Evidence-based guidelines for treating bipolar disorder: Revised second edition-recommendations from the British association for psychopharmacology

Journal of Psychopharmacology

Volumn 23, Issue 4, 2009, Pages 346-388

  Goodwin, G M ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

Antidepressants; Antipsychotics; Bipolar disorder; CBT; Depression; Evidence based guidelines; Lithium; Mood stabilizers; Treatment

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CARBAMAZEPINE; CHLORPROMAZINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONAZEPAM; CLOZAPINE; CORTICOSTEROID; DROPERIDOL; DULOXETINE; FLUOXETINE; HALOPERIDOL; LAMOTRIGINE; LEVODOPA; LITHIUM; LORAZEPAM; NEUROLEPTIC AGENT; OLANZAPINE; OXCARBAZEPINE; QUETIAPINE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; TRANQUILIZER; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; VALPROATE SEMISODIUM; VALPROIC ACID; VENLAFAXINE; ZIPRASIDONE;

ANEMIA; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BIPOLAR MANIA; CLINICAL TRIAL; COGNITIVE THERAPY; COMORBIDITY; CONGENITAL MALFORMATION; CONSENSUS DEVELOPMENT; DEVELOPMENTAL DISORDER; DIFFERENTIAL DIAGNOSIS; DRUG CHOICE; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; DRUG MEGADOSE; DRUG RESPONSE; DRUG SUBSTITUTION; DRUG USE; DRUG WITHDRAWAL; DYSLIPIDEMIA; ELECTROCONVULSIVE THERAPY; EVIDENCE BASED MEDICINE; EXTRAPYRAMIDAL SYMPTOM; FAMILY THERAPY; GROUP THERAPY; HEALTH CARE ACCESS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERPROLACTINEMIA; LIVER DYSFUNCTION; MANIA; MEDICAL DECISION MAKING; NEURAL TUBE DEFECT; ORGANIZATION; OVARY POLYCYSTIC DISEASE; PATIENT COMPLIANCE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PSYCHOEDUCATION; PSYCHOTHERAPY; RELAPSE; REVIEW; SIDE EFFECT; TARDIVE DYSKINESIA; TERATOGENICITY; THROMBOCYTOPENIA; WEIGHT GAIN;

ANTIDEPRESSIVE AGENTS; ANTIMANIC AGENTS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; COMBINED MODALITY THERAPY; CONSENSUS; CONSENSUS DEVELOPMENT CONFERENCES AS TOPIC; DRUG THERAPY, COMBINATION; EVIDENCE-BASED MEDICINE; HEALTH PLANNING GUIDELINES; HUMANS; PSYCHOTHERAPY; RECURRENCE;

EID: 65649095161     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109102919     Document Type: Review

References (290)

1. Adab N, Kini U, Vinten J, Ayres J, Baker G, Clayton-Smith J, (2004) The longer term outcome of children born to mothers with epilepsy. Journal of Neurology Neurosurgery and Psychiatry 75 (11). 1575 - 1583.
2. Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfeld R, (2000) Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord 59 (Suppl. 1). S5 - S30.
3. Allen MH, Currier GW, Hughes DH, Reyes-Harde M, Docherty JP, (2001) The Expert Consensus Guideline Series. Treatment of behavioral emergencies. Postgrad Med May: 1 - 88.
4. Altshuler LL, Cohen L, Szuba MP, Burt VK, Gitlin M, Mintz J, (1996) "Pharmacologic management of psychiatric illness during pregnancy: Dilemmas and guidelinesg". American Journal of Psychiatry 153 (5). 592 - 606.
5. Altshuler L, Kiriakos L, Calcagno J, Goodman R, Gitlin M, Frye M, (2001) The impact of antidepressant discontinuation versus antidepressant continuation on 1-year risk for relapse of bipolar depression: a retrospective chart review. J Clin Psychiatry 62: 612 - 616.
6. A'lvarez-Jiménez M, Gonzalez-Blanch C, Vazquez-Barquero JL, Perez-Iglesias R, Martinez-Garcia O, Perez-Pardal T, (2006) Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: A randomized controlled trial. J Clin Psychiatry 67: 1253 - 1260.
7. American Academy of Paediatrics Committee on Drugs (2000) Use of psychoactive medications during pregnancy and possible effects on the fetus and newborn. Pediatrics 105: 880 - 887.
8. American Psychiatric Association (1994) Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). Washington, DC: American Psychiatric Association.
9. American Psychiatric Association (2002) Practice guideline for the treatment of patients with bipolar disorder (revision). Am J Psychiatry 159: 1 - 50.
10. Anderson IM, (2001) Meta-analytical studies on new antidepressants. Br Med Bull 57: 161 - 178.
11. Anderson IM, Ferrier NI, Baldwin CR, Cowen PJ, Howard L, Lewis G, (2008) Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol 22: 343 - 396.
12. Andrew HG, (1994) Clinical relationship of extrapyramidal symptoms and tardive dyskinesia. Can J Psychiatry 39: S76 - S80.
13. Angst F, Stassen HH, Clayton PJ, Angst J, (2002) Mortality of patients with mood disorders: follow-up over 34-38 years. J Affect Disord 68: 167 - 181.
14. Angst J, (1998) The emerging epidemiology of hypomania and bipolar II disorder. J Affect Disord 50: 143 - 151.
15. Angst J, Gamma A, Benazzi F, Ajdacic V, Eich D, Rossler W, (2003) Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord 73: 133 - 146.
16. Angst J, Preisig M, (1995) Course of a clinical cohort of unipolar, bipolar and schizoaffective patients. Results of a prospective study from 1959 to 1985. Schweiz Arch Neurol Psychiatr 146: 5 - 16.
17. Angst J, Sellaro R, (2000) Historical perspectives and natural history of bipolar disorder. Biol Psychiatry 48: 445 - 457.
18. Arts B, Jabben N, Krabbendam L, van Os J, (2008) Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 38: 771 - 785.
19. Ashcroft R, (2000) Giving medicine a fair trial. Trials should not second guess what patients want. BMJ 320: 1686.
20. Austin MP, Mitchell PB, (1998) Use of psychotropic medications in breast-feeding women: acute and prophylactic treatment. Aust N Z J Psychiatry 32: 778 - 784.
21. Bain M, Juszczak E, McInneny K, Kendell RE, (2000) Obstetric complications and affective psychoses. Two case-control studies based on structured obstetric records. Br J Psychiatry 176: 523 - 526.
22. Baker RW, Brown E, Akiskal HS, Calabrese JR, Ketter TA, Schuh LM, (2004) Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania. B J Psychiatry 185: 472 - 478.
23. Baldessarini RJ, Hennen J, Wilson M, Calabrese J, Chengappa R, Keck PE, (2003) Olanzapine versus placebo in acute mania - Treatment responses in subgroups. J Clin Psychopharmacol 23: 370 - 376.
24. Baruzzi A, Albani F, Riva R, (1994) Oxcarbazepine - Pharmacokinetic Interactions and Their Clinical Relevance. Epilepsia 35: S14 - S19.
25. Bauer MS, McBride L, Williford WO, Glick H, Kinosian B, Altshuler L, (2006a) Collaborative care for bipolar disorder: Part I. Intervention and implementation in a randomized effectiveness trial. Psychiatr Serv 57: 927 - 936.
