Prevalence of basal core promoter and precore mutations in Chinese chronic hepatitis B patients and correlation with serum HBeAg titers

Journal of Medical Virology

Volumn 81, Issue 5, 2009, Pages 807-814

  Qin, Yanli ^a,b   Zhang, Jiming ^a,b   Mao, Richeng ^a,b   Guo, Hongying ^a,b   Yin, Youkuan ^a,b   Wu, Xianghui ^a,b   Weng, Xinhua ^a,b   Wands, Jack ^c   Tong, Shuping ^c  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c BROWN UNIVERSITY   (United States)

Author keywords

Chronic hepatitis B; Core promoter mutations; Genotypes; HBeAg titer; Precore mutation; Restriction fragment length polymorphism

Indexed keywords

DNA; HEPATITIS B(E) ANTIGEN;

ADULT; ARTICLE; CHINESE; DNA SEQUENCE; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROPARTICLE ENZYME IMMUNOASSAY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREVALENCE; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VIRUS MUTATION; VIRUS TITRATION;

ADULT; BASE SEQUENCE; CHINA; DNA, VIRAL; FEMALE; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREVALENCE; PROMOTER REGIONS, GENETIC; PROTEIN PRECURSORS; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

HEPATITIS B VIRUS;

EID: 65649083350     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21439     Document Type: Article

References (38)

