the College of American Pathologists. Virchows Arch 2007, 451(1): 19-25.
    • (2007) Virchows Arch , vol.451 , Issue.1 , pp. 19-25
    • Dietel, M.1    Ellis, I.O.2    Höfler, H.3
  • 54
    • 0036677314 scopus 로고    scopus 로고
    • Chromogenic in situ hybridization: A novel approach to a practical and sensitive method for the detection of HER2 oncogene in archival human breast carcinoma
    • Dandachi, N., Dietze, O. and Hauser-Kronberger, C. Chromogenic in situ hybridization: A novel approach to a practical and sensitive method for the detection of HER2 oncogene in archival human breast carcinoma. Lab Invest 2002, 82(8): 1007-14.
    • (2002) Lab Invest , vol.82 , Issue.8 , pp. 1007-1014
    • Dandachi, N.1    Dietze, O.2    Hauser-Kronberger, C.3
  • 55
    • 16644388989 scopus 로고    scopus 로고
    • Comparison of chromogenic in situ hybridization with other methodologies for HER2 status assessment in breast cancer
    • Hauser-Kronberger, C. and Dandachi, N. Comparison of chromogenic in situ hybridization with other methodologies for HER2 status assessment in breast cancer. J Mol Histol 2004, 35(6): 647-53.
    • (2004) J Mol Histol , vol.35 , Issue.6 , pp. 647-653
    • Hauser-Kronberger, C.1    Dandachi, N.2
  • 56
    • 16544373965 scopus 로고    scopus 로고
    • Her2 amplification: Correlation of chromogenic in situ hybridization with immunohistochemistry and fluorescence in situ hybridization
    • Wixom, C.R., Albers, E.A. and Weidner, N. Her2 amplification: Correlation of chromogenic in situ hybridization with immunohistochemistry and fluorescence in situ hybridization. Appl. Immunohistochem Mol Morphol 2004, 12(3): 248-51.
    • (2004) Appl. Immunohistochem Mol Morphol , vol.12 , Issue.3 , pp. 248-251
    • Wixom, C.R.1    Albers, E.A.2    Weidner, N.3
  • 57
    • 28044458147 scopus 로고    scopus 로고
    • Role of chromogenic in situ hybridization (CISH) in the evaluation of HER2 status in breast carcinoma: Comparison with immunohistochemistry and FISH
    • Li-Ning-T, E., Ronchetti, R., Torres-Cabata, C. et al. Role of chromogenic in situ hybridization (CISH) in the evaluation of HER2 status in breast carcinoma: comparison with immunohistochemistry and FISH. Int J Surg Pathol 2005, 13(4): 343-51.
    • (2005) Int J Surg Pathol , vol.13 , Issue.4 , pp. 343-351
    • Li-Ning-T, E.1    Ronchetti, R.2    Torres-Cabata, C.3
  • 58
    • 33645539711 scopus 로고    scopus 로고
    • Chromogenic in situ hybridisation testing for HER2 gene amplification in breast cancer produces highly reproducible results concordant with fluorescence in situ hybridisation and immunohistochemistry
    • Bilous, M., Morey, A., Armes, J. et al. Chromogenic in situ hybridisation testing for HER2 gene amplification in breast cancer produces highly reproducible results concordant with fluorescence in situ hybridisation and immunohistochemistry. Pathology 2006, 38(2): 120-4.
    • (2006) Pathology , vol.38 , Issue.2 , pp. 120-124
    • Bilous, M.1    Morey, A.2    Armes, J.3
  • 59
    • 33645298450 scopus 로고    scopus 로고
    • Chromogenic in situ hybridization: A viable alternative to fluorescence in-situ hybridization in the HER2 testing algorithm
    • Hanna, W.M. and Kwok, K. Chromogenic in situ hybridization: a viable alternative to fluorescence in-situ hybridization in the HER2 testing algorithm. Mod Pathol 2006, 19(4): 481-7.
    • (2006) Mod Pathol , vol.19 , Issue.4 , pp. 481-487
    • Hanna, W.M.1    Kwok, K.2
  • 60
    • 40449131620 scopus 로고    scopus 로고
    • Chromogenic in situ hybridisation for the assessment of HER2 status in breast cancer: An international validation ring study
    • van de Vijver, M., Bilous, M., Hanna, W. et al. Chromogenic in situ hybridisation for the assessment of HER2 status in breast cancer: an international validation ring study. Breast Cancer Res 2007, 9(5): R68.
    • (2007) Breast Cancer Res , vol.9 , Issue.5
    • van de Vijver, M.1    Bilous, M.2    Hanna, W.3
  • 61
    • 34447295638 scopus 로고    scopus 로고
    • Chromogenic and fluorescent in situ hybridization in breast cancer
    • Lambros, M.B., Natrajan, R. and Reis-Filho, J.S. Chromogenic and fluorescent in situ hybridization in breast cancer. Hum Pathol 2007, 38(8): 1105-22.
    • (2007) Hum Pathol , vol.38 , Issue.8 , pp. 1105-1122
    • Lambros, M.B.1    Natrajan, R.2    Reis-Filho, J.S.3
  • 62
    • 34447308664 scopus 로고    scopus 로고
    • Chromogenic in situ hybridisation (CISH) should be an accepted method in the routine diagnostic evaluation of HER2 status in breast cancer
    • Di Palma, S., Collins, N., Faulkes, C. et al. Chromogenic in situ hybridisation (CISH) should be an accepted method in the routine diagnostic evaluation of HER2 status in breast cancer. J Clin Pathol 2007, 60(9): 1067-8.
