Primary mediastinal large B-cell lymphoma

Clinical Advances in Hematology and Oncology

Volumn 7, Issue 2, 2009, Pages 125-133

  Faris, Jason ^a   LaCasce, Ann ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Anthracycline; Diffuse large B cell lymphoma; Positron emission tomography scan; Primary mediastinal B cell lymphoma; Rituximab

Indexed keywords

ANTHRACYCLINE; BLEOMYCIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; FOLINIC ACID; METHOTREXATE; PREDNISONE; RITUXIMAB; VINCRISTINE; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PREDNISOLONE; VAP CYCLO PROTOCOL; VAP-CYCLO PROTOCOL;

B CELL LYMPHOMA; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL FEATURE; CLINICAL TRIAL; DRUG RESPONSE; HODGKIN DISEASE; HUMAN; LARGE CELL LYMPHOMA; MEDIASTINUM TUMOR; NODULAR SCLEROSIS HODGKIN LYMPHOMA; POSITRON EMISSION TOMOGRAPHY; PRIMARY TUMOR; REVIEW; ADULT; ARTICLE; FEMALE; GENE EXPRESSION PROFILING; GENETICS; MALE; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; SEX RATIO;

ADULT; ANTHRACYCLINES; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYCLOPHOSPHAMIDE; DOXORUBICIN; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; MEDIASTINAL NEOPLASMS; PREDNISOLONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEX DISTRIBUTION; VINCRISTINE;

EID: 65649128635     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (85)

