Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents

European Journal of Pharmacology

Volumn 521, Issue 1-3, 2005, Pages 59-69

  Loke, Weng Keong ^a   Sim, Meng Kwoon ^b   Go, Mei Lin ^b  

^a DSO NATIONAL LABORATORIES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Acetylcholine; Anticonvulsant effect; Non reactivation effect; Pralidoxime derivative; Sedative effect; Soman poisoning

Indexed keywords

ACETYLCHOLINE; ATROPINE; BENZYL DERIVATIVE; O BENZYLPYRIDINE 2 CARBALDOXIME METHIODIDE; O BUT 2 YNYLPYRIDINE 2 CARBALDOXIME METHIODIDE; O METHYLPYRIDINE 2 CARBALDOXIME METHIODIDE; O PROP 2 YNYLPYRIDINE 2 CARBALDOXIME METHIODIDE; PRALIDOXIME; SOMAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; ATTENUATION; CONTROLLED STUDY; CONVULSION; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROENCEPHALOGRAM; FEMALE; HISTOPATHOLOGY; INTOXICATION; LD 50; MICRODIALYSIS; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEDATION;

3,4-DIHYDROXYPHENYLACETIC ACID; ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; ATROPINE; BENZENE DERIVATIVES; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; CORPUS STRIATUM; DOPAMINE; DRUG SYNERGISM; ELECTROENCEPHALOGRAPHY; FEMALE; HOMOVANILLIC ACID; HYDROXYINDOLEACETIC ACID; MICE; MICRODIALYSIS; NEUROPROTECTIVE AGENTS; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; SEIZURES; SEROTONIN; SOMAN; SURVIVAL RATE; TIME FACTORS;

EID: 26444463117     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.07.033     Document Type: Article

References (21)

1. L.M. Borland, and A.C. Michael Voltammetric study of the control of striatal dopamine release by glutamate Journal of Neurochemistry 91 2004 220 229
2. Y.L. Bronstein, and L.C. Cummings Neurochemistry of frontal-subcortical circuits D.G. Lichter L.C. Cummings Frontal-subcortical Circuits in Psychiatric and Neurological Disorders 2001 The Guilford Press New York, NY 65 73
3. M.G. Hamilton, and P.M. Lundy HI-6 therapy of soman and tabun poisoning in primates and rodents Archives of Toxicology 63 1989 144 149
4. N. Howard-Jones A CIOMS ethical code for animal experimentation WHO Chronicals 39 1985 51 56
5. 3H-N-methylscopolamine binding in guinea-pig myocardium by an antidote against organophosphate intoxication Pharmacology and Toxicology 63 1988 163 168
6. Y. Kloog, R. Galron, D. Balderman, and M. Sokolovsky Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximes Archives of Toxicology 58 1985 37 39
7. W.K. Loke, M.K. Sim, and M.L. Go O-substituted derivatives of pralidoxime: muscarinic properties and protection against soman pressor effects in rats European Journal of Pharmacology 442 2002 279 287
8. J.H. McDonough Jr., and T.-M. Shih Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology Neuroscience and Biobehavioural Reviews 21 1997 559 579
9. J.H. McDonough Jr., T.R. Clark, T.W. Slone Jr., D. Zoeffel, K. Brown, S. Kim, and C.D. Smith Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by the nerve agent soman Neurotoxicology 19 3 1998 381 392
10. M. Prioux-Guyonneau, C. Coudray-Lucas, H.M. Cog, Y. Cohen, and J. Wepierre Modification of rat brain 5-hydroxytryptamine metabolism by sublethal doses of organophosphate agents Acta Pharmacologica et Toxicologica 51 1982 278 284
11. T.M. Shih, and J.H. McDonough Jr. Neurochemical mechanisms in soman-induced seizures Journal of Applied Toxicology 17 4 1997 255 264
12. T.M. Shih, C.E. Whalley, and J.J. Valdes A comparison of cholinergic effects of hi-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning Toxicology Letters 55 1991 131 147
13. T.M. Shih, J.H. McDonough Jr., and I. Koplovitz Anticonvulsants for soman-induced seizure activity Journal of Biomedical Science 6 1999 86 96
14. J.S. Silvestre, A.G. Fernandez, and J.M. Palacios Preliminary evidence for an involvement of the cholinergic system in the sedative effects of rolipram in rats Pharmacology, Biochemistry and Behaviour 64 1 1999 1 5
15. M.K. Sim, and S.E. Lim Discovery of a novel soluble form of monoamine oxidase in the rat brain Biochemical Pharmacology 43 6 1992 1181 1184
16. S. Sparenborg, L.H. Brennecke, and E.T. Beers Pharmacological dissociation of the motor and electrical aspects of convulsive status epilepticus induced by the cholinesterase inhibitor soman Epilepsy Research 14 1993 95 103
17. D.M. Treiman, N.Y. Walton, and C. Kendrick A progressive sequence of electroencephalographic changes during generalised convulsive status epilepticus Epilepsy Research 5 1990 49 60
18. H.P.M. van Helden, R.W. Busker, B.P.C. Melchers, and P.L.B. Bruijnzeel Pharmacological effects of oximes: how relevant are they? Archives of Toxicology 70 1996 779 786
19. 5 muscarinic receptor knock-out mice The Journal of Neuroscience 22 15 2002 6347 6352
20. L.A. Zimmer, M. Ennis, M. El-Etri, and M.T. Shipley Anatomical localization and time course of Fos expression following soman-induced seizures The Journal of Comparative Neurology 378 1997 468 481
21. L.A. Zimmer, M. Ennis, R.G. Wiley, and M.T. Shipley Nerve gas-induced seizures: role of acetylcholine in the rapid induction of Fos and glial fibrillary acidic protein in piriform cortex The Journal of Neuroscience 18 10 1998 3897 3908