    • (2007) J Clin Pathol , vol.60 , Issue.9 , pp. 1067-1068
    • Di Palma, S.1    Collins, N.2    Faulkes, C.3
  • 63
    • 36649030622 scopus 로고    scopus 로고
    • Expression and amplification of Her2, EGFR and cyclin D1 in breast cancer: Immunohistochemistry and chromogenic in situ hybridization
    • Cho, E.Y., Choi, Y.L., Han, J.J. et al. Expression and amplification of Her2, EGFR and cyclin D1 in breast cancer: immunohistochemistry and chromogenic in situ hybridization. Pathol Int 2008, 58(1): 17-25.
    • (2008) Pathol Int , vol.58 , Issue.1 , pp. 17-25
    • Cho, E.Y.1    Choi, Y.L.2    Han, J.J.3
  • 64
    • 46149089425 scopus 로고    scopus 로고
    • Comparison of chromogenic in situ hybridisation with fluorescence in situ hybridisation and immunohistochemistry for the assessment of her-2/neu oncogene in archival material of breast carcinoma
    • Pothos, A., Plastira, K., Plastiras, A. et al. Comparison of chromogenic in situ hybridisation with fluorescence in situ hybridisation and immunohistochemistry for the assessment of her-2/neu oncogene in archival material of breast carcinoma. Acta Histochem Cytochem 2008, 41(3): 59-64.
    • (2008) Acta Histochem Cytochem , vol.41 , Issue.3 , pp. 59-64
    • Pothos, A.1    Plastira, K.2    Plastiras, A.3
  • 65
    • 24144496077 scopus 로고    scopus 로고
    • The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: A fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study
    • Downs-Kelty, E., Yoder, B.J., Stoler, M. et al. The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study. Am J Surg Pathol 2005, 29(9): 1221-7.
    • (2005) Am J Surg Pathol , vol.29 , Issue.9 , pp. 1221-1227
    • Downs-Kelty, E.1    Yoder, B.J.2    Stoler, M.3
  • 66
    • 36849081991 scopus 로고    scopus 로고
    • HER-2, TOP2A and chromosome 17 alterations in breast cancer
    • Beser, A.R., Tuzlali, S., Guzey, D. et al. HER-2, TOP2A and chromosome 17 alterations in breast cancer. Pathol Oncol Res 2007, 13(3): 180-5.
    • (2007) Pathol Oncol Res , vol.13 , Issue.3 , pp. 180-185
    • Beser, A.R.1    Tuzlali, S.2    Guzey, D.3
  • 67
    • 35448973389 scopus 로고    scopus 로고
    • HER2 status in early breast cancer. relevance of cell staining patterns, gene amplification and polysomy 17
    • Torrisi, R., Rotmensz, N., Bagnardi, V. et al. HER2 status in early breast cancer. relevance of cell staining patterns, gene amplification and polysomy 17. Eur J Cancer 2007, 43(16): 2339-44.
    • (2007) Eur J Cancer , vol.43 , Issue.16 , pp. 2339-2344
    • Torrisi, R.1    Rotmensz, N.2    Bagnardi, V.3
  • 68
    • 40449125433 scopus 로고    scopus 로고
    • The effect of chromosome 17 polysomy on HER-2/neu status in breast cancer
    • Hyun, C.L., Lee, H.E., Kim, K.S. et al. The effect of chromosome 17 polysomy on HER-2/neu status in breast cancer. J Clin Pathol 2008, 61(3): 317-21.
    • (2008) J Clin Pathol , vol.61 , Issue.3 , pp. 317-321
    • Hyun, C.L.1    Lee, H.E.2    Kim, K.S.3
  • 69
    • 38449109687 scopus 로고    scopus 로고
    • Central HER2 IHC and FISH analysis in a trastuzumab (Herceptin) phase II monotherapy study: Assessment of test sensitivity and impact of chromosome 17 polysomy
    • Hofmann, M., Stoss, O., Gaiser, T. et al. Central HER2 IHC and FISH analysis in a trastuzumab (Herceptin) phase II monotherapy study: assessment of test sensitivity and impact of chromosome 17 polysomy. J Clin Pathol 2008, 61(1): 89-94.
    • (2008) J Clin Pathol , vol.61 , Issue.1 , pp. 89-94
    • Hofmann, M.1    Stoss, O.2    Gaiser, T.3
  • 70
    • 39549093225 scopus 로고    scopus 로고
    • CALGB 150002: Correlation of HER2 and chromosome 17 (ch17) copy number with trAstuzumab (T) efficacy in CALGB 9840, poclitaxel (P) with or without T in HER2+ and HER2- metastatic breast Cancer (MBC)
    • Kaufman, P.A., Broadwater, G. and Lezon-Geyda, K. CALGB 150002: Correlation of HER2 and chromosome 17 (ch17) copy number with trAstuzumab (T) efficacy in CALGB 9840, poclitaxel (P) with or without T in HER2+ and HER2- metastatic breast Cancer (MBC). J Clin Oncol 2007, 25:1009.
    • (2007) J Clin Oncol , vol.25 , pp. 1009
    • Kaufman, P.A.1    Broadwater, G.2    Lezon-Geyda, K.3
  • 71
    • 59149084546 scopus 로고    scopus 로고
    • Evaluation of chromosome 17 (Chr-17) polysomy in HER2 FISH-negative metastatic breast cancer (MBC) patients enrolled in a randomized phase III study of paclitaxel and lapatinib
    • Livingston, R.B., Downey, L., Di Leo, A. et al. Evaluation of chromosome 17 (Chr-17) polysomy in HER2 FISH-negative metastatic breast cancer (MBC) patients enrolled in a randomized phase III study of paclitaxel and lapatinib. J Clin Oncol 2008, 26: 1006.
