One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene

Journal of Bioscience and Bioengineering

Volumn 107, Issue 6, 2009, Pages 596-598

  Machida, Kazuhiro ^a   Aritoku, Yasuhide ^a   Tsuchida, Toshio ^a  

^a MERCIAN CORPORATION   (Japan)

Author keywords

Cytochrome P450 monooxygenase; Fermentation; One pot; Pladienolide; Streptomycetes

Indexed keywords

CYTOCHROME P450 GENES; CYTOCHROME P450 MONOOXYGENASE; HYDROXYLASE; ONE-POT; PLADIENOLIDE; PLATENSIS; PRODUCTION LEVELS; STREPTOMYCES PLATENSIS; STREPTOMYCETES;

BIOCHEMICAL ENGINEERING; FERMENTATION;

GENE ENCODING;

ANTINEOPLASTIC AGENT; CYTOCHROME P450; DNA FRAGMENT; PLADIENOLIDE; PLADIENOLIDE D; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BIOSYNTHESIS; CANCER CELL CULTURE; FERMENTATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLDA GENE; POLYMERASE CHAIN REACTION; PROMOTER REGION; STREPTOMYCES; STREPTOMYCES PLATENSIS;

BACTERIAL PROTEINS; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; FERMENTATION; MACROLIDES; STREPTOMYCES;

STREPTOMYCES PLATENSIS; STREPTOMYCINEAE;

EID: 65549156148     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.01.023     Document Type: Article

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