26. Bauer MS, McBride L, Williford WO, Glick H, Kinosian B, Altshuler L, (2006b) Collaborative care for bipolar disorder: Part II. Impact on clinical outcome, function, and costs. Psychiatr Serv 57: 937 - 945.
27. Bauer MS, Wisniewski SR, Marangell LB, Chessick CA, Allen MH, Dennehy EB, (2006c) Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). J Clin Psychiatry 67: 48 - 55.
28. Bhagwagar Z, Goodwin GM, (2002) The role of lithium in the treatment of bipolar depression. Clin Neurosci Res 2: 222 - 227.
29. Biel MG, Peselow E, Mulcare L, Case BG, Fieve R, (2007) Continuation versus discontinuation of lithium in recurrent bipolar illness: a naturalistic study. Bipolar Disord 9: 435 - 442.
30. Birmaher B, Axelson D, (2006) Course and outcome of bipolar spectrum disorder in children and adolescents: A review of the existing literature. Dev Psychopathol 18: 1023 - 1035.
31. Birmaher B, Axelson D, Strober M, Gill MK, Valeri S, Chiappetta L, (2006) Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63: 175 - 183.
32. Black DW, Winokur G, Nasrallah A, (1987) Suicide in subtypes of major affective disorder. A comparison with general population suicide mortality. Arch Gen Psychiatry 44: 878 - 880.
33. Blacker D, Tsuang MT, (1992) Contested boundaries of bipolar disorder and the limits of categorical diagnosis in psychiatry. Am J Psychiatry 149: 1473 - 1483.
34. Blader JC, Carlson GA, (2007) Increased rates of bipolar disorder diagnoses among U.S. child, adolescent, and adult inpatients, 1996-2004. Biol Psychiatry 62: 107 - 114.
35. Bostwick JM, Pankratz VS, (2000) Affective disorders and suicide risk: a reexamination. Am J Psychiatry 157: 1925 - 1932.
36. Bottlender R, Rudolf D, Strauss A, Moller HJ, (2001) Mood-stabilisers reduce the risk of developing antidepressant-induced maniform states in acute treatment of bipolar I depressed patients. J Affect Disord 63: 79 - 83.
37. Bowden CL, (2005) Atypical antipsychotic augmentation of mood stabilizer therapy in bipolar disorder. J Clin Psychiatry 66: 12 - 19.
38. Bowden CL, Brugger AM, Swann AC, Calabrese JR, Janicak PG, Petty F, (1994) Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group. JAMA 271: 918 - 924.
39. Bowden CL, Calabrese JR, McElroy SL, Rhodes LJ, Keck PE, Cookson J, (1999) The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biol Psychiatry 45: 953 - 958.
40. Braff DL, Freedman R, (2008) Clinically responsible genetic testing in neuropsychiatric patients: A bridge too far and too soon. Am J Psychiatry 165: 952 - 955.
41. Brown ES, Khan DA, Nejtek VA, (1999) The psychiatric side effects of corticosteroids. Ann Allergy Asthma Immunol 83: 495 - 503.
42. Brown ES, Suppes T, Khan DA, Carmody TJ, (2002) Mood changes during prednisone bursts in outpatients with asthma. J Clin Psychopharmacol 22: 55 - 61.
43. Browne R, Byrne M, Mulryan N, Scully A, Morris M, Kinsella A, (2000) Labour and delivery complications at birth and later mania. An Irish case register study. Br J Psychiatry 176: 369 - 372.
44. Burgess S, Geddes J, Hawton K, Townsend E, Jamison K, Goodwin G, (2001) Lithium for maintenance treatment of mood disorders. Cochrane Database Syst Rev: CD003013.
45. Burns T, White I, Byford S, Fiander M, Creed F, Fahy T, (2002) Exposure to case management: relationships to patient characteristics and outcome. Report from the UK700 trial. Br J Psychiatry 181: 236 - 241.
46. Byrne SM, Cooper Z, Fairburn CG, (2004) Psychological predictors of weight regain in obesity. Behav Res Ther 42: 1341 - 1356.
47. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD, (1999) A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 60: 79 - 88.
48. Calabrese JR, Shelton MD, Rapport DJ, Kujawa M, Kimmel SE, Caban S, (2001) Current research on rapid cycling bipolar disorder and its treatment. J Affect Disord 67: 241 - 255.
49. Cassano GB, Rucci P, Frank E, Fagiolini A, Dell'osso L, Shear MK, (2004) The mood spectrum in unipolar and bipolar disorder: arguments for a unitary approach. Am J Psychiatry 161: 1264 - 1269.
50. Cassidy F, Forest K, Murry E, Carroll BJ, (1998) A factor analysis of the signs and symptoms of mania. Arch Gen Psychiatry 55: 27 - 32.
51. Cassidy F, Pieper CF, Carroll BJ, (2001) Subtypes of mania determined by grade of membership analysis. Neuropsychopharmacology 25: 373 - 383.
52. Castberg I, Skogvoll E, Spigset O, (2007) Quetiapine and drug interactions: Evidence from a routine therapeutic drug monitoring service. J Clin Psychiatry 68: 1540 - 1545.
53. Chaudron LH, Jefferson JW, (2000) Mood stabilizers during breastfeeding: a review. J Clin Psychiatry 61: 79 - 90.
54. Chen YW, Dilsaver SC, (1996) Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other axis I disorders. Biol Psychiatry 39: 896 - 899.
55. Chengappa KNR, Schwarzman LK, Hulihan JF, Xiang J, Rosenthal NR, (2006) Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: A randomized, placebo-controlled trial. J Clin Psychiatry 67: 1698 - 1706.
56. Chou JC, Zito JM, Vitrai J, Craig TJ, Allingham BH, Czobor P, (1996) Neuroleptics in acute mania: a pharmacoepidemiologic study. Ann Pharmacother 30: 1396 - 1398.
57. Cipriani A, Pretty H, Hawton K, Geddes JR, (2005) Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: A systematic review of randomized trials. Am J Psychiatry 162: 1805 - 1819.
58. Clark L, Iversen SD, Goodwin GM, (2002) Sustained attention deficit in bipolar disorder. Br J Psychiatry 180: 313 - 319.
59. Clement S, Singh SP, Burns T, (2003) Status of bipolar disorder research. Bibliometric study. Br J Psychiatry 182: 148 - 152.
60. Clyburn LD, Stones MJ, Hadjistavropoulos T, Tuokko H, (2000) Predicting caregiver burden and depression in Alzheimer's disease. J Gerontol B Psychol Sci Soc Sci 55: S2 - S13.
61. Colom F, Vieta E, Martínez-Arán A, Reinares M, Goikolea JM, Benabarre A, (2003) A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry 60: 402 - 407.
62. Colom F, Vieta E, Sanchez-Moreno J, Palomino-Otiniano R, Reinares M, Goikolea JM, (2009) Group psychoeducation for stabilised bipolar disorders: five-year outcome of a randomised clinical trial. British Journal of Psychiatry 194: 260 - 265.
63. Compton MT, Daumit GL, Druss BG, (2006) Cigarette smoking and overweight/obesity among individuals with serious mental illnesses: A preventive perspective. Harv Rev Psychiatry 14: 212 - 222.
