Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa

Malaria Journal

Volumn 6, Issue , 2007, Pages

  Nahum, Alain ^a   Erhart, Annette ^b   Gazard, Dorothée ^c   Agbowai, Carine ^a   Van Overmeir, Chantal ^b   Van Loen, Harry ^b   Menten, Joris ^b   Akogbeto, Martin ^a   Coosemans, Marc ^b   Massougbodji, Achille ^c   D'Alessandro, Umberto ^b  

^a Centre de Recherches Entomologiques de Cotonou (CREC)   (Benin)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c UNIVERSITY OF ABOMEY CALAVI   (Benin)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ARTEMETHER PLUS BENFLUMETOL; ARTESUNATE; CHLOROQUINE; FANSIDAR; PYRIMETHAMINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; SESQUITERPENE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE; UNCLASSIFIED DRUG;

AFRICA; ARTICLE; BENIN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG LEGISLATION; DRUG POTENTIATION; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; POLYMERASE CHAIN REACTION; PREGNANT WOMAN; PRESCHOOL CHILD; PREVALENCE; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TREATMENT FAILURE; TREATMENT OUTCOME; ANALYSIS OF VARIANCE; ANEMIA; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION; DRUG EFFECT; FEVER; FOLLOW UP; KAPLAN MEIER METHOD; PARASITOLOGY; PLASMODIUM FALCIPARUM; RESPIRATORY TRACT INFECTION; TIME;

ANALYSIS OF VARIANCE; ANEMIA; ANIMALS; ANTIMALARIALS; ARTEMISININS; BENIN; CHILD, PRESCHOOL; CHLOROQUINE; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; FEVER; FOLLOW-UP STUDIES; HUMANS; INFANT; KAPLAN-MEIERS ESTIMATE; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; RESPIRATORY TRACT INFECTIONS; SESQUITERPENES; SULFADOXINE; TIME FACTORS; TREATMENT OUTCOME;

EID: 39549084968     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-6-170     Document Type: Article

References (27)