1. Alestig E, Hannoun C, Horal P, Lindh M. 2001. Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant. J Clin Microbiol 39:3200-3203.
2. Amini-Bavil-Olyaee S, Sarrami-Forooshani R, Adeli A, Mahboudi F, Sabahi F, Nafisi H, Zali MR, Azizi M. 2005. A novel accurate amplification created restriction site method for determination of the wild type and the precore mutant hepatitis B virus variants. J Virol Methods 127:19-23.
3. Arauz-Ruiz P, Norder H, Visona A, Magnius LO. 1997. Genotype F prevails in HBV infected patients of Hispanic origin in Central America and may carry the precore stop mutant. J Med Virol 51:305-312.
4. Baptista M, Kramvis A, Kew MC. 1999. High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 29:946-953.
5. Blum H, Liang T, Galun E, Wands J. 1991. Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. Hepatology 14:56-63.
6. Buckwold V, Xu Z, Chen M, Yen T, Ou J. 1996. Effects of a naturally occurring mutation in the hepatitis B virus basal core prooter on precore gene expression and viral replication. J Virol 70:5845-5851.
7. Carman WF, Hadziyannis S, Mcgarvey MJ, Jacyna MR, Karayiannis P, Makris A, Thomas C. 1989. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2:588-591.
8. Chan H, Hussain M, Lok A. 1999. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology 29:976-984.
9. Chu C, Lok A. 2002a. Clinical significance of hepatitis B virus genotypes. Hepatology 35:1274-1276.
10. Chu C, Hussain M, Lok A. 2002b. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 122:1756-1762.
11. Chu C, Keeffe EB, Han SH, Perrillo RP, Min AD, Soldevila-Pico C, Carey W, Jr., Luketic RB, Terrault VA, Lok NAS, and the U.S.HBV Epidemiology Study Group. 2003. Prevalence of HBV precore/core promoter variants in the United States. Hepatology 38:619-628.
12. Fried MW, Piratvisuth T, Lau GK, Maecellin P, Chow WC, Cookslev G, Luo KX, Paik SW, Liaw YF, Button P, Popescu M. 2008. HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon Alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology 47:428-434.
13. Honda A, Yokosuka O, Ehata T, Tagawa M, Imazeki F, Saisho H. 1999. Detection of mutations in the enhancer 2/core promoter region of hepatitis B virus in patients with chronic hepatitis B virus infection: Comparison with mutations in precore and core regions in relation to clinical status. J Med Virol 57:337-344.
14. Kao JH, Chen DS. 2002. Global control of hepatitis B virus infection. Lancet Infect Dis 2:395-403.
15. Kidd-Ljunggren K, Oberg M, Kidd A. 1997. Hepatitis B virus X gene 1751 to 1764 mutations: Implications for HBeAg status and disease. J Gen Virol 78:1469-1478.
16. Kirschberg O, Schüttler C, Repp R, Schaefer S. 2004. A multiplex-PCR to identify hepatitis B virus genotypes A-F. J Clin Virol 29:39-43.
17. Kurosaki M, Enomoto N, Asahina Y, Sakuna I, Ikada T, Tozuka S, Izumi N, Marumo F, Sato C. 1996. Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B. J Med Virol 49:115-123.
18. Li J-S, Tong SP, Wen Y-M, Vitvitski L, Zhang Q, Trepo C. 1993. Hepatitis B virus genotype A rarely circulates as an HBeAg-minus mutant: Possible contribution of a single nucleotide in the precore region. J Virol 67:5402-5410.
19. Lindh M, Hannoun C, Dhillon AP, Norkrans G, Horal P. 1999. Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers. J Infect Dis 179:775-782.
20. Lok AS, Akarca U, Greene S. 1994. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pregenome encapsidation signal. Proc Natl Acad Sci USA 91:4077-4081.
21. Magnius L, Norder H. 1995. Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology 38:24-34.
22. Moriyama K, Okamoto H, Tsuda F, Mayumi M. 1996. Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections. Virology 226:269-280.
23. Naito H, Hayashi S, Abe K. 2001. Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J Clin Microbiol 39:362-364.
24. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyakawa Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M. 1990. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64:1298-1303.
25. Okamoto H, Yotsumoto S, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi M. 1994. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 68:8102-8110.
26. Orito E, Ichida T, Sakugawa H, Sata M, Horiike N, Hino K, Okita K, Okanoue T, Iino S, Tanaka E, Suzuki K, Watanabe H, Hige S, Mizokami M. 2001a. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology 34:590-594.
27. Orito E, Mizokami M, Sakugawa H, Michitaka K, Ishikawa K, Ichida T, Okanoue T, Yotsuvanaqi H, Iino S. 2001b. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Hepatology 33:218-223.
28. Parekh S, Zoulim F, Ahn SH, Tsai A, Li JS, Kawai S, Khan N, Trépo C, Wands J, Tong SP. 2003. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 77:6601-6612.
29. Simmonds P, Midgley S. 2005. Recombination in the genesis and evolution of hepatitis B virus genotypes. J Virol 79:15467-15476.
30. Sumi H, Yokosuka O, Seki N, Arai M, Imazeki F, Kurihara T, Kanda T, Fukai K, Kato M, Saisho H. 2003. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology 37:19-26.
31. Takahashi K, Aoyama K, Ohno N, Iwata K, Akahane Y, Baba K, Yoshizawa H, Mishiro S. 1995. The precore/core promoter mutant (T1762A1764) of hepatitis B virus: Clinical significance and an easy method for detection. J Gen Virol 76:3159-3164.
32. Tamura K, Jakobsen I, Nei M. 2001. MEGA2: Molecular evolutionary genetics analysis software. Bioinformatics 17:1244-1245.
33. Tong SP, Li JS, Vitvitski L, Trépo C. 1990. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 176:596-603.
34. Tong SP, Diot C, Gripon P, Li JS, Vitviski L, Trépo C, Guguen-Guillouzo C. 1991. In vitro replication competence of a cloned hepatitis B virus variant with a nonsense mutation in the distal pre-C region. Virology 181:733-737.
35. Xing L, Zhu C, Shi H, Han F. 2000. Detection of core promoter mutants in chronic hepatitis B virus. Chinese J Exp Clin Virol 2:163-165.
36. Yuen M, Sablon E, Yuan H, Wong D, Hui C, Wong B, Chan A, Lai C. 2003. Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma. Hepatology 37:562-567. (Pubitemid 36258778)
37. Zeng G, Wang Z, Wen S, Jiang J, Wang L, Cheng J, Tan D, Xiao F, Ma S, Li W, Luo K, Naoumov NV, Hou J. 2005. Geographic distribution, virologic and clinical characteristics of hepatitis B virus genotypes in China. J Viral Hepat 12:609-617.
38. Zhou J, Zeng X, Yin Y, Guo X, Zhang J. 2004. Sequence diversity analysis of CagA gene and corresponding protein in Helicobacter pylori. World Chin J Digestol 12:1307-1312.