64. Compton MT, Nemeroff CB, (2000) The treatment of bipolar depression. J Clin Psychiatry 61 (Suppl. 9). 57 - 67.
65. Cookson J, (2001) Use of antipsychotic drugs and lithium in mania. Br J Psychiatry 178 (Suppl. 41). s148 - s156.
66. Correll CU, Leucht S, Kane JM, (2004) Lower risk for tardive dyskinesia associated with second-generation antipsychotics: A systematic review of 1-year studies. Am J Psychiatry 161: 414 - 425.
67. Coryell W, Solomon D, Turvey C, Keller M, Leon AC, Endicott J, (2003) The long-term course of rapid-cycling bipolar disorder. Arch Gen Psychiatry 60: 914 - 920.
68. Cummings JL, Mendez MF, (1984) Secondary mania with focal cerebrovascular lesions. Am J Psychiatry 141: 1084 - 1087.
69. Denicoff KD, Leverich GS, Nolen WA, Rush AJ, McElroy SL, Keck PE, (2000) Validation of the prospective NIMH-Life-Chart Method (NIMH-LCM-p) for longitudinal assessment of bipolar illness. Psychol Med 30: 1391 - 1397.
70. Department of Health (1999) A National Service Framework for Mental Health. London: Department of Health, pp. 1 - 149.
71. Dickstein DP, Treland JE, Snow J, McClure EB, Mehta MS, Towbin KE, (2004) Neuropsychological performance in pediatric bipolar disorder. Biol Psychiatry 55: 32 - 39.
72. Dubicka B, Carlson GA, Vail A, Harrington R, (2008) Prepubertal mania: diagnostic differences between US and UK clinicians. Eur Child Adolesc Psychiatry 17: 153 - 161.
73. Duncan S, (2001) Polycystic ovarian syndrome in women with epilepsy: a review. Epilepsia 42 (Suppl. 3). 60 - 65.
74. Duncan S, Mercho S, Lopes-Cendes I, Seni MH, Benjamin A, Dubeau F, (2001) Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality. Epilepsia 42: 750 - 753.
75. Ebbesen F, Joergensen A, Hoseth E, Kaad PH, Moeller M, Holsteen V, (2000) Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. Arch Dis Child Fetal Neonatal Ed 83: F124 - F129.
76. Eddy DM, (1990) Clinical decision making: from theory to practice. Designing a practice policy. Standards, guidelines, and options. JAMA 263: 3077, 3081, 3084.
77. Einarson TR, Einarson A, (2005) Newer antidepressants in pregnancy and rates of major malformations: a meta-analysis of prospective comparative studies. Pharmacoepidemiol Drug Saf 14: 823 - 827.
78. Esparon J, Kolloori J, Naylor GJ, McHarg AM, Smith AH, Hopwood SE, (1986) Comparison of the prophylactic action of flupenthixol with placebo in lithium treated manic-depressive patients. Br J Psychiatry 148: 723 - 725.
79. Fadden G, Bebbington P, Kuipers L, (1987) The burden of care: the impact of functional psychiatric illness on the patient's family. Br J Psychiatry 150: 285 - 292.
80. Fagiolini A, Frank E, Rucci P, Cassano GB, Turkin S, Kupfer DJ, (2007) Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorder. Bipolar Disord 9: 462 - 467.
81. Frances AJ, Kahn DA, Carpenter D, Docherty JP, Donovan SL, (1998) The Expert Consensus Guidelines for treating depression in bipolar disorder. J Clin Psychiatry 59 (Suppl. 4). 73 - 79.
82. Frangou S, Donaldson S, Hadjulis M, Landau S, Goldstein LH, (2005) The Maudsley Bipolar Disorder Project: Executive dysfunction in bipolar disorder I and its clinical correlates. Biol Psychiatry 58: 859 - 864.
83. Frank E, Kupfer DJ, Thase ME, Mallinger AG, Swartz HA, Fagiolini AM, (2005) Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry 62: 996 - 1004.
84. Freeman MP, Freeman SA, McElroy SL, (2002) The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues. J Affect Disord 68: 1 - 23.
85. Frye MA, Ketter TA, Kimbrell TA, Dunn RT, Speer AM, Osuch EA, (2000) A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol 20: 607 - 614.
86. Gao KM, Kemp DE, Ganocy SJ, Gajwani P, Xia GH, Calabrese JR, (2008) Anti psychotic-induced extrapyramidal side effects in bipolar disorder and schizophrenia - A systematic review. J Clin Psychopharmacol 28: 203 - 209.
87. Geddes J, Freemantle N, Harrison P, Bebbington P, (2000) Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis. BMJ 321: 1371 - 1376.
88. Geddes J, Goodwin G, (2001) Bipolar disorder: clinical uncertainty, evidence-based medicine and large-scale randomised trials. Br J Psychiatry 178 (Suppl. 41). s191 - s194.
89. Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM, (2004) Long-term lithium therapy for bipolar disorder: Systematic review and meta-analysis of randomized controlled trialls. Am J Psychiatry 161: 217 - 222.
90. Geddes JR, Calabrese J, Goodwin GM, (2009) Lamotrigine for treatment of bipolar depression: independent meta-analysis and metaregression of individual patient data from five randomized trials. Br J Psychiatry 194: 4 - 9.
91. Geddes JR, Carney SM, Davies C, Furukawa T, Kupfer DJ, Frank E, (2003) Relapse prevention with antidepressant drug treatment in depressive disorders. Lancet 361: 643 - 651.
92. Geller B, Sun K, Zimerman B, Luby J, Frazier J, Williams M, (1995) Complex and rapid-cycling in bipolar children and adolescents: a preliminary study. J Affect Disord 34: 259 - 268.
93. Ghaemi SN, Hsu DJ, Soldani F, Goodwin FK, (2003) Antidepressants in bipolar disorder: the case for caution. Bipolar Disord 5: 421 - 433.
94. Ghaemi SN, Lenox MS, Baldessarini RJ, (2001) Effectiveness and safety of long-term antidepressant treatment in bipolar disorder. J Clin Psychiatry 62: 565 - 569.
95. Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM, (2004) Antidepressants for bipolar depression: A systematic review of randomized, controlled trials. Am J Psychiatry 161: 1537 - 1547.
96. Goldstein J, Nyberg S, Takano A, Grimm S, Gulyas B, McCarthy D, (2007) PET-measured D2, 5HT2A, and NET occupancy by quetiapine and n-desalkyl- quetiapine (norquetiapine) in non-human primates. Int J Psychiatry Clin Pract 11: 322.
97. Goldstein TR, Frye MA, Denicoff KD, Smith-Jackson E, Leverich GS, Bryan AL, (1999) Antidepressant discontinuation-related mania: critical prospective observation and theoretical implications in bipolar disorder. J Clin Psychiatry 60: 563 - 567.
98. Goodwin GM, (1994) Recurrence of mania after lithium withdrawal. Implications for the use of lithium in the treatment of bipolar affective disorder. Br J Psychiatry 164: 149 - 152.
99. Goodwin GM, (2002) Hypomania - whats in a name. Br J Psychiatry 181: 94 - 95.
100. Goodwin GM, (2003) Evidence-based guidelines for treating bipolar disorder: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 17: 149 - 173.
101. Goodwin GM, Anderson I, Arango C, Bowden CL, Henry C, Mitchell PB, (2008) ECNP consensus meetin Bipolar depression. Nice, March 2007. Eur Neuropsychopharmacol 18: 535 - 549.
102. Goodwin GM, Bowden CL, Calabrese JR, Grunze H, Kasper S, White R, (2004) A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 65: 432 - 441.