    • (2008) J Clin Oncol , vol.26 , pp. 1006
    • Livingston, R.B.1    Downey, L.2    Di Leo, A.3
  • 72
    • 33846568336 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer
    • Wolff, A.C., Hammond, M.E., Schwartz, J.N. et al. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. Arch Pathol Lab Med 2007, 131(1): 18.
    • (2007) Arch Pathol Lab Med , vol.131 , Issue.1 , pp. 18
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 73
    • 0035873962 scopus 로고    scopus 로고
    • Discrepancies in clinical laboratory testing of eligibility for trAstuzumab therapy: Apparent immunohistochemical false-positives do not get the message
    • Tubbs, R.R., Pettay, J.D., Roche, P.C. et al. Discrepancies in clinical laboratory testing of eligibility for trAstuzumab therapy: apparent immunohistochemical false-positives do not get the message. J Clin Oncol 2001, 19(10): 2714-21.
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2714-2721
    • Tubbs, R.R.1    Pettay, J.D.2    Roche, P.C.3
  • 74
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negotive breast cancer
    • Paik, S., Shak, S., Tang, G. et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negotive breast cancer. N Engl J Med 2004, 351(27): 2817-26.
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 75
    • 45749157664 scopus 로고    scopus 로고
    • Commercialized multigene predictors of clinical outcome for breast cancer
    • Ross, J.S., Hatzis, C., Symmans, W.F. et al. Commercialized multigene predictors of clinical outcome for breast cancer. Oncologist 2008, 13(5): 477-93.
    • (2008) Oncologist , vol.13 , Issue.5 , pp. 477-493
    • Ross, J.S.1    Hatzis, C.2    Symmans, W.F.3
  • 76
    • 65649119214 scopus 로고    scopus 로고
    • Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2-HER2 dimerization in a clinic-based cohort of patients with metastatic breast cancer
    • Bates, M.R, Desmedt, C., Sperinde, J. et al. Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2-HER2 dimerization in a clinic-based cohort of patients with metastatic breast cancer. J Clin Oncol 2007, 25: 10557.
    • (2007) J Clin Oncol , vol.25 , pp. 10557
    • Bates, M.R.1    Desmedt, C.2    Sperinde, J.3
  • 77
    • 62649117739 scopus 로고    scopus 로고
    • Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2:HER2 dimerization in a clinic-based cohort of patients with metostatic breast cancer
    • Toi, M., Sperinde, J., Huang, W. et al. Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2:HER2 dimerization in a clinic-based cohort of patients with metostatic breast cancer. J Clin Oncol 2007, 25: 1025.
    • (2007) J Clin Oncol , vol.25 , pp. 1025
    • Toi, M.1    Sperinde, J.2    Huang, W.3
  • 78
    • 0028937151 scopus 로고
    • Activation state-specific monoclonal antibody detects tyrosine phospharylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor
    • DiGiovanna, M.P. and Stern, D.F. Activation state-specific monoclonal antibody detects tyrosine phospharylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor. Cancer Res 1995, 55(9):1946-55.
    • (1995) Cancer Res , vol.55 , Issue.9 , pp. 1946-1955
    • DiGiovanna, M.P.1    Stern, D.F.2
  • 79
    • 0034666345 scopus 로고    scopus 로고
    • Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): A study of incidence and correlation with outcome in breast cancer
    • Thor, A.D., Liu, S., Edgerton, S. et al. Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer. J Clin Oncol 2000, 18(18): 3230-9.
    • (2000) J Clin Oncol , vol.18 , Issue.18 , pp. 3230-3239
    • Thor, A.D.1    Liu, S.2    Edgerton, S.3
  • 80
    • 26844498595 scopus 로고    scopus 로고
    • Phosphorylated/activated HER2 as a marker of clinical resistance to single agent taxane chemotherapy for metastatic breast cancer
    • Modi, S., DiGiovanna, M.P., Lu, Z. et al. Phosphorylated/activated HER2 as a marker of clinical resistance to single agent taxane chemotherapy for metastatic breast cancer. Cancer Invest 2005, 23: 48.
    • (2005) Cancer Invest , vol.23 , pp. 48
    • Modi, S.1    DiGiovanna, M.P.2    Lu, Z.3
  • 81
    • 3543086886 scopus 로고    scopus 로고
    • Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer
    • Carney, W.P., Neumann, R., Lipton, A. et al. Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer. Clin Breast Cancer 2004, 5(2): 105-16.
    • (2004) Clin Breast Cancer , vol.5 , Issue.2 , pp. 105-116
    • Carney, W.P.1    Neumann, R.2    Lipton, A.3
  • 82
    • 14644401104 scopus 로고    scopus 로고
    • Serum HER2 extracellular domain in metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel: Association with HER2 status by immunohistochemistry and fluorescence in situ hybridization and with response rate
    • Fornier, M.N., Seidman, A.D., Schwartz, M.K. et al. Serum HER2 extracellular domain in metastatic breast cancer patients treated with weekly trastuzumab and paclitaxel: association with HER2 status by immunohistochemistry and fluorescence in situ hybridization and with response rate. Ann Oncol 2005, 16(2): 234-9.
    • (2005) Ann Oncol , vol.16 , Issue.2 , pp. 234-239
    • Fornier, M.N.1    Seidman, A.D.2    Schwartz, M.K.3
  • 83
    • 33746589461 scopus 로고    scopus 로고
    • Predicting tissue HER2 status using serum HER2 levels in patients with metastatic breast cancer
    • Kong, SY, Nam, B.H., Lee, K.S. et al. Predicting tissue HER2 status using serum HER2 levels in patients with metastatic breast cancer. Clin Chem 2006, 52(8): 1510-5.
