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Volumn 75, Issue 4, 2009, Pages 307-311

Oral metabolism and efficacy of Kalanchoe pinnata flavonoids in a murine model of cutaneous leishmaniasis

Author keywords

Crassulaceae; HPLC DAD MS; Kalanchoe pinnata; Leishmaniasis; Metabolism; Quercetin glycosides

Indexed keywords

ANTIPARASITIC AGENT; KALANCHOE PINNATA EXTRACT; PLANT EXTRACT; QUERCETIN; QUERCETIN 3 O ALPHA LEVO ARABINOPYRANOSYL (1-2) ALPHA LEVO RHAMNOPYRANOSIDE; QUERCETIN 3 O ALPHA LEVO RHAMNOPYRANOSIDE; QUERCETIN DERIVATIVE; QUERCITRIN; STIBOGLUCONATE SODIUM; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; DRUG DERIVATIVE; FLAVONE DERIVATIVE;

EID: 65649100399     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0028-1088382     Document Type: Article
Times cited : (61)

References (26)
  • 1
    • 68949152675 scopus 로고    scopus 로고
    • Division of Control of Tropical Diseases (accessed in 2008)
    • World Health Organization, Division of Control of Tropical Diseases. http://www.who.int/tdr/diseases/leish/diseaseinfo (accessed in 2008)
  • 2
    • 0036240055 scopus 로고    scopus 로고
    • Chemotherapy of leishmaniasis
    • Croft SL, Yardley V. Chemotherapy of leishmaniasis. Curr Pharm Des 2002; 8: 319-342
    • (2002) Curr Pharm des , vol.8 , pp. 319-342
    • Croft, S.L.1    Yardley, V.2
  • 3
    • 0033036519 scopus 로고    scopus 로고
    • The anti-leishmanial effect of Kalanchoe is mediated by nitric oxide intermediates
    • Da Silva SAG, Costa SS, Rossi-Bergmann B. The anti-leishmanial effect of Kalanchoe is mediated by nitric oxide intermediates. Parasitology 1999; 118: 575-582
    • (1999) Parasitology , vol.118 , pp. 575-582
    • Da Silva, S.A.G.1    Costa, S.S.2    Rossi-Bergmann, B.3
  • 9
    • 0242316279 scopus 로고    scopus 로고
    • A simple fluorimetric method for assessing drug and vaccine efficacy in cutaneous leishmaniasis using Leishmania amazonensis expressing green fluorescence protein
    • Rossi-Bergmann B, Falcão CAB, Lenglet A, Santos CRB, Pinto DC, Traub- Cseko Y. A simple fluorimetric method for assessing drug and vaccine efficacy in cutaneous leishmaniasis using Leishmania amazonensis expressing green fluorescence protein. Mem Inst Oswaldo Cruz 1999; 94: 74
    • (1999) Mem Inst Oswaldo Cruz , vol.94 , pp. 74
    • Rossi-Bergmann, B.1    Falcão, C.A.B.2    Lenglet, A.3    Santos, C.R.B.4    Pinto, D.C.5    Traub-Cseko, Y.6
  • 11
    • 0025616120 scopus 로고
    • Anti-inflammatory action of Bryophyllum pinnatum leaf extract
    • Pal S, Chaudhuri AKN. Anti-inflammatory action of Bryophyllum pinnatum leaf extract. Fitoterapia 1990; 6: 527-533
    • (1990) Fitoterapia , vol.6 , pp. 527-533
    • Pal, S.1    Chaudhuri, A.K.N.2
  • 12
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52: 673-751
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 13
    • 0034199017 scopus 로고    scopus 로고
    • Luteolin, an abundant dietary component is a potent antileishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis
    • Mittra B, Saha A, Chowdhury AR, Pal C, Mandal S, Mukhopadhyay S et al. Luteolin, an abundant dietary component is a potent antileishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mol Med 2000; 6: 527-541
    • (2000) Mol Med , vol.6 , pp. 527-541
    • Mittra, B.1    Saha, A.2    Chowdhury, A.R.3    Pal, C.4    Mandal, S.5    Mukhopadhyay, S.6
  • 14
    • 15944422910 scopus 로고    scopus 로고
    • Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis
    • DOI 10.1016/j.freeradbiomed.2005.01.014
    • Sen G, Mandal S, Roy SS, Mukhopadhyay S, Biswas T. Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis. Free Radic Biol Med 2005; 38: 1257-1264 (Pubitemid 40445542)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.9 , pp. 1257-1264
    • Sen, G.1    Mandal, S.2    Roy, S.S.3    Mukhopadhyay, S.4    Biswas, T.5
  • 15
    • 0036968461 scopus 로고    scopus 로고
    • Quercetin: Critical evaluation as an antileishmanial agent in vivo in hamsters using different vesicular delivery modes
    • Sarkar S, Mandal S, Sinha J, Mukhopadhyay S, Das N, Basu MK. Quercetin: critical evaluation as an antileishmanial agent in vivo in hamsters using different vesicular delivery modes. J Drug Target 2002; 10: 573-578
    • (2002) J Drug Target , vol.10 , pp. 573-578
    • Sarkar, S.1    Mandal, S.2    Sinha, J.3    Mukhopadhyay, S.4    Das, N.5    Basu, M.K.6
  • 16
    • 42149150965 scopus 로고    scopus 로고
    • Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity
    • Sen G, Mukhopadhyay S, Ray M, Biswas T. Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity. J Antimicrob Chemother 2008; 61: 1066-1075
    • (2008) J Antimicrob Chemother , vol.61 , pp. 1066-1075
    • Sen, G.1    Mukhopadhyay, S.2    Ray, M.3    Biswas, T.4
  • 17
    • 29144509689 scopus 로고    scopus 로고
    • Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays
    • DOI 10.1016/j.exppara.2005.08.014, PII S0014489405002274
    • Jean-Moreno V, Rojas R, Goyeneche D, Coombs GH,Walker J. Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. Exp Parasitol 2006; 112: 21-30 (Pubitemid 41796476)
    • (2006) Experimental Parasitology , vol.112 , Issue.1 , pp. 21-30
    • Jean-Moreno, V.1    Rojas, R.2    Goyeneche, D.3    Coombs, G.H.4    Walker, J.5
  • 18
    • 33645755408 scopus 로고    scopus 로고
    • Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies
    • Tasdemir D, Kaiser M, Brun R, Yardley V, Schmidt TJ, Tosun F et al. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrob Agents Chemother 2006; 50: 1352-1364
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1352-1364
    • Tasdemir, D.1    Kaiser, M.2    Brun, R.3    Yardley, V.4    Schmidt, T.J.5    Tosun, F.6
  • 19
    • 1642528478 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids
    • Walle T. Absorption and metabolism of flavonoids. Free Radic Biol Med 2004; 36: 829-837
    • (2004) Free Radic Biol Med , vol.36 , pp. 829-837
    • Walle, T.1
  • 20
    • 0037300834 scopus 로고    scopus 로고
    • Metabolism of quercetin-7- And quercetin-3-glucuronides by an in vitro hepatic model: The role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
    • O'Leary KA, Day AJ, Needs PW, Mellon FA, O'Brien NM, Williamson G. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol 2003; 65: 479-491
    • (2003) Biochem Pharmacol , vol.65 , pp. 479-491
    • O'Leary, K.A.1    Day, A.J.2    Needs, P.W.3    Mellon, F.A.4    O'Brien, N.M.5    Williamson, G.6
  • 21
    • 0034672514 scopus 로고    scopus 로고
    • Conjugation position of quercetin glucuronides and effect on biological activity
    • Day AJ, Bao Y, Morgan MRA, Williamson G. Conjugation position of quercetin glucuronides and effect on biological activity. Free Radic Biol Med 2000; 29: 1234-1243
    • (2000) Free Radic Biol Med , vol.29 , pp. 1234-1243
    • Day, A.J.1    Bao, Y.2    Morgan, M.R.A.3    Williamson, G.4
  • 22
    • 0037377562 scopus 로고    scopus 로고
    • Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    • DOI 10.1016/S0006-2952(03)00039-X
    • Day AJ, Gee JM, Dupont MS, Johnson IT, Williamson G. Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 2003; 65: 1199-1206 (Pubitemid 36349759)
    • (2003) Biochemical Pharmacology , vol.65 , Issue.7 , pp. 1199-1206
    • Day, A.J.1    Gee, J.M.2    Dupont, M.S.3    Johnson, I.T.4    Williamson, G.5
  • 24
    • 5344241165 scopus 로고    scopus 로고
    • Mass spectrometric methods for the determination of flavonoids in biological samples
    • DOI 10.1016/j.freeradbiomed.2004.07.026, PII S0891584904006021
    • Prasain JK, Wang CC, Barnes S. Mass spectrometric methods for the determination of flavonoids in biological samples. Free Radic Biol Med 2004; 37: 1324-1350 (Pubitemid 39349236)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.9 , pp. 1324-1350
    • Prasain, J.K.1    Wang, C.-C.2    Barnes, S.3
  • 25
    • 20444447208 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine
    • DOI 10.1016/j.jchromb.2005.05.009, PII S1570023205003375
    • Wang L, Morris ME. Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine. J Chromatogr B 2005; 821: 194-201 (Pubitemid 40827027)
    • (2005) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.821 , Issue.2 , pp. 194-201
    • Wang, L.1    Morris, M.E.2
  • 26
    • 1042290475 scopus 로고    scopus 로고
    • Cellular uptake and metabolism of flavonoids and their metabolites: Implications for their bioactivity
    • DOI 10.1016/j.abb.2003.11.010
    • Spencer JPE, El Mohsen MMA, Rice-Evans C. Cellular uptake andmetabolism of flavonoids and their metabolites: implications for their bioactivity. Arch Biochem Biophys 2004; 423: 148-161 (Pubitemid 38198224)
    • (2004) Archives of Biochemistry and Biophysics , vol.423 , Issue.1 , pp. 148-161
    • Spencer, J.P.E.1    Abd El Mohsen, M.M.2    Rice-Evans, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.