103. Goodwin GM, Geddes JR, (2007) What is the heartland of psychiatry. Br J Psychiatry 191: 189 - 191.
104. Greil W, Ludwig-Mayerhofer W, Erazo N, Schöchlin C, Schmidt S, Engel RR, (1997) Lithium versus carbamazepine in the maintenance treatment of bipolar disorders-a randomised study. J Affect Disord 43: 151 - 161.
105. Grunhaus L, Schreiber S, Dolberg OT, Hirshman S, Dannon PN, (2002) Response to ECT in major depression: are there differences between unipolar and bipolar depression. Bipolar Disord 4: 91 - 93.
106. Gunderson JG, Weinberg I, Daversa MT, Kueppenbender KD, Zanarini MC, Shea MT, (2006) Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. Am J Psychiatry 163: 1173 - 1178.
107. Haddad PM, Pal BR, Clarke P, Wieck A, Sridhiran S, (2005) Neonatal symptoms following maternal paroxetine treatment: Serotonin toxicity or paroxetine discontinuation syndrome. J Psychopharmacol 19: 554 - 557.
108. Haddad PM, Wieck A, (2004) Antipsychotic-induced hyperprolactinaemia: Mechanisms, clinical features and management. Drugs 64: 2291 - 2314.
109. Harris EC, Barraclough B, (1997) Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170: 205 - 228.
110. Hartong EGTM, Moleman P, Hoogduin CAL, Broekman TG, Nolen WA, (2003) Prophylactic efficacy of lithium versus carbamazepine in treatment-naive bipolar patients. J Clin Psychiatry 64: 144 - 151.
111. Hawton K, (1987) Assessment of suicide risk. Br J Psychiatry 150: 145 - 153.
112. Hawton K, Sutton L, Haw C, Sinclair J, Harriss L, (2005) Suicide and attempted suicide in bipolar disorder: A systematic review of risk factors 12. J Clin Psychiatry 66: 693 - 704.
113. Hiller W, Dichtl G, Hecht H, Hundt W, von Zerssen D, (1993) An empirical comparison of diagnoses and reliabilities in ICD-10 and DSM-III-R. Eur Arch Psychiatry Clin Neurosci 242: 209 - 217.
114. Horne R, Weinman J, (1999) Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res 47: 555 - 567.
115. Howard L, Kirkwood G, Leese M, (2007) Risk of hip fracture in patients with a history of schizophrenia. Br J Psychiatry 190: 129 - 134.
116. Hoyer EH, Mortensen PB, Olesen AV, (2000) Mortality and causes of death in a total national sample of patients with affective disorders admitted for the first time between 1973 and 1993. Br J Psychiatry 176: 76 - 82.
117. Jacobson SJ, Jones K, Johnson K, Ceolin L, Kaur P, Sahn D, (1992) Prospective Multicenter Study of Pregnancy Outcome After Lithium Exposure During 1st Trimester. Lancet 339 (8792). 530 - 533.
118. Javaid MK, Cooper C, (2002) Prenatal and childhood influences on osteoporosis. Best Pract Res Clin Endocrinol Metab 16: 349 - 367.
119. Joffe H, (2007) Reproductive biology and psychotropic treatments in premenopausal women with bipolar disorder. J Clin Psychiatry 68: 10 - 15.
120. Johnson RE, McFarland BH, (1996) Lithium use and discontinuation in a health maintenance organization. Am J Psychiatry 153: 993 - 1000.
121. Johnstone EC, Crow TJ, Frith CD, Owens DG, (1988) The Northwick Park "functionalg" psychosis study: diagnosis and treatment response. Lancet 2: 119 - 125.
122. Jones I, Craddock N, (2001) Familiality of the puerperal trigger in bipolar disorder: Results of a family study. American Journal of Psychiatry 158 (6). 913 - 917.
123. Judd LL, Akiskal HS, Schettler PJ, Endicott J, Maser J, Solomon DA, (2002) The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 59: 530 - 537.
124. Kallen BAJ, Olausson PO, (2007) Maternal use of selective serotonin re-uptake inhibitors in early pregnancy and infant congenital malformations. Birth Defects Res Part A-Clin Mol Teratol 79: 301 - 308.
125. Källen B, Tandberg A, (1983) Lithium and Pregnancy - A Cohort Study on Manic-Depressive Women. Acta Psychiatrica Scandinavica 68 (2). 134 - 139.
126. Kaneko S, Battino D, Andermann E, Wada K, Kan R, Takeda A, (1999) Congenital malformations due to antiepileptic drugs. Epilepsy Res 33: 145 - 158.
127. Kapur S, Remington G, (2001) Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia. Annu Rev Med 52: 503 - 517.
128. Keck PE, Calabrese JR, McIntyre RS, McQuade RD, Carson WH, Eudicone JA, (2007) Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: A 100-week, double-blind study versus placebo. J Clin Psychiatry 68: 1480 - 1491.
129. Keck P-EJ, McElroy SL, Strakowski SM, Soutullo CA, (2000) Antipsychotics in the treatment of mood disorders and risk of tardive dyskinesia. J Clin Psychiatry 61 (Suppl. 4). 33 - 38.
130. Kemp R, Kirov G, Everitt B, Hayward P, David A, (1998) Randomised controlled trial of compliance therapy. 18-month follow-up. Br J Psychiatry 172: 413 - 419.
131. Kendell RE, (1987) Diagnosis and classification of functional psychoses. Br Med Bull 43: 499 - 513.
132. Kendell RE, Gourlay J, (1970) The clinical distinction between the affective psychoses and schizophrenia. Br J Psychiatry 117: 261 - 266.
133. Kessing LV, Andersen PK, Mortensen PB, Bolwig TG, (1998) Recurrence in affective disorder. I. Case register study. Br J Psychiatry 172: 23 - 28.
134. Kessing LV, Mortensen PB, (1999) Recovery from episodes during the course of affective disorder: a case-register study. Acta Psychiatr Scand 100: 279 - 287.
135. Kessler RC, Rubinow DR, Holmes C, Abelson JM, Zhao S, (1997) The epidemiology of DSM-III-R bipolar I disorder in a general population survey. Psychol Med 27: 1079 - 1089.
136. Ketter TA, Calabrese JR, (2002) Stabilization of mood from below versus above baseline in bipolar disorder: a new nomenclature. J Clin Psychiatry 63: 146 - 151.
137. Kilbourne AM, Cornelius JR, Han XY, Pincus HA, Shad M, Salloum I, (2004) Burden of general medical conditions among individuals with bipolar disorder. Bipolar Disord 6: 368 - 373.
138. Kupka RW, Altshuler LL, Nolen WA, Suppes T, Luckenbaugh DA, Leverich GS, (2007) Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord 9: 531 - 535.
139. Kushner SF, Khan A, Lane R, Olson WH, (2006) Topiramate monotherapy in the management of acute mania: results of four double-blind placebo-controlled trials. Bipolar Disord 8: 15 - 27.
140. Lam D, (2006) What can we conclude from studies on psychotherapy in bipolar disorder? Invited commentary on cognitive-behavioural therapy for severe and recurrent bipolar disorders. Br J Psychiatry 188: 321 - 322.
141. Lam D, Donaldson C, Brown Y, Malliaris Y, (2005a) Burden and marital and sexual satisfaction in the partners of bipolar patients. Bipolar Disord 7: 431 - 440.