1. Lichtenstein AK, Levine AL, Taylor CR, et al. Primary mediastinal lymphoma in adults. Am J Med. 1980;68:509-514.
2. Levitt LJ, Aisenberg AC, Harris NL, et al. Primary non-Hodgkin's lymphoma of the mediastinum. Cancer. 1982:50:2486-2492.
3. Falini B, Venturi S, Martelli M, et al. Mediastinal large B-cell lymphoma: clinical and immunohistological findings in 18 patients treated with different third generation regimens. Br J Haematol. 1995;89:780-789.
4. Savage KJ. Primary mediastinal large B-cell lymphoma. Oncologist. 2006;11:488-495.
5. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361-1392.
6. Jaffee ES, Harris NL, Stein H, et al. Pathology and genetics of tumors of hematopoietic and lymphoid tissues. In World Health Organization classification of tumors, vol. 3. Kleihues P, Sobin L (eds). IARC Press, Lyon, 2001.
7. Kirn D, Mauch P, Shaffer K, et al. Large-cell and immunoblastic lymphoma of the mediastinum: prognostic features and treatment outcome in 57 patients. J Clin Oncol. 1993; 11:1336-1343.
8. Abou-Elella AA, Weisenburger DD, Vose JM, et al. Primary mediastinal large B-cell lymphoma: A clinicopathological study of 43 patients from the Nebraska Lymphoma Study Group. J Clin Oncol. 1999;17:784-790.
9. Deshpande A, Bierman PJ, Vose J, et al. Diffuse large B cell lymphoma with mediastinal mass at presentation. J Clin Oncol (ASCO Annual Meeting Abstracts). 2004;22(14S):6585.
10. Hamlin PA, Portlock CS, Straus DJ, et al. Primary mediastinal large B-cell lymphoma: optimal therapy and prognostic factor analysis in 141 consecutive patients treated at Memorial Sloan Kettering from 1980 to 1999. Br J Haematol. 2005;130:691-699.
11. Dao-Guang C, Yu Y, Cai-Zhu P, Hui W, Xue-Zhen H. Primary mediastinal large B-cell lymphoma: a report of 24 cases with literature review. Chinese J Can. 2008;27:187-190.
12. Lazzarino M, Orlandi E, Paulli M, et al. Primary mediastinal B-cell lymphoma with sclerosis: an aggressive tumor with distinctive clinical and pathologic features. J Clin Oncol. 1993;11:2306-2313.
13. Bishop PC, Wilson WH, Pearson D, et al. CNS involvement in primary mediastinal large B-cell lymphoma. J Clin Oncol. 1999; 17:2479-2485.
14. Addis BJ and Isaacson PG. Large cell lymphoma of the mediastinum: a B-cell tumour of probable thymic origin. Histopath. 1986;10:379-390.
15. Isaacson PG, Norton AJ, Addis BJ. The human thymus contains a novel population of B lymphocytes. Lancet. 187;2:1488-1491.
16. Hofmann WJ, Momburg F, Möller P. Thymic medullary cells expressing B lymphocyte antigens. Hum Pathol. 1988;19:1280-1287.
17. Moller P, Lammler B, Eberlein-Gonska M, et al. Primary mediastinal clear cell lymphoma of B-cell type. Virchows Arch A Pathol Anat Histopathol. 1986;409: 79-92.
18. Perrone T, Frizzera G, Rosai J. Mediastinal diffuse large-cell lymphoma with sclerosis. A clinicopathologic study of 60 cases. Am J Surg Pathol. 1986;10: 176-191.
19. Scarpa A, Bonetti F, Menestrina F. Mediastinal large cell lymphoma with sclerosis. Genotypic analysis establishes its B nature. Virhows Arch [A]. 1987;412: 17-21.
20. Boleti E, Johnson PWM. Primary mediastinal B-cell lymphoma. Hematol Oncol. 2007;25:157-163.
21. Rodriquez J, Gutierrez A, Piris M. Primary mediastinal B-cell lymphoma: Treatment and therapeutic targets. Leuk Lymphoma. 2008;1-12.
22. Pileri SA, Gaidano G, Zinzani PL, et al. Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins. Am J Pathol. 2003;162:243-253.
23. Kanavaros P, Gaulard P, Charlotte F, et al. Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas. Am J Pathol. 1995;146:735-741.
24. Lamarre L, Jacobson JO, Aisenberg AC, et al. Primary large cell lymphoma of the mediastinum: A histologic and immunophenotypic study of 29 cases. Am J Surg Pathol. 1989;13:730-739.
25. Banks PM, Warnke RA. Mediastinal (thymic) large B-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, editors. World Health Organization Classification of Tumours. Pathology and genetics of Tumours of Hematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2001.
26. Joos S, Otano-Joos MI, Ziegler S, et al. Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood. 1996;87:1571-1578.
27. Bentz M, Barth TF, Bruderlein S, et al. Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line. Genes Chromosomes Cancer. 2001;30:393-401.
28. Bea S, Zettl A, Wright G, et al. Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood. 2005;106:3183-3190.
29. Weniger MA, Gesk S, Ehrlich S, et al. Gains of REL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein. Genes Chromsomes Cancer. 2007;46:406-415.
30. Scarpa A, Taruscio D, Scardoni M, et al. Nonrandom chromosomal imbalances in primary mediastinal B-cell lymphoma detected by arbitrarily primed PCR fingerprinting. Genes Chromosomes Cancer. 1999;26:203-209.