    • (2006) Clin Chem , vol.52 , Issue.8 , pp. 1510-1515
    • Kong, S.Y.1    Nam, B.H.2    Lee, K.S.3
  • 84
    • 43049106865 scopus 로고    scopus 로고
    • Evaluation of serum HER2 extracellular domain in early breast cancer patients: Correlation with clinicopathological parameters and survival
    • Ludovini, V., Gori, S., Colozza, M. et al. Evaluation of serum HER2 extracellular domain in early breast cancer patients: correlation with clinicopathological parameters and survival. Ann Oncol 2008, 19(5): 883-90.
    • (2008) Ann Oncol , vol.19 , Issue.5 , pp. 883-890
    • Ludovini, V.1    Gori, S.2    Colozza, M.3
  • 85
    • 3242688126 scopus 로고    scopus 로고
    • Prognostic significance of serum HER2 and CA 15-3 at the time of diagnosis of metastatic breast cancer
    • Fehm, T., Jäger, W., Krämer, S. et al. Prognostic significance of serum HER2 and CA 15-3 at the time of diagnosis of metastatic breast cancer. Anticancer Res 2004, 24(3b): 1987-92.
    • (2004) Anticancer Res , vol.24 , Issue.3 B , pp. 1987-1992
    • Fehm, T.1    Jäger, W.2    Krämer, S.3
  • 86
    • 33644528230 scopus 로고    scopus 로고
    • Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies
    • Esteva, F.J., Cheli, C.D., Fritsche, H. et al. Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies. Breast Cancer Res 2005, 7(4): R436-43.
    • (2005) Breast Cancer Res , vol.7 , Issue.4
    • Esteva, F.J.1    Cheli, C.D.2    Fritsche, H.3
  • 87
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli, M., Budd, G.T., Ellis, M.J. et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004, 351(8): 781-91.
    • (2004) N Engl J Med , vol.351 , Issue.8 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 88
    • 51649120140 scopus 로고    scopus 로고
    • Review: Biological relevance of disseminated tumor cells in cancer patients
    • Riethdorf, S., Wikman, H. and Pantet, K. Review: Biological relevance of disseminated tumor cells in cancer patients. Int J Cancer 2008, 123(9): 1991-2006.
    • (2008) Int J Cancer , vol.123 , Issue.9 , pp. 1991-2006
    • Riethdorf, S.1    Wikman, H.2    Pantet, K.3
  • 89
    • 33645688204 scopus 로고    scopus 로고
    • HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients
    • Wülfing, P., Borchard, J., Buerger, H. et al. HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients. Clin Cancer Res 2006, 12(6): 1715-20.
    • (2006) Clin Cancer Res , vol.12 , Issue.6 , pp. 1715-1720
    • Wülfing, P.1    Borchard, J.2    Buerger, H.3
  • 90
    • 67349253810 scopus 로고    scopus 로고
    • Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: An option for monitoring response to breast cancer related therapies
    • Advance publication
    • Tewes, M., Aktas, B., Welt, A. et al. Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies. Breast Cancer Res Treat 2008, Advance publication.
    • (2008) Breast Cancer Res Treat
    • Tewes, M.1    Aktas, B.2    Welt, A.3
  • 91
    • 47549118633 scopus 로고    scopus 로고
    • Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer
    • Ignatiadis, M., Kallergi, G., Ntoulia, M. et al. Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer. Clin Cancer Res 2008, 14(9): 2593-600.
    • (2008) Clin Cancer Res , vol.14 , Issue.9 , pp. 2593-2600
    • Ignatiadis, M.1    Kallergi, G.2    Ntoulia, M.3
  • 92
    • 58549116921 scopus 로고    scopus 로고
    • HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer
    • Lang, J.E., Mosalpuria, K., Cristofanilli, M. et al. HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer. Breast Cancer Res Treat 2009, 113(3): 501-7.
    • (2009) Breast Cancer Res Treat , vol.113 , Issue.3 , pp. 501-507
    • Lang, J.E.1    Mosalpuria, K.2    Cristofanilli, M.3
  • 93
    • 20444477166 scopus 로고    scopus 로고
    • Global gene expression profiling of circulating tumor cells
    • Smimov, D.A., Zweitzig, D.R., Foulk, B.W. et al. Global gene expression profiling of circulating tumor cells. Cancer Res 2005, 65(12): 4993-7.
    • (2005) Cancer Res , vol.65 , Issue.12 , pp. 4993-4997
    • Smimov, D.A.1    Zweitzig, D.R.2    Foulk, B.W.3
  • 94
    • 33745455993 scopus 로고    scopus 로고
    • Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: Correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection
    • Pinzani, P., Salvadori, B., Simi, L. et al. Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection. Hum Pathol 2006, 37(6): 711-8.
    • (2006) Hum Pathol , vol.37 , Issue.6 , pp. 711-718
    • Pinzani, P.1    Salvadori, B.2    Simi, L.3
  • 95
    • 41649102601 scopus 로고    scopus 로고
    • Molecular signature detection of circulating tumor cells using a panel of selected genes
    • Gervasoni, A., Monasterio Muñoz, R.M., Wengler, G.S. et al. Molecular signature detection of circulating tumor cells using a panel of selected genes. Cancer Lett 2008, 263(2): 267-79.