142. Lam DH, Hayward P, Watkins ER, Wright K, Sham P, (2005b) Relapse prevention in patients with bipolar disorder: Cognitive therapy outcome after 2 years. Am J Psychiatry 162: 324 - 329.
143. Lam D, Watkins E, Hayward P, Bight J, Wright K, Kerr N, (2003) A randomised controlled study of cognitive therapy of relapse prevention for bipolar affective disorder - outcome of the first year. Arch Gen Psychiatry 60: 145 - 152.
144. Lebensohn ZM, (1999) The history of electroconvulsive therapy in the United States and its place in American psychiatry: a personal memoir. Compr Psychiatry 40: 173 - 181.
145. Lehman D, Meyer JM, (2005) Decreased bone mineral density in male schizophrenia patients. Schizophr Res 76: 131 - 133.
146. Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS, (2003) Defining clinical phenotypes of juvenile mania. American Journal of Psychiatry 160 (3). 430 - 437.
147. Leonard S, Adler LE, Benhammou K, Berger R, Breese CR, Drebing C, (2001) Smoking and mental illness. Pharmacol Biochem Behav 70: 561 - 570.
148. Leventhal H, Diefenbach M, Leventhal EA, (1992) Illness cognition: Using common sense to understand treatment adherence and affect cognition interactions. Cognit Ther Res 16: 143 - 163.
149. Leverich GS, McElroy SL, Suppes T, Keck Jr. P-E, Denicoff KD, Nolen WA, (2002) Early physical and sexual abuse associated with an adverse course of bipolar illness. Biol Psychiatry 51: 288 - 297.
150. Licht RW, (1998) Drug treatment of mania: a critical review. Acta Psychiatr Scand 97: 387 - 397.
151. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, (2005) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. New Engl J Med 353: 1209 - 1223.
152. Lingam R, Scott J, (2002) Treatment non-adherence in affective disorders. Acta Psychiatr Scand 105: 164 - 172.
153. Lish JD, Dime-Meenan S, Whybrow PC, Price RA, Hirschfeld RM, (1994) The National Depressive and Manic-depressive Association (DMDA) survey of bipolar members. J Affect Disord 31: 281 - 294.
154. Littlejohn R, Leslie F, Cookson J, (1994) Depot antipsychotics in the prophylaxis of bipolar affective disorder. Br J Psychiatry 165: 827 - 829.
155. Lloyd T, Jones PB, (2002) The Epidemiology of First-Onset Mania. In: MT Tsuang, M Tohen, (eds). Textbook in psychiatric epidemiology, Chichester, NY: Wiley-Liss, pp. 445 - 458.
156. Lowe MR, Batchelor DH, (1986) Depot neuroleptics and manic depressive psychosis. Int Clin Psychopharmacol 1 (Suppl. 1). 53 - 62.
157. MacQueen GM, Young LT, Joffe RT, (2001) A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand 103: 163 - 170.
158. Macritchie K, Geddes JR, Scott J, Haslam D, De Lima M, Goodwin G, (2003) Valproate for acute mood episodes in bipolar disorder (Cochrane Review). Cochrane Database Syst Rev: CD004052.
159. Macritchie KA, Geddes JR, Scott J, Haslam DR, Goodwin GM, (2001) Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev: CD003196.
160. Maj M, Pirozzi R, Formicola AM, Bartoli L, Bucci P, (2000) Reliability and validity of the DSM-IV diagnostic category of schizoaffective disorder: preliminary data. J Affect Disord 57: 95 - 98.
161. Maj M, Pirozzi R, Formicola AM, Tortorella A, (1999) Reliability and validity of four alternative definitions of rapid-cycling bipolar disorder. Am J Psychiatry 156: 1421 - 1424.
162. Malempati RN, Bond DJ, Yatham LN, (2008) Depot risperidone in the outpatient management of bipolar disorder: a 2-year study of 10 patients. Int Clin Psychopharmacol 23: 88 - 94.
163. Marangell LB, Suppes T, Zboyan HA, Prashad SJ, Fischer G, Snow D, (2008) A 1-year pilot study of vagus nerve stimulation in treatment-resistant rapid-cycling bipolar disorder. J Clin Psychiatry 69: 183 - 189.
164. Martinez-Aran A, Vieta E, Reinares M, Colom F, Torrent C, Sanchez-Moreno J, (2004) Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am J Psychiatry 161: 262 - 270.
165. McClellan J, Kowatch R, Findling RL, (2007) Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 46: 107 - 125.
166. McCombs JS, Ahn J, Tencer T, Shi LZ, (2007) The impact of unrecognized bipolar disorders among patients treated for depression with antidepressants in the fee-for-services California Medicaid (Medi-Cal) program: A 6-year retrospective analysis. J Affect Disord 97: 171 - 179.
167. McElroy SL, Keck P-EJ, Strakowski SM, (1996) Mania, psychosis, and antipsychotics. J Clin Psychiatry 57 (Suppl. 3). 14 - 26.
168. McKenna K, Koren G, Tetelbaum M, Wilton L, Shakir S, av-Citrin, O (2005) Pregnancy outcome of women using atypical antipsychotic drugs: A prospective comparative study. J Clin Psychiatry 66: 444 - 449.
169. Mendez MF, (2000) Mania in neurologic disorders. Curr Psychiatry Rep 2: 440 - 445.
170. Merikangas KR, Akiskal HS, Angst J, Greenberg PE, Hirschfeld RM, Petukhova M, (2007) Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 64: 543 - 552.
171. Meyer JM, Davis VG, Goff DC, McEvoy JP, Nasrallah HA, Davis SM, (2008) Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: Prospective data from phase 1. Schizophr Res 101: 273 - 286.
172. Meyer JM, Koro CE, (2004) The effects of antipsychotic therapy on serum lipids: a comprehensive review. Schizophr Res 70: 1 - 17.
173. Miklowitz DJ, Axelson DA, Birmaher B, George El, Taylor DO, Schneck CD, (2008) Family-focused treatment for adolescents with bipolar disorder - Results of a 2-year randomized trial. Archives of General Psychiatry 65 (9). 1053 - 1061.
174. Miklowitz DJ, George EL, Richards JA, Simoneau TL, Suddath RL, (2003) A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Arch Gen Psychiatry 60: 904 - 912.
175. Miklowitz DJ, Goldstein MJ, (1990) Behavioral Family Treatment for Patients with Bipolar Affective-Disorder. Behav Modif 14: 457 - 489.
176. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Kogan JN, Sachs GS, (2007) Intensive psychosocial intervention enhances functioning in patients with bipolar depression: Results from a 9-month Randomized controlled trial. Am J Psychiatry 164: 1340 - 1347.
177. Mitchell PB, Goodwin GM, Johnson GF, Hirschfeld RMA, (2008) Diagnostic guidelines for bipolar depression: a probabilistic approach. Bipolar Disord 10: 144 - 152.
178. Mitchell PB, Wilhelm K, Parker G, Austin MP, Rutgers P, Malhi GS, (2001) The clinical features of bipolar depression: a comparison with matched major depressive disorder patients. J Clin Psychiatry 62: 212 - 216.
179. Mizrahi R, Rusjan P, Agid O, Graff A, Mamo DC, Zipursky RB, (2007) Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D-2 receptors: A PET study in schizophrenia. Am J Psychiatry 164: 630 - 637.
