Effects of cytokines on mechanical and epithelial bioelectric responses to methacholine and hyperosmolarity in guinea-pig airways: An in vitro study

European Journal of Pharmacology

Volumn 612, Issue 1-3, 2009, Pages 115-121

  Ismailoglu, Ugur B ^a,b   Scott, Michael R Van ^c   Fedan, Jeffrey S ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Cytokine; Epithelium derived relaxing factor; Guinea pig trachea; Hyperosmolarity; Lipopolysaccharide; Smooth muscle contractility; Transepithelial potential difference

Indexed keywords

EPITHELIUM DERIVED RELAXING FACTOR; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MANNITOL; METHACHOLINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AIRWAY CONSTRICTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; GUINEA PIG; HYPEROSMOLARITY; HYPERPOLARIZATION; IN VITRO STUDY; MALE; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE; TRACHEA MUSCLE;

ANIMALS; BIOMECHANICS; BRONCHOCONSTRICTOR AGENTS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; EPITHELIAL CELLS; GUINEA PIGS; LIPOPOLYSACCHARIDES; MALE; METHACHOLINE CHLORIDE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OSMOLAR CONCENTRATION; PERFUSION; RESPIRATORY MUCOSA; RESPIRATORY SYSTEM; TIME FACTORS; TRACHEA;

EID: 65549164426     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.04.025     Document Type: Article

References (37)