    • (2008) Cancer Lett , vol.263 , Issue.2 , pp. 267-279
    • Gervasoni, A.1    Monasterio Muñoz, R.M.2    Wengler, G.S.3
  • 96
    • 0035727902 scopus 로고    scopus 로고
    • Engineered antibodies take center stage
    • Huston, J.S. and George, A.J. Engineered antibodies take center stage. Hum Antibodies 2001, 10(3-4): 127-42.
    • (2001) Hum Antibodies , vol.10 , Issue.3-4 , pp. 127-142
    • Huston, J.S.1    George, A.J.2
  • 97
    • 0035680514 scopus 로고    scopus 로고
    • Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer
    • Hortobagyi, G.N. Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer. Semin Oncol. 2001, 28(6, Suppl. 18): 43-7.
    • (2001) Semin Oncol , vol.28 , Issue.6 and SUPPL. 18 , pp. 43-47
    • Hortobagyi, G.N.1
  • 98
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for Metastatic breast cancer that overexpresses HER2
    • Slamon, D.J., Leyland-Jones, B., Shak, S. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for Metastatic breast cancer that overexpresses HER2. N Engl J Med 2001, 344(11): 783-92.
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 99
    • 65649122148 scopus 로고    scopus 로고
    • HercepTest package Insert. Dako Corporation, Glostrup, Denmark
    • HercepTest package Insert. Dako Corporation, Glostrup, Denmark.
  • 100
    • 0032921406 scopus 로고    scopus 로고
    • Increased HER2 with U.S. Food and Drug Administration-approved antibody
    • Roche, P.C. and Ingle, J.N. Increased HER2 with U.S. Food and Drug Administration-approved antibody. J Clin Oncol 1999, 17(1): 434.
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 434
    • Roche, P.C.1    Ingle, J.N.2
  • 101
    • 25144453930 scopus 로고    scopus 로고
    • Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab
    • Dybdal, N., Leiberman, C., Anderson, S. et al. Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab. Breast Cancer Res Treat 2005, 93(1): 3-11.
    • (2005) Breast Cancer Res Treat , vol.93 , Issue.1 , pp. 3-11
    • Dybdal, N.1    Leiberman, C.2    Anderson, S.3
  • 102
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel, C.L., Cobteigh, M.A., Tripathy, D. et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002, 20(3): 719-26.
    • (2002) J Clin Oncol , vol.20 , Issue.3 , pp. 719-726
    • Vogel, C.L.1    Cobteigh, M.A.2    Tripathy, D.3
  • 103
    • 0035873815 scopus 로고    scopus 로고
    • Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification
    • Seidman, A.D., Fornier, M.N., Esteva, F.J. et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. J Clin Oncol 2001, 19(10): 2587-95.
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2587-2595
    • Seidman, A.D.1    Fornier, M.N.2    Esteva, F.J.3
  • 104
    • 0012890297 scopus 로고    scopus 로고
    • HER-2 testing and correlation with efficacy in Trastuzumab therapy
    • Fornier, M., Risio, M., Van Poznak, C. and Seidman, A. HER-2 testing and correlation with efficacy in Trastuzumab therapy. Oncology 2003, 16(10): 1340-58.
    • (2003) Oncology , vol.16 , Issue.10 , pp. 1340-1358
    • Fornier, M.1    Risio, M.2    Van Poznak, C.3    Seidman, A.4
  • 105
    • 0036170370 scopus 로고    scopus 로고
    • A testing algorithm for determination of HER2 status in patients with breast cancer
    • Nichols, D.W., Wolff, D.J., Self, S. et al. A testing algorithm for determination of HER2 status in patients with breast cancer. Ann Clin Lab Sci 2002, 32(1): 3-11.
    • (2002) Ann Clin Lab Sci , vol.32 , Issue.1 , pp. 3-11
    • Nichols, D.W.1    Wolff, D.J.2    Self, S.3
  • 106
    • 0036836117 scopus 로고    scopus 로고
    • Testing for HER-2/neu in breast cancer: Is fluorescence in situ hybridization superior in predicting outcome?
    • Yaziji, H. and Gown, A.M. Testing for HER-2/neu in breast cancer: is fluorescence in situ hybridization superior in predicting outcome? Adv Anat Pathol 2002, 9(6): 338-44.
    • (2002) Adv Anat Pathol , vol.9 , Issue.6 , pp. 338-344
    • Yaziji, H.1    Gown, A.M.2
  • 107
    • 0037099732 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu gene amplification and overexpression: Comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens
    • Press, M.F., Slamon, D.J. and Flom, K.J. Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens. J Clin Oncol 2002, 20(14): 3095-105.
    • (2002) J Clin Oncol , vol.20 , Issue.14 , pp. 3095-3105
    • Press, M.F.1    Slamon, D.J.2    Flom, K.J.3
  • 108
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond, E.H., Perez, E.A., Bryant, J. et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005, 353(16): 1673-84.
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 109
    • 41449105551 scopus 로고    scopus 로고
    • HER2 status and benefit from adjuvant trastuzumab in breast cancer
    • Paik, S., Kim, C. and Wolmark, N. HER2 status and benefit from adjuvant trastuzumab in breast cancer. N Engl J Med 2008, 358(13): 1409-11.
    • (2008) N Engl J Med , vol.358 , Issue.13 , pp. 1409-1411
    • Paik, S.1    Kim, C.2    Wolmark, N.3
  • 110
    • 34447568389 scopus 로고    scopus 로고
    • Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer
    • de Alava, E., Ocaña, A., Abad, M. et al. Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer. J Clin Oncol 2007, 25(19): 2656-63.