180. Moller HJ, Baldwin DS, Goodwin G, Kasper S, Okasha A, Stein DJ, (2008) Do SSRIs or antidepressants in general increase suicidality? WPA section on pharmacopsychiatry: consensus statement. Eur Arch Psychiatry Clin Neurosci 258: 3 - 23.
181. Moller HJ, Bottlender R, Grunze H, Strauss A, Wittmann J, (2001) Are antidepressants less effective in the acute treatment of bipolar I compared to unipolar depression. J Affect Disord 67: 141 - 146.
182. Moller HJ, Grunze H, (2000) Have some guidelines for the treatment of acute bipolar depression gone too far in the restriction of antidepressants. Eur Arch Psychiatry Clin Neurosci 250: 57 - 68.
183. Monaco F, Cicolin A, (1999) Interactions between anticonvulsant and psychoactive drugs. Epilepsia 40 (Suppl. 10). S71 - S76.
184. Montgomery SA, Schatzberg AF, Guelfi JD, Kasper S, Nemeroff C, Swann A, (2000) Pharmacotherapy of depression and mixed states in bipolar disorder. J Affect Disord 59 (Suppl.1). S39 - S56.
185. Moreno C, Laje G, Blanco C, Jiang H, Schmidt AB, Olfson M, (2007) National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch Gen Psychiatry 64: 1032 - 1039.
186. Morriss R, Benjamin B, (2008) Lithium and eGFR: a new routinely available tool for the prevention of chronic kidney disease. Br J Psychiatry 193: 93 - 95.
187. Morriss R, Marshall M, Harris A, (2002) Bipolar affective disorder-left out in the cold. Too late for the national service framework but local initiatives may be possible. BMJ 324: 61 - 62.
188. Mukherjee S, Sackeim HA, Schnur DB, (1994) Electroconvulsive therapy of acute manic episodes: a review of 50 years' experience. Am J Psychiatry 151: 169 - 176.
189. Muller-Oerlinghausen B, Retzow A, Henn FA, Giedke H, Walden J, (2000) Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: a prospective, randomized, double-blind, placebo-controlled, multicenter study. European Valproate Mania Study Group. J Clin Psychopharmacol 20: 195 - 203.
190. Munk-Olsen T, Laursen TM, Pedersen CB, Mors O, Mortensen PB, (2006) New parents and mental disorders - A population-based register study. JAMA-Journal of the American Medical Association 296 (21). 2582 - 2589.
191. Naranjo CA, Herrmann N, Mittmann N, Bremner KE, (1995) Recent advances in geriatric psychopharmacology. Drugs Aging 7: 184 - 202.
192. National Institute for Health and Clinical Excellence (NICE) (2006) The management of bipolar disorder in adults, children and adolescents, in primary and secondary care. London: National Collaborating Centre for Mental Health.
193. Newcomer JW, (2007) Antipsychotic medications: Metabolic and cardiovascular risk. J Clin Psychiatry 68: 8 - 13.
194. Nutt DJ, Sharpe M, (2008) Uncritical positive regard? Issues in the efficacy and safety of psychotherapy. J Psychopharmacol 22: 3 - 6.
195. Oates M, (2003) Suicide: the leading cause of maternal death. Br J Psychiatry 183: 279 - 281.
196. Okuma T, Kishimoto A, (1998) A history of investigation on the mood stabilizing effect of carbamazepine in Japan. Psychiatry Clin Neurosci 52: 3 - 12.
197. Oquendo MA, Lizardi D, Greenwald S, Weissman MM, Mann JJ, (2004) Rates of lifetime suicide attempt and rates of lifetime major depression in different ethnic groups in the United States. Acta Psychiatr Scand 110: 446 - 451.
198. Oquendo MA, Waternaux C, Brodsky B, Parsons B, Haas GL, Malone KM, (2000) Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and nonattempters. J Affect Disord 59: 107 - 117.
199. Osborn DPJ, Levy G, Nazareth I, Petersen I, Islam A, King MB, (2007) Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Research Database. Arch Gen Psychiatry 64: 242 - 249.
200. Owen MJ, Craddock N, Jablensky A, (2007) The genetic deconstruction of psychosis. Schizophr Bull 33: 905 - 911.
201. Pande AC, Crockatt JG, Janney CA, Werth JL, Tsaroucha G, (2000) Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group. Bipolar Disord 2: 249 - 255.
202. Parker G, Tully L, Olley A, Hadzi-Pavlovic D, (2006) SSRIs as mood stabilizers for Bipolar II Disorder? A proof of concept study. J Affect Disord 92: 205 - 214.
203. Peet M, (1994) Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants. Br J Psychiatry 164: 549 - 550.
204. Perlick D, Clarkin JF, Sirey J, Raue P, Greenfield S, Struening E, (1999) Burden experienced by care-givers of persons with bipolar affective disorder. Br J Psychiatry 175: 56 - 62.
205. Perlis RH, Ostacher MJ, Patel JK, Marangell LB, Zhang HW, Wisniewski SR, (2006) Predictors of recurrence in bipolar disorder: Primary outcomes from the systematic treatment enhancement program for bipolar disorder (STEP-BD). American Journal of Psychiatry 163 (2). 217 - 224.
206. Perry A, Tarrier N, Morriss R, McCarthy E, Limb K, (1999) Randomised controlled trial of efficacy of teaching patients with bipolar disorder to identify early symptoms of relapse and obtain treatment. BMJ 318: 149 - 153.
207. Post RM, Altshuler LL, Leverich GS, Frye MA, Nolen WA, Kupka RW, (2006) Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. Br J Psychiatry 189: 124 - 131.
208. Post RM, Ketter TA, Pazzaglia PJ, Denicoff K, George MS, Callahan A, (1996) Rational polypharmacy in the bipolar affective disorders. Epilepsy Res 26 (Suppl. 11). 153 - 180.
209. Potash JB, DePaulo J-RJ, (2000) Searching high and low: a review of the genetics of bipolar disorder. Bipolar Disord 2: 8 - 26.
210. Powell J, Geddes J, Deeks J, Goldacre M, Hawton K, (2000) Suicide in psychiatric hospital in-patients - Risk factors and their predictive power. Br J Psychiatry 176: 266 - 272.
211. Prien RF, Caffey E-MJ, Klett CJ, (1972) Comparison of lithium carbonate and chlorpromazine in the treatment of mania. Report of the Veterans Administration and National Institute of Mental Health Collaborative Study Group. Arch Gen Psychiatry 26: 146 - 153.
212. Prien RF, Kupfer DJ, Mansky PA, Small JG, Tuason VB, Voss CB, (1984) Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination. Arch Gen Psychiatry 41: 1096 - 1104.
213. Rea MM, Tompson MC, Miklowitz DJ, Goldstein MJ, Hwang S, Mintz J, (2003) Family-focused treatment versus individual treatment for bipolar disorder: Results of a randomized clinical trial. J Consult Clin Psychol 71: 482 - 492.
214. Read J, van Os J, Morrison AP, Ross CA, (2005) Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 112: 330 - 350.
215. Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV, (2002) Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. J Affective Disord 70: 19 - 26.
216. Reinares A, Vieta E, Colom F, Martinez-Aran A, Torrent C, Comes A, (2006) What really matters to bipolar patients' caregivers: Sources of family burden. J Affective Disord 94: 157 - 163.