1. Ahdieh M., Vandenbos T., and Youakim A. Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ. Am. J. Physiol. Cell. Physiol. 281 (2001) C2029-2038
2. Brass D.M., Savov J.D., Gavett S.H., Haykal-Coates N., and Schwartz D.A. Subchronic endotoxin inhalation causes persistent airway disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 285 (2003) L755-761
3. Brass D.M., Savov J.D., Whitehead G.S., Maxwell A.B., and Schwartz D.A. LPS binding protein is important in the airway response to inhaled endotoxin. J. Allergy Clin. Immunol. 114 (2004) 586-592
4. Chen H., Munakata M., Amishima M., Ukita H., Masaki Y., Homma Y., and Kawakami Y. Gamma-interferon modifies guinea pig airway functions in vitro. Eur. Respir. J 7 (1994) 74-80
5. Coyne C.B., Vanhook M.K., Gambling T.M., Carson J.L., Boucher R.C., and Johnson L.G. Regulation of airway tight junctions by proinflammatory cytokines. Mol. Biol. Cell 13 (2002) 3218-3234
6. Dortch-Carnes J., Van Scott M.R., and Fedan J.S. Changes in smooth muscle tone during osmotic challenge in relation to epithelial bioelectric events in guinea pig isolated trachea. J. Pharmacol. Exp. Ther. 289 (1999) 911-917
7. Fedan J.S., Dowdy J.A., Johnston R.A., and Van Scott M.R. Hyperosmolar solution effects in guinea pig airways. I. Mechanical responses to relative changes in osmolarity. J. Pharmacol. Exp. Ther. 308 (2004) 10-18
8. Fedan J.S., and Frazer D.G. Influence of epithelium on the reactivity of guinea pig isolated, perfused trachea to bronchoactive drugs. J. Pharmacol. Exp. Ther. 262 (1992) 741-750
9. Fedan J.S., Millecchia L.L., Johnston R.A., Rengasamy A., Hubbs A., Dey R.D., Yuan L.X., Watson D., Goldsmith W.T., Reynolds J.S., Orsini L., Dortch-Carnes J., Cutler D., and Frazer D.G. Effect of ozone treatment on airway reactivity and epithelium-derived relaxing factor in guinea pigs. J. Pharmacol. Exp. Ther. 293 (2000) 724-734
10. Fedan J.S., Warner T.E., Yuan L.X., Robinson V., and Frazer D.G. Nitric oxide synthase inhibitor and lipopolysaccharide effects on reactivity of guinea pig airways. J. Pharmacol. Exp. Ther. 272 (1995) 1141-1150
11. Fedan J.S., Wu D.X., and Van Scott M.R. Altered ion transport and responsiveness to methacholine and hyperosmolarity in air interface-cultured guinea-pig tracheal epithelium. J Pharmacol. Toxicol. Methods 55 (2007) 135-143
12. Galietta L.J., Folli C., Marchetti C., Romano L., Carpani D., Conese M., and Zegarra-Moran O. Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-γ. Am. J. Physiol. Lung Cell. Mol. Physiol. 278 (2000) L1186-1194
13. Galietta L.J., Pagesy P., Folli C., Caci E., Romio L., Costes B., Nicolis E., Cabrini G., Goossens M., Ravazzolo R., and Zegarra-Moran O. IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J. Immunol. 168 (2002) 839-845
14. Grunig G., Warnock M., Wakil A.E., Venkayya R., Brombacher F., Rennick D.M., Sheppard D., Mohrs M., Donaldson D.D., Locksley R.M., and Corry D.B. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282 (1998) 2261-2263
15. Huang J., Frazer D.G., Millecchia L.L., and Fedan J.S. Brief exposure of air-filled guinea-pig isolated trachea to low levels of toluene diisocyanate (TDI) vapor in vitro increases reactivity to methacholine. Toxicology 124 (1997) 83-93
16. Ismailoglu U.B., Sahin-Erdemli I., Sungur A., and Ilhan M. Effects of lipopolysaccharide on epithelium-dependent relaxation in coaxial bioassay. Eur. J. Pharmacol. 487 (2004) 233-239
17. Jiang H., Qu J., He L., Pan J., Chen X., Li L., Zhu D., and Cao Y. Airway hyperresponsiveness induced by repetitive intraperitoneal injection of lipopolysacharide and the involvement of inflammation and nitric oxide in guinea pigs. Inflamm Res 55 (2006) 286-292
18. Johnston R.A., Van Scott M.R., Kommineni C., Millecchia L.L., Dortch-Carnes J., and Fedan J.S. Hyperosmolar solution effects in guinea pig airways. IV. Lipopolysaccharide-induced alterations in airway reactivity and epithelial bioelectric responses to methacholine and hyperosmolarity. J. Pharmacol. Exp. Ther. 308 (2004) 37-46
19. Kuperman D.A., Huang X., Koth L.L., Chang G.H., Dolganov G.M., Zhu Z., Elias J.A., Sheppard D., and Erle D.J. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8 (2002) 885-889
20. Martin T.R. Recognition of bacterial endotoxin in the lungs. Am. J. Respir. Cell Mol. Biol. 23 (2000) 128-132
21. Michel O., Kips J., Duchateau J., Vertongen F., Robert L., Collet H., Pauwels R., and Sergysels R. Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care Med. 154 (1996) 1641-1646
22. Monick M.M., Yarovinsky T.O., Powers L.S., Butler N.S., Carter A.B., Gudmundsson G., and Hunninghake G.W. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J. Biol. Chem. 278 (2003) 53035-53044
23. Munakata M., Chen H., Nasuhara Y., Sato A., Takahashi T., Sato R., Homma Y., and Kawakami Y. Interleukin-1 beta decreases sensitivity of guinea-pig airway to potassium chloride and isoproterenol by an epithelium-dependent mechanism. Respirology 1 (1996) 61-67
24. Munakata M., Mitzner W., and Menkes H. Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea. J. Appl. Physiol. 64 (1988) 466-471
25. Murakami D., Yamada H., Yajima T., Masuda A., Komune S., and Yoshikai Y. Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses. Clin. Exp. Allergy 37 (2007) 339-347
26. Perkins C., Wills-Karp M., and Finkelman F.D. IL-4 induces IL-13-independent allergic airway inflammation. J. Allergy Clin. Immunol. 118 (2006) 410-419
27. Saito T., Yamamoto T., Kazawa T., Gejyo H., and Naito M. Expression of toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouse. Cell Tissue Res. 321 (2005) 75-88
28. Savov J.D., Brass D.M., Lawson B.L., McElvania-Tekippe E., Walker J.K., and Schwartz D.A. Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. Am. J. Physiol. Lung Cell. Mol. Physiol. 289 (2005) L329-337
29. Shore S.A., and Moore P.E. Effects of cytokines on contractile and dilator responses of airway smooth muscle. Clin. Exp. Pharmacol. Physiol. 29 (2002) 859-866
30. Smerz-Bertling C., and Duschl A. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270 (1995) 966-970
31. Smith J.A., Frazer D.G., and Fedan J.S. Alteration in the modulatory role of respiratory epithelium after exposure of guinea pigs to respirable cotton dust. J. Pharmacol. Exp. Ther. 264 (1993) 683-688
32. Suzuki K., Kawahara K., Terada N., Nomura T., Konno A., and Fukuda Y. Effect of ion transport inhibitors and methacholine on short-circuit current of isolated guinea pig nasal epithelium. Jpn. J. Physiol. 49 (1999) 99-106
33. Tamaoki J., Yamawaki I., Takeyama K., Chiyotani A., Yamauchi F., and Konno K. Interleukin-1 beta inhibits airway smooth muscle contraction via epithelium-dependent mechanism. Am. J Respir. Crit. Care Med. 149 (1994) 134-137
34. Tliba O., Deshpande D., Chen H., Van Besien C., Kannan M., Panettieri Jr. R.A., and Amrani Y. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br. J. Pharmacol. 140 (2003) 1159-1162
35. Toward T.J., and Broadley K.J. Airway reactivity, inflammatory cell influx and nitric oxide in guinea-pig airways after lipopolysaccharide inhalation. Br J Pharmacol 131 (2000) 271-281
36. Wills-Karp M., Luyimbazi J., Xu X., Schofield B., Neben T.Y., Karp C.L., and Donaldson D.D. Interleukin-13: central mediator of allergic asthma. Science 282 (1998) 2258-2261
37. Wu Z.X., Satterfield B.E., Fedan J.S., and Dey R.D. Interleukin-1β-induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway. Am. J. Physiol. Lung Cell. Mol. Physiol. 283 (2002) L909-917