    • (2007) J Clin Oncol , vol.25 , Issue.19 , pp. 2656-2663
    • de Alava, E.1    Ocaña, A.2    Abad, M.3
  • 111
    • 35948951183 scopus 로고    scopus 로고
    • Pothologic complete response to trastuzumab-based neoadjuvant therapy is related to the level of HER-2 amplification
    • Arnould, L., Arveux, P., Couturier, J. et al. Pothologic complete response to trastuzumab-based neoadjuvant therapy is related to the level of HER-2 amplification. Clin Cancer Res 2007, 13(21): 6404-9.
    • (2007) Clin Cancer Res , vol.13 , Issue.21 , pp. 6404-6409
    • Arnould, L.1    Arveux, P.2    Couturier, J.3
  • 112
    • 65649118454 scopus 로고    scopus 로고
    • Han, H., Kim, J., Inn, S. et al. Magnitude of HER2 amplification as a predictive factor for HER2-overexpressing metastatic breast cancer treated with weekly paclitaxel plus trastuzumab as first-line chemotherapy. J Clin Oncol 2008, 26(May 20 Suppl): Abst 1053.
    • Han, H., Kim, J., Inn, S. et al. Magnitude of HER2 amplification as a predictive factor for HER2-overexpressing metastatic breast cancer treated with weekly paclitaxel plus trastuzumab as first-line chemotherapy. J Clin Oncol 2008, 26(May 20 Suppl): Abst 1053.
  • 113
    • 0035169666 scopus 로고    scopus 로고
    • Mechanism of action of trastuzumab and scientific update
    • Baselga, J., Albanell, J., Molina, M.A. et al. Mechanism of action of trastuzumab and scientific update. Semin Oncol 2001, 28(5, Suppl. 16): 4-11.
    • (2001) Semin Oncol , vol.28 , Issue.5 and SUPPL. 16 , pp. 4-11
    • Baselga, J.1    Albanell, J.2    Molina, M.A.3
  • 114
    • 0037434791 scopus 로고    scopus 로고
    • Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
    • Cho, H.S., Mason, K., Ramyar, K.X. et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003, 421(6924): 756-60.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 756-760
    • Cho, H.S.1    Mason, K.2    Ramyar, K.X.3
  • 115
    • 35748949531 scopus 로고    scopus 로고
    • Optimizing engagement of the immune system by anti-tumor antibodies: An engineer's perspective
    • Desjarlais, J.R., Lazar, G.A., Zhukovsky, E.A. et al. Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective. Drug Discov Today 2007, 12(21-22): 898-910.
    • (2007) Drug Discov Today , vol.12 , Issue.21-22 , pp. 898-910
    • Desjarlais, J.R.1    Lazar, G.A.2    Zhukovsky, E.A.3
  • 116
    • 35548961447 scopus 로고    scopus 로고
    • A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects
    • Strome, S.E., Sausville, E.A. and Mann, D. A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist 2007, 12(9): 1084-95.
    • (2007) Oncologist , vol.12 , Issue.9 , pp. 1084-1095
    • Strome, S.E.1    Sausville, E.A.2    Mann, D.3
  • 118
    • 30744432128 scopus 로고    scopus 로고
    • Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies
    • Iannello, A. and Ahmad, A. Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies. Cancer Metastasis Rev 2005, 24(4): 487-99.
    • (2005) Cancer Metastasis Rev , vol.24 , Issue.4 , pp. 487-499
    • Iannello, A.1    Ahmad, A.2
  • 119
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
    • Musolino, A., Naldi, N., Bortesi, B. et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol 2008, 26: 178.
    • (2008) J Clin Oncol , vol.26 , pp. 178
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3
  • 120
    • 9244219598 scopus 로고    scopus 로고
    • Breast cancer-loss of PTEN predicts resistance to treatment
    • Pandolfi, P.P. Breast cancer-loss of PTEN predicts resistance to treatment. N Engl J Med 2004, 351(22): 2337-8.
    • (2004) N Engl J Med , vol.351 , Issue.22 , pp. 2337-2338
    • Pandolfi, P.P.1
  • 121
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata, Y., Lan, K.H., Zhou, X. et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004, 6(2): 117-27.
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 122
    • 5144220639 scopus 로고    scopus 로고
    • Successful targeting of ErbB2 receptors-is PTEN the key?
    • Crowder, R.J., Lombardi, D.P. and Ellis, M.J. Successful targeting of ErbB2 receptors-is PTEN the key? Cancer Cell 2004, 6(2): 103-4.
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 103-104
    • Crowder, R.J.1    Lombardi, D.P.2    Ellis, M.J.3
  • 123
    • 35148854641 scopus 로고    scopus 로고
    • PI3 kinase activation and response to Trastuzumab Therapy: What's neu with herceptin resistance?
    • Park, B.H. and Davidson, N.E. PI3 kinase activation and response to Trastuzumab Therapy: what's neu with herceptin resistance? Cancer Cell 2007, 12(4): 297-9.
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 297-299
    • Park, B.H.1    Davidson, N.E.2
  • 124
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as o major determinant of trastuzumab resistance in breast cancer
    • Berns, K., Horlings, H.M., Hennessy, B.T. et al. A functional genetic approach identifies the PI3K pathway as o major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12(4): 395-402.
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 125
    • 0027715434 scopus 로고
    • Detection of c-erbB-2 amplification in breast cancer by in situ hybridization
    • Smith, K.L., Robbins, RD., Dawkins, H.J.S. et al. Detection of c-erbB-2 amplification in breast cancer by in situ hybridization. Breast 1993, 2: 234-8.