217. Reis M, Kallen B, (2008) Maternal use of antipsychotics in early pregnancy and delivery outcome. J Clin Psychopharmacol 28: 279 - 288.
218. Rice F, Jones I, Thapar A, (2007) The impact of gestational stress and prenatal growth on emotional problems in offspring: a review. Acta Psychiatr Scand 115: 171 - 183.
219. Robertson E, Jones I, Haque S, Holder R, Craddock N, (2005) Risk of puerperal and non-puerperal recurrence of illness following bipolar affective puerperal (post-partum) psychosis. British Journal of Psychiatry 186: 258 - 259.
220. Rosa FW, (1991) Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med 324: 674 - 677.
221. Rush AJ, Trivedi MH, Wisniewski SR, Stewart JW, Nierenberg AA, Thase ME, (2006) Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. New England Journal of Medicine 354 (12). 1231 - 1242.
222. Sachs GS, Grossman F, Ghaemi SN, Okamoto A, Bowden CL, (2002) Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety. Am J Psychiatry 159: 1146 - 1154.
223. Sachs GS, Nierenberg AA, Calabrese JR, Marangell LB, Wisniewski SR, Gyulai L, (2007) Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 356: 1711 - 1722.
224. Sachs GS, Printz DJ, Kahn DA, Carpenter D, Docherty JP, (2000) The Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder 2000. A Postgraduate Medicine Special Report. Aril 2000: 1 - 104.
225. Sajatovic M, (2002) Treatment of bipolar disorder in older adults. Int J Geriatr Psychiatry 17: 865 - 873.
226. Salloum IM, Thase ME, (2000) Impact of substance abuse on the course and treatment of bipolar disorder. Bipolar Disord 2: 269 - 280.
227. Samren EB, van Duijn CM, Christiaens GC, Hofman A, Lindhout D, (1999) Antiepileptic drug regimens and major congenital abnormalities in the offsprin Ann Neurol 46: 739 - 746.
228. Sato T, Bottlender R, Kleindienst N, Moller HJ, (2002) Syndromes and phenomenological subtypes underlying acute mania: a factor analytic study of 576 manic patients. Am J Psychiatry 159: 968 - 974.
229. Savitz JB, van der Merwe L, Stein DJ, Solms M, Ramesar RS, (2008) Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma. Bipolar Disord 10: 479 - 494.
230. Scott J, (1996) Cognitive therapy of affective disorders: a review. J Affect Disord 37: 1 - 11.
231. Scott J, Garland A, Moorhead S, (2001) A pilot study of cognitive therapy in bipolar disorders. Psychol Med 31: 459 - 467.
232. Scott J, Paykel E, Morriss R, Bentall R, Kinderman P, Johnson T, (2006) Cognitive-behavioural therapy for severe and recurrent bipolar disorders - Randomised controlled trial. Br J Psychiatry 188: 313 - 320.
233. Scott J, Pope M, (2002) Nonadherence with mood stabilizers: prevalence and predictors. J Clin Psychiatry 63: 384 - 390.
234. Scott J, Stanton B, Garland A, Ferrier IN, (2000) Cognitive vulnerability in patients with bipolar disorder. Psychol Med 30: 467 - 472.
235. Shekelle PG, Woolf SH, Eccles M, Grimshaw J, (1999a) Developing guidelines. BMJ 318: 593 - 596.
236. Shekelle PG, Woolf SH, Eccles M, Grimshaw J, (1999b) Clinical guidelines: developing guidelines. BMJ 318: 593 - 596.
237. Shelton RC, Papakostas GI, (2008) Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder. Acta Psychiatr Scand 117: 253 - 259.
238. Simon GE, Cunningham ML, Davis RL, (2002) Outcomes of prenatal antidepressant exposure. Am J Psychiatry 159: 2055 - 2061.
239. Simon GE, Ludman EJ, Bauer MS, Unutzer J, Operskalski B, (2006) Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry 63: 500 - 508.
240. Simon GE, Ludman EJ, Unutzer J, Bauer MS, Operskalski B, Rutter C, (2005) Randomized trial of a population-based care program for people with bipolar disorder. Psychol Med 35: 13 - 24.
241. Simon NM, Otto MW, Wisniewski SR, Fossey M, Sagduyu K, Frank E, (2004) Anxiety disorder comorbidity in bipolar disorder patients: Data from the first 500 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Am J Psychiatry 161: 2222 - 2229.
242. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, (2008) Whole-genome association study of bipolar disorder. Mol Psychiatry 13: 558 - 569.
243. Smith LA, Cornelius V, Warnock A, Tacchi MJ, Taylor D, (2007a) Acute bipolar mania: a systematic review and meta-analysis of co-therapy vs. monotherapy. Acta Psychiatr Scand 115: 12 - 20.
244. Smith LA, Cornelius V, Warnock A, Tacchi MJ, Taylor D, (2007b) Pharmacological interventions for acute bipolar mania: a systematic review of randomized placebo-controlled trials. Bipolar Disord 9: 551 - 560.
245. Smith LF, Whitfield MJ, (1995) Women's knowledge of taking oral contraceptive pills correctly and of emergency contraception: effect of providing information leaflets in general practice. Br J Gen Pract 45: 409 - 414.
246. Smith S, Yeomans D, Bushe CJP, Eriksson C, Harrison T, Holmes R, (2007c) A well-being programme in severe mental illness. Reducing risk for physical ill-health: A post-programme service evaluation at 2 years. Eur Psychiatry 22: 413 - 418.
247. Sproule BA, Hardy BG, Shulman KI, (2000) Differential pharmacokinetics of lithium in elderly patients. Drugs Aging 16: 165 - 177.
248. Straker D, Correll CU, Kramer-Ginsberg E, Abdulhamid N, Koshy F, Rubens E, (2005) Cost-effective screening for the metabolic syndrome in patients treated with second-generation antipsychotic medications. Am J Psychiatry 162: 1217 - 1221.
249. Strakowski SM, DelBello MP, Fleck DE, Arndt S, (2000) The impact of substance abuse on the course of bipolar disorder. Biol Psychiatry 48: 477 - 485.
250. Strakowski SM, MeElroy, SL, Keck, P-WJ, West, SA (1994) The co-occurrence of mania with medical and other psychiatric disorders. Int J Psychiatry Med 24: 305 - 328.
251. Suppes T, Eudicone J, McQuade R, Pikalov A, Carlson B, (2008) Efficacy and safety of aripiprazole in subpopulations with acute manic or mixed episodes of bipolar I disorder. J Affect Disord 107: 145 - 154.
252. Suppes T, Webb A, Paul B, Carmody T, Kraemer H, Rush AJ, (1999) Clinical outcome in a randomized 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania. Am J Psychiatry 156: 1164 - 1169.
253. Swann AC, Bowden CL, Calabrese JR, Dilsaver SC, Morris DD, (2002) Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania. Neuropsychopharmacology 26: 530 - 536.
254. Swartz HA, Frank E, (2001) Psychotherapy for bipolar depression: a phase-specific treatment strategy. Bipolar Disord 3: 11 - 22.
255. ten Have M, Vollebergh W, Bijl R, Nolen WA, (2002) Bipolar disorder in the general population in The Netherlands (prevalence, consequences and care utilisation). results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS). J Affect Disord 68: 203 - 213.
256. Terp IM, Mortensen PB, (1998) Post-partum psychoses. Clinical diagnoses and relative risk of admission after parturition. Br J Psychiatry 172: 521 - 526.
