Exon junction complex enhances translation of spliced mRNAs at multiple steps

Biochemical and Biophysical Research Communications

Volumn 384, Issue 3, 2009, Pages 334-340

  Lee, Hyung Chul ^a   Choe, Junho ^a   Chi, Sung Gil ^a   Kim, Yoon Ki ^a  

^a Korea University   (South Korea)

Author keywords

eIF4AIII; Exon junction complex; Internal ribosome entry site; Nonsense mediated mRNA decay; Splicing; Y14

Indexed keywords

INITIATION FACTOR 4A; MESSENGER RNA; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; EXON; EXON JUNCTION COMPLEX; GENE CONSTRUCT; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; INTRON; MOLECULAR MECHANICS; PRIORITY JOURNAL; RIBOSOME; RNA SPLICING; RNA TRANSLATION; WESTERN BLOTTING;

EUKARYOTIC INITIATION FACTOR-4A; EXONS; HELA CELLS; HUMANS; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA SPLICING; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS;

EID: 65649092162     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.123     Document Type: Article

References (29)

1. Le Hir H., Nott A., and Moore M.J. How introns influence and enhance eukaryotic gene expression. Trends Biochem. Sci. 28 (2003) 215-220
2. Diem M.D., Chan C.C., Younis I., and Dreyfuss G. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Nat. Struct. Mol. Biol. 14 (2007) 1173-1179
3. Gudikote J.P., Imam J.S., Garcia R.F., and Wilkinson M.F. RNA splicing promotes translation and RNA surveillance. Nat. Struct. Mol. Biol. 12 (2005) 801-809
4. Ma X.M., Yoon S.O., Richardson C.J., Julich K., and Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133 (2008) 303-313
5. Nott A., Le Hir H., and Moore M.J. Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev. 18 (2004) 210-222
6. Nott A., Meislin S.H., and Moore M.J. A quantitative analysis of intron effects on mammalian gene expression. RNA 9 (2003) 607-617
7. Tange T.O., Nott A., and Moore M.J. The ever-increasing complexities of the exon junction complex. Curr. Opin. Cell Biol. 16 (2004) 279-284
8. Le Hir H., Izaurralde E., Maquat L.E., and Moore M.J. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 19 (2000) 6860-6869
9. Behm-Ansmant I., Kashima I., Rehwinkel J., Sauliere J., Wittkopp N., and Izaurralde E. MRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett. 581 (2007) 2845-2853
10. Chang Y.F., Imam J.S., and Wilkinson M.F. The nonsense-mediated decay RNA surveillance pathway. Annu. Rev. Biochem. 76 (2007) 51-74
11. Isken O., and Maquat L.E. Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev. 21 (2007) 1833-1856
12. Hachet O., and Ephrussi A. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Nature 428 (2004) 959-963
13. Palacios I.M., Gatfield D., St Johnston D., and Izaurralde E. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 427 (2004) 753-757
14. Le Hir H., and Seraphin B. EJCs at the heart of translational control. Cell 133 (2008) 213-216
15. Giorgi C., and Moore M.J. The nuclear nurture and cytoplasmic nature of localized mRNPs. Semin. Cell Dev. Biol. 18 (2007) 186-193
16. Li Q., Imataka H., Morino S., Rogers Jr. G.W., Richter-Cook N.J., Merrick W.C., and Sonenberg N. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol. Cell. Biol. 19 (1999) 7336-7346
17. Kim Y.K., Back S.H., Rho J., Lee S.H., and Jang S.K. La autoantigen enhances translation of BiP mRNA. Nucleic Acids Res. 29 (2001) 5009-5016
18. Wilson J.E., Powell M.J., Hoover S.E., and Sarnow P. Naturally occurring dicistronic cricket paralysis virus RNA is regulated by two internal ribosome entry sites. Mol. Cell. Biol. 20 (2000) 4990-4999
19. Wilson J.E., Pestova T.V., Hellen C.U., and Sarnow P. Initiation of protein synthesis from the A site of the ribosome. Cell 102 (2000) 511-520
20. Kim Y.K., Furic L., Desgroseillers L., and Maquat L.E. Mammalian Staufen1 recruits Upf1 to specific mRNA 3′UTRs so as to elicit mRNA decay. Cell 120 (2005) 195-208
21. Gehring N.H., Neu-Yilik G., Schell T., Hentze M.W., and Kulozik A.E. Y14 and hUpf3b form an NMD-activating complex. Mol. Cell 11 (2003) 939-949
22. Lee H.C., Cho H., and Kim Y.K. Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation. Biochem. Biophys. Res. Commun. 369 (2008) 1160-1165
23. Oh N., Kim K.M., Choe J., and Kim Y.K. Pioneer round of translation mediated by nuclear cap-binding proteins CBP80/20 occurs during prolonged hypoxia. FEBS Lett. 581 (2007) 5158-5164
24. Cho H., Kim K.M., and Kim Y.K. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. Mol. Cell 33 (2009) 75-86
25. Ferraiuolo M.A., Lee C.S., Ler L.W., Hsu J.L., Costa-Mattioli M., Luo M.J., Reed R., and Sonenberg N. A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc. Natl. Acad. Sci. USA 101 (2004) 4118-4123
26. Kataoka N., Yong J., Kim V.N., Velazquez F., Perkinson R.A., Wang F., and Dreyfuss G. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol. Cell 6 (2000) 673-682
27. Shibuya T., Tange T.O., Stroupe M.E., and Moore M.J. Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. RNA 12 (2006) 360-374
28. Sun X., Perlick H.A., Dietz H.C., and Maquat L.E. A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. Proc. Natl. Acad. Sci. USA 95 (1998) 10009-10014
29. Doudna J.A., and Sarnow P. Translation initiation by viral internal ribosome entry sites. In: Mathews M.B., Sonenberg N., and Hershey J.W.B. (Eds). Translational Control in Biology and Medicine (2007), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 129-154