    • (1993) Breast , vol.2 , pp. 234-238
    • Smith, K.L.1    Robbins, R.D.2    Dawkins, H.J.S.3
  • 126
    • 33745435244 scopus 로고    scopus 로고
    • Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggests pro-apoptotic function of dysregulated cMYC in vivo
    • Abst 46
    • Kim, C., Bryant, J., Horne, Z. et al. Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggests pro-apoptotic function of dysregulated cMYC in vivo. Breast Cancer Res Treat 2005, 94(56): Abst 46.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.56
    • Kim, C.1    Bryant, J.2    Horne, Z.3
  • 127
    • 58149225358 scopus 로고    scopus 로고
    • Biomarkers as potential predictors of pathologic complete response (pCR) in the NOAH trial of neoadjuvant trastuzumab in patients (pts) with HER2-positive locally advanced breast cancer (LABC)
    • Abst 504
    • Gianni, L., Eiermann, W., Pusztai, L. et al. Biomarkers as potential predictors of pathologic complete response (pCR) in the NOAH trial of neoadjuvant trastuzumab in patients (pts) with HER2-positive locally advanced breast cancer (LABC). J Clin Oncol 2008, 26(Suppl.): Abst 504.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Gianni, L.1    Eiermann, W.2    Pusztai, L.3
  • 128
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • Nahta, R., Yuan, L.X., Zhang, B. et al. Insulin-like growth factor-1 receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005, 65(23): 11118-28.
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.2    Zhang, B.3
  • 129
    • 65649122931 scopus 로고    scopus 로고
    • Relation between Insulin-like growth factor-1 receptor (ICF-1R) expression and the efficacy of trastuzumab (T) monotherapy for hormone-resistant HER2-postitive metastatic breast cancer (MBC)
    • Shimizu, C., Hasegawa, T., Ando, M. et al. Relation between Insulin-like growth factor-1 receptor (ICF-1R) expression and the efficacy of trastuzumab (T) monotherapy for hormone-resistant HER2-postitive metastatic breast cancer (MBC). J Clin Oncol 2004, 22: 9578.
    • (2004) J Clin Oncol , vol.22 , pp. 9578
    • Shimizu, C.1    Hasegawa, T.2    Ando, M.3
  • 130
    • 28244468422 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer
    • Köstler, W.J., Hudelist, G., Rabitsch, W. et al. Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer. J Cancer Res Clin Oncol 2006, 132(1): 9-18.
    • (2006) J Cancer Res Clin Oncol , vol.132 , Issue.1 , pp. 9-18
    • Köstler, W.J.1    Hudelist, G.2    Rabitsch, W.3
  • 131
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu, Y., Zi, X., Zhao, Y. et al. Insulin-like growth factor-1 receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001, 93(24): 1852-7.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.24 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3
  • 132
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta, R., Yu, D., Hung, M.C. et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006, 3(5): 269-80.
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3
  • 133
    • 0036187710 scopus 로고    scopus 로고
    • NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
    • Molina, M.A., Saez, R., Ramsey, E.E. et al. NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin Cancer Res 2002, 8(2): 347-53.
    • (2002) Clin Cancer Res , vol.8 , Issue.2 , pp. 347-353
    • Molina, M.A.1    Saez, R.2    Ramsey, E.E.3
  • 134
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p9SHER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti, M., Rojo, F., Ocaña, A. et al. Expression of p9SHER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 2007, 99(8): 628-38.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.8 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocaña, A.3
  • 135
    • 0141956319 scopus 로고    scopus 로고
    • Her-2/neu-triggered intracellular tyrosine kinase activation: In vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment
    • Hudelist, G., Kostler, W.J. and Attems, J. et al. Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment. Br J Cancer 2003, 89(6): 983-91.
    • (2003) Br J Cancer , vol.89 , Issue.6 , pp. 983-991
    • Hudelist, G.1    Kostler, W.J.2    Attems, J.3
  • 136
    • 30544434252 scopus 로고    scopus 로고
    • Topoisomerose II- gene amplification as a predictor of responsiveness to anthracycline-containing chemotherapy in the Cancer International Research Group 006 clinical trial of trastuzumab (Herceptin) in the adjuvant setting
    • Press, M.F., Bernstein, L., Sauter, G. et al. Topoisomerose II- gene amplification as a predictor of responsiveness to anthracycline-containing chemotherapy in the Cancer International Research Group 006 clinical trial of trastuzumab (Herceptin) in the adjuvant setting. Breast Cancer Res Treat 2005, 94: S54.
    • (2005) Breast Cancer Res Treat , vol.94
    • Press, M.F.1    Bernstein, L.2    Sauter, G.3
  • 137
    • 33947246109 scopus 로고    scopus 로고
    • Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
    • Harris, L.N., You, F., Schnitt, S.J. et al. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res 2007, 13(4): 1198-207.
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1198-1207
    • Harris, L.N.1    You, F.2    Schnitt, S.J.3
  • 138
    • 35448969823 scopus 로고    scopus 로고
    • Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
    • Palyi-Krekk, Z., Barok, M., Isola, J. et al. Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer. Eur J Cancer 2007, 43(16): 2423-33.
    • (2007) Eur J Cancer , vol.43 , Issue.16 , pp. 2423-2433
    • Palyi-Krekk, Z.1    Barok, M.2    Isola, J.3
  • 139
    • 0036316476 scopus 로고    scopus 로고
    • Combined biological therapy of breast cancer using manoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor
    • Pegram, M.D. and Reese, D.M. Combined biological therapy of breast cancer using manoclonal antibodies directed against HER2/neu protein and vascular endothelial growth factor. Semin Oncol 2002, 29(3 Suppl 11): 29-37.