257. Thase ME, Jonas A, Khan A, Bowden CL, Wu XL, McQuade RD, (2008) Aripiprazole monotherapy in non-psychotic bipolar I depression. J Clin Psychopharmacol 28: 13 - 20.
258. The UK, ECT Review Group (2003) Electroconvulsive therapy - systematic review and meta-analysis of efficacy and safety in depressive disorders. Lancet 361: 799 - 808.
259. Thies-Flechtner K, Muller-Oerlinghausen B, Seibert W, Walther A, Greil W, (1996) Effect of prophylactic treatment on suicide risk in patients with major affective disorders. Data from a randomized prospective trial. Pharmacopsychiatry 29: 103 - 107.
260. Tohen M, Calabrese JR, Sachs GS, Banov MD, Detke HC, Risser R, (2006) Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine. Am J Psychiatry 163: 247 - 256.
261. Tohen M, Greil W, Calabrese JR, Sachs GS, Yatham LN, Oerlinghausen BM, (2005) Olanzapine versus lithium in the maintenance treatment of bipolar disorder: A 12-month, randomized, double-blind, controlled clinical trial. Am J Psychiatry 162: 1281 - 1290.
262. Tohen M, Vieta E, Calabrese J, Ketter TA, Sachs G, Bowden C, (2003) Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Arch Gen Psychiatry 60: 1079 - 1088.
263. Tondo L, Hennen J, Baldessarini RJ, (2001) Lower suicide risk with long-term lithium treatment in major affective illness: a meta-analysis. Acta Psychiatr Scand 104: 163 - 172.
264. Tondo L, Isacsson G, Baldessarini RJ, (2003) Suicidal behaviour in bipolar disorder - Risk and prevention 15. Cns Drugs 17: 491 - 511.
265. Tyrer SP, Brittlebank AD, (1993) Misdiagnosis of bipolar affective disorder as personality disorder. Can J Psychiatry 38: 587 - 589.
266. Valenti M, Benabarre A, Garcia-Amador M, Molina O, Bernardo M, Vieta E, (2008) Electroconvulsive therapy in the treatment of mixed states in bipolar disorder. Eur Psychiatry 23: 53 - 56.
267. Valtonen H, Suominen K, Mantere O, Leppamaki S, Arvilommi P, Isometsa EI, (2005) Suicidal ideation and attempts in bipolar I and II disorders. 11th, Journal of Clinical Psychiatry 66 (11). 1456 - 1462.
268. van Leeuwen AM, Molders J, Sterkmans P, Mielants P, Martens C, Toussaint C, (1977) Droperidol in acutely agitated patients. A double-blind placebo-controlled study. J Nerv Ment Dis 164: 280 - 283.
269. Vieta E, Phillips ML, (2007) Deconstructing bipolar disorder: a critical review of its diagnostic validity and a proposal for DSM-V and ICD-11. Schizophr Bull 33: 886 - 892.
270. Vieta E, Brecher M, Suppes T, Liu S, Paulsson B, (2008a) Quetiapine in the maintenance treatment of bipolar I disorder: Combined data from two long-term, phase III studies. Int J Neuropsychopharmacol 11: 185 - 186.
271. Vieta E, Calabrese JR, Goikolea JM, Raines S, Macfadden W, (2007) Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: a randomized, double-blind, placebo-controlled study. Bipolar Disord 9: 413 - 425.
272. Vieta E, Nieto E, Autet A, Rosa AR, Goikolea JM, Cruz N, (2008b) A long-term prospective study on the outcome of bipolar patients treated with long-acting injectable risperidone. World J Biol Psychiatry 9: 219 - 224.
273. Viguera AC, Nonacs R, Cohen LS, Tondo L, Murray A, Baldessarini RJ, (2000) Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. Am J Psychiatry 157: 179 - 184.
274. Viguera AC, Whitfield T, Baldessarini RJ, Newport DJ, Stowe Z, Reminick A, (2007) Risk of recurrence in women with bipolar disorder during pregnancy: Prospective study of mood stabilizer discontinuation. Am J Psychiatry 164: 1817 - 1824.
275. Wagner KD, Kowatch RA, Emslie GJ, Findling RL, Wilens TE, McCague K, (2006) A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents. Am J Psychiatry 163: 1179 - 1186.
276. Wals M, Hillegers MH, Reichart CG, Ormel J, Nolen WA, Verhulst FC, (2001) Prevalence of psychopathology in children of a bipolar parent. J Am Acad Child Adolesc Psychiatry 40: 1094 - 1102.
277. Wehr TA, Sack DA, Rosenthal NE, (1987) Sleep reduction as a final common pathway in the genesis of mania. Am J Psychiatry 144: 201 - 204.
278. Weisler RH, Calabrese JR, Thase ME, Arvekvist R, Stening G, Paulsson B, (2008) Efficacy of quetiapine monotherapy for the treatment of depressive episodes in bipolar I disorder: A post hoc analysis of combined results from 2 double-blind, randomized, placebo-controlled studies. J Clin Psychiatry 69: 769 - 782.
279. Weisler RH, Hirschfeld R, Cutler AJ, Gazda T, Ketter TA, Keck PE, (2006) Extended-release carbamazepine capsules as monotherapy in bipolar disorder - Pooled results from two randomised, double-blind, placebo-controlled trials. Cns Drugs 20: 219 - 231.
280. Weiss RD, Griffin ML, Kolodziej ME, Greenfield SF, Najavits LM, Daley DC, (2007) A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 164: 100 - 107.
281. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-6U7.
282. Wheeldon TJ, Robertson C, Eagles JM, Reid IC, (1999) The views and outcomes of consenting and non-consenting patients receiving ECT. Psychol Med 29: 221 - 223.
283. White E, Cheung P, Silverstone T, (1993) Depot antipsychotics in bipolar affective disorder. Int Clin Psychopharmacol 8: 119 - 122.
284. Winokur G, Coryell W, Keller M, Endicott J, Akiskal H, (1993) A prospective follow-up of patients with bipolar and primary unipolar affective disorder. Arch Gen Psychiatry 50: 457 - 465.
285. Wogelius P, Norgaard M, Gislum M, Pedersen L, Munk E, Mortensen PB, (2006) Maternal use of selective serotonin reuptake inhibitors and risk of congenital malformations. Epidemiology 17: 701 - 704.
286. Yazici O, Kora K, Polat A, Saylan M, (2004) Controlled lithium discontinuation in bipolar patients with good response to long-term lithium prophylaxis. J Affect Disord 80: 269 - 271.
287. Young AH, Carlsson A, Olausson B, Paulsson B, Brecher M, (2008) A double-blind, placebo-controlled study with acute and continuation phase of Quetiapine and Lithium in adults with bipolar depression (EMBOLDEN I). Eur Psychiatry 23: S239.
288. Young BK, Camicioli R, Ganzini L, (1997) Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment. Drugs Aging 10: 367 - 383.
289. Youngstrom EA, Birmaher B, Findling RL, (2008) Pediatric bipolar disorder: validity, phenomenology, and recommendations for diagnosis. Bipolar Disord 10: 194 - 214.
290. Zarate CA, Tohen M, (2004) Double-blind comparison of the continued use of antipsychotic treatment versus its discontinuation in remitted manic patients. Am J Psychiatry 161: 169 - 171.