3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3999-4012

  Bhattacharjee, Apurba K ^a   Gordon, Jonathan A ^b   Marek, Elizabeth ^a   Campbell, Amy ^a   Gordon, Richard K ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Richard Montgomery High School   (United States)

Author keywords

3D pharmacophore; Antimuscarinic agents; BL58125; mAChEs; QSAR; Quantum chemical

Indexed keywords

(DIISOPROPYLAMINO)METHYL 4 AMINOBENZOATE; 1 [3 (DIMETHYLAMINO)PROPYL]PIPERIDIN 4 YL 2 HYDROXY 2,2 DIPHENYLACETATE; 1 ETHYL 1 [2 (3 HYDROXY 2 PHENYLPROPANOYLOXY)ETHYL]PIPERIDINIUM; 1 METHYLPIPERIDIN 4 YL 3 HYDROXY 2 [4 (TRIFLUOROMETHYL)PHENYL]PROPANOATE; 2 (2,2 DIPHENYLACETOXY) N,N,N TRIMETHYLETHANAMINIUM; 2 (3,4 DICHLOROPHENYLAMINO) N,N DIETHYL N METHYL 2 OXOETHANAMINIUM; 2 (DIETHYLAMINO)ETHYL 2,2 DIPHENYLPROPANOATE; 2 [(HYDROXYIMINO)METHYL] 1 METHYL 3 (TERT PENTYLOXYMETHYL) 1H IMIDAZOL 3 IUM; 2,2 DIPHENYLPROPIONATE DERIVATIVE; 4 [2 (BENZOYLOXY)PROPAN 2 YL] 3 METHYLTHIAZOL 3 IUM; 4 CYCLOPENTYL 4 HYDROXY N,N,N TRIMETHYL 4 (THIOPHEN 2 YL)BUT 2 YN 1 AMINIUM; AB 39587; AE 04963; AE 08907; AF 70711; AJ 78856; AS 67031; ATROPINE; BL 09220; BL 13260; BL 58125; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; ZW 62841;

ARTICLE; COMPUTER MODEL; DRUG SYNTHESIS; HYDROGEN BOND; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY; REACTION ANALYSIS; RECEPTOR BLOCKING;

ANIMALS; ATROPINE; CELL LINE; GUINEA PIGS; ILIUM; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; PANCREAS; PROPIONATES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUANTUM THEORY; RATS;

CAVIA; RATTUS;

EID: 65549169007     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.001     Document Type: Article

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