    • (2002) Semin Oncol , vol.29 , Issue.3 SUPPL. 11 , pp. 29-37
    • Pegram, M.D.1    Reese, D.M.2
  • 140
    • 56449092072 scopus 로고    scopus 로고
    • MicroRNA-221/222 confers tomoxifen resistance in breast cancer by targeting p27(Kip1)
    • Miller, T.E., Ghoshal, K., Ramaswamy, B. et al. MicroRNA-221/222 confers tomoxifen resistance in breast cancer by targeting p27(Kip1). J Biol Chem 2008, 283(44): 29897-903.
    • (2008) J Biol Chem , vol.283 , Issue.44 , pp. 29897-29903
    • Miller, T.E.1    Ghoshal, K.2    Ramaswamy, B.3
  • 141
    • 51549083821 scopus 로고    scopus 로고
    • Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases
    • Medina, P.J. and Goodin, S. Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther 2008, 30(8): 1426-47.
    • (2008) Clin Ther , vol.30 , Issue.8 , pp. 1426-1447
    • Medina, P.J.1    Goodin, S.2
  • 142
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer, C.E., Forster, J., Lindquist, D. et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006, 355(26): 2733-43.
    • (2006) N Engl J Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 143
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomorker analyses
    • Cameron, D., Casey, M., Press, M. et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomorker analyses. Breast Cancer Res Treat 2008, 112(3): 533-43.
    • (2008) Breast Cancer Res Treat , vol.112 , Issue.3 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3
  • 144
    • 44849108294 scopus 로고    scopus 로고
    • A phase II study of lapatinib monotherapy in chemotherapy- refractory HER2-positive and HER2-negative advanced or metastatic breast cancer
    • Burstein, H.J., Stomiolo, A.M., Franco, S. et al. A phase II study of lapatinib monotherapy in chemotherapy- refractory HER2-positive and HER2-negative advanced or metastatic breast cancer. Ann Oncol 2008, 19(6): 1068-74.
    • (2008) Ann Oncol , vol.19 , Issue.6 , pp. 1068-1074
    • Burstein, H.J.1    Stomiolo, A.M.2    Franco, S.3
  • 145
    • 33746512271 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastasis in patients with HER2+ breast cancer
    • Lin, N.U., Carey, L.A., Liu, M.C. et al. Phase II trial of lapatinib for brain metastasis in patients with HER2+ breast cancer. J Clin Oncol 2006, 24: 503.
    • (2006) J Clin Oncol , vol.24 , pp. 503
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 146
    • 59149094750 scopus 로고    scopus 로고
    • Lapatinib and paclitaxel in HER2-negative, extracellular domain (ECD) positive metastatic breast cancer (MBC) in a randomized phase III study
    • Abstr 1017
    • Finn, R.S., Gagnon, R., Di Leo, A. et al. Lapatinib and paclitaxel in HER2-negative, extracellular domain (ECD) positive metastatic breast cancer (MBC) in a randomized phase III study. J Clin Oncol 2008, 26(Suppl): Abstr 1017.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Finn, R.S.1    Gagnon, R.2    Di Leo, A.3
  • 148
    • 59149098589 scopus 로고    scopus 로고
    • Correlation of HER2 gene amplification, HER2 and ECFR expression (protein and mRNA) with lapatinib efficacy in women with metastatic breast cancer
    • Press, M.F., Finn, R.S., Di Leo, A. et al. Correlation of HER2 gene amplification, HER2 and ECFR expression (protein and mRNA) with lapatinib efficacy in women with metastatic breast cancer. J Clin Oncol 2008, 26: 1007.
    • (2008) J Clin Oncol , vol.26 , pp. 1007
    • Press, M.F.1    Finn, R.S.2    Di Leo, A.3
  • 149
    • 51049091694 scopus 로고    scopus 로고
    • Activity of lapatinib is independent of ECFR expression level in HER2-overexpressing breast cancer cells
    • Zhang, D., Pal, A., Bornmann, W.G. et al. Activity of lapatinib is independent of ECFR expression level in HER2-overexpressing breast cancer cells. Mol Cancer Ther 2008, 7(7): 1846-50.
    • (2008) Mol Cancer Ther , vol.7 , Issue.7 , pp. 1846-1850
    • Zhang, D.1    Pal, A.2    Bornmann, W.G.3
  • 150
    • 51049091694 scopus 로고    scopus 로고
    • Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells
    • Martin, A.P., Miller, A., Emad, L. et al. Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells. Mol Cancer Ther 2008, 7: 1846-50.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1846-1850
    • Martin, A.P.1    Miller, A.2    Emad, L.3
  • 151
    • 33847369020 scopus 로고    scopus 로고
    • Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: Effects on insulin-like growth factor I signaling
    • Nahta, R., Yuan, L.X., Du, Y. et al. Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. Mol Cancer Ther 2007, 6(2): 667-74.
    • (2007) Mol Cancer Ther , vol.6 , Issue.2 , pp. 667-674
    • Nahta, R.1    Yuan, L.X.2    Du, Y.3
  • 152
    • 33646746413 scopus 로고    scopus 로고
    • A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
    • Xia, W., Bacus, S., Hegde, P. et al. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer. Proc Natl Acad Sci U S A 2006, 103(20): 7795-800.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.20 , pp. 7795-7800
    • Xia, W.1    Bacus, S.2    Hegde, P.3
  • 153
    • 33847013396 scopus 로고    scopus 로고
    • Lapatinib anti-tumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers
    • Xia, W., Husain, I., Liu, L. et al. Lapatinib anti-tumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer Res 2007, 67(3): 1170-5.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1170-1175
    • Xia, W.1    Husain, I.2    Liu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.