31. deLeeuw RJ, Savage KJ, Gascoyne RD, et al. Identification of copy number alterations in primary mediastinal B-cell lymphoma by tiling resolution array comparative genomic hybridization. Proc Am Assoc Cancer Res. 2005;46:.
32. Kimm deLeeuw RJ, Savage KJ, et al. Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. Genes Chromosomes Cancer 2007;46(12): 1090-1097.
33. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503-511.
34. Rosenwald A, Wright G, Chan WC. The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma. NEJM. 2002;346:1937-1947.
35. Rosenwald A, Wright G, Leroy K et al. Molecular diagnosis of primary mediastinal B-cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med. 2003;198:851-862.
36. Savage KJ, Monti S, Kutok JL, et al. The molecular signature of mediastinal large cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood. 2003;102:3871-3879.
37. Wright G, Tan B, Rosenwald A, et al. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA. 2003;100:9991-9996.
38. Copie-Bergman C, Gaulard P, Maouche-Chretien L, et al. The MAL gene is expressed in primary mediastinal large B-cell lymphoma. Blood. 1999;15: 3567-3575.
39. Copie-Bergman C, Boulland ML, Dehoulle C, et al. Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma. Blood. 2003;101:2756-2761.
40. Rodig SJ, Savage KJ, LaCasce, AS et al. Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma. Am J Surg Pathol. 2007;31:106-112.
41. Joos S, Granzow M, Holtgreve-Grez H, et al. Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. Int J Cancer. 2003;103:489-495.
42. Jaffe ES, Muller-Hermelink K. Relationship between Hodgkin's disease and non-Hodgkin's lymphomas. In Hodgkin's Disease, Hoppe RT, Mauch PM, Armitage JO, Diehl V, Weiss LM (eds). Lippincott Williams & Wilkens: Philadelphia, PA, 2007, 181-191.
43. Gonzalez CL, Medeiros LJ, Jaffe ES. Composite lymphoma: a clinicopathologic analysis of nine patients with Hodgkin's disease and B-cell non-Hodgkin's lymphoma. Am J Clin Pathol. 1991;96:81-89.
44. Zarate-Osorno A, Medeiros LJ, Longo DL, et al. Non-Hodgkin's lymphomas arising in patients successfully treated for Hodgkin's disease: a clinical, histologic, and immunophenotypic study of 14 cases. Am J Surg Pathol. 1992;16:885-895.
45. Traverse-Glehen A, Pittaluga S, Gaulard P, et al. Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. Am J Surg Pathol. 2005;29:1411-1421.
46. Garcia JF, Mollejo M, Fraga M, et al. Large B-cell lymphoma with Hodgkin's features. Histopathology. 2005;47:101-110.
47. Guiter C, Dusanter-Fourt I, Copie-Bergman C, et al. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood. 2004;104: 543-549.
48. Melzner I, Bucur AJ, Brüderlein S, et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood. 2005;105:2535-2542.
49. Weniger MA, Melzner I, Menz CK, et al. Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. Oncogene. 2006;25:2679-2684.
50. Melzner I, Weniger MA, Menz CK, Moller P. Absence of the JAK2 V617F mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Leukemia. 2006;20:157-158.
51. Marafioti, Pozzobon M, Hansmann ML, et al. Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma. Leukemia. 2005;19:856-861.
52. Todeschini G, Ambrosetti A, Meneghini V, et al. Mediastinal large B-cell lymphoma with sclerosis: a clinical study of 21 patients. J Clin Oncol. 1990;8: 804-808.
53. Lavabre-Bertrand T, Donadio D, Fegueux N, et al: A study of 15 cases of primary mediastinal lymphoma of B-cell type. Cancer. 1992;69:2561-2566.
54. Haioun C, Gaulard P, Roudot-Thoraval F, et al. Mediastinal diffuse large-cell lymphoma with sclerosis: a condition with a poor prognosis. Am J Clin Oncol. 1989;12:425-429.
55. Lazzarino M, Orlandi E, Paulli M, et al. Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: a multicenter study of 106 patients. J Clin Oncol. 1997; 15:1646-1653.
56. Zinzani PL, Martelli M, Bertini M, et al. Induction strategies for primary mediastinal large B-cell lymphoma with sclerosis: a retrospective multinational study on 426 previously untreated patients. Haematologica. 2002;87:1258-1264.
57. Todeschini G, Secchi S, Morra E, et al. Primary mediastinal large B-cell lymphoma (PMLBCL): long-term result from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B. Br J Cancer. 2004;90:372-376.
58. Savage KJ, Al-Rajhi N, Voss N, et al. Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience. Ann Oncol. 2006;17:123-130.
59. Fisher RI, Gaynor ER, Dahlberg S, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med. 1993;328:1002-1006.
60. Coiffier B, Lepage E, Briere J et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:235-242.
61. Pfreundschuh M, Trumper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large B-cell lymphoma: A randomised controlled trial by the Mabthera International Trial (MinT) group. Lancet Oncol. 2006;7:379-391.