1. Programme National de Lutte contre le Paludisme, Politique nationale de lutte contre le paludisme et cadre stratégique de mise en æuvre. Cotonou 2005
2. Programme National de Lutte contre le Paludisme, Atelier de consensus sur le changement de la politique de traitement antipaludique. Cotonou 2004
3. Programme National de Lutte contre le Paludisme, Reprise du dépouillement des fiches de suivi et individuelles des enfants retenus pour le test de chimiosensibilité réalisé en 2002 au Bénin. Cotonou 2003
4. Chloroquine-resistant falciparum malaria in Benin. J Le Bras I Hatin P Bourée O Coco-Cianci J-P Garin M Rey G Charmot R Roue, Lancet 1986 2 1043 1044 10.1016/S0140-6736(86)92657-7 2877211
5. Five cases of chloroquine-resistant malaria in Benin, Africa. M Rosenheim T Prazuck O Brandicourt B Diquet A Datry M Danis M Gentilini, Trans R Soc Trop Med Hyg 1987 81 498 10.1016/0035-9203(87)90174-X 3318023
6. Evolution de la chimio-sensibilité de Plasmodium falciparum à la chloroquine et à la méfloquine au Bénin entre 1980 et 1989. J-P Chippaux A Massougbodji M Akogbeto R Josse T Zohoun B-C Sadeler, Bull Soc Path Ex 1990 83 320 329
7. Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission: [WHO/MAL/96.1077]. Geneva 1996
8. Report of a WHO consultation, Monitoring anti-malarial drugs resistance. Geneva 2002
9. Programme National de Lutte contre le Paludisme, Information essentielles sur le Traitement Préventif Intermittent Infantile du paludisme (TPIi). Cotonou 2006
10. Etude des aspects épidémiologiques du paludisme côtier lagunaire au Bénin. M Akogbeto, Thèse de Doctorat ès-Science Université de Paris XI 1992
11. Le paludisme urbain côtier à Cotonou (République du Bénin). Etude entomologique. M Akogbeto J-P Chippaux M Coluzzi, Rev Epidemiol Santé Publique 1992 40 233 9
12. Malaria transmission in the lagoon area of Cotonou, Benin. M Akogbeto D Modiano A Bosman, Parassitologia 1992 34 147 154 1339969
13. Severe falciparum malaria. World Health Organization, Trans R Soc Trop Med Hyg 2000 94 1 90 10.1016/S0035-9203(00)90300-6 10748883
14. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. CV Plowe A Djimde M Bouare O Doumbo TE Wellems, Am J Trop Med Hyg 1995 52 565 568 7611566
15. Frequency of cross-fertilization in the human malaria parasite Plasmodium falciparum. LC Ranford-Cartwright P Balfe R Carter D Walliker, Parasitology 1993 107 11 18 8355994
16. World Health Organization, Assessment and monitoring of antimalarial drug efficay for the treatment of uncomplicated falciparum malaria. Geneva 2003
17. A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria. FP Mockenhaupt S Ehrhardt SY Dzisi J Teun Bousema N Wassilew J Schreiber SD Anemana JP Cramer RN Otchwemah RW Sauerwein TA Eggelte U Bienzle, Trop Med Int Health 2005 10 512 520 10.1111/j.1365-3156.2005.01427.x 15941413
18. Efficacies of artesunate plus, either sulfadoxine-pyrimethamine or amodiaquine, for the treatment of uncomplicated Plasmodium falciparum malaria in Eastern Sudan. AM Ibrahium MM Kheir ME Osman IF Khalil M Alifrangis KA Elmardi EM Malik I Adam, Ann Trop Med Parasitol 2007 101 15 21 10.1179/136485907X156924 17244406
19. Genetic alteration in drug resistance markers of Plasmodium falciparum. YD Sharma, Indian J Med Res 2005 121 13 22 15713974
20. Mutations in Plasmodium falciparum digestive vacuole transmembrane protein Pfcrt and evidence for their role in chloroquine resistance. DA Fidock T Nomura AT Talley RA Cooper S Dzekunov MT Ferdig LM Ursos AS Sidhu B Naude K Deitsch XZ Su JC Wootton PD Roepe TE Wellems, Mol Cell 2000 6 861 871 10.1016/S1097-2765(05)00077-8 11090624
21. A molecular marker for chloroquine-resistant falciparum malaria. A Djimde OK Doumbo JF Cortese K Kayentao S Doumbo Y Diourte A Dicko XZ Su T Nomura DA Fidock TE Wellems CV Plowe D Coulibaly, N Engl J Med 2001 344 257 263 10.1056/NEJM200101253440403 11172152
22. Evidence for selection for the tyrosine-86 allele of the Pfmdr1 gene of Plasmodium falciparum by chloroquine and amodiaquine. MT Duraisingh CJ Drakeley O Muller R Bailey G Snounou GAT Targett BM Greenwood DC Warhurst, Parasitology 1997 114 205 211 10.1017/S0031182096008487 9075340
23. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. CT Happi GO Gbotosho OA Folarin OM Bolaji A Sowunmi DE Kyle W Milhous DF Wirth AMJ Oduola, Am J Trop Med Hyg 2006 75 155 161 16837724
24. Roles specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. C Dokomajilar ZM Lankoande G Dorsey I Zongo J-B Ouedraogo PJ Rosenthal, Am J Trop Med Hyg 2006 75 162 165 16837725
25. Effects of artesunate-mefloquine combination resistance in western Thailand: a prospective study. F Nosten M van Vugt R Price C Luxemburger KL Thaway A Brockman R McGready F ter Kuile S Looareesuwan NJ White, Lancet 2000 356 297 302 10.1016/S0140-6736(00)02505-8 11071185
26. Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria. K Stepniewska NJ White, Malar J 2006 22 127 10.1186/1475-2875-5-127
27. A cost-effectiveness analysis of artemether lumefantrine for treatment of uncomplicated malaria in Zambia. P Chanda F Masiye BM Chitah N Sipilanyambe M Hawela P Banda T Okorosobo, Malar J 2007 6 21 17313682 10.1186/1475-2875-6-21