62. Sehn LH, Donaldson J, Chhanabhai M, et al. Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B-cell lymphoma in British Columbia. J Clin Oncol. 2005;23:5027-5033.
63. Dunleavy K, Pittaluga S, Janik J, et al. Primary mediastinal large B-cell lymphoma (PMBL) outcome is significantly improved by the addition of rituximab to dose adjusted (DA)-EPOCH and overcomes the need for radiation. Blood. 2005;106;929a.
64. Zinzani PL, Martelli M, Magagnoli M, et al. Treatment and clinical management of primary mediastinal large B-cell lymphoma with sclerosis: MACOP-B regimen and mediastinal radiotherapy monitored by 67gallium scan in 50 patients. Blood. 1999;94:3289-3293.
65. Zinzani PL. Importance of gallium scan restaging for curative treatment of mediastinal lymphomas. Haematologica. 2001;86:1229-1230.
66. Mazzarotto R, Boso C, Vianello F, et al. Primary mediastinal large B-cell lymphoma: results of intensive chemotherapy regimens (MACOP-B/ VACOP-B) plus involved field radiotherapy on 53 patients. A single institution experience. Int J Radiat Oncol Biol Phys. 2007;68:823-829.
67. De Sanctis V, Finolezzi E, Falchetto M, et al. MACOP-B and Involved-Field Radiotherapy Is an Effective and Safe Therapy for Primary Mediastinal Large B Cell Lymphoma. Int J Radiat Oncol Biol Phys. 2008;72:1154-1160.
68. Popat U, Przepiork D, Champlin R, et al. High-dose chemotherapy for relapsed and refractory diffuse large B-cell lymphoma: mediastinal localization predicts for a favorable outcome. J Clin Oncol. 1998;16:63-69.
69. Sehn LH, Antin JH, Shulman LN, et al. Primary diffuse large B-cell lymphoma of the mediastinum: outcome following high dose chemotherapy and autologous hematopoietic cell transplantation. Blood. 1998;91:717-723.
70. Cairoli R, Grillo G, Tedeschi A, et al. Efficacy of an early intensification treatment integrating chemotherapy, autologous stem cell transplantation and radiotherapy for poor risk primary mediastinal large B cell lymphoma with sclerosis. Bone Marrow Transplant. 2002;29:473-477.
71. Rodriguez J, Conde E, Gutierrez A, et al. Primary mediastinal large cell lymphoma (PMBL): frontline treatment with autologous stem cell transplantation (ASCT). The GEL-TAMO experience. Hematol Oncol. 2008;26:171-178.
72. van Besien K, Kelta M, Bahaguna P. Primary mediastinal B-cell lymphoma: a review of pathology and management. J Clin Oncol. 2001;19:1855-1864.
73. Cazals-Hatem D, Lepage E, Brice P, et al. Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA ("Groupe d'Etude des Lymphomes de l'Adulte") study. Am J Surg Pathol. 1996; 20:877-888.
74. Bieri S, Roggero E, Zucca E, et al. Primary mediastinal large B-cell lymphoma (PMLCL): the need for prospective controlled clinical trials. Leuk Lymphoma. 1999;35:139-146.
75. Jochelson M, Mauch P, Balikian J, et al. The significance of the residual mediastinal mass in treated Hodgkin's disease. J Clin Oncol. 1985;3:637-640.
76. Radford JA, Cowan RA, Flanagan M, et al. The significance of residual mediastinal abnormality on the chest radiograph following treatment for Hodgkin's disease. J Clin Oncol. 1988;6:940-946.
77. Canellos GP. Residual mass in lymphoma may not be residual disease. J Clin Oncol. 1988;6:931-933.
78. Zinzani PL, Tani M, Trisolini R, et al. Histological verification of positive positron emission tomography findings in the follow-up of patients with mediastinal lymphoma. Haematologica. 2007;92:771-777
79. Jacobson JO, Aisenberg AC, Lamarre L, et al. Mediastinal large cell lymphoma: an uncommon subset of adult lymphoma curable with combined modality therapy. Cancer. 1988;62:1893-1898.
80. Bertini M, Orsucci L, Vitolo U, Levis A, Todeschini G, Meneghini V, et al. Stage II large B-cell lymphoma with sclerosis treated with MACOP-B. Ann Oncol. 1991;2:733-737.
81. Rodriguez J, Pugh WC, Romaguera JE, et al. Primary mediastinal large cell lymphoma is characterized by an inverted pattern of large tumoral mass and low beta 2 microglobulin levels in serum and frequently elevated levels of serum lactate dehydrogenase. Ann Oncol. 1994;9:847-849.
82. Zinzani PL, Bendandi M, Frezza G, et al. Primary Mediastinal B-cell lymphoma with sclerosis: clinical and therapeutic evaluation of 22 patients. Leuk Lymphoma. 1996;21:311-316.
83. Martelli MP, Martelli M, Pescarmona E, et al. MACOP-B and involved field radiation therapy is an effective therapy for primary mediastinal large B-cell lymphoma with sclerosis. Ann Oncol. 1998;9:1027-1029.
84. Nguyen LN, Ha CS, Hess M, et al. The outcome of combined-modality treatments for stage I and II primary large B-cell lymphoma of the mediastinum. Int J Rad Onc Biol Phys. 2000;47:1281-1285.
85. Zinzani PL, Martelli M, Bendandi M, et al. Primary mediastinal large B-cell lymphoma with sclerosis: a clinical study of 89 patients treated with MACOP-B chemotherapy and radiation therapy. Haematologica. 2